DT-Web

DB03233 - Phosphoric Acid Mono-[3-Amino-5-(5-Methyl-2,4-Dioxo-3,4-Dihydro-2h-Pyrimidin-1-Yl)-Tetrahydro-Furan-2-Ylmethyl] Ester


Identification
Name Phosphoric Acid Mono-[3-Amino-5-(5-Methyl-2,4-Dioxo-3,4-Dihydro-2h-Pyrimidin-1-Yl)-Tetrahydro-Furan-2-Ylmethyl] Ester
Accession Number DB03233 (EXPT02401)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 321.2237
Groups experimental
Monoisotopic Weight 321.072586393
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Thymidylate kinase
Name Thymidylate kinase
Gene Name DTYMK
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.157

Predictions


Id Partner name Gene Name Score
2251 Thymidylate kinase tmk 0.157
3522 Thymidylate kinase tmk 0.157
509 Thymidine kinase TK 0.0515
570 Thymidine kinase TK 0.0515
2559 Thymidine kinase TK 0.0515
3430 Thymidine kinase tdk 0.0515
3518 Thymidine kinase TK 0.0515
5301 Thymidine kinase tdk 0.0515
5771 Thymidine kinase ORF36 0.0515
7009 Thymidine kinase ORF36 0.0515
4275 PCZA361.16 Not Available 0.0293
4276 DNA polymerase III subunit epsilon dnaQ 0.0293
1353 DNA topoisomerase 1 TOP1 0.025
3552 DNA topoisomerase 1 topA 0.025
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0214
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0214
24 Thymidylate synthase TMP1 0.0151
359 Thymidylate synthase TYMS 0.0151
2626 Thymidylate synthase thyA 0.0151
2729 Thymidylate synthase thyA 0.0151
5352 Thymidylate synthase THYA 0.0151
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0079
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0079
5646 Galactokinase GALK1 0.0079
5302 TrwB trwB 0.0079
5265 FtsH ftsH 0.0079
5312 Kinesin-like protein KIF1A KIF1A 0.0072
2615 Chemotaxis protein cheA cheA 0.0068
1881 Hexokinase-1 HK1 0.0068
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0068
2371 Pantothenate kinase coaA 0.0068
2892 Acetylglutamate kinase argB 0.0067
3550 Acetylglutamate kinase argB 0.0067
825 Arsenical pump-driving ATPase ASNA1 0.0067
3435 Arsenical pump-driving ATPase arsA 0.0067
2727 S-adenosylmethionine synthetase metK 0.0065
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0063
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0062
4178 DNA repair protein RAD51 homolog 1 RAD51 0.0062
5649 Potassium-transporting ATPase B chain kdpB 0.0062
3794 Osmolarity sensor protein envZ envZ 0.0062
5643 General secretion pathway protein E epsE 0.0062
5641 Rod shape-determining protein MreB TM_0588 0.0062
5645 DNA topoisomerase 4 subunit B parE 0.0062
6227 DNA topoisomerase 4 subunit B parE 0.0062
5642 Chaperone clpB clpB 0.0062
5644 Sensor protein phoQ phoQ 0.0062
2867 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ispE 0.0054
6433 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 PFKFB4 0.0054
4751 Mitogen-activated protein kinase 12 MAPK12 0.0054
2397 Dihydroxyacetone kinase dhaK 0.0054
740 Argininosuccinate synthase ASS1 0.0054
865 Argininosuccinate synthase ASS1 0.0054
2680 Argininosuccinate synthase argG 0.0054
3194 Argininosuccinate synthase argG 0.0054
2852 DNA mismatch repair protein mutL mutL 0.0054
3822 Actin, alpha skeletal muscle ACTA1 0.0052
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0052
207 Glutathione synthetase GSS 0.0052
5269 Glutathione synthetase gshB 0.0052
2299 UDP-N-acetylmuramate--L-alanine ligase murC 0.005
3231 Death-associated protein kinase 1 DAPK1 0.0049
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0049
1721 Glycogen synthase kinase-3 beta GSK3B 0.0048
887 DNA gyrase subunit B gyrB 0.0045
4150 DNA gyrase subunit B gyrB 0.0045
6225 DNA gyrase subunit B gyrB 0.0045
936 Ephrin type-A receptor 2 EPHA2 0.0044
958 Insulin-like growth factor 1 receptor IGF1R 0.0041
4192 DNA topoisomerase 2-beta TOP2B 0.0036
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0036
1836 Mitogen-activated protein kinase 10 MAPK10 0.0035
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0033
2236 Casein kinase II subunit alpha CSNK2A1 0.0032
5304 UPF0166 protein TM_0021 TM_0021 0.0028
3199 Phosphopantetheine adenylyltransferase coaD 0.0028
3543 Phosphopantetheine adenylyltransferase coaD 0.0028
3567 Phosphopantetheine adenylyltransferase coaD 0.0028
5289 Phosphopantetheine adenylyltransferase coaD 0.0028
5288 Shikimate kinase aroK 0.0028
5287 Signaling protein Not Available 0.0028
5292 Putative partitioning protein TT_C1605 0.0028
5276 Chromosomal replication initiator protein dnaA dnaA 0.0028
