DT-Web

DB02754 - 9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine


Identification
Name 9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine
Accession Number DB02754 (EXPT02694)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 371.4335
Groups experimental
Monoisotopic Weight 371.195739691
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Heat shock protein HSP 90-beta
Name Heat shock protein HSP 90-beta
Gene Name HSP90AB1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.3703
Heat shock protein HSP 90-alpha
Name Heat shock protein HSP 90-alpha
Gene Name HSP90AA1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.9721

Predictions


Id Partner name Gene Name Score
2091 Endoplasmin HSP90B1 0.1753
6840 Virulence sensor histidine kