DT-Web

DB00165 - Pyridoxine


Identification
Name Pyridoxine
Accession Number DB00165 (APRD00204, NUTR00002)
Type small molecule
Description Pyridoxine is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body. Pyridoxal 5-phosphate is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and vitamin B6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 169.1778
Groups approved
Monoisotopic Weight 169.073893223
Pharmacology
Indication For the treatment of vitamin B6 deficiency and for the prophylaxis of isoniazid-induced peripheral neuropathy.
Mechanism of action Vitamin B6 is the collective term for a group of three related compounds, pyridoxine (PN), pyridoxal (PL) and pyridoxamine (PM), and their phosphorylated derivatives, pyridoxine 5'-phosphate (PNP), pyridoxal 5'-phosphate (PLP) and pyridoxamine 5'-phosphate (PMP). Although all six of these compounds should technically be referred to as vitamin B6, the term vitamin B6 is commonly used interchangeably with just one of them, pyridoxine. Vitamin B6, principally in its biologically active coenzyme form pyridoxal 5'-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA).
Absorption The B vitamins are readily absorbed from the gastrointestinal tract, except in malabsorption syndromes. Pyridoxine is absorbed mainly in the jejunum.
Protein binding 22%
Biotransformation Hepatic.
Route of elimination Not Available
Toxicity Oral Rat LD50 = 4 gm/kg. Toxic effects include convulsions, dyspnea, hypermotility, diarrhea, ataxia and muscle weakness.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Pyridoxal kinase
Name Pyridoxal kinase
Gene Name PDXK
Pharmacological action yes
Actions ligand
References
  • Adams JB, George F, Audhya T: Abnormally high plasma levels of vitamin B6 in children with autism not taking supplements compared to controls not taking supplements. J Altern Complement Med. 2006 Jan-Feb;12(1):59-63. - Pubmed
  • Newman JA, Das SK, Sedelnikova SE, Rice DW: The crystal structure of an ADP complex of Bacillus subtilis pyridoxal kinase provides evidence for the parallel emergence of enzyme activity during evolution. J Mol Biol. 2006 Oct 20;363(2):520-30. Epub 2006 Aug 12. - Pubmed
  • Kim SY, An JJ, Kim DW, Choi SH, Lee SH, Hwang SI, Kwon OS, Kang TC, Won MH, Cho SW, Park J, Eum WS, Lee KS, Choi SY: Tat-mediated protein transduction of human brain pyridoxine-5-P oxidase into PC12 cells. J Biochem Mol Biol. 2006 Jan 31;39(1):76-83. - Pubmed
  • Nagahashi Y, Tazoe M, Hoshino T: Cloning of the pyridoxine 5'-phosphate phosphatase gene (pdxP) and vitamin B6 production in pdxP recombinant Sinorhizobium meliloti. Biosci Biotechnol Biochem. 2008 Feb;72(2):421-7. Epub 2008 Feb 7. - Pubmed
DTHybrid score 1.0766

Enzymes


Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions inhibitor
References
  • Tangjarukij C, Navasumrit P, Zelikoff JT, Ruchirawat M: The effects of pyridoxine deficiency and supplementation on hematological profiles, lymphocyte function, and hepatic cytochrome P450 in B6C3F1 mice. J Immunotoxicol. 2009 Sep;6(3):147-60. doi: 10.1080/15476910903083866. - Pubmed
DTHybrid score 0.212

Predictions


Id Partner name Gene Name Score
4200 Cytochrome P450 1A2 CYP1A2 0.0698
4512 Cytochrome P450 3A4 CYP3A4 0.0459
4119 Cytochrome P450 2D6 CYP2D6 0.0376
1588 Multidrug resistance protein 1 ABCB1 0.0312
6013 Cytochrome P450 2E1 CYP2E1 0.0298
4757 Cytochrome P450 2C9 CYP2C9 0.0281
5312 Kinesin-like protein KIF1A KIF1A 0.0258
4118 Cytochrome P450 3A5 CYP3A5 0.0257
6016 Cytochrome P450 2C19 CYP2C19 0.0256
4924 Cytochrome P450 2C8 CYP2C8 0.0246
1898 Cytochrome P450 1B1 CYP1B1 0.0245
2615 Chemotaxis protein cheA cheA 0.0241
3669 Ribokinase rbsK 0.024
5466 Putative sugar kinase STM4066 0.0239
2878 Probable serine/threonine-protein kinase pknB pknB 0.0238
2621 Thermoresistant gluconokinase gntK 0.0237
4517 Probable butyrate kinase 2 buk2 0.0237
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.023
5718 Cytochrome P450 2A6 CYP2A6 0.0227
2299 UDP-N-acetylmuramate--L-alanine ligase murC 0.0219
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0219
2717 Folylpolyglutamate synthase fgs 0.0197
6030 Cytochrome P450 2B6 CYP2B6 0.0194
36 Insulin receptor INSR 0.0189
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0147
6107 Cytochrome P450 3A7 CYP3A7 0.0141
468 Cytochrome P450 4A11 CYP4A11 0.0106
20 Prostaglandin G/H synthase 1 PTGS1 0.0086