5266 Activator of hgdC 0.0028
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0028
5259 Transcriptional regulator ntrC1 0.0028
6699 Transcriptional regulator Cgl2612 0.0028
2874 Nitrogenase iron protein 1 nifH1 0.0028
4346 Polynucleotide kinase pseT 0.0028
5283 D-alanine--D-alanine ligase B ddlB 0.0028
5293 Shikimate kinase 2 aroL 0.0028
5281 Plasmid segregation protein parM parM 0.0028
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0028
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0028
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0028
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0028
5291 Glycogen synthase 1 glgA1 0.0028
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0028
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0028
5315 Chaperone protein htpG htpG 0.0028
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0028
5299 D-alanine--D-alanine ligase ddl 0.0028
6598 D-alanine--D-alanine ligase ddl 0.0028
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0028
5277 Preprotein translocase subunit secA secA 0.0028
5308 Preprotein translocase secA 1 subunit secA1 0.0028
5264 DNA replication protein REP 0.0028
5285 Kinesin heavy chain KIF5B 0.0028
5284 Large T antigen Not Available 0.0028
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0028
5261 Phosphoribosylformylglycinamidine synthase purL 0.0028
4106 Guanylate kinase GUK1 0.0024
4516 Guanylate kinase gmk 0.0024
413 Amidophosphoribosyltransferase PPAT 0.0024
2515 Amidophosphoribosyltransferase purF 0.0024
3714 Amidophosphoribosyltransferase purF 0.0024
5189 Trimethylamine dehydrogenase tmd 0.0024
4837 Cag-alfa cag-alfa 0.0024
4774 NTPase P4 Not Available 0.0024
4839 DNA polymerase III subunit tau dnaX 0.0024
4838 PMS1 protein homolog 2 PMS2 0.0024
2270 Dephospho-CoA kinase coaE 0.0024
6277 Heat shock cognate 71 kDa protein HSPA8 0.0024
2284 Adenylate kinase adk 0.0024
2296 Adenylate kinase adk 0.0024
2311 Adenylate kinase adk 0.0024
2312 Adenylate kinase Not Available 0.0024
3470 Hypothetical protein MG245 homolog MPN_348 0.0024
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0024
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0024
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0024
3175 Glutamate--cysteine ligase gshA 0.0024
3426 Glutamine synthetase glnA 0.0024
3987 Glutamine synthetase GLUL 0.0024
2390 Nonsecretory ribonuclease RNASE2 0.0022
2683 Mono-ADP-ribosyltransferase C3 C3 0.0022
2922 Glycerol kinase glpK 0.0022
340 Apoptotic protease-activating factor 1 APAF1 0.0022
5271 Focal adhesion kinase 1 PTK2 0.0022
2282 Protein recA recA 0.0021
2315 Protein recA recA 0.0021
2332 Protein recA recA 0.0021
5263 Protein recA recA 0.0021
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.002
3669 Ribokinase rbsK 0.002
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.002
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.002
408 Riboflavin kinase RFK 0.002
5300 Antigen peptide transporter 1 TAP1 0.002
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0019
2697 Uridine-cytidine kinase 2 UCK2 0.0019
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0019
2334 Dethiobiotin synthetase bioD 0.0019
6555 Dethiobiotin synthetase bioD 0.0019
788 Creatine kinase M-type CKM 0.0019
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0018
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0018
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0018
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0018
702 UMP-CMP kinase CMPK1 0.0017
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0017
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0017
6395 Myosin-14 MYH14 0.0017
48 Pyridoxal kinase PDXK 0.0017
2091 Endoplasmin HSP90B1 0.0017
1422 Serine/threonine-protein kinase 6 AURKA 0.0017
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0016
3379 Kinesin-like protein KIF11 KIF11 0.0016
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0016
5294 Nucleoside diphosphate kinase A NME1 0.0015
504 Mast/stem cell growth factor receptor KIT 0.0015
5682 Ribonuclease pancreatic RNASE1 0.0014
4773 Deoxycytidine kinase DCK 0.0013
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0013
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0013
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0012
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