DT-Web

DB07931 - 4-[(1R,2S)-1-ethyl-2-(4-hydroxyphenyl)butyl]phenol


Identification
Name 4-[(1R,2S)-1-ethyl-2-(4-hydroxyphenyl)butyl]phenol
Accession Number DB07931
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 270.3661
Groups experimental
Monoisotopic Weight 270.161979948
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Aldo-keto reductase family 1 member C1
Name Aldo-keto reductase family 1 member C1
Gene Name AKR1C1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.4846

Predictions


Id Partner name Gene Name Score
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.1313
578 Endothelin-1 receptor EDNRA 0.0761
373 Transthyretin TTR 0.0459
6143 Solute carrier family 22 member 7 SLC22A7 0.0201
290 Prostaglandin G/H synthase 2 PTGS2 0.0189
20 Prostaglandin G/H synthase 1 PTGS1 0.0177
587 Serum albumin ALB 0.0165
1729 Solute carrier family 22 member 6 SLC22A6 0.0164
6149 Solute carrier family 22 member 10 SLC22A10 0.0154
1588 Multidrug resistance protein 1 ABCB1 0.0138
4757 Cytochrome P450 2C9 CYP2C9 0.0137
738 Monocarboxylate transporter 1 SLC16A1 0.0108
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0098
1024 Solute carrier family 22 member 11 SLC22A11 0.0089
4924 Cytochrome P450 2C8 CYP2C8 0.0085
6016 Cytochrome P450 2C19 CYP2C19 0.0081
6142 Solute carrier family 22 member 8 SLC22A8 0.0078
646 Malate dehydrogenase, cytoplasmic MDH1 0.0059
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0058
666 NADP-dependent malic enzyme ME1 0.0058
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0056
5346 Oxidoreductase, aldo/keto reductase family TM_1009 0.0054
4403 Protein iolS iolS 0.0054
5330 General stress protein 69 yhdN 0.0054
5322 Oxidoreductase ydhF ydhF 0.0054
5333 Alcohol dehydrogenase, iron-containing TM_0920 0.0054
5326 Oxidoreductase, short chain dehydrogenase/reductase family TM_0441 0.0054
5157 Dehydrogenase/reductase SDR family member 11 DHRS11 0.0054
5332 MtdA bifunctional protein mtdA 0.0054
5342 NADH-dependent butanol dehydrogenase, putative TM_0820 0.0054
3772 3-oxoacyl-[acyl-carrier-protein] reductase fabG 0.0054
3778 NAD(P) transhydrogenase subunit beta pntB 0.0054
5343 NADP-dependent fatty aldehyde dehydrogenase aldH 0.0054
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0051
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.005
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0049
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0048
2375 ADP-L-glycero-D-manno-heptose-6-epimerase hldD 0.0047
654 Flavin reductase BLVRB 0.0047
5073 Ferredoxin--NADP reductase petH 0.0047
5076 Ferredoxin--NADP reductase fpr 0.0047
5119 Ferredoxin--NADP reductase petH 0.0047
5121 Ferredoxin--NADP reductase fpr 0.0047
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0047
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0046
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0046
5328 Prostaglandin F synthase Tb11.02.2310 0.0046
2305 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 0.0046
4582 Putative pteridine reductase 2 ptr2 0.0046
2286 Isocitrate dehydrogenase [NADP] icd 0.0046
2302 Isocitrate dehydrogenase [NADP] icd 0.0046
2771 Isocitrate dehydrogenase [NADP] icd 0.0046
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0046
989 L-xylulose reductase DCXR 0.0046
3446 NADP-dependent alcohol dehydrogenase adh 0.0046
2636 Shikimate dehydrogenase aroE 0.0046
3515 Shikimate dehydrogenase aroE 0.0046
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0044
444 Alcohol dehydrogenase 1B ADH1B 0.0043
6862 Aldo-keto reductase family 1 member B10 AKR1B10 0.0043
4531 Putative ketoacyl reductase actIII 0.0042
6297 Prostaglandin reductase 1 PTGR1 0.0042
3062 Aspartate-semialdehyde dehydrogenase asd 0.0042
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0042
2675 Pteridine reductase 1 PTR1 0.0041
2159 Quinone oxidoreductase CRYZ 0.004
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.004
1124 Sepiapterin reductase SPR 0.004
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.004
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0037
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0037
822 Aldose reductase AKR1B1 0.0037
365 Dihydrofolate reductase DHFR 0.0035
2381 Dihydrofolate reductase DFR1 0.0035
2833 Dihydrofolate reductase Not Available 0.0035
2931 Dihydrofolate reductase folA 0.0035
3544 Dihydrofolate reductase folA 0.0035
3682 Dihydrofolate reductase folA 0.0035
6642 Dihydrofolate reductase folA 0.0035
6756 Dihydrofolate reductase dfrA 0.0035
76 Nitric-oxide synthase, brain NOS1 0.0027
4120 NADPH--cytochrome P450 reductase POR 0.0027
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0019
816 Biliverdin reductase A BLVRA 0.0018
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0018
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0018
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0018
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0017
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0017
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0017
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0017
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0017
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0017
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0017
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0017
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0017
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0017
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0017
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0017
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0017
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0017
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0017
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0017
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0017
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0017
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0017
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0017
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0017
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0017
