DT-Web

DB03023 - 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine


Identification
Name 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
Accession Number DB03023 (EXPT02634)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 302.782
Groups experimental
Monoisotopic Weight 302.117248276
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Proto-oncogene tyrosine-protein kinase LCK
Name Proto-oncogene tyrosine-protein kinase LCK
Gene Name LCK
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.4396
Tyrosine-protein kinase Lyn
Name Tyrosine-protein kinase Lyn
Gene Name LYN
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.4291
Proto-oncogene tyrosine-protein kinase Src
Name Proto-oncogene tyrosine-protein kinase Src
Gene Name SRC
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.7871

Predictions


Id Partner name Gene Name Score
2599 Tyrosine-protein kinase HCK HCK 0.0915
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0828
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0763
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0565
504 Mast/stem cell growth factor receptor KIT 0.0496
2216 Fibroblast growth factor receptor 4 FGFR4 0.0417
2240 Cell division protein kinase 2 CDK2 0.039
3856 Fibroblast growth factor receptor 3 FGFR3 0.0384
1588 Multidrug resistance protein 1 ABCB1 0.0382
5787 Angiopoietin-1 receptor TEK 0.0361
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0348
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0314
823 Fibroblast growth factor receptor 2 FGFR2 0.0314
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0301
4512 Cytochrome P450 3A4 CYP3A4 0.03
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0295
165 FL cytokine receptor FLT3 0.0292
6782 Ribosomal protein S6 kinase alpha-1 RPS6KA1 0.0273
407 Vascular endothelial growth factor receptor 2 KDR 0.0255
844 Epidermal growth factor receptor EGFR 0.0221
6460 Casein kinase I isoform gamma-3 CSNK1G3 0.0207
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0191
1540 Mitogen-activated protein kinase 14 MAPK14 0.0187
2473 Tyrosine-protein kinase CSK CSK 0.0164
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.0163
776 Bile salt export pump ABCB11 0.0162
4118 Cytochrome P450 3A5 CYP3A5 0.0155
936 Ephrin type-A receptor 2 EPHA2 0.015
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0143
2530 Protein kinase C theta type PRKCQ 0.0131
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0124
4609 U1 small nuclear ribonucleoprotein A SNRPA 0.0117
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0116
4924 Cytochrome P450 2C8 CYP2C8 0.0116
2408 Tyrosine-protein kinase SYK SYK 0.0114
1721 Glycogen synthase kinase-3 beta GSK3B 0.0113
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0112
1063 Signal transducer and activator of transcription 5B STAT5B 0.0109
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0108
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0107
4119 Cytochrome P450 2D6 CYP2D6 0.0105
484 Tyrosine-protein kinase ABL2 ABL2 0.0102
4563 Acetyl transferase rimL 0.0102
2750 Aspartate 1-decarboxylase panD 0.0102
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0095
3490 Sigma factor sigB regulation protein rsbQ rsbQ 0.0094
228 Beta platelet-derived growth factor receptor PDGFRB 0.009
4600 Malonamidase E2 Not Available 0.0088
4608 Putative cytochrome P450 SCO1207 0.0085
4963 Putative cytochrome P450 SCO2884 0.0085
6254 Putative cytochrome P450 SCO6998 0.0085
6142 Solute carrier family 22 member 8 SLC22A8 0.008
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0073
1898 Cytochrome P450 1B1 CYP1B1 0.0054
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0047
5643 General secretion pathway protein E epsE 0.0046
5641 Rod shape-determining protein MreB TM_0588 0.0046
4178 DNA repair protein RAD51 homolog 1 RAD51 0.0046
5649 Potassium-transporting ATPase B chain kdpB 0.0046
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0046
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0046
3794 Osmolarity sensor protein envZ envZ 0.0046
5644 Sensor protein phoQ phoQ 0.0046
5642 Chaperone clpB clpB 0.0046
5645 DNA topoisomerase 4 subunit B parE 0.0046
6227 DNA topoisomerase 4 subunit B parE 0.0046
6024 Cytochrome P450 1A1 CYP1A1 0.0045
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0041
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0041
2282 Protein recA recA 0.0041
2315 Protein recA recA 0.0041
2332 Protein recA recA 0.0041
5263 Protein recA recA 0.0041
5646 Galactokinase GALK1 0.0041
5302 TrwB trwB 0.0041
5265 FtsH ftsH 0.0041
2867 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ispE 0.004
4751 Mitogen-activated protein kinase 12 MAPK12 0.004
6433 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 PFKFB4 0.004
2852 DNA mismatch repair protein mutL mutL 0.004
740 Argininosuccinate synthase ASS1 0.004
865 Argininosuccinate synthase ASS1 0.004
2680 Argininosuccinate synthase argG 0.004
3194 Argininosuccinate synthase argG 0.004
2397 Dihydroxyacetone kinase dhaK 0.004
4200 Cytochrome P450 1A2 CYP1A2 0.0038
5312 Kinesin-like protein KIF1A KIF1A 0.0037
3231 Death-associated protein kinase 1 DAPK1 0.0037
2299 UDP-N-acetylmuramate--L-alanine ligase murC 0.0037
