DT-Web

DB03977 - N-Trimethyllysine


Identification
Name N-Trimethyllysine
Accession Number DB03977 (EXPT02087)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 189.2752
Groups experimental
Monoisotopic Weight 189.160302926
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Cytochrome c
Name Cytochrome c
Gene Name CYCS
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.8697
Calmodulin
Name Calmodulin
Gene Name CALM1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.4434

Predictions


Id Partner name Gene Name Score
20 Prostaglandin G/H synthase 1 PTGS1 0.0542
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0464
722 Troponin I, cardiac muscle TNNI3 0.0347
4119 Cytochrome P450 2D6 CYP2D6 0.03
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0224
1588 Multidrug resistance protein 1 ABCB1 0.0208
1654 Interleukin-1 beta IL1B 0.0192
831 D(2) dopamine receptor DRD2 0.0191
6030 Cytochrome P450 2B6 CYP2B6 0.0189
494 Caspase-1 CASP1 0.0187
4200 Cytochrome P450 1A2 CYP1A2 0.0183
4757 Cytochrome P450 2C9 CYP2C9 0.0173
1089 Cartilage oligomeric matrix protein COMP 0.0168
1108 Calpastatin CAST 0.0168
2077 Caspase-3 CASP3 0.0162
4923 Cytochrome c3 DvMF_2499 0.0159
4945 Cytochrome c3 Not Available 0.0159
4949 Cytochrome c3 DVU_3171 0.0159
4968 Cytochrome c3 cytc3 0.0159
4997 Cytochrome c3 SO_2727 0.0159
5219 Cytochrome c3 cyd 0.0159
4948 Cytochrome c-553 Not Available 0.0159
4902 Nine-heme cytochrome c Ddes_2038 0.0159
3189 High-molecular-weight cytochrome c hmcA 0.0159
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0159
6048 Troponin C, skeletal muscle TNNC2 0.0157
183 Vascular endothelial growth factor A VEGFA 0.0156
3152 Cytochrome c'' cycA 0.0148
5221 Cytochrome c3, 13 kDa Not Available 0.0148
5220 Split-Soret cytochrome c Ddes_2150 0.0148
3700 Cytochrome c-552 precursor nrfA 0.0148
65 Matrix metalloproteinase-9 Not Available 0.0147
2392 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0146
3032 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0146
4386 Hemoglobin-like protein HbN glbN 0.0145
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.014
22 30S ribosomal protein S4 rpsD 0.0138
6714 30S ribosomal protein S4 rpsD 0.0138
6013 Cytochrome P450 2E1 CYP2E1 0.0138
3221 Cytochrome c4 cc4 0.0136
4512 Cytochrome P450 3A4 CYP3A4 0.0135
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0132
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0132
275 Arachidonate 5-lipoxygenase ALOX5 0.0131
140 30S ribosomal protein S9 rpsI 0.0131
6719 30S ribosomal protein S9 rpsI 0.0131
6725 30S ribosomal protein S9 rpsI 0.0131
3127 Nitrite reductase nirS 0.0129
3284 Nitrite reductase nirS 0.0129
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0129
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0127
2314 Triosephosphate isomerase TPI 0.0123
3417 Triosephosphate isomerase tpiA 0.0123
3443 Triosephosphate isomerase tpiA 0.0123
6346 Triosephosphate isomerase TPI1 0.0123
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.012
556 Alpha-1A adrenergic receptor ADRA1A 0.0118
2795 Methionine aminopeptidase 2 METAP2 0.0117
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0112
4924 Cytochrome P450 2C8 CYP2C8 0.0109
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0109
6142 Solute carrier family 22 member 8 SLC22A8 0.0105
5682 Ribonuclease pancreatic RNASE1 0.0104
3923 Cholinesterase BCHE 0.01
23 D(1A) dopamine receptor DRD1 0.0098
2132 Protein S100-B S100B 0.0096
1024 Solute carrier family 22 member 11 SLC22A11 0.0096
6859 Protein S100-A4 S100A4 0.0094
6143 Solute carrier family 22 member 7 SLC22A7 0.0093
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0087
6016 Cytochrome P450 2C19 CYP2C19 0.0083
