DT-Web

Protease


Partner ID 4623
Name Protease
Synonyms 4220
Gene name PROF
General function Involved in peptidase activity
Specific function Not Available
Gene sequence + ...

ATGAGAAAGAAGAAAAAGGTGTTTTTATCTGTTTTATCAGCTGCAGCGATTTTGTCGACTGTTGCGTTAAGTAATCCATCTGCAGGTGGTGCAAGGAATTTTGATCTGGATTTCAAAGGAATTCAGACAACAACTGATGCTAAAGGTTTCTCCAAGCAGGGGCAGACTGGTGCTGCTGCTTTTCTGGTGGAATCTGAAAATGTGAAACTCCCAAAAGGTTTGCAGAAGAAGCTTGAAACAGTCCCGGCAAATAATAAACTCCATATTATCCAATTCAATGGACCAATTTTAGAAGAAACAAAACAGCAGCTGGAAAAAACAGGGGCAAAGATTCTCGACTACATACCTGATTATGCTTACATTGTCGAGTATGAGGGCGATGTTAAGTCAGCAACAAGCACCATTGAGCACGTGGAATCCGTGGAGCCTTATTTGCCGATATACAGAATAGATCCCCAGCTTTTCACAAAAGGGGCATCAGAGCTTGTAAAAGCAGTGGCGCTTGATACAAAGCAGAAAAATAAAGAGGTGCAATTAAGAGGCATCGAACAAATCGCACAATTCGCAATAAGCAATGATGTGCTATATATTACGGCAAAGCCTGAGTATAAGGTGATGAATGATGTTGCGCGTGGAATTGTCAAAGCGGATGTGGCTCAGAGCAGCTACGGGTTGTATGGACAAGGACAGATCGTAGCGGTTGCCGATACAGGGCTTGATACAGGTCGCAATGACAGTTCGATGCATGAAGCCTTCCGCGGGAAAATTACTGCATTATATGCATTGGGACGGACGAATAATGCCAATGATACGAATGGTCATGGTACGCATGTGGCTGGCTCCGTATTAGGAAACGGCTCCACTAATAAAGGAATGGCGCCTCAGGCGAATCTAGTCTTCCAATCTATCATGGATAGCGGTGGGGGACTTGGAGGACTACCTTCGAATCTGCAAACCTTATTCAGCCAAGCATACAGTGCTGGTGCCAGAATTCATACAAACTCCTGGGGAGCAGCAGTGAATGGGGCTTACACAACAGATTCCAGAAATGTGGATGACTATGTGCGCAAAAATGATATGACGATCCTTTTCGCTGCCGGGAATGAAGGACCGAACGGCGGAACCATCAGTGCACCAGGCACAGCTAAAAATGCAATAACAGTCGGAGCTACGGAAAACCTCCGCCCAAGCTTTGGGTCTTATGCGGACAATATCAACCATGTGGCACAGTTCTCTTCACGTGGACCGACAAAGGATGGACGGATCAAACCGGATGTCATGGCACCGGGAACGTTCATACTATCAGCAAGATCTTCTCTTGCACCGGATTCCTCCTTCTGGGCGAACCATGACAGTAAATATGCATACATGGGTGGAACGTCCATGGCTACACCGATCGTTGCTGGAAACGTGGCACAGCTTCGTGAGCATTTTGTGAAAAACAGAGGCATCACACCAAAGCCTTCTCTATTAAAAGCGGCACTGATTGCCGGTGCAGCTGACATCGGCCTTGGCTACCCGAACGGTAACCAAGGATGGGGACGAGTGACATTGGATAAATCCCTGAACGTTGCCTATGTGAACGAGTCCAGTTCTCTATCCACCAGCCAAAAAGCGACGTACTCGTTTACTGCTACTGCCGGCAAGCCTTTGAAAATCTCCCTGGTATGGTCTGATGCCCCTGCGAGCACAACTGCTTCCGTAACGCTTGTCAATGATCTGGACCTTGTCATTACCGCTCCAAATGGCACACAGTATGTAGGAAATGACTTTACTTCGCCATACAATGATAACTGGGATGGCCGCAATAACGTAGAAAATGTATTTATTAATGCACCACAAAGCGGGACGTATACAATTGAGGTACAGGCTTATAACGTACCGGTTGGACCACAGACCTTCTCGTTGGCAATTGTGAATTAA
Protein sequence + ...

