DT-Web

DB04106 - Fotemustine


Identification
Name Fotemustine
Accession Number DB04106 (EXPT03300)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 315.691
Groups experimental
Monoisotopic Weight 315.075084952
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Thioredoxin reductase 1, cytoplasmic
Name Thioredoxin reductase 1, cytoplasmic
Gene Name TXNRD1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.5195

Predictions


Id Partner name Gene Name Score
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0863
3560 Gentamicin 3'-acetyltransferase aacC1 0.0751
2826 Glucose--fructose oxidoreductase gfo 0.0557
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0557
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0557
2675 Pteridine reductase 1 PTR1 0.0545
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0467
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0461
833 Organic cation/carnitine transporter 1 SLC22A4 0.0317
1569 G1/S-specific cyclin-D1 CCND1 0.0263
6145 Solute carrier family 22 member 1 SLC22A1 0.026
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0233
1714 Mitogen-activated protein kinase 3 MAPK3 0.023
1176 Mitogen-activated protein kinase 1 MAPK1 0.0203
1629 Transcription factor AP-1 JUN 0.0196
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0183
1898 Cytochrome P450 1B1 CYP1B1 0.0122
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0107
6024 Cytochrome P450 1A1 CYP1A1 0.01
1588 Multidrug resistance protein 1 ABCB1 0.0084
4512 Cytochrome P450 3A4 CYP3A4 0.0073
5109 Outer membrane protein p64k or PM-6 m-6 0.0054
5122 Mersacidin decarboxylase mrsD 0.0054
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0054
5115 FkbI fkbI 0.0054
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0054
5095 Putidaredoxin reductase camA 0.0054
3763 5,10-methylenetetrahydrofolate reductase metF 0.0054
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0054
5094 5,10-methylenetetrahydrofolate reductase metF 0.0054
5083 Cryptochrome DASH cry 0.0054
526 Thioredoxin reductase trxB 0.0054
3767 Thioredoxin reductase trxB 0.0054
5078 Amine oxidase, flavin-containing PSPTO1126 0.0054
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0054
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0054
5111 Phenylacetone monooxygenase pamO 0.0054
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0054
3133 UDP-galactopyranose mutase glf 0.0054
5099 UDP-galactopyranose mutase glf 0.0054
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0054
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0054
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0054
5081 L-aspartate oxidase nadB 0.0054
1410 Oxidoreductase HSD17B6 0.0054
4725 Oxidoreductase Not Available 0.0054
5124 Oxidoreductase Not Available 0.0054
4477 Dihydrolipoyl dehydrogenase lpdV 0.0049
5077 Dihydrolipoyl dehydrogenase Not Available 0.0049
5117 Dihydrolipoyl dehydrogenase lpd 0.0049
4486 Phenol 2-hydroxylase component B pheA2 0.0049
4439 Ferredoxin reductase bphA4 0.0049
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0047
5073 Ferredoxin--NADP reductase petH 0.0047
5076 Ferredoxin--NADP reductase fpr 0.0047
5119 Ferredoxin--NADP reductase petH 0.0047
5121 Ferredoxin--NADP reductase fpr 0.0047
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0047
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0047
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0047
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0047
3594 Deoxyribodipyrimidine photo-lyase phr 0.0047
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0047
5080 Deoxyribodipyrimidine photo-lyase phr 0.0047
2268 Cholesterol oxidase choB 0.0047
2822 Cholesterol oxidase choA 0.0047
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0047
2526 NADPH-ferredoxin reductase fprA fprA 0.0047
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0047
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0047
2470 Pyruvate oxidase pox5 0.0047
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0047
5072 N,N-dimethylglycine oxidase dmg 0.0047
4440 NADH peroxidase npr 0.0045
3102 Flavohemoprotein hmp 0.0045
4969 Flavohemoprotein hmp 0.0045
2893 Glycine oxidase thiO 0.0043
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0043
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0043
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0041
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0041
2823 Trypanothione reductase TPR 0.0041
2567 Thymidylate synthase thyX thyX 0.0041
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0041
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.004
327 Glutathione reductase gor 0.004
5110 Glutathione reductase GR2 0.004
2769 P-hydroxybenzoate hydroxylase pobA 0.0039
2809 P-hydroxybenzoate hydroxylase pobA 0.0039
126 D-lactate dehydrogenase dld 0.0039
3545 D-lactate dehydrogenase Not Available 0.0039
4510 D-lactate dehydrogenase ldhA 0.0039
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
2380 Monomeric sarcosine oxidase soxA 0.0038
6645 D-amino-acid oxidase DAO 0.0036
714 Glutathione reductase, mitochondrial GSR 0.003
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0029
76 Nitric-oxide synthase, brain NOS1 0.0028
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0026
4120 NADPH--cytochrome P450 reductase POR 0.0025
3939 Amine oxidase [flavin-containing] B MAOB 0.0022
3947 Xanthine dehydrogenase/oxidase XDH 0.0021
3941 Amine oxidase [flavin-containing] A MAOA 0.002
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