DT-Web

DB06994 - (2S,3S)-3-{3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-cyclopentylidene-4-cyclopropyl-1-fluorobutan-2-amine


Identification
Name (2S,3S)-3-{3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-cyclopentylidene-4-cyclopropyl-1-fluorobutan-2-amine
Accession Number DB06994
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 453.958
Groups experimental
Monoisotopic Weight 453.128918283
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Dipeptidyl peptidase 4
Name Dipeptidyl peptidase 4
Gene Name DPP4
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.6909

Predictions


Id Partner name Gene Name Score
957 Glucagon-like peptide 1 receptor GLP1R 0.0193
5660 Esterase EstB estB 0.0178
4512 Cytochrome P450 3A4 CYP3A4 0.0162
3095 Complement factor B CFB 0.0155
294 Neprilysin MME 0.015
2517 Subtilisin BPN' apr 0.0129
4681 Aminopeptidase Not Available 0.0114
3526 Pseudomonalisin pcp 0.0114
1588 Multidrug resistance protein 1 ABCB1 0.0104
6231 Pepsin A PGA3 0.0093
2300 Lysozyme E 0.0071
3633 Lysozyme R 0.0071
5597 Lysozyme 17 0.0071
4119 Cytochrome P450 2D6 CYP2D6 0.006
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0052
4924 Cytochrome P450 2C8 CYP2C8 0.0052
862 Multidrug resistance-associated protein 1 ABCC1 0.0048
4118 Cytochrome P450 3A5 CYP3A5 0.0037
6142 Solute carrier family 22 member 8 SLC22A8 0.0036
6220 Aryl hydrocarbon receptor AHR 0.0016
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0015
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0015
6136 Multidrug resistance-associated protein 5 ABCC5 0.0012
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0012
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0012
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0012
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0011
4878 Glycoprotein hormones alpha chain CGA 0.0011
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0011
1072 Granzyme B GZMB 0.0011
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0011
4877 Beta-mannanase man 0.0011
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0011
4856 CD209 antigen CD209 0.0011
4889 Ig epsilon chain C region IGHE 0.0011
4189 Alpha-galactosidase A GLA 0.0011
4869 Major capsid protein A430L 0.0011
4852 Reticulon-4 receptor RTN4R 0.0011
4880 Membrane cofactor protein CD46 0.0011
4845 ADAM 33 ADAM33 0.0011
757 Fusion glycoprotein F0 F 0.0011
4875 Fusion glycoprotein F0 F 0.0011
4721 Beta-1,4-mannanase manA 0.0011
4850 Beta-2-glycoprotein 1 APOH 0.0011
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0011
1354 Beta-glucuronidase GUSB 0.0011
442 Envelope glycoprotein gp41 0.0011
4859 Envelope glycoprotein env 0.0011
3352 Structural polyprotein Not Available 0.0011
3628 Structural polyprotein Not Available 0.0011
4892 Structural polyprotein Not Available 0.0011
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0011
2164 Multidrug resistance-associated protein 4 ABCC4 0.001
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.001
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.001
793 T-cell surface antigen CD2 CD2 0.001
4193 Atrial natriuretic peptide clearance receptor NPR3 0.001
4861 Interleukin-6 receptor alpha chain IL6R 0.001
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.001
3837 Cytokine receptor common beta chain CSF2RB 0.001
1379 Interleukin-12 subunit beta IL12B 0.0009
4890 Hemagglutinin HA 0.0009
6566 Hemagglutinin Not Available 0.0009
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0009
6858 Inactive carboxylesterase 4 CES1P1 0.0009
1184 Interferon beta IFNB1 0.0009
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0009
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0009
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0009
2297 Genome polyprotein Not Available 0.0009
2322 Genome polyprotein Not Available 0.0009
2694 Genome polyprotein Not Available 0.0009
2719 Genome polyprotein Not Available 0.0009
2860 Genome polyprotein Not Available 0.0009
2928 Genome polyprotein Not Available 0.0009
3160 Genome polyprotein Not Available 0.0009
3260 Genome polyprotein Not Available 0.0009
4783 Genome polyprotein Not Available 0.0009
5726 Genome polyprotein Not Available 0.0009
5779 Genome polyprotein Not Available 0.0009
5867 Genome polyprotein Not Available 0.0009
6253 Genome polyprotein Not Available 0.0009
6301 Genome polyprotein Not Available 0.0009
6380 Genome polyprotein Not Available 0.0009
6381 Genome polyprotein Not Available 0.0009
6437 Genome polyprotein Not Available 0.0009
6520 Genome polyprotein Not Available 0.0009
6521 Genome polyprotein Not Available 0.0009
6652 Genome polyprotein Not Available 0.0009
6734 Genome polyprotein Not Available 0.0009
6735 Genome polyprotein Not Available 0.0009
6736 Genome polyprotein Not Available 0.0009
6737 Genome polyprotein Not Available 0.0009
6738 Genome polyprotein Not Available 0.0009
6739 Genome polyprotein Not Available 0.0009
6744 Genome polyprotein Not Available 0.0009
6748 Genome polyprotein Not Available 0.0009
6894 Genome polyprotein Not Available 0.0009
6898 Genome polyprotein Not Available 0.0009
1859 Prostatic acid phosphatase ACPP 0.0009
3444 Cyanovirin-N Not Available 0.0009
3140 Hemagglutinin-neuraminidase HN 0.0009
3609 Hemagglutinin-neuraminidase HN 0.0009
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0009
6030 Cytochrome P450 2B6 CYP2B6 0.0008
4787 Envelope glycoprotein gp160 env 0.0008
4820 Envelope glycoprotein gp160 env 0.0008
5727 Envelope glycoprotein gp160 env 0.0008
4666 Fucose-binding lectin PA-IIL lecB 0.0008
2372 Bifunctional tail protein 9 0.0008
6107 Cytochrome P450 3A7 CYP3A7 0.0008
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0008
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0008
554 Low-density lipoprotein receptor LDLR 0.0008
852 Heparin cofactor 2 SERPIND1 0.0008
3480 Mannan endo-1,4-beta-mannosidase manA 0.0008
64 Neuraminidase NA 0.0008
641 Neuraminidase NA 0.0008
2676 Neuraminidase NA 0.0008
3026 Neuraminidase NA 0.0008
3519 Neuraminidase NA 0.0008
6007 Neuraminidase NA 0.0008
1439 Lactotransferrin LTF 0.0007
6016 Cytochrome P450 2C19 CYP2C19 0.0007
1243 Cathepsin D CTSD 0.0007
595 Fibrinogen alpha chain FGA 0.0007
4757 Cytochrome P450 2C9 CYP2C9 0.0007
958 Insulin-like growth factor 1 receptor IGF1R 0.0007
2430 Chondroitinase B cslB 0.0007
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0007
6307 Ig gamma-2 chain C region IGHG2 0.0007
2581 Chondroitinase AC cslA 0.0007
6500 Phospholipase A2 PLA2G1B 0.0007
6847 Lactase-phlorizin hydrolase LCT 0.0007
3814 Complement C1r subcomponent C1R 0.0006
2207 Rhodopsin RHO 0.0006
309 Antithrombin-III SERPINC1 0.0006
4785 Ig gamma-1 chain C region IGHG1 0.0006
76 Nitric-oxide synthase, brain NOS1 0.0005
4604 Liver carboxylesterase 1 CES1 0.0005
3923 Cholinesterase BCHE 0.0004
20 Prostaglandin G/H synthase 1 PTGS1 0.0003
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