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0079
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0076
1729 Solute carrier family 22 member 6 SLC22A6 0.0076
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0075
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0075
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0072
4118 Cytochrome P450 3A5 CYP3A5 0.007
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.007
6024 Cytochrome P450 1A1 CYP1A1 0.0069
1262 Corticotropin-lipotropin POMC 0.0064
492 Histamine H1 receptor HRH1 0.0062
6107 Cytochrome P450 3A7 CYP3A7 0.006
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0057
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0057
705 Glutamate receptor 1 GRIA1 0.0056
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0054
3830 Calreticulin CALR 0.0053
6106 Cytochrome P450 2C18 CYP2C18 0.0053
537 ATP synthase delta chain, mitochondrial ATP5D 0.0053
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0052
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0052
5718 Cytochrome P450 2A6 CYP2A6 0.0052
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0051
450 Muscarinic acetylcholine receptor M4 CHRM4 0.005
6035 Nuclear receptor ROR-beta RORB 0.005
6034 Hydroxyindole O-methyltransferase ASMT 0.005
482 Glycine receptor subunit alpha-1 GLRA1 0.005
6036 Eosinophil peroxidase EPX 0.005
3947 Xanthine dehydrogenase/oxidase XDH 0.0048
587 Serum albumin ALB 0.0047
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0047
378 Alpha-2C adrenergic receptor ADRA2C 0.0046
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0045
629 Alpha-2B adrenergic receptor ADRA2B 0.0045
6147 Solute carrier family 22 member 3 SLC22A3 0.0045
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0044
765 Indoleamine 2,3-dioxygenase IDO1 0.0044
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0043
362 Melatonin receptor type 1B MTNR1B 0.0042
571 Melatonin receptor type 1A MTNR1A 0.0042
766 Beta-2 adrenergic receptor ADRB2 0.0042
467 Delta-type opioid receptor OPRD1 0.0041
696 Kappa-type opioid receptor OPRK1 0.0041
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.004
318 Alpha-2A adrenergic receptor ADRA2A 0.004
6144 Solute carrier family 22 member 2 SLC22A2 0.0039
638 D(3) dopamine receptor DRD3 0.0039
847 Mu-type opioid receptor OPRM1 0.0039
6145 Solute carrier family 22 member 1 SLC22A1 0.0038
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0034
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0033
4905 Cytochrome c2 Not Available 0.0031
4939 Cytochrome c2 cycA 0.0031
4964 Cytochrome c2 cycA 0.0031
4979 Cytochrome c2 cycA 0.0031
6673 Cytochrome c2 cycA 0.0031
4934 Cytochrome c-551 nirM 0.0031
5218 Cytochrome c-551 nirM 0.0031
4936 Cytochrome c2 iso-2 Not Available 0.0031
4916 Cyanoglobin glbN 0.0031
4998 Hemoglobin-like protein yjbI yjbI 0.0031
4943 Cytochrome c6 petJ 0.0031
4981 Iron-starvation protein PigA pigA 0.0031
4994 Hemoglobin-like protein HbO glbO 0.0031
4915 Cytochrome c-550 psbV 0.0031
4959 Cytochrome c-550 psbV 0.0031
5216 Cytochrome c-550 psbV 0.0031
4925 Cytochrome c-type protein SHP shp 0.0031
4999 Cytochrome P450 165B3 CYP165B3 0.0031
4947 Bacterial hemoglobin vhb 0.0031
4975 Cytochrome c-556 RPA3973 0.0031
4942 Diheme cytochrome c napB napB 0.0031
4984 Neuroglobin NGB 0.0031
3116 Bacterioferritin bfr 0.0031
4906 Bacterioferritin bfr 0.0031
4965 Bacterioferritin bfr 0.0031
4935 Cytochrome c-554 cycA1 0.0031
4937 Cytochrome oxidase subunit II rcoxA 0.0031
4961 Hemophore HasA hasA 0.0031
4910 Cytoglobin CYGB 0.0031
4904 Cytochrome c family protein GSU1996 0.0031
4907 Cytochrome c-L moxG 0.0031
6865 Cytochrome c-L moxG 0.0031
4954 Soluble cytochrome b558 Not Available 0.0031
