DT-Web

DB00085 - Pancrelipase


Identification
Name Pancrelipase
Accession Number DB00085 (BIOD00067, BTD00067)
Type biotech
Description Pancrelipase is an enzyme mixture isolated from porcine or bovine pancreas, sometimes called pancreatin. It contains 3 enzymes: amylase, lipase, and a protease (chymotrypsin). Pancrelipase is marketed under several brand names such as Ultresa(TM) and Viokace(TM).
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 131125.6000
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication For treatment of exocrine pancreatic insufficiency in cystic fibrosis (Ultresa(TM)), chronic pancreatitis (Viokace(TM) in combination with a proton pump inhibitor), and pancreatectomy (Viokace(TM) in combination with a proton pump inhibitor).
Mechanism of action The lipase, protease and amylase components of pancrelipase break down fat, protein, and starches, respectively, in the small intestine. Lipase hydrolyzes fats into glycerol and fatty acids. Protease converts proteins into proteoses and derived substances, while amylase converts starches into dextrins and sugars.
Absorption Pancrelipase is not significantly absorbed from the gastrointestinal tract.
Protein binding Pancrelipase acts locally, so there is minimal plasma protein binding.
Biotransformation Pancrelipase acts locally, so there is minimal metabolism.
Route of elimination Pancrelipase is eliminated in the feces.
Toxicity Overdose symptoms may include diarrhea or stomach upset. The most common adverse reactions seen are ear, neck, and abdominal pain; headache, nasal congestion, and beta-hemolytic streptococcal infection.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Iron If pancrelipase and iron salts are used in combination then monitor therapy. Pancrelipase may decrease the absorption of iron salts except for ferumoxytol, iron dextran complex, and iron sucrose.
Food Interactions
  • Delayed release capsules should not be broken or crushed, but for those patients who cannot swallow the capsules, sprinkle the contents of the capsule onto soft acidic foods (pH of <=4.5). Alkaline foods with a higher pH will promote early release of pancrelipase followed by enzyme inactivation in the stomach.
  • Multivitamins/minerals which have vitamins ADEK, folate, or iron: If pancrelipase is used in combination with multivitamins/minerals that have vitamins ADEK, folate, or iron then monitor therapy because pancrelipase may decrease absorption of iron in these multivitamin/mineral products.
  • Take pancrelipase with meals and a sufficient amount of water.

Targets


Dietary fat
Name Dietary fat
Gene Name Not Available
Pharmacological action yes
Actions cleavage
References
  • Svendsen A: Lipase protein engineering. Biochim Biophys Acta. 2000 Dec 29;1543(2):223-238. - Pubmed
DTHybrid score Not Available
Dietary protein
Name Dietary protein
Gene Name Not Available
Pharmacological action yes
Actions cleavage
References
  • Rawlings ND, Barrett AJ: Families of serine peptidases. Methods Enzymol. 1994;244:19-61. - Pubmed
DTHybrid score Not Available
Dietary starch
Name Dietary starch
Gene Name Not Available
Pharmacological action yes
Actions cleavage
References
  • Udani J, Hardy M, Madsen DC: Blocking carbohydrate absorption and weight loss: a clinical trial using Phase 2 brand proprietary fractionated white bean extract. Altern Med Rev. 2004 Mar;9(1):63-9. - Pubmed
DTHybrid score Not Available

Predictions


Id Partner name Gene Name Score
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