6014 Cytochrome P450 2A13 CYP2A13 0.0084
605 Fumarate reductase flavoprotein subunit frdA 0.0083
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0083
3673 Fumarate reductase flavoprotein subunit fccA 0.0083
4912 Fumarate reductase flavoprotein subunit ifcA 0.0083
6549 Fumarate reductase flavoprotein subunit frdA 0.0083
776 Bile salt export pump ABCB11 0.008
2499 Tubulin beta-2C chain TUBB2C 0.0079
777 Tumor necrosis factor TNF 0.0077
136 Estrogen receptor ESR1 0.0074
613 Atrial natriuretic peptide receptor A NPR1 0.0072
2449 Tubulin alpha-3 chain TUBA1A 0.0072
1729 Solute carrier family 22 member 6 SLC22A6 0.0072
193 Beta-1 adrenergic receptor ADRB1 0.0067
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0067
1517 Beta-3 adrenergic receptor ADRB3 0.0067
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0066
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0066
587 Serum albumin ALB 0.0066
6106 Cytochrome P450 2C18 CYP2C18 0.0065
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0064
6144 Solute carrier family 22 member 2 SLC22A2 0.0062
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0062
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.006
6145 Solute carrier family 22 member 1 SLC22A1 0.0058
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0058
790 DNA polymerase subunit alpha B POLA2 0.0058
766 Beta-2 adrenergic receptor ADRB2 0.0056
6147 Solute carrier family 22 member 3 SLC22A3 0.0055
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0054
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
871 Glucocorticoid receptor NR3C1 0.0052
290 Prostaglandin G/H synthase 2 PTGS2 0.0051
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0051
862 Multidrug resistance-associated protein 1 ABCC1 0.005
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.005
820 Glycine receptor subunit alpha-2 GLRA2 0.005
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0048
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0047
3932 Glutathione S-transferase A2 GSTA2 0.0047
3811 Cytochrome P450 19A1 CYP19A1 0.0047
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0046
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0046
1820 Beta-nerve growth factor NGF 0.0044
4228 Keratin, type II cytoskeletal 7 KRT7 0.0044
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0043
1714 Mitogen-activated protein kinase 3 MAPK3 0.0041
6142 Solute carrier family 22 member 8 SLC22A8 0.0041
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0041
318 Alpha-2A adrenergic receptor ADRA2A 0.0041
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.004
118 Organic cation/carnitine transporter 2 SLC22A5 0.004
33 Cystine/glutamate transporter SLC7A11 0.004
6766 O-GlcNAcase BT_4395 BT_4395 0.004
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
3199 Phosphopantetheine adenylyltransferase coaD 0.0038
3543 Phosphopantetheine adenylyltransferase coaD 0.0038
3567 Phosphopantetheine adenylyltransferase coaD 0.0038
5289 Phosphopantetheine adenylyltransferase coaD 0.0038
5288 Shikimate kinase aroK 0.0038
5304 UPF0166 protein TM_0021 TM_0021 0.0038
5287 Signaling protein Not Available 0.0038
5292 Putative partitioning protein TT_C1605 0.0038
5266 Activator of hgdC 0.0038
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0038
5259 Transcriptional regulator ntrC1 0.0038
6699 Transcriptional regulator Cgl2612 0.0038
2874 Nitrogenase iron protein 1 nifH1 0.0038
4346 Polynucleotide kinase pseT 0.0038
5293 Shikimate kinase 2 aroL 0.0038
5281 Plasmid segregation protein parM parM 0.0038
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0038
5276 Chromosomal replication initiator protein dnaA dnaA 0.0038
5315 Chaperone protein htpG htpG 0.0038
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0038
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0038
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0038
5291 Glycogen synthase 1 glgA1 0.0038
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0038
5283 D-alanine--D-alanine ligase B ddlB 0.0038
5284 Large T antigen Not Available 0.0038
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0038
5285 Kinesin heavy chain KIF5B 0.0038
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0038
5299 D-alanine--D-alanine ligase ddl 0.0038
6598 D-alanine--D-alanine ligase ddl 0.0038
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0038
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0038
