DT-Web

DB06731 - Seproxetine


Identification
Name Seproxetine
Accession Number DB06731
Type small molecule
Description Seproxetine, also known as (S)-norfluoxetine, is a selective serotonin reuptake inhibitor (SSRI). It is an active metabolite of fluoxetine. Seproxetine was being investigated by Eli Lilly as an antidepressant but development was never completed and the drug was never marketed.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 295.2995
Groups Not Available
Monoisotopic Weight 295.118398754
Pharmacology
Indication Not Available
Mechanism of action Seproxetine, also known as (S)-norfluoxetine, is a selective serotonin reuptake inhibitor (SSRI). It is an active metabolite of fluoxetine. Seproxetine was being investigated by Eli Lilly as an antidepressant but development was never completed and the drug was never marketed.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Enzymes


Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions inhibitor
References
DTHybrid score 0.2504
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions inhibitor
References
DTHybrid score 0.2094

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.1786
1588 Multidrug resistance protein 1 ABCB1 0.0913
4119 Cytochrome P450 2D6 CYP2D6 0.0846
6016 Cytochrome P450 2C19 CYP2C19 0.0705
4757 Cytochrome P450 2C9 CYP2C9 0.0685
4924 Cytochrome P450 2C8 CYP2C8 0.0625
4200 Cytochrome P450 1A2 CYP1A2 0.0587
6030 Cytochrome P450 2B6 CYP2B6 0.0403
6024 Cytochrome P450 1A1 CYP1A1 0.0298
6013 Cytochrome P450 2E1 CYP2E1 0.0269
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0259
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0257
6031 Cytochrome P450 3A43 CYP3A43 0.0231
847 Mu-type opioid receptor OPRM1 0.0215
862 Multidrug resistance-associated protein 1 ABCC1 0.0206
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0206
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0191
5718 Cytochrome P450 2A6 CYP2A6 0.019
587 Serum albumin ALB 0.0186
6106 Cytochrome P450 2C18 CYP2C18 0.0173
6145 Solute carrier family 22 member 1 SLC22A1 0.0164
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0153
776 Bile salt export pump ABCB11 0.0146
320 5-hydroxytryptamine 1A receptor HTR1A 0.014
1898 Cytochrome P450 1B1 CYP1B1 0.0132
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.013
467 Delta-type opioid receptor OPRD1 0.0129
492 Histamine H1 receptor HRH1 0.0127
737 Mineralocorticoid receptor NR3C2 0.0119
6144 Solute carrier family 22 member 2 SLC22A2 0.0119
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0116
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0116
824 Sodium-dependent serotonin transporter SLC6A4 0.0115
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0115
696 Kappa-type opioid receptor OPRK1 0.0115
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0115
831 D(2) dopamine receptor DRD2 0.0114
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0113
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0111
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0111
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.011
20 Prostaglandin G/H synthase 1 PTGS1 0.011
6143 Solute carrier family 22 member 7 SLC22A7 0.011
638 D(3) dopamine receptor DRD3 0.0105
502 5-hydroxytryptamine 2A receptor HTR2A 0.0104
871 Glucocorticoid receptor NR3C1 0.0103
6182 Cytochrome P450 2J2 CYP2J2 0.01
6148 Multidrug resistance-associated protein 7 ABCC10 0.01
614 Progesterone receptor PGR 0.0099
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0096
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0093
3811 Cytochrome P450 19A1 CYP19A1 0.0092
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0091
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.009
220 Sodium channel protein type 5 subunit alpha SCN5A 0.009
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0089
1729 Solute carrier family 22 member 6 SLC22A6 0.0089
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0088
4148 Serine/threonine-protein kinase mTOR MTOR 0.0086
260 Cytochrome P450 51 ERG11 0.0082
761 Cytochrome P450 51 ERG11 0.0082
3163 Cytochrome P450 51 cyp51 0.0082
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0081
341 5-hydroxytryptamine 3 receptor HTR3A 0.0081
731 HIV-1 protease HIV-1 protease 0.0081
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.008
556 Alpha-1A adrenergic receptor ADRA1A 0.008
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0079
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0079
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0077
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0077
6147 Solute carrier family 22 member 3 SLC22A3 0.0074
817 DNA topoisomerase 2-alpha TOP2A 0.0074
756 Sex hormone-binding globulin SHBG 0.0071
811 Translocator protein TSPO 0.0071
318 Alpha-2A adrenergic receptor ADRA2A 0.007
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0069
2164 Multidrug resistance-associated protein 4 ABCC4 0.0068
