DT-Web

DB03708 - Adenosine-5'-Phosphosulfate


Identification
Name Adenosine-5'-Phosphosulfate
Accession Number DB03708 (EXPT00441)
Type small molecule
Description 5'-Adenylic acid, monoanhydride with sulfuric acid. The initial compound formed by the action of ATP sulfurylase on sulfate ions after sulfate uptake. Synonyms: adenosine sulfatophosphate; APS. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 427.284
Groups experimental
Monoisotopic Weight 427.019898895
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


ATP sulfurylase
Name ATP sulfurylase
Gene Name TTHA0666
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 1.281
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1
Name Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1
Gene Name PAPSS1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available

Predictions


Id Partner name Gene Name Score
3116 Bacterioferritin bfr 0.0244
4906 Bacterioferritin bfr 0.0244
4965 Bacterioferritin bfr 0.0244
3238 Multidrug resistance protein mexA mexA 0.0244
3709 Glycerol uptake facilitator protein glpF 0.0244
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0244
3173 Enolase eno 0.0244
3393 TGF-beta receptor type-2 TGFBR2 0.0244
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0244
2852 DNA mismatch repair protein mutL mutL 0.0213
6459 Glycodelin PAEP 0.0196
3221 Cytochrome c4 cc4 0.0185
3191 Histidinol dehydrogenase hisD 0.0185
4692 A/G-specific adenine glycosylase mutY 0.0181
740 Argininosuccinate synthase ASS1 0.018
865 Argininosuccinate synthase ASS1 0.018
2680 Argininosuccinate synthase argG 0.018
3194 Argininosuccinate synthase argG 0.018
4311 tRNA TRDMT1 0.0176
4325 tRNA trmD 0.0176
4328 tRNA trmD 0.0176
2802 Endoglucanase G celCCG 0.0171
6316 ADP-ribosylation factor 1 ARF1 0.0166
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0147
444 Alcohol dehydrogenase 1B ADH1B 0.0142
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0141
904 Glutathione S-transferase P GSTP1 0.0116
6013 Cytochrome P450 2E1 CYP2E1 0.007
1588 Multidrug resistance protein 1 ABCB1 0.006
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0053
5304 UPF0166 protein TM_0021 TM_0021 0.0053
5293 Shikimate kinase 2 aroL 0.0053
5288 Shikimate kinase aroK 0.0053
5292 Putative partitioning protein TT_C1605 0.0053
3199 Phosphopantetheine adenylyltransferase coaD 0.0053
3543 Phosphopantetheine adenylyltransferase coaD 0.0053
3567 Phosphopantetheine adenylyltransferase coaD 0.0053
5289 Phosphopantetheine adenylyltransferase coaD 0.0053
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0053
5281 Plasmid segregation protein parM parM 0.0053
5287 Signaling protein Not Available 0.0053
5266 Activator of hgdC 0.0053
5259 Transcriptional regulator ntrC1 0.0053
6699 Transcriptional regulator Cgl2612 0.0053
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0053
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0053
4346 Polynucleotide kinase pseT 0.0053
5283 D-alanine--D-alanine ligase B ddlB 0.0053
5315 Chaperone protein htpG htpG 0.0053
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0053
2874 Nitrogenase iron protein 1 nifH1 0.0053
5276 Chromosomal replication initiator protein dnaA dnaA 0.0053
5284 Large T antigen Not Available 0.0053
5291 Glycogen synthase 1 glgA1 0.0053
5264 DNA replication protein REP 0.0053
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0053
5299 D-alanine--D-alanine ligase ddl 0.0053
6598 D-alanine--D-alanine ligase ddl 0.0053
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0053
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0053
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0053
5261 Phosphoribosylformylglycinamidine synthase purL 0.0053
5277 Preprotein translocase subunit secA secA 0.0053
5308 Preprotein translocase secA 1 subunit secA1 0.0053
5285 Kinesin heavy chain KIF5B 0.0053
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0053
4106 Guanylate kinase GUK1 0.0046
4516 Guanylate kinase gmk 0.0046
2270 Dephospho-CoA kinase coaE 0.0046
3470 Hypothetical protein MG245 homolog MPN_348 0.0046
