DT-Web

DB07266 - 8-ethyl-3,10,10-trimethyl-4,5,6,8,10,12-hexahydropyrazolo[4',3':6,7]cyclohepta[1,2-b]pyrrolo[2,3-f]indol-9(1H)-one


Identification
Name 8-ethyl-3,10,10-trimethyl-4,5,6,8,10,12-hexahydropyrazolo[4',3':6,7]cyclohepta[1,2-b]pyrrolo[2,3-f]indol-9(1H)-one
Accession Number DB07266
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 348.4415
Groups experimental
Monoisotopic Weight 348.19501141
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Serine/threonine-protein kinase 6
Name Serine/threonine-protein kinase 6
Gene Name AURKA
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.4765

Predictions


Id Partner name Gene Name Score
6246 Serine/threonine-protein kinase PLK1 PLK1 0.0907
2240 Cell division protein kinase 2 CDK2 0.0469
4750 Protein S100-A11 S100A11 0.0278
3482 Cell division protein kinase 7 CDK7 0.0242
4751 Mitogen-activated protein kinase 12 MAPK12 0.0242
3005 Threonine-phosphate decarboxylase cobD 0.0242
2530 Protein kinase C theta type PRKCQ 0.0223
1176 Mitogen-activated protein kinase 1 MAPK1 0.0156
2207 Rhodopsin RHO 0.0156
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0131
5304 UPF0166 protein TM_0021 TM_0021 0.0024
3199 Phosphopantetheine adenylyltransferase coaD 0.0024
3543 Phosphopantetheine adenylyltransferase coaD 0.0024
3567 Phosphopantetheine adenylyltransferase coaD 0.0024
5289 Phosphopantetheine adenylyltransferase coaD 0.0024
5293 Shikimate kinase 2 aroL 0.0024
5288 Shikimate kinase aroK 0.0024
5287 Signaling protein Not Available 0.0024
5292 Putative partitioning protein TT_C1605 0.0024
5266 Activator of hgdC 0.0024
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0024
5259 Transcriptional regulator ntrC1 0.0024
6699 Transcriptional regulator Cgl2612 0.0024
5299 D-alanine--D-alanine ligase ddl 0.0024
6598 D-alanine--D-alanine ligase ddl 0.0024
5283 D-alanine--D-alanine ligase B ddlB 0.0024
5281 Plasmid segregation protein parM parM 0.0024
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0024
5276 Chromosomal replication initiator protein dnaA dnaA 0.0024
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0024
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0024
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0024
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0024
5291 Glycogen synthase 1 glgA1 0.0024
2874 Nitrogenase iron protein 1 nifH1 0.0024
4346 Polynucleotide kinase pseT 0.0024
5264 DNA replication protein REP 0.0024
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0024
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0024
5285 Kinesin heavy chain KIF5B 0.0024
5315 Chaperone protein htpG htpG 0.0024
5277 Preprotein translocase subunit secA secA 0.0024
5284 Large T antigen Not Available 0.0024
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0024
5308 Preprotein translocase secA 1 subunit secA1 0.0024
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0024
5261 Phosphoribosylformylglycinamidine synthase purL 0.0024
2284 Adenylate kinase adk 0.0021
2296 Adenylate kinase adk 0.0021
2311 Adenylate kinase adk 0.0021
2312 Adenylate kinase Not Available 0.0021
3470 Hypothetical protein MG245 homolog MPN_348 0.0021
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0021
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0021
2270 Dephospho-CoA kinase coaE 0.0021
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0021
4774 NTPase P4 Not Available 0.0021
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0021
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0021
4106 Guanylate kinase GUK1 0.0021
4516 Guanylate kinase gmk 0.0021
5646 Galactokinase GALK1 0.0021
5265 FtsH ftsH 0.0021
3426 Glutamine synthetase glnA 0.0021
3987 Glutamine synthetase GLUL 0.0021
413 Amidophosphoribosyltransferase PPAT 0.0021
2515 Amidophosphoribosyltransferase purF 0.0021
3714 Amidophosphoribosyltransferase purF 0.0021
5302 TrwB trwB 0.0021
3175 Glutamate--cysteine ligase gshA 0.0021
4838 PMS1 protein homolog 2 PMS2 0.0021
4837 Cag-alfa cag-alfa 0.0021
4839 DNA polymerase III subunit tau dnaX 0.0021
6277 Heat shock cognate 71 kDa protein HSPA8 0.0021
5189 Trimethylamine dehydrogenase tmd 0.0021
2683 Mono-ADP-ribosyltransferase C3 C3 0.0019
2390 Nonsecretory ribonuclease RNASE2 0.0019
2922 Glycerol kinase glpK 0.0019
5271 Focal adhesion kinase 1 PTK2 0.0019
5312 Kinesin-like protein KIF1A KIF1A 0.0019
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0018
3669 Ribokinase rbsK 0.0018
2371 Pantothenate kinase coaA 0.0018
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0018
2892 Acetylglutamate kinase argB 0.0018
3550 Acetylglutamate kinase argB 0.0018
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0018
825 Arsenical pump-driving ATPase ASNA1 0.0018
3435 Arsenical pump-driving ATPase arsA 0.0018
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0018
2615 Chemotaxis protein cheA cheA 0.0018
1881 Hexokinase-1 HK1 0.0018
2727 S-adenosylmethionine synthetase metK 0.0017
340 Apoptotic protease-activating factor 1 APAF1 0.0017
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0017
5300 Antigen peptide transporter 1 TAP1 0.0017
408 Riboflavin kinase RFK 0.0017
2282 Protein recA recA 0.0017
2315 Protein recA recA 0.0017
2332 Protein recA recA 0.0017
5263 Protein recA recA 0.0017
2334 Dethiobiotin synthetase bioD 0.0016
6555 Dethiobiotin synthetase bioD 0.0016
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0016
2697 Uridine-cytidine kinase 2 UCK2 0.0016
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0016
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0016
788 Creatine kinase M-type CKM 0.0016
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0016
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0016
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0016
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0016
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0015
6395 Myosin-14 MYH14 0.0015
2091 Endoplasmin HSP90B1 0.0015
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0015
48 Pyridoxal kinase PDXK 0.0015
2251 Thymidylate kinase tmk 0.0015
2254 Thymidylate kinase DTYMK 0.0015
3522 Thymidylate kinase tmk 0.0015
702 UMP-CMP kinase CMPK1 0.0014
3379 Kinesin-like protein KIF11 KIF11 0.0014
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0014
3822 Actin, alpha skeletal muscle ACTA1 0.0014
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0014
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0014
207 Glutathione synthetase GSS 0.0014
5269 Glutathione synthetase gshB 0.0014
504 Mast/stem cell growth factor receptor KIT 0.0013
509 Thymidine kinase TK 0.0013
570 Thymidine kinase TK 0.0013
2559 Thymidine kinase TK 0.0013
3430 Thymidine kinase tdk 0.0013
3518 Thymidine kinase TK 0.0013
5301 Thymidine kinase tdk 0.0013
5771 Thymidine kinase ORF36 0.0013
7009 Thymidine kinase ORF36 0.0013
1721 Glycogen synthase kinase-3 beta GSK3B 0.0013
5294 Nucleoside diphosphate kinase A NME1 0.0013
5682 Ribonuclease pancreatic RNASE1 0.0012
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0011
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0011
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0011
4773 Deoxycytidine kinase DCK 0.001
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