5261 Phosphoribosylformylglycinamidine synthase purL 0.0038
5277 Preprotein translocase subunit secA secA 0.0038
5308 Preprotein translocase secA 1 subunit secA1 0.0038
5264 DNA replication protein REP 0.0038
341 5-hydroxytryptamine 3 receptor HTR3A 0.0038
833 Organic cation/carnitine transporter 1 SLC22A4 0.0038
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0038
1176 Mitogen-activated protein kinase 1 MAPK1 0.0038
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0037
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0037
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0037
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0037
461 Glycine receptor subunit alpha-3 GLRA3 0.0035
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0035
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0034
844 Epidermal growth factor receptor EGFR 0.0034
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0034
4203 Histamine N-methyltransferase HNMT 0.0034
1757 Myeloperoxidase MPO 0.0034
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0034
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0033
492 Histamine H1 receptor HRH1 0.0033
1010 Cytochrome P450 51A1 CYP51A1 0.0033
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0032
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0032
4774 NTPase P4 Not Available 0.0031
5646 Galactokinase GALK1 0.0031
5265 FtsH ftsH 0.0031
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0031
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0031
5302 TrwB trwB 0.0031
6277 Heat shock cognate 71 kDa protein HSPA8 0.0031
3470 Hypothetical protein MG245 homolog MPN_348 0.0031
4838 PMS1 protein homolog 2 PMS2 0.0031
4837 Cag-alfa cag-alfa 0.0031
4839 DNA polymerase III subunit tau dnaX 0.0031
4106 Guanylate kinase GUK1 0.0031
4516 Guanylate kinase gmk 0.0031
5189 Trimethylamine dehydrogenase tmd 0.0031
413 Amidophosphoribosyltransferase PPAT 0.0031
2515 Amidophosphoribosyltransferase purF 0.0031
3714 Amidophosphoribosyltransferase purF 0.0031
2270 Dephospho-CoA kinase coaE 0.0031
2284 Adenylate kinase adk 0.0031
2296 Adenylate kinase adk 0.0031
2311 Adenylate kinase adk 0.0031
2312 Adenylate kinase Not Available 0.0031
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0031
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0031
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0031
465 Calmodulin CALM1 0.0031
3175 Glutamate--cysteine ligase gshA 0.0031
3426 Glutamine synthetase glnA 0.0031
3987 Glutamine synthetase GLUL 0.0031
504 Mast/stem cell growth factor receptor KIT 0.0031
2112 Toll-like receptor 9 TLR9 0.0029
2683 Mono-ADP-ribosyltransferase C3 C3 0.0029
340 Apoptotic protease-activating factor 1 APAF1 0.0029
6220 Aryl hydrocarbon receptor AHR 0.0029
2390 Nonsecretory ribonuclease RNASE2 0.0028
5300 Antigen peptide transporter 1 TAP1 0.0028
5271 Focal adhesion kinase 1 PTK2 0.0028
2922 Glycerol kinase glpK 0.0028
6148 Multidrug resistance-associated protein 7 ABCC10 0.0028
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0028
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0028
6146 High affinity copper uptake protein 1 SLC31A1 0.0028
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0027
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0027
2282 Protein recA recA 0.0027
2315 Protein recA recA 0.0027
2332 Protein recA recA 0.0027
5263 Protein recA recA 0.0027
408 Riboflavin kinase RFK 0.0027
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0027
4311 tRNA TRDMT1 0.0027
4325 tRNA trmD 0.0027
4328 tRNA trmD 0.0027
2236 Casein kinase II subunit alpha CSNK2A1 0.0027
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0026
3947 Xanthine dehydrogenase/oxidase XDH 0.0026
106 Cannabinoid receptor 2 CNR2 0.0026
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0026
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0026
2371 Pantothenate kinase coaA 0.0026
1881 Hexokinase-1 HK1 0.0026
2892 Acetylglutamate kinase argB 0.0026
3550 Acetylglutamate kinase argB 0.0026
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0026
825 Arsenical pump-driving ATPase ASNA1 0.0026
3435 Arsenical pump-driving ATPase arsA 0.0026
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0026
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0026
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0025
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0025
