DT-Web

DB07100 - 4-CHLORO-6-(4-PIPERAZIN-1-YL-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOL


Identification
Name 4-CHLORO-6-(4-PIPERAZIN-1-YL-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOL
Accession Number DB07100
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 294.737
Groups experimental
Monoisotopic Weight 294.088353451
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Heat shock protein HSP 90-alpha
Name Heat shock protein HSP 90-alpha
Gene Name HSP90AA1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.746

Predictions


Id Partner name Gene Name Score
3456 Heat shock protein HSP 90-beta HSP90AB1 0.1073
111 Cysteinyl leukotriene receptor 2 CYSLTR2 0.0107
1448 fMet-Leu-Phe receptor FPR1 0.0107
325 Prostaglandin D2 receptor PTGDR 0.0107
2091 Endoplasmin HSP90B1 0.0077
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0076
512 DNA-directed RNA polymerase alpha chain rpoA 0.0073
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0073
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0064
284 DNA-directed RNA polymerase beta chain rpoB 0.0059
5773 DNA-directed RNA polymerase beta chain rpoB 0.0059
4200 Cytochrome P450 1A2 CYP1A2 0.0027
4512 Cytochrome P450 3A4 CYP3A4 0.0023
5315 Chaperone protein htpG htpG 0.0008
5304 UPF0166 protein TM_0021 TM_0021 0.0008
5293 Shikimate kinase 2 aroL 0.0008
5287 Signaling protein Not Available 0.0008
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0008
3199 Phosphopantetheine adenylyltransferase coaD 0.0008
3543 Phosphopantetheine adenylyltransferase coaD 0.0008
3567 Phosphopantetheine adenylyltransferase coaD 0.0008
5289 Phosphopantetheine adenylyltransferase coaD 0.0008
5288 Shikimate kinase aroK 0.0008
5276 Chromosomal replication initiator protein dnaA dnaA 0.0008
5292 Putative partitioning protein TT_C1605 0.0008
5266 Activator of hgdC 0.0008
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0008
2874 Nitrogenase iron protein 1 nifH1 0.0008
4346 Polynucleotide kinase pseT 0.0008
5281 Plasmid segregation protein parM parM 0.0008
5259 Transcriptional regulator ntrC1 0.0008
6699 Transcriptional regulator Cgl2612 0.0008
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0008
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0008
5299 D-alanine--D-alanine ligase ddl 0.0008
6598 D-alanine--D-alanine ligase ddl 0.0008
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0008
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0008
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0008
5284 Large T antigen Not Available 0.0008
5291 Glycogen synthase 1 glgA1 0.0008
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0008
5264 DNA replication protein REP 0.0008
5277 Preprotein translocase subunit secA secA 0.0008
5283 D-alanine--D-alanine ligase B ddlB 0.0008
5308 Preprotein translocase secA 1 subunit secA1 0.0008
5285 Kinesin heavy chain KIF5B 0.0008
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0008
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0008
5261 Phosphoribosylformylglycinamidine synthase purL 0.0008
4106 Guanylate kinase GUK1 0.0007
4516 Guanylate kinase gmk 0.0007
3470 Hypothetical protein MG245 homolog MPN_348 0.0007
5189 Trimethylamine dehydrogenase tmd 0.0007
2284 Adenylate kinase adk 0.0007
2296 Adenylate kinase adk 0.0007
2311 Adenylate kinase adk 0.0007
2312 Adenylate kinase Not Available 0.0007
5302 TrwB trwB 0.0007
4837 Cag-alfa cag-alfa 0.0007
4774 NTPase P4 Not Available 0.0007
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0007
413 Amidophosphoribosyltransferase PPAT 0.0007
2515 Amidophosphoribosyltransferase purF 0.0007
3714 Amidophosphoribosyltransferase purF 0.0007
5646 Galactokinase GALK1 0.0007
3175 Glutamate--cysteine ligase gshA 0.0007
6277 Heat shock cognate 71 kDa protein HSPA8 0.0007
2270 Dephospho-CoA kinase coaE 0.0007
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0007
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0007
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0007
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0007
4838 PMS1 protein homolog 2 PMS2 0.0007
3426 Glutamine synthetase glnA 0.0007
3987 Glutamine synthetase GLUL 0.0007
5265 FtsH ftsH 0.0007
4839 DNA polymerase III subunit tau dnaX 0.0007
2683 Mono-ADP-ribosyltransferase C3 C3 0.0006
2390 Nonsecretory ribonuclease RNASE2 0.0006
5271 Focal adhesion kinase 1 PTK2 0.0006
2922 Glycerol kinase glpK 0.0006
5312 Kinesin-like protein KIF1A KIF1A 0.0006
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0006
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0006
2371 Pantothenate kinase coaA 0.0006
2892 Acetylglutamate kinase argB 0.0006
3550 Acetylglutamate kinase argB 0.0006
2615 Chemotaxis protein cheA cheA 0.0006
3669 Ribokinase rbsK 0.0006
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0006
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0006
825 Arsenical pump-driving ATPase ASNA1 0.0006
3435 Arsenical pump-driving ATPase arsA 0.0006
1881 Hexokinase-1 HK1 0.0006
340 Apoptotic protease-activating factor 1 APAF1 0.0005
5300 Antigen peptide transporter 1 TAP1 0.0005
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0005
2727 S-adenosylmethionine synthetase metK 0.0005
408 Riboflavin kinase RFK 0.0005
2282 Protein recA recA 0.0005
2315 Protein recA recA 0.0005
2332 Protein recA recA 0.0005
5263 Protein recA recA 0.0005
2334 Dethiobiotin synthetase bioD 0.0005
6555 Dethiobiotin synthetase bioD 0.0005
2697 Uridine-cytidine kinase 2 UCK2 0.0005
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0005
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0005
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0005
788 Creatine kinase M-type CKM 0.0005
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0005
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0005
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0005
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0005
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0005
6395 Myosin-14 MYH14 0.0005
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0005
48 Pyridoxal kinase PDXK 0.0005
2251 Thymidylate kinase tmk 0.0005
2254 Thymidylate kinase DTYMK 0.0005
3522 Thymidylate kinase tmk 0.0005
1422 Serine/threonine-protein kinase 6 AURKA 0.0005
702 UMP-CMP kinase CMPK1 0.0005
3379 Kinesin-like protein KIF11 KIF11 0.0005
3822 Actin, alpha skeletal muscle ACTA1 0.0004
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0004
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0004
207 Glutathione synthetase GSS 0.0004
5269 Glutathione synthetase gshB 0.0004
504 Mast/stem cell growth factor receptor KIT 0.0004
509 Thymidine kinase TK 0.0004
570 Thymidine kinase TK 0.0004
2559 Thymidine kinase TK 0.0004
3430 Thymidine kinase tdk 0.0004
3518 Thymidine kinase TK 0.0004
5301 Thymidine kinase tdk 0.0004
5771 Thymidine kinase ORF36 0.0004
7009 Thymidine kinase ORF36 0.0004
1721 Glycogen synthase kinase-3 beta GSK3B 0.0004
5294 Nucleoside diphosphate kinase A NME1 0.0004
5682 Ribonuclease pancreatic RNASE1 0.0004
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0004
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0004
4773 Deoxycytidine kinase DCK 0.0003
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