4909 CooA protein cooA 0.0031
5000 HemO hemO 0.0031
4971 Nonaheme cytochrome c hmcA 0.0031
4931 Cytochrome P450 167A1 CYP167A1 0.0031
644 Heme oxygenase 2 HMOX2 0.0031
4982 Heme oxygenase 2 pbsA2 0.0031
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0031
4922 Cytochrome c, putative SO_4144 0.0031
4989 Cytochrome c551 peroxidase ccp 0.0031
5222 Cytochrome c551 peroxidase ccpA 0.0031
4976 Apocytochrome f petA 0.0031
6407 Apocytochrome f petA 0.0031
4903 Methyl-accepting chemotaxis protein Tar4 0.0031
4972 P450cin cinA 0.0031
4764 Cytochrome P450 165C4 CYP165C4 0.0031
4960 Putative cytochrome P450-family protein SCO7417 0.0031
4926 Heme-based aerotactic transducer hemAT hemAT 0.0031
4952 Catalase/peroxidase katA 0.0031
4993 Hydroxylamine oxidoreductase hao1 0.0031
3093 Catalase HPII katE 0.0031
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0031
502 5-hydroxytryptamine 2A receptor HTR2A 0.0028
1757 Myeloperoxidase MPO 0.0028
737 Mineralocorticoid receptor NR3C2 0.0027
4990 PpcA ppcA 0.0027
4920 Peroxidase/catalase katG 0.0027
3375 Acidic cytochrome c3 Not Available 0.0026
2119 Cytochrome b5 CYB5A 0.0026
4813 Heme oxygenase hmuO 0.0026
5769 Heme oxygenase Not Available 0.0026
4385 Cytochrome c' Not Available 0.0026
4967 Cytochrome c' cycA 0.0026
5038 Cytochrome c' Not Available 0.0026
5223 Cytochrome c' cycP 0.0026
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0026
3570 Cytochrome P450 152A1 cypC 0.0026
4988 Sulfite oxidase, mitochondrial SUOX 0.0026
4037 Hypothetical protein GPX1 0.0026
4297 Hypothetical protein SP_1951 0.0026
4521 Hypothetical protein BC_2969 0.0026
4540 Hypothetical protein TM_1070 0.0026
4555 Hypothetical protein MT1739 0.0026
4569 Hypothetical protein mshD 0.0026
4578 Hypothetical protein PA3270 0.0026
4747 Hypothetical protein PA3967 0.0026
5177 Hypothetical protein TM_0096 0.0026
5194 Hypothetical protein PA1204 0.0026
5240 Hypothetical protein Rv2991 0.0026
5370 Hypothetical protein TM_1158 0.0026
5710 Hypothetical protein Tb927.5.1360 0.0026
2915 Sensor protein fixL fixL 0.0026
4944 Sensor protein fixL fixL 0.0026
4992 Cytochrome c peroxidase Not Available 0.0026
4289 Cytochrome P450 TT_P0059 0.0026
6262 Cytochrome P450 staP 0.0026
1898 Cytochrome P450 1B1 CYP1B1 0.0024
3670 Soluble cytochrome b562 precursor cybC 0.0024
3291 Cytochrome c-552 cycA 0.0024
4927 Cytochrome c-552 nrfA 0.0024
4938 Cytochrome c-552 cycA 0.0024
4953 Cytochrome c-552 nrfA 0.0024
5217 Cytochrome c-552 cycM 0.0024
3411 Cytochrome P450 121 cyp121 0.0024
2617 Nitric oxide synthase oxygenase nos 0.0024
2701 Nitric oxide synthase oxygenase nos 0.0024
3102 Flavohemoprotein hmp 0.0024
4969 Flavohemoprotein hmp 0.0024
3811 Cytochrome P450 19A1 CYP19A1 0.0024
136 Estrogen receptor ESR1 0.0023
2230 Catalase CAT 0.0023
3249 Catalase katA 0.0023
3625 Catalase katA 0.0023
4539 Catalase katA 0.0023
4941 Catalase katB 0.0023
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0023
394 Calcineurin subunit B isoform 1 PPP3R1 0.0022
6742 Recoverin RCVRN 0.0022
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0022
2528 Fatty acid metabolism regulator protein fadR 0.0022
6740 Fatty acid metabolism regulator protein fadR 0.0022
6753 Apolipoprotein M APOM 0.0022
6747 Chalcone/stilbene synthase family protein MT1417 0.0022
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0022
6743 Non-fluorescent flavoprotein luxF 0.0022
6751 Gag polyprotein gag 0.0022
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0022
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0022
6749 Polyprotein Not Available 0.0022
4608 Putative cytochrome P450 SCO1207 0.0022
4963 Putative cytochrome P450 SCO2884 0.0022
6254 Putative cytochrome P450 SCO6998 0.0022