5646 Galactokinase GALK1 0.0046
2284 Adenylate kinase adk 0.0046
2296 Adenylate kinase adk 0.0046
2311 Adenylate kinase adk 0.0046
2312 Adenylate kinase Not Available 0.0046
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0046
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0046
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0046
4837 Cag-alfa cag-alfa 0.0046
4774 NTPase P4 Not Available 0.0046
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0046
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0046
3426 Glutamine synthetase glnA 0.0046
3987 Glutamine synthetase GLUL 0.0046
413 Amidophosphoribosyltransferase PPAT 0.0046
2515 Amidophosphoribosyltransferase purF 0.0046
3714 Amidophosphoribosyltransferase purF 0.0046
4839 DNA polymerase III subunit tau dnaX 0.0046
5302 TrwB trwB 0.0046
3175 Glutamate--cysteine ligase gshA 0.0046
5265 FtsH ftsH 0.0046
5189 Trimethylamine dehydrogenase tmd 0.0046
6277 Heat shock cognate 71 kDa protein HSPA8 0.0046
4838 PMS1 protein homolog 2 PMS2 0.0046
2390 Nonsecretory ribonuclease RNASE2 0.0043
2683 Mono-ADP-ribosyltransferase C3 C3 0.0043
2922 Glycerol kinase glpK 0.0043
5271 Focal adhesion kinase 1 PTK2 0.0043
5312 Kinesin-like protein KIF1A KIF1A 0.0043
340 Apoptotic protease-activating factor 1 APAF1 0.0042
2282 Protein recA recA 0.004
2315 Protein recA recA 0.004
2332 Protein recA recA 0.004
5263 Protein recA recA 0.004
3669 Ribokinase rbsK 0.004
2892 Acetylglutamate kinase argB 0.004
3550 Acetylglutamate kinase argB 0.004
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.004
2371 Pantothenate kinase coaA 0.004
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.004
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.004
825 Arsenical pump-driving ATPase ASNA1 0.004
3435 Arsenical pump-driving ATPase arsA 0.004
2615 Chemotaxis protein cheA cheA 0.004
1881 Hexokinase-1 HK1 0.004
408 Riboflavin kinase RFK 0.004
5300 Antigen peptide transporter 1 TAP1 0.0039
2727 S-adenosylmethionine synthetase metK 0.0038
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0038
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0038
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0037
788 Creatine kinase M-type CKM 0.0037
2697 Uridine-cytidine kinase 2 UCK2 0.0037
2334 Dethiobiotin synthetase bioD 0.0037
6555 Dethiobiotin synthetase bioD 0.0037
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0037
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0036
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0036
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0036
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0035
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0035
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0034
6395 Myosin-14 MYH14 0.0034
2091 Endoplasmin HSP90B1 0.0034
702 UMP-CMP kinase CMPK1 0.0034
48 Pyridoxal kinase PDXK 0.0034
2251 Thymidylate kinase tmk 0.0033
2254 Thymidylate kinase DTYMK 0.0033
3522 Thymidylate kinase tmk 0.0033
1422 Serine/threonine-protein kinase 6 AURKA 0.0033
3379 Kinesin-like protein KIF11 KIF11 0.0032
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0032
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0032
207 Glutathione synthetase GSS 0.0031
5269 Glutathione synthetase gshB 0.0031
3822 Actin, alpha skeletal muscle ACTA1 0.0031
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0031
509 Thymidine kinase TK 0.003
570 Thymidine kinase TK 0.003
2559 Thymidine kinase TK 0.003
3430 Thymidine kinase tdk 0.003
3518 Thymidine kinase TK 0.003
5301 Thymidine kinase tdk 0.003
5771 Thymidine kinase ORF36 0.003
7009 Thymidine kinase ORF36 0.003
504 Mast/stem cell growth factor receptor KIT 0.0029
5294 Nucleoside diphosphate kinase A NME1 0.0029
1721 Glycogen synthase kinase-3 beta GSK3B 0.0029
5682 Ribonuclease pancreatic RNASE1 0.0027
4773 Deoxycytidine kinase DCK 0.0026
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0026
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0026
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0024
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