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0067
590 5-hydroxytryptamine 2C receptor HTR2C 0.0067
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0066
118 Organic cation/carnitine transporter 2 SLC22A5 0.0066
632 Alpha-1B adrenergic receptor ADRA1B 0.0063
232 Corticosteroid-binding globulin SERPINA6 0.0063
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0062
468 Cytochrome P450 4A11 CYP4A11 0.0062
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0062
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0062
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0062
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0061
713 Sodium-dependent dopamine transporter SLC6A3 0.0061
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.006
23 D(1A) dopamine receptor DRD1 0.0059
378 Alpha-2C adrenergic receptor ADRA2C 0.0058
768 FK506-binding protein 1A FKBP1A 0.0058
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0058
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0057
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0056
844 Epidermal growth factor receptor EGFR 0.0055
477 DNA topoisomerase 4 subunit A parC 0.0055
886 DNA topoisomerase 4 subunit A parC 0.0055
6226 DNA topoisomerase 4 subunit A parC 0.0055
504 Mast/stem cell growth factor receptor KIT 0.0055
885 5-hydroxytryptamine 1B receptor HTR1B 0.0055
404 DNA gyrase subunit A gyrA 0.0054
6224 DNA gyrase subunit A gyrA 0.0054
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0054
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0054
228 Beta platelet-derived growth factor receptor PDGFRB 0.0053
432 D(4) dopamine receptor DRD4 0.0053
766 Beta-2 adrenergic receptor ADRB2 0.0053
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0053
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0052
6142 Solute carrier family 22 member 8 SLC22A8 0.0052
26 Vascular endothelial growth factor receptor 3 FLT4 0.0051
208 DNA-directed RNA polymerase beta' chain rpoC 0.0051
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0051
833 Organic cation/carnitine transporter 1 SLC22A4 0.0051
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0051
723 Cytosolic phospholipase A2 PLA2G4A 0.005
32 Vascular endothelial growth factor receptor 1 FLT1 0.0049
427 Substance-P receptor TACR1 0.0049
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0048
94 5-hydroxytryptamine 4 receptor HTR4 0.0048
1010 Cytochrome P450 51A1 CYP51A1 0.0046
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0046
29 Tubulin beta-1 chain TUBB1 0.0046
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0046
465 Calmodulin CALM1 0.0045
629 Alpha-2B adrenergic receptor ADRA2B 0.0045
407 Vascular endothelial growth factor receptor 2 KDR 0.0044
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0044
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0044
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0044
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0044
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0044
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0044
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0044
1256 5-hydroxytryptamine 6 receptor HTR6 0.0044
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0044
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0044
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0043
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0043
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0043
6220 Aryl hydrocarbon receptor AHR 0.0043
165 FL cytokine receptor FLT3 0.0043
705 Glutamate receptor 1 GRIA1 0.0042
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0042
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0042
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0042
6020 Aldehyde oxidase AOX1 0.0041
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0041
469 Annexin A1 ANXA1 0.0041
5923 Microtubule-associated protein tau MAPT 0.0041
5924 Microtubule-associated protein 4 MAP4 0.0041
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.004
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.004
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.004
725 5-hydroxytryptamine 1D receptor HTR1D 0.004
716 5-hydroxytryptamine 7 receptor HTR7 0.004
380 Cytochrome P450 17A1 CYP17A1 0.0039
2539 Tubulin alpha-1 chain TUBA4A 0.0038
4604 Liver carboxylesterase 1 CES1 0.0038
1852 Microtubule-associated protein 2 MAP2 0.0038
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0037
818 50S ribosomal protein L10 rplJ 0.0037
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0037
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0036
6136 Multidrug resistance-associated protein 5 ABCC5 0.0036
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0036
273 Apoptosis regulator Bcl-2 BCL2 0.0036
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0036
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0036
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0036