2892 Acetylglutamate kinase argB 0.0035
3550 Acetylglutamate kinase argB 0.0035
2615 Chemotaxis protein cheA cheA 0.0035
2371 Pantothenate kinase coaA 0.0035
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0035
1881 Hexokinase-1 HK1 0.0035
825 Arsenical pump-driving ATPase ASNA1 0.0035
3435 Arsenical pump-driving ATPase arsA 0.0035
2727 S-adenosylmethionine synthetase metK 0.0034
887 DNA gyrase subunit B gyrB 0.0033
4150 DNA gyrase subunit B gyrB 0.0033
6225 DNA gyrase subunit B gyrB 0.0033
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0032
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0032
958 Insulin-like growth factor 1 receptor IGF1R 0.003
2251 Thymidylate kinase tmk 0.0029
2254 Thymidylate kinase DTYMK 0.0029
3522 Thymidylate kinase tmk 0.0029
3822 Actin, alpha skeletal muscle ACTA1 0.0027
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0027
1836 Mitogen-activated protein kinase 10 MAPK10 0.0026
207 Glutathione synthetase GSS 0.0026
5269 Glutathione synthetase gshB 0.0026
4192 DNA topoisomerase 2-beta TOP2B 0.0026
2236 Casein kinase II subunit alpha CSNK2A1 0.0024
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0013
2300 Lysozyme E 0.0013
3633 Lysozyme R 0.0013
5597 Lysozyme 17 0.0013
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0013
5591 Complement component C8 gamma chain C8G 0.0013
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0013
5582 Regulator of transcription; stringent starvation protein A sspA 0.0013
2838 Ribose-5-phosphate isomerase A rpiA 0.0013
2952 Ribose-5-phosphate isomerase A rpiA 0.0013
5595 Ribose-5-phosphate isomerase A rpiA 0.0013
4238 50S ribosomal protein L4 rplD 0.0013
5578 50S ribosomal protein L4 rplD 0.0013
6173 50S ribosomal protein L4 rplD 0.0013
6219 50S ribosomal protein L4 rplD 0.0013
4695 UPF0124 protein yfiH yfiH 0.0013
5590 N utilization substance protein B homolog nusB 0.0013
5588 Cell division protein FtsY TM_0570 0.0013
4375 Glutamine synthetase 1 glnA1 0.0013
5587 Iron(III)-binding periplasmic protein fbpA 0.0013
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0013
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.0013
5593 Transferase Not Available 0.0013
5581 Beta-fructosidase bfrA 0.0013
5060 Intron-associated endonuclease 1 ITEVIR 0.0013
5575 Short tail fiber protein 12 0.0013
5600 Pyruvate decarboxylase pdc 0.0013
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0013
5580 Hexon protein PII 0.0013
5574 Invasin YPTB1668 0.0013
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0011
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0011
4992 Cytochrome c peroxidase Not Available 0.0011
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0011
4533 Glyoxalase family protein BC_1747 0.0011
3132 Tryptophan synthase alpha chain trpA 0.0011
6568 Tryptophan synthase alpha chain trpA 0.0011
5328 Prostaglandin F synthase Tb11.02.2310 0.0011
3729 Citrate synthase gltA 0.0011
4575 Citrate synthase cit 0.0011
4580 Citrate synthase gltA 0.0011
5006 RNASE4 protein RNASE4 0.0011
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0011
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0011
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0011
2555 Pol polyprotein pol 0.0011
3242 Pol polyprotein gag-pol 0.0011
3471 Pol polyprotein gag-pro-pol 0.0011
5256 Pol polyprotein pol 0.0011
6469 Pol polyprotein gag-pol 0.0011
6565 Pol polyprotein Not Available 0.0011
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.001
2603 Beta-lactamase II blm 0.001
3583 6-phosphogluconolactonase pgl 0.001
2149 Angiogenin ANG 0.001
2521 Cell division protein ftsZ ftsZ 0.001
3301 Cell division protein ftsZ ftsZ 0.001
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.001
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.001
2286 Isocitrate dehydrogenase [NADP] icd 0.001
2302 Isocitrate dehydrogenase [NADP] icd 0.001
2771 Isocitrate dehydrogenase [NADP] icd 0.001
3486 Fumarate hydratase class II fumC 0.001
2942 Sialidase nanH 0.001
3546 Sialidase nedA 0.001
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.0009
857 Malate dehydrogenase, mitochondrial MDH2 0.0009
1123 Eosinophil cationic protein RNASE3 0.0009
332 Beta-lactamase blaZ 0.0009
2478 Beta-lactamase ampC 0.0009
2613 Beta-lactamase ampC 0.0009
2635 Beta-lactamase ampC 0.0009
2700 Beta-lactamase penP 0.0009
5445 Beta-lactamase blaB 0.0009
6019 Beta-lactamase SHV-7 0.0009
6701 Beta-lactamase cphA 0.0009
2697 Uridine-cytidine kinase 2 UCK2 0.0009
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0009
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0009
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0009
2452 Tryptophanyl-tRNA synthetase trpS 0.0009
5579 Carboxypeptidase B CPB1 0.0008
3384 Macrophage migration inhibitory factor MIF 0.0008
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0008
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0008
411 Glycine N-methyltransferase GNMT 0.0008
128 Adenine phosphoribosyltransferase APRT 0.0007
5682 Ribonuclease pancreatic RNASE1 0.0006
822 Aldose reductase AKR1B1 0.0006
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0006
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