2727 S-adenosylmethionine synthetase metK 0.0025
788 Creatine kinase M-type CKM 0.0025
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0025
68 Cannabinoid receptor 1 CNR1 0.0025
6043 Putative G-protein coupled receptor 44 GPR44 0.0024
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0024
817 DNA topoisomerase 2-alpha TOP2A 0.0024
2697 Uridine-cytidine kinase 2 UCK2 0.0024
569 Retinal dehydrogenase 2 ALDH1A2 0.0024
2334 Dethiobiotin synthetase bioD 0.0024
6555 Dethiobiotin synthetase bioD 0.0024
16 Adenosine A1 receptor ADORA1 0.0024
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0024
1178 Adenosine A2a receptor ADORA2A 0.0023
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0023
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0023
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0023
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0023
146 Androgen receptor AR 0.0023
1569 G1/S-specific cyclin-D1 CCND1 0.0023
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0023
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0023
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0023
611 Retinal dehydrogenase 1 ALDH1A1 0.0022
84 Nuclear receptor 0B1 NR0B1 0.0022
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0022
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0022
702 UMP-CMP kinase CMPK1 0.0022
6395 Myosin-14 MYH14 0.0022
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0022
2091 Endoplasmin HSP90B1 0.0022
1192 Sulfotransferase 1A1 SULT1A1 0.0022
2251 Thymidylate kinase tmk 0.0022
2254 Thymidylate kinase DTYMK 0.0022
3522 Thymidylate kinase tmk 0.0022
5934 Cytochrome P450 26A1 CYP26A1 0.0022
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0021
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0021
373 Transthyretin TTR 0.0021
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0021
823 Fibroblast growth factor receptor 2 FGFR2 0.0021
207 Glutathione synthetase GSS 0.0021
5269 Glutathione synthetase gshB 0.0021
1422 Serine/threonine-protein kinase 6 AURKA 0.0021
3379 Kinesin-like protein KIF11 KIF11 0.0021
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0021
3456 Heat shock protein HSP 90-beta HSP90AB1 0.002
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.002
590 5-hydroxytryptamine 2C receptor HTR2C 0.002
831 D(2) dopamine receptor DRD2 0.002
556 Alpha-1A adrenergic receptor ADRA1A 0.002
3822 Actin, alpha skeletal muscle ACTA1 0.002
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.002
606 Cytochrome P450 27, mitochondrial CYP27A1 0.002
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0019
1629 Transcription factor AP-1 JUN 0.0019
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0019
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0019
581 Cytochrome P450 2R1 CYP2R1 0.0019
509 Thymidine kinase TK 0.0019
570 Thymidine kinase TK 0.0019
2559 Thymidine kinase TK 0.0019
3430 Thymidine kinase tdk 0.0019
3518 Thymidine kinase TK 0.0019
5301 Thymidine kinase tdk 0.0019
5771 Thymidine kinase ORF36 0.0019
7009 Thymidine kinase ORF36 0.0019
122 P2Y purinoceptor 12 P2RY12 0.0019
5294 Nucleoside diphosphate kinase A NME1 0.0019
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0019
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0019
3830 Calreticulin CALR 0.0018
1721 Glycogen synthase kinase-3 beta GSK3B 0.0018
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0018
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0018
1992 Vitamin D-binding protein GC 0.0018
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0018
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0018
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0018
4773 Deoxycytidine kinase DCK 0.0018
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0017
1024 Solute carrier family 22 member 11 SLC22A11 0.0017
6034 Hydroxyindole O-methyltransferase ASMT 0.0017
6035 Nuclear receptor ROR-beta RORB 0.0017
6036 Eosinophil peroxidase EPX 0.0017
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0017
976 Platelet glycoprotein IX GP9 0.0017
5682 Ribonuclease pancreatic RNASE1 0.0017
400 Coagulation factor IX F9 0.0017
5461 Coagulation factor IX F9 0.0017
1374 Natriuretic peptides B NPPB 0.0017
1827 Gap junction alpha-1 protein GJA1 0.0017
1908 Vascular cell adhesion protein 1 VCAM1 0.0017
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0017