4238 50S ribosomal protein L4 rplD 0.0036
5578 50S ribosomal protein L4 rplD 0.0036
6173 50S ribosomal protein L4 rplD 0.0036
6219 50S ribosomal protein L4 rplD 0.0036
1196 Complement decay-accelerating factor CD55 0.0036
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0035
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0033
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0033
4237 50S ribosomal protein L22 rplV 0.0033
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0033
1656 CYP2B protein CYP2B 0.0032
1525 Heparin-binding growth factor 2 FGF2 0.0032
84 Nuclear receptor 0B1 NR0B1 0.0032
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0032
6141 Sodium/bile acid cotransporter SLC10A1 0.0031
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0031
4120 NADPH--cytochrome P450 reductase POR 0.0031
290 Prostaglandin G/H synthase 2 PTGS2 0.0031
2808 Chloramphenicol acetyltransferase 3 cat3 0.0031
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.003
2268 Cholesterol oxidase choB 0.003
2822 Cholesterol oxidase choA 0.003
238 Peroxisome proliferator-activated receptor gamma PPARG 0.003
528 5-hydroxytryptamine 1E receptor HTR1E 0.0029
6137 Multidrug resistance-associated protein 6 ABCC6 0.0029
3601 Dihydropteroate synthase 1 folP1 0.0028
3807 Dihydropteroate synthase 1 folP1 0.0028
3808 Dihydropteroate synthase 2 folP2 0.0028
2417 Chloramphenicol acetyltransferase cat 0.0028
3278 Chloramphenicol acetyltransferase cat 0.0028
193 Beta-1 adrenergic receptor ADRB1 0.0028
239 Coagulation factor X F10 0.0028
2283 Steroid Delta-isomerase ksi 0.0028
2920 Steroid Delta-isomerase ksi 0.0028
146 Androgen receptor AR 0.0028
136 Estrogen receptor ESR1 0.0028
777 Tumor necrosis factor TNF 0.0028
2810 Dr hemagglutinin structural subunit draA 0.0028
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0028
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0027
3913 Glutamic acid decarboxylase GAD65 0.0027
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0026
4773 Deoxycytidine kinase DCK 0.0026
54 Prothrombin F2 0.0026
5300 Antigen peptide transporter 1 TAP1 0.0025
319 Opioid receptor, sigma 1 OPRS1 0.0025
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0025
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0025
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0024
1483 Membrane copper amine oxidase AOC3 0.0024
1630 Integrin beta-2 ITGB2 0.0024
1050 Bile salt sulfotransferase SULT2A1 0.0024
976 Platelet glycoprotein IX GP9 0.0024
163 D(1B) dopamine receptor DRD5 0.0024
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0023
3941 Amine oxidase [flavin-containing] A MAOA 0.0023
952 Dipeptidyl peptidase 4 DPP4 0.0023
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0023
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0023
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0023
1770 Phospholipase C PLCL1 0.0023
2841 Phospholipase C plc 0.0023
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0023
789 Alpha-1D adrenergic receptor ADRA1D 0.0023
738 Monocarboxylate transporter 1 SLC16A1 0.0023
3086 Plasmepsin-2 Not Available 0.0023
124 Histamine H2 receptor HRH2 0.0022
153 Dopamine beta-hydroxylase DBH 0.0022
3904 Alanine aminotransferase 2 GPT2 0.0022
735 Alanine aminotransferase 1 GPT 0.0022
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0022
814 Ryanodine receptor 1 RYR1 0.0022
161 Tubulin beta chain TUBB 0.0022
312 Tubulin beta chain TUB2 0.0022
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0022
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0022
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0021
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0021
174 Sigma 1-type opioid receptor SIGMAR1 0.0021
6048 Troponin C, skeletal muscle TNNC2 0.002
719 Retinoic acid receptor responder protein 1 RARRES1 0.002
770 Retinoic acid-induced protein 3 GPRC5A 0.002
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.002
6102 Arylamine N-acetyltransferase 2 NAT2 0.002
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.002
823 Fibroblast growth factor receptor 2 FGFR2 0.002
6044 Serum paraoxonase/lactonase 3 PON3 0.002
1024 Solute carrier family 22 member 11 SLC22A11 0.002
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0019
33 Cystine/glutamate transporter SLC7A11 0.0019
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0019
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0019
1618 High affinity nerve growth factor receptor NTRK1 0.0019
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0019
1517 Beta-3 adrenergic receptor ADRB3 0.0019
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0018
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0018
16 Adenosine A1 receptor ADORA1 0.0018
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0018
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0018
1178 Adenosine A2a receptor ADORA2A 0.0018