MRKKKKVFLSVLSAAAILSTVALSNPSAGGARNFDLDFKGIQTTTDAKGFSKQGQTGAAAFLVESENVKLPKGLQKKLETVPANNKLHIIQFNGPILEETKQQLEKTGAKILDYIPDYAYIVEYEGDVKSATSTIEHVESVEPYLPIYRIDPQLFTKGASELVKAVALDTKQKNKEVQLRGIEQIAQFAISNDVLYITAKPEYKVMNDVARGIVKADVAQSSYGLYGQGQIVAVADTGLDTGRNDSSMHEAFRGKITALYALGRTNNANDTNGHGTHVAGSVLGNGSTNKGMAPQANLVFQSIMDSGGGLGGLPSNLQTLFSQAYSAGARIHTNSWGAAVNGAYTTDSRNVDDYVRKNDMTILFAAGNEGPNGGTISAPGTAKNAITVGATENLRPSFGSYADNINHVAQFSSRGPTKDGRIKPDVMAPGTFILSARSSLAPDSSFWANHDSKYAYMGGTSMATPIVAGNVAQLREHFVKNRGITPKPSLLKAALIAGAADIGLGYPNGNQGWGRVTLDKSLNVAYVNESSSLSTSQKATYSFTATAGKPLKISLVWSDAPASTTASVTLVNDLDLVITAPNGTQYVGNDFTSPYNDNWDGRNNVENVFINAPQSGTYTIEVQAYNVPVGPQTFSLAIVN
GO Classification
function
endopeptidase activity
serine-type endopeptidase activity
subtilase activity
catalytic activity
hydrolase activity
peptidase activity
process
proteolysis
physiological process
metabolism
macromolecule metabolism
protein metabolism
cellular protein metabolism
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB02235 Methionine Sulfoxide

Associated as Prediction

Id Name
DB01732 (4r,5s,6s,7r)-1,3-Dibenzyl-4,7-Bis(Phenoxymethyl)-5,6-Dihydroxy-1,3 Diazepan-2-One
DB01824 (3s)-Tetrahydrofuran-3-Yl (1r,2s)-3-[4-((1r)-2-{[(S)-Amino(Hydroxy)Methyl]Oxy}-2,3-Dihydro-1h-Inden-1-Yl)-2-Benzyl-3-Oxopyrrolidin-2-Yl]-1-Benzyl-2-Hydroxypropylcarbamate
DB01887 Inhibitor BEA369
DB01891 Tl-3-093
DB02009 L-756,423
DB02033 N-(3-Cyclopropyl(5,6,7,8,9,10-Hexahydro-2-Oxo-2h-Cycloocta[B]Pyran-3-Yl)Methyl)Phenylbenzensulfonamide
DB02235 Methionine Sulfoxide
DB02629 Inhibitor Bea403
DB02683 Inhibitor Bea428
DB02704 (2r,3r,4r,5r)-3,4-Dihydroxy-N,N'-Bis[(1s,2r)-2-Hydroxy-2,3-Dihydro-1h-Inden-1-Yl]-2,5-Bis(2-Phenylethyl)Hexanediamide
DB02768 Tert-Butyloxycarbonyl Group
DB02785 N-[2(S)-Cyclopentyl-1(R)-Hydroxy-3(R)Methyl]-5-[(2(S)-Tertiary-Butylamino-Carbonyl)-4-(N1-(2)-(N-Methylpiperazinyl)-3-Chloro-Pyrazinyl-5-Carbonyl)-Piperazino]-4(S)-Hydroxy-2(R)-Phenylmethyl-Pentanamide
DB02972 1-Benzyl-(R)-Propylamine
DB03014 Heme
DB03076 AHA047
DB03141 3-({5-Benzyl-6-Hydroxy-2,4-Bis-(4-Hydroxy-Benzyl)-3-Oxo-[1,2,4]-Triazepane-1-Sulfonyl)-Benzonitrile
DB03803 Inhibitor Msa367
DB03908 Inhibitor Bea322
DB04042 2-[4-(Hydroxy-Methoxy-Methyl)-Benzyl]-7-(4-Hydroxymethyl-Benzyl)-1,1-Dioxo-3,6-Bis-Phenoxymethyl-1lambda6-[1,2,7]Thiadiazepane-4,5-Diol
DB04190 Inhibitor Bea425
DB04255 Inhibitor Bea388
DB04547 Inhibitor Bea409
DB04708 (S)-TETRAHYDROFURAN-3-YL (2S,3S)-4-((S)-4-((1R,3R)-3-(2-AMINO-2-OXOETHYL)-2,3-DIHYDRO-1H-INDEN-1-YL)-2-BENZYL-3-OXO-2,3-DIHYDRO-1H-PYRROL-2-YL)-3-HYDROXY-1-PHENYLBUTAN-2-YLCARBAMATE
DB06874 (6-[4-(AMINOMETHYL)-2,6-DIMETHYLPHENOXY]-2-{[4-(AMINOMETHYL)PHENYL]AMINO}-5-BROMOPYRIMIDIN-4-YL)METHANOL
DB07018 5-ETHYL-3-[(2-METHOXYETHYL)METHYLAMINO]-6-METHYL-4-(3-METHYLBENZYL)PYRIDIN-2(1H)-ONE
DB07035 (2E)-3-{3-[(5-ETHYL-3-IODO-6-METHYL-2-OXO-1,2-DIHYDROPYRIDIN-4-YL)OXY]PHENYL}ACRYLONITRILE
DB07191 4-({6-AMINO-5-BROMO-2-[(4-CYANOPHENYL)AMINO]PYRIMIDIN-4-YL}OXY)-3,5-DIMETHYLBENZONITRILE
DB07327 (2-ACETYL-5-METHYLANILINO)(2,6-DIBROMOPHENYL)ACETAMIDE
DB07332 ALPHA-(2,6-DICHLOROPHENYL)-ALPHA-(2-ACETYL-5-METHYLANILINO)ACETAMIDE
DB07337 4-[4-AMINO-6-(5-CHLORO-1H-INDOL-4-YLMETHYL)-[1,3,5]TRIAZIN-2-YLAMINO]-BENZONITRILE
DB07343 4-[4-AMINO-6-(2,6-DICHLORO-PHENOXY)-[1,3,5]TRIAZIN-2-YLAMINO]-BENZONITRILE
DB07451 1-(5-BROMO-PYRIDIN-2-YL)-3-[2-(6-FLUORO-2-HYDROXY-3-PROPIONYL-PHENYL)-CYCLOPROPYL]-UREA
DB07578 3-[4-(2-METHYL-IMIDAZO[4,5-C]PYRIDIN-1-YL)BENZYL]-3H-BENZOTHIAZOL-2-ONE
DB07806 (2R,4S)-2-[(R)-BENZYLCARBAMOYL-PHENYLACETYL-METHYL]-5,5-DIMETHYL-THIAZOLIDINE-4-CARBOXYLIC ACID
DB07885 (S)-4-ISOPROPOXYCARBONYL-6-METHOXY-3-METHYLTHIOMETHYL-3,4-DIHYDROQUINOXALIN-2(1H)-THIONE
DB07961 1-(4-CYANO-PHENYL)-3-[2-(2,6-DICHLORO-PHENYL)-1-IMINO-ETHYL]-THIOUREA
DB08034 (E)-3,4-DIHYDROXY-N'-[(2-METHOXYNAPHTHALEN-1-YL)METHYLENE]BENZOHYDRAZIDE
DB08212 1-[2-(3-ACETYL-2-HYDROXY-6-METHOXY-PHENYL)-CYCLOPROPYL]-3-(5-CYANO-PYRIDIN-2-YL)-THIOUREA
DB08223 N-{(1S,2R)-1-BENZYL-3-[(CYCLOPROPYLMETHYL)(2-FURYLSULFONYL)AMINO]-2-HYDROXYPROPYL}-N'-METHYLSUCCINAMIDE
DB08281 O-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl] (4-bromophenyl)thiocarbamate
DB08282 O-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl] (4-chlorophenyl)thiocarbamate
DB08284 O-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl] (4-iodophenyl)thiocarbamate
DB08372 1-[2-(4-ETHOXY-3-FLUOROPYRIDIN-2-YL)ETHYL]-3-(5-METHYLPYRIDIN-2-YL)THIOUREA
DB08414 6-CHLORO-2-(1-FURO[2,3-C]PYRIDIN-5-YL-ETHYLSULFANYL)-PYRIMIDIN-4-YLAMINE
DB08425 3(S)-AMINO-4-PHENYL-BUTAN-2(R)-OL
DB08428 3(S)-AMINO-4-PHENYL-BUTAN-2(S)-OL
DB08457 4-(3,5-DIMETHYLPHENOXY)-5-(FURAN-2-YLMETHYLSULFANYLMETHYL)-3-IODO-6-METHYLPYRIDIN-2(1H)-ONE
DB08592 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile
DB08598 4-CHLORO-8-METHYL-7-(3-METHYL-BUT-2-ENYL)-6,7,8,9-TETRAHYDRO-2H-2,7,9A-TRIAZA-BENZO[CD]AZULENE-1-THIONE
DB08600 5-CHLORO-8-METHYL-7-(3-METHYL-BUT-2-ENYL)-6,7,8,9-TETRAHYDRO-2H-2,7,9A-TRIAZA-BENZO[CD]AZULENE-1-THIONE
DB08639 4-[4-(2,4,6-TRIMETHYL-PHENYLAMINO)-PYRIMIDIN-2-YLAMINO]-BENZONITRILE
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