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0017
380 Cytochrome P450 17A1 CYP17A1 0.0017
477 DNA topoisomerase 4 subunit A parC 0.0016
886 DNA topoisomerase 4 subunit A parC 0.0016
6226 DNA topoisomerase 4 subunit A parC 0.0016
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0016
1063 Signal transducer and activator of transcription 5B STAT5B 0.0016
4103 Proteasome subunit beta type 2 PSMB2 0.0016
4102 Proteasome subunit beta type 5 PSMB5 0.0016
4101 Proteasome subunit beta type 1 PSMB1 0.0016
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0016
404 DNA gyrase subunit A gyrA 0.0016
6224 DNA gyrase subunit A gyrA 0.0016
295 Carbonic anhydrase 1 CA1 0.0016
814 Ryanodine receptor 1 RYR1 0.0016
6182 Cytochrome P450 2J2 CYP2J2 0.0016
378 Alpha-2C adrenergic receptor ADRA2C 0.0016
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0016
822 Aldose reductase AKR1B1 0.0016
629 Alpha-2B adrenergic receptor ADRA2B 0.0016
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0015
604 Vitamin K-dependent protein Z PROZ 0.0015
2164 Multidrug resistance-associated protein 4 ABCC4 0.0015
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0015
765 Indoleamine 2,3-dioxygenase IDO1 0.0015
251 Alcohol dehydrogenase 1A ADH1A 0.0015
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0015
632 Alpha-1B adrenergic receptor ADRA1B 0.0015
885 5-hydroxytryptamine 1B receptor HTR1B 0.0014
6141 Sodium/bile acid cotransporter SLC10A1 0.0014
770 Retinoic acid-induced protein 3 GPRC5A 0.0014
719 Retinoic acid receptor responder protein 1 RARRES1 0.0014
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0014
6031 Cytochrome P450 3A43 CYP3A43 0.0014
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0014
268 Adenosine A2b receptor ADORA2B 0.0014
422 Vitamin K-dependent protein C PROC 0.0014
1245 Vitamin K-dependent protein S PROS1 0.0014
571 Melatonin receptor type 1A MTNR1A 0.0014
362 Melatonin receptor type 1B MTNR1B 0.0014
638 D(3) dopamine receptor DRD3 0.0014
936 Ephrin type-A receptor 2 EPHA2 0.0013
6143 Solute carrier family 22 member 7 SLC22A7 0.0013
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0013
856 Vitamin D3 receptor VDR 0.0013
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0013
484 Tyrosine-protein kinase ABL2 ABL2 0.0013
444 Alcohol dehydrogenase 1B ADH1B 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
320 5-hydroxytryptamine 1A receptor HTR1A 0.0013
6131 Carbonic anhydrase 14 CA14 0.0013
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0013
756 Sex hormone-binding globulin SHBG 0.0013
183 Vascular endothelial growth factor A VEGFA 0.0013
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0013
4192 DNA topoisomerase 2-beta TOP2B 0.0013
6163 Copper-transporting ATPase 2 ATP7B 0.0013
6165 Copper-transporting ATPase 1 ATP7A 0.0013
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0012
267 Plasminogen activator inhibitor 1 SERPINE1 0.0012
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0012
23 D(1A) dopamine receptor DRD1 0.0012
482 Glycine receptor subunit alpha-1 GLRA1 0.0012
228 Beta platelet-derived growth factor receptor PDGFRB 0.0012
789 Alpha-1D adrenergic receptor ADRA1D 0.0012
6136 Multidrug resistance-associated protein 5 ABCC5 0.0012
997 Protein kinase C beta type PRKCB 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
824 Sodium-dependent serotonin transporter SLC6A4 0.0012
4122 Histone deacetylase 2 HDAC2 0.0012
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0012
1275 Estrogen sulfotransferase SULT1E1 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0012
869 Estrogen receptor beta ESR2 0.0012
502 5-hydroxytryptamine 2A receptor HTR2A 0.0011
634 Squalene monooxygenase SQLE 0.0011
7196 Squalene monooxygenase ERG1 0.0011
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0011
908 Glutathione S-transferase theta-1 GSTT1 0.0011
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0011
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0011
627 11-cis retinol dehydrogenase RDH5 0.0011
517 Alcohol dehydrogenase 1C ADH1C 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0011
798 Osteocalcin BGLAP 0.0011
1970 Protein kinase C alpha type PRKCA 0.0011
6102 Arylamine N-acetyltransferase 2 NAT2 0.0011
6221 Steroid hormone receptor ERR1 ESRRA 0.0011
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0011
1050 Bile salt sulfotransferase SULT2A1 0.0011