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0018
572 Integrin alpha-L ITGAL 0.0018
569 Retinal dehydrogenase 2 ALDH1A2 0.0018
2112 Toll-like receptor 9 TLR9 0.0018
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0018
267 Plasminogen activator inhibitor 1 SERPINE1 0.0018
1864 RET proto-oncogene RET 0.0017
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0017
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0017
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0017
1353 DNA topoisomerase 1 TOP1 0.0017
3552 DNA topoisomerase 1 topA 0.0017
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0017
4122 Histone deacetylase 2 HDAC2 0.0017
611 Retinal dehydrogenase 1 ALDH1A1 0.0017
131 Synaptic vesicular amine transporter SLC18A2 0.0017
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
4311 tRNA TRDMT1 0.0016
4325 tRNA trmD 0.0016
4328 tRNA trmD 0.0016
869 Estrogen receptor beta ESR2 0.0016
6174 50S ribosomal protein L32 rpmF 0.0016
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0016
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0016
5934 Cytochrome P450 26A1 CYP26A1 0.0016
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0016
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0016
1757 Myeloperoxidase MPO 0.0016
6221 Steroid hormone receptor ERR1 ESRRA 0.0016
4203 Histamine N-methyltransferase HNMT 0.0016
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0015
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0015
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0015
3939 Amine oxidase [flavin-containing] B MAOB 0.0015
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0015
4192 DNA topoisomerase 2-beta TOP2B 0.0015
780 Retinoic acid receptor RXR-gamma RXRG 0.0015
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0014
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0014
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0014
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0014
3932 Glutathione S-transferase A2 GSTA2 0.0014
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0013
1192 Sulfotransferase 1A1 SULT1A1 0.0013
88 Retinoic acid receptor RXR-beta RXRB 0.0013
122 P2Y purinoceptor 12 P2RY12 0.0013
162 Retinoic acid receptor gamma-1 RARG 0.0013
1650 Heme carrier protein 1 SLC46A1 0.0013
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0013
6014 Cytochrome P450 2A13 CYP2A13 0.0012
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0012
3809 Estrogen-related receptor gamma ESRRG 0.0012
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0012
284 DNA-directed RNA polymerase beta chain rpoB 0.0012
5773 DNA-directed RNA polymerase beta chain rpoB 0.0012
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0012
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0012
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0012
295 Carbonic anhydrase 1 CA1 0.0011
3923 Cholinesterase BCHE 0.0011
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0011
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0011
275 Arachidonate 5-lipoxygenase ALOX5 0.001
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.001
1063 Signal transducer and activator of transcription 5B STAT5B 0.001
6085 Fatty acid-binding protein, intestinal FABP2 0.001
2216 Fibroblast growth factor receptor 4 FGFR4 0.001
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0009
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0009
751 Potassium channel subfamily K member 6 KCNK6 0.0009
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0009
3856 Fibroblast growth factor receptor 3 FGFR3 0.0008
936 Ephrin type-A receptor 2 EPHA2 0.0008
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0008
484 Tyrosine-protein kinase ABL2 ABL2 0.0008
172 Potassium channel subfamily K member 1 KCNK1 0.0008
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0008
7 Nitric oxide synthase, inducible NOS2 0.0008
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0008
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0008
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0008
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0008
70 Type-1 angiotensin II receptor AGTR1 0.0007
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0007
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0007
6824 Tyrosine-protein kinase Lyn LYN 0.0007
5787 Angiopoietin-1 receptor TEK 0.0007
921 Glutamate receptor 2 GRIA2 0.0007
1039 Histone deacetylase 9 HDAC9 0.0007
908 Glutathione S-transferase theta-1 GSTT1 0.0007
6432 Transporter snf 0.0006
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0006
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0006
3947 Xanthine dehydrogenase/oxidase XDH 0.0006
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0006
904 Glutathione S-transferase P GSTP1 0.0005
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0005
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0004
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