DT-Web

DB08293 - (5E)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE


Identification
Name (5E)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE
Accession Number DB08293
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 324.756
Groups experimental
Monoisotopic Weight 324.076451361
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Heat shock protein HSP 90-beta
Name Heat shock protein HSP 90-beta
Gene Name HSP90AB1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.263

Predictions


Id Partner name Gene Name Score
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.226
2091 Endoplasmin HSP90B1 0.1676
6840 Virulence sensor histidine kinase phoQ phoQ 0.0437
6839 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial PDK3 0.0381
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.031
5315 Chaperone protein htpG htpG 0.0021
5304 UPF0166 protein TM_0021 TM_0021 0.0021
5293 Shikimate kinase 2 aroL 0.0021
5287 Signaling protein Not Available 0.0021
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0021
3199 Phosphopantetheine adenylyltransferase coaD 0.0021
3543 Phosphopantetheine adenylyltransferase coaD 0.0021
3567 Phosphopantetheine adenylyltransferase coaD 0.0021
5289 Phosphopantetheine adenylyltransferase coaD 0.0021
5266 Activator of hgdC 0.0021
5288 Shikimate kinase aroK 0.0021
5276 Chromosomal replication initiator protein dnaA dnaA 0.0021
5292 Putative partitioning protein TT_C1605 0.0021
5259 Transcriptional regulator ntrC1 0.0021
6699 Transcriptional regulator Cgl2612 0.0021
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0021
2874 Nitrogenase iron protein 1 nifH1 0.0021
4346 Polynucleotide kinase pseT 0.0021
5281 Plasmid segregation protein parM parM 0.0021
5264 DNA replication protein REP 0.0021
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0021
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0021
5299 D-alanine--D-alanine ligase ddl 0.0021
6598 D-alanine--D-alanine ligase ddl 0.0021
5283 D-alanine--D-alanine ligase B ddlB 0.0021
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0021
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0021
5284 Large T antigen Not Available 0.0021
5291 Glycogen synthase 1 glgA1 0.0021
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0021
5277 Preprotein translocase subunit secA secA 0.0021
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0021
5285 Kinesin heavy chain KIF5B 0.0021
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0021
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0021
5261 Phosphoribosylformylglycinamidine synthase purL 0.0021
5308 Preprotein translocase secA 1 subunit secA1 0.0021
3470 Hypothetical protein MG245 homolog MPN_348 0.0018
4106 Guanylate kinase GUK1 0.0018
4516 Guanylate kinase gmk 0.0018
2284 Adenylate kinase adk 0.0018
2296 Adenylate kinase adk 0.0018
2311 Adenylate kinase adk 0.0018
2312 Adenylate kinase Not Available 0.0018
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0018
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0018
5265 FtsH ftsH 0.0018
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0018
5302 TrwB trwB 0.0018
4837 Cag-alfa cag-alfa 0.0018
4774 NTPase P4 Not Available 0.0018
3175 Glutamate--cysteine ligase gshA 0.0018
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0018
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0018
2270 Dephospho-CoA kinase coaE 0.0018
5646 Galactokinase GALK1 0.0018
6277 Heat shock cognate 71 kDa protein HSPA8 0.0018
3426 Glutamine synthetase glnA 0.0018
3987 Glutamine synthetase GLUL 0.0018
413 Amidophosphoribosyltransferase PPAT 0.0018
2515 Amidophosphoribosyltransferase purF 0.0018
3714 Amidophosphoribosyltransferase purF 0.0018
4838 PMS1 protein homolog 2 PMS2 0.0018
4839 DNA polymerase III subunit tau dnaX 0.0018
5189 Trimethylamine dehydrogenase tmd 0.0018
2683 Mono-ADP-ribosyltransferase C3 C3 0.0017
2390 Nonsecretory ribonuclease RNASE2 0.0017
2922 Glycerol kinase glpK 0.0017
5271 Focal adhesion kinase 1 PTK2 0.0017
5312 Kinesin-like protein KIF1A KIF1A 0.0017
2892 Acetylglutamate kinase argB 0.0016
3550 Acetylglutamate kinase argB 0.0016
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0016
3669 Ribokinase rbsK 0.0016
2371 Pantothenate kinase coaA 0.0016
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0016
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0016
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0016
2615 Chemotaxis protein cheA cheA 0.0016
825 Arsenical pump-driving ATPase ASNA1 0.0016
3435 Arsenical pump-driving ATPase arsA 0.0016
1881 Hexokinase-1 HK1 0.0016
2727 S-adenosylmethionine synthetase metK 0.0015
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0015
340 Apoptotic protease-activating factor 1 APAF1 0.0015
5300 Antigen peptide transporter 1 TAP1 0.0015
408 Riboflavin kinase RFK 0.0015
2282 Protein recA recA 0.0015
2315 Protein recA recA 0.0015
2332 Protein recA recA 0.0015
5263 Protein recA recA 0.0015
2334 Dethiobiotin synthetase bioD 0.0014
6555 Dethiobiotin synthetase bioD 0.0014
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0014
2697 Uridine-cytidine kinase 2 UCK2 0.0014
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0014
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0014
788 Creatine kinase M-type CKM 0.0014
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0014
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0014
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0014
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0014
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0013
6395 Myosin-14 MYH14 0.0013
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0013
48 Pyridoxal kinase PDXK 0.0013
2251 Thymidylate kinase tmk 0.0013
2254 Thymidylate kinase DTYMK 0.0013
3522 Thymidylate kinase tmk 0.0013
1422 Serine/threonine-protein kinase 6 AURKA 0.0013
702 UMP-CMP kinase CMPK1 0.0013
3379 Kinesin-like protein KIF11 KIF11 0.0013
3822 Actin, alpha skeletal muscle ACTA1 0.0012
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0012
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0012
207 Glutathione synthetase GSS 0.0012
5269 Glutathione synthetase gshB 0.0012
504 Mast/stem cell growth factor receptor KIT 0.0011
509 Thymidine kinase TK 0.0011
570 Thymidine kinase TK 0.0011
2559 Thymidine kinase TK 0.0011
3430 Thymidine kinase tdk 0.0011
3518 Thymidine kinase TK 0.0011
5301 Thymidine kinase tdk 0.0011
5771 Thymidine kinase ORF36 0.0011
7009 Thymidine kinase ORF36 0.0011
1721 Glycogen synthase kinase-3 beta GSK3B 0.0011
5294 Nucleoside diphosphate kinase A NME1 0.0011
5682 Ribonuclease pancreatic RNASE1 0.001
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.001
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.001
4773 Deoxycytidine kinase DCK 0.0009
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