751 Potassium channel subfamily K member 6 KCNK6 0.0011
3941 Amine oxidase [flavin-containing] A MAOA 0.0011
3007 Carbonic anhydrase 12 CA12 0.0011
4205 Carbonic anhydrase 9 CA9 0.0011
6137 Multidrug resistance-associated protein 6 ABCC6 0.0011
4120 NADPH--cytochrome P450 reductase POR 0.0011
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0011
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0011
2408 Tyrosine-protein kinase SYK SYK 0.0011
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0011
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0011
6126 Carbonic anhydrase 7 CA7 0.001
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.001
780 Retinoic acid receptor RXR-gamma RXRG 0.001
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.001
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.001
369 Coagulation factor VII F7 0.001
172 Potassium channel subfamily K member 1 KCNK1 0.001
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.001
896 Glutathione S-transferase Mu 1 GSTM1 0.001
3937 Fatty-acid amide hydrolase FAAH 0.001
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.001
345 Plasma retinol-binding protein RBP4 0.001
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.001
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.001
3917 Methylenetetrahydrofolate reductase MTHFR 0.0009
88 Retinoic acid receptor RXR-beta RXRB 0.0009
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0009
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0009
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0009
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0009
260 Cytochrome P450 51 ERG11 0.0009
761 Cytochrome P450 51 ERG11 0.0009
3163 Cytochrome P450 51 cyp51 0.0009
3957 Adenosine deaminase ADA 0.0009
162 Retinoic acid receptor gamma-1 RARG 0.0009
904 Glutathione S-transferase P GSTP1 0.0009
469 Annexin A1 ANXA1 0.0009
6020 Aldehyde oxidase AOX1 0.0009
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0009
3809 Estrogen-related receptor gamma ESRRG 0.0009
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0009
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0008
592 Carbonic anhydrase 4 CA4 0.0008
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0008
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0008
737 Mineralocorticoid receptor NR3C2 0.0008
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0008
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0008
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0008
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0008
239 Coagulation factor X F10 0.0008
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0008
614 Progesterone receptor PGR 0.0007
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0007
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0007
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0007
6085 Fatty acid-binding protein, intestinal FABP2 0.0007
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0007
2981 Phospholipase A2, membrane associated PLA2G2A 0.0007
164 Histamine H4 receptor HRH4 0.0007
275 Arachidonate 5-lipoxygenase ALOX5 0.0007
4604 Liver carboxylesterase 1 CES1 0.0006
54 Prothrombin F2 0.0006
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0006
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0006
357 Carbonic anhydrase 2 CA2 0.0006
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0006
7 Nitric oxide synthase, inducible NOS2 0.0006
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0006
528 5-hydroxytryptamine 1E receptor HTR1E 0.0005
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0005
3939 Amine oxidase [flavin-containing] B MAOB 0.0005
1256 5-hydroxytryptamine 6 receptor HTR6 0.0005
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0005
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0005
921 Glutamate receptor 2 GRIA2 0.0005
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0005
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0005
716 5-hydroxytryptamine 7 receptor HTR7 0.0005
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0005
432 D(4) dopamine receptor DRD4 0.0004
725 5-hydroxytryptamine 1D receptor HTR1D 0.0004
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0004
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0004
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0003
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