605 Fumarate reductase flavoprotein subunit frdA 0.0021
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0021
3673 Fumarate reductase flavoprotein subunit fccA 0.0021
4912 Fumarate reductase flavoprotein subunit ifcA 0.0021
6549 Fumarate reductase flavoprotein subunit frdA 0.0021
2972 6-deoxyerythronolide B hydroxylase eryF 0.0021
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0021
260 Cytochrome P450 51 ERG11 0.002
761 Cytochrome P450 51 ERG11 0.002
3163 Cytochrome P450 51 cyp51 0.002
789 Alpha-1D adrenergic receptor ADRA1D 0.002
5961 Insulin INS 0.002
518 Peroxidase/catalase T katG 0.002
6755 Poliovirus receptor PVR 0.0019
6527 Lymphocyte antigen 96 LY96 0.0019
693 Hemoglobin subunit beta HBB 0.0019
6268 Hydroxyacid oxidase 1 HAO1 0.0019
632 Alpha-1B adrenergic receptor ADRA1B 0.0018
6750 ADP-ribosylation factor 6 ARF6 0.0018
810 Heme oxygenase 1 HMOX1 0.0018
3391 Heme oxygenase 1 pbsA1 0.0018
6524 Protein tonB tonB 0.0018
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0018
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0018
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0017
358 Cystathionine beta-synthase CBS 0.0017
4210 Toll-like receptor 4 TLR4 0.0017
2616 Ganglioside GM2 activator GM2A 0.0017
2298 Cytochrome P450-cam camC 0.0016
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0016
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0016
76 Nitric-oxide synthase, brain NOS1 0.0015
2297 Genome polyprotein Not Available 0.0015
2322 Genome polyprotein Not Available 0.0015
2694 Genome polyprotein Not Available 0.0015
2719 Genome polyprotein Not Available 0.0015
2860 Genome polyprotein Not Available 0.0015
2928 Genome polyprotein Not Available 0.0015
3160 Genome polyprotein Not Available 0.0015
3260 Genome polyprotein Not Available 0.0015
4783 Genome polyprotein Not Available 0.0015
5726 Genome polyprotein Not Available 0.0015
5779 Genome polyprotein Not Available 0.0015
5867 Genome polyprotein Not Available 0.0015
6253 Genome polyprotein Not Available 0.0015
6301 Genome polyprotein Not Available 0.0015
6380 Genome polyprotein Not Available 0.0015
6381 Genome polyprotein Not Available 0.0015
6437 Genome polyprotein Not Available 0.0015
6520 Genome polyprotein Not Available 0.0015
6521 Genome polyprotein Not Available 0.0015
6652 Genome polyprotein Not Available 0.0015
6734 Genome polyprotein Not Available 0.0015
6735 Genome polyprotein Not Available 0.0015
6736 Genome polyprotein Not Available 0.0015
6737 Genome polyprotein Not Available 0.0015
6738 Genome polyprotein Not Available 0.0015
6739 Genome polyprotein Not Available 0.0015
6744 Genome polyprotein Not Available 0.0015
6748 Genome polyprotein Not Available 0.0015
6894 Genome polyprotein Not Available 0.0015
6898 Genome polyprotein Not Available 0.0015
6316 ADP-ribosylation factor 1 ARF1 0.0015
6085 Fatty acid-binding protein, intestinal FABP2 0.0014
864 Gag-Pol polyprotein gag-pol 0.0014
2237 Gag-Pol polyprotein gag-pol 0.0014
2326 Gag-Pol polyprotein gag-pol 0.0014
2451 Gag-Pol polyprotein gag-pol 0.0014
2901 Gag-Pol polyprotein gag-pol 0.0014
3165 Gag-Pol polyprotein gag-pol 0.0014
3722 Gag-Pol polyprotein gag-pol 0.0014
6306 Gag-Pol polyprotein gag-pol 0.0014
6624 Gag-Pol polyprotein gag-pol 0.0014
7 Nitric oxide synthase, inducible NOS2 0.0014
291 Nitric-oxide synthase, endothelial NOS3 0.0014
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0013
768 FK506-binding protein 1A FKBP1A 0.0012
2427 Ferrichrome-iron receptor fhuA 0.0012
6228 Nuclear receptor coactivator 1 NCOA1 0.0012
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0011
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0011
290 Prostaglandin G/H synthase 2 PTGS2 0.001
↑