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0017
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0017
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0017
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0017
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0017
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0017
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0017
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0017
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0017
644 Heme oxygenase 2 HMOX2 0.0017
4982 Heme oxygenase 2 pbsA2 0.0017
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0017
729 GDP-L-fucose synthetase TSTA3 0.0017
3463 GDP-L-fucose synthetase fcl 0.0017
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0017
167 L-lactate dehydrogenase C chain LDHC 0.0017
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0017
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0017
206 3-keto-steroid reductase HSD17B7 0.0017
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0017
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0017
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0017
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0017
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0017
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0017
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0017
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0017
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0017
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0017
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0017
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0017
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0017
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0017
711 UDP-glucose 6-dehydrogenase UGDH 0.0017
3672 UDP-glucose 6-dehydrogenase hasB 0.0017
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0017
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0017
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0017
107 C-4 methylsterol oxidase SC4MOL 0.0017
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0017
3726 D-3-phosphoglycerate dehydrogenase serA 0.0017
4291 D-3-phosphoglycerate dehydrogenase serA 0.0017
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0017
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0017
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0017
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0017
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0017
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0017
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0017
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0017
643 Peroxisomal bifunctional enzyme EHHADH 0.0017
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0017
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0017
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0017
34 7-dehydrocholesterol reductase DHCR7 0.0017
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0017
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0017
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0017
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0017
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0017
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0016
328 Sorbitol dehydrogenase SORD 0.0016
597 Dihydropteridine reductase QDPR 0.0016
396 Alcohol dehydrogenase 4 ADH4 0.0016
857 Malate dehydrogenase, mitochondrial MDH2 0.0016
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0016
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0016
77 L-lactate dehydrogenase B chain LDHB 0.0016
12 Alcohol dehydrogenase class 3 ADH5 0.0015
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0015
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0015
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0015
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0015
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0015
473 L-lactate dehydrogenase A chain LDHA 0.0015
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0015
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0015
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0014
6026 Alcohol dehydrogenase 6 ADH6 0.0014
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0014
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0014
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0014
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0014
13 Aminomethyltransferase, mitochondrial AMT 0.0014
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0014
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0014
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0014
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0014
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0014
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0014
626 Cysteine dioxygenase type 1 CDO1 0.0014
627 11-cis retinol dehydrogenase RDH5 0.0014
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0014
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0014
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0014
569 Retinal dehydrogenase 2 ALDH1A2 0.0013
611 Retinal dehydrogenase 1 ALDH1A1 0.0013
251 Alcohol dehydrogenase 1A ADH1A 0.0013
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0013
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0013
810 Heme oxygenase 1 HMOX1 0.0013
3391 Heme oxygenase 1 pbsA1 0.0013
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0012
279 Tyrosinase TYR 0.0012
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0012
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0012
380 Cytochrome P450 17A1 CYP17A1 0.0012
714 Glutathione reductase, mitochondrial GSR 0.0011
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0011
517 Alcohol dehydrogenase 1C ADH1C 0.0011
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.001
468 Cytochrome P450 4A11 CYP4A11 0.001
6020 Aldehyde oxidase AOX1 0.0009
3947 Xanthine dehydrogenase/oxidase XDH 0.0009
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