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6,7-dimethyl-8-ribityllumazine synthase


Partner ID 2333
Name 6,7-dimethyl-8-ribityllumazine synthase
Synonyms 4136
Gene name ribH
General function Coenzyme transport and metabolism
Specific function Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes the condensation of 5-amino-6-(1'-D)-ribityl-amino- 2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4- phosphate yielding 6,7-dimethyl-8-lumazine
Gene sequence + ...

GTGCCGGATCTGCCGTCGCTGGATGCGTCTGGTGTGCGGCTGGCGATTGTCGCCAGCAGCTGGCACGGAAAGATCTGCGACGCGCTGTTGGACGGCGCCCGCAAGGTGGCCGCCGGGTGTGGCCTCGATGACCCGACTGTGGTTCGGGTGCTCGGCGCGATCGAGATTCCGGTGGTGGCGCAGGAATTGGCCCGCAATCATGATGCCGTCGTCGCACTTGGCGTCGTGATCCGCGGTCAGACACCACATTTCGACTACGTGTGCGATGCGGTAACCCAGGGACTGACCCGGGTATCGCTGGATTCCTCGACGCCGATCGCCAACGGCGTGCTGACCACCAACACCGAGGAGCAGGCGCTGGATCGGGCGGGGCTACCGACGTCGGCCGAGGACAAGGGCGCCCAGGCGACTGTGGCAGCCCTGGCCACCGCGTTGACCCTGCGCGAGCTGCGCGCTCACTCGTGA
Protein sequence + ...

MKGGAGVPDLPSLDASGVRLAIVASSWHGKICDALLDGARKVAAGCGLDDPTVVRVLGAIEIPVVAQELARNHDAVVALGVVIRGQTPHFDYVCDAVTQGLTRVSLDSSTPIANGVLTTNTEEQALDRAGLPTSAEDKGAQATVAALATALTLRELRAHS
GO Classification
component
riboflavin synthase complex
protein complex
unlocalized protein complex
function
riboflavin synthase activity
catalytic activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
process
vitamin metabolism
water-soluble vitamin metabolism
riboflavin and derivative metabolism
riboflavin metabolism
riboflavin biosynthesis
physiological process
metabolism
cellular metabolism
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB01692 Dithioerythritol
DB02135 4-{2,6,8-Trioxo-9-[(2r,3s,4r)-2,3,4,5-Tetrahydroxypentyl]-1,2,3,6,8,9-Hexahydro-7h-Purin-7-Yl}Butyl Dihydrogen Phosphate
DB02184 (2s,3s)-1,4-Dimercaptobutane-2,3-Diol
DB02290 3-{2,6,8-Trioxo-9-[(2s,3s,4r)-2,3,4,5-Tetrahydroxypentyl]-1,2,3,6,8,9-Hexahydro-7h-Purin-7-Yl}Propyl Dihydrogen Phosphate
DB02693 (4s,5s)-1,2-Dithiane-4,5-Diol
DB02711 4-{2,6,8-Trioxo-9-[(2s,3r,4r)-2,3,4,5-Tetrahydroxypentyl]-1,2,3,6,8,9-Hexahydro-7h-Purin-7-Yl}Butyl Dihydrogen Phosphate
DB03022 3-{2,6,8-Trioxo-9-[(2r,3s,4r)-2,3,4,5-Tetrahydroxypentyl]-1,2,3,6,8,9-Hexahydro-7h-Purin-7-Yl}Propyl Dihydrogen Phosphate
DB03812 3-{2,6,8-Trioxo-9-[(2s,3r,4r)-2,3,4,5-Tetrahydroxypentyl]-1,2,3,6,8,9-Hexahydro-7h-Purin-7-Yl}Propyl Dihydrogen Phosphate
DB03973 3-{2,6,8-Trioxo-9-[(2r,3r,4r)-2,3,4,5-Tetrahydroxypentyl]-1,2,3,6,8,9-Hexahydro-7h-Purin-7-Yl}Propyl Dihydrogen Phosphate
DB08016 4-(6-CHLORO-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL) BUTYL PHOSPHATE

Associated as Prediction

Id Name
DB00432 Trifluridine
DB00495 Zidovudine
DB01692 Dithioerythritol
DB02135 4-{2,6,8-Trioxo-9-[(2r,3s,4r)-2,3,4,5-Tetrahydroxypentyl]-1,2,3,6,8,9-Hexahydro-7h-Purin-7-Yl}Butyl Dihydrogen Phosphate
DB02184 (2s,3s)-1,4-Dimercaptobutane-2,3-Diol
DB02214 6,7-Dioxo-5h-8-Ribitylaminolumazine
DB02290 3-{2,6,8-Trioxo-9-[(2s,3s,4r)-2,3,4,5-Tetrahydroxypentyl]-1,2,3,6,8,9-Hexahydro-7h-Purin-7-Yl}Propyl Dihydrogen Phosphate
DB02452 Thymidine-5'-Triphosphate
DB02693 (4s,5s)-1,2-Dithiane-4,5-Diol
DB02711 4-{2,6,8-Trioxo-9-[(2s,3r,4r)-2,3,4,5-Tetrahydroxypentyl]-1,2,3,6,8,9-Hexahydro-7h-Purin-7-Yl}Butyl Dihydrogen Phosphate
DB03022 3-{2,6,8-Trioxo-9-[(2r,3s,4r)-2,3,4,5-Tetrahydroxypentyl]-1,2,3,6,8,9-Hexahydro-7h-Purin-7-Yl}Propyl Dihydrogen Phosphate
DB03654 S,S-Propylthiocysteine
DB03812 3-{2,6,8-Trioxo-9-[(2s,3r,4r)-2,3,4,5-Tetrahydroxypentyl]-1,2,3,6,8,9-Hexahydro-7h-Purin-7-Yl}Propyl Dihydrogen Phosphate
DB03973 3-{2,6,8-Trioxo-9-[(2r,3r,4r)-2,3,4,5-Tetrahydroxypentyl]-1,2,3,6,8,9-Hexahydro-7h-Purin-7-Yl}Propyl Dihydrogen Phosphate
DB04128 5-Nitroso-6-Ribityl-Amino-2,4(1h,3h)-Pyrimidinedione
DB04162 5-Nitro-6-Ribityl-Amino-2,4(1h,3h)-Pyrimidinedione
DB04262 3-(7-Hydroxy-8-Ribityllumazine-6-Yl) Propionic Acid
DB04447 1,4-Dithiothreitol
DB08016 4-(6-CHLORO-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL) BUTYL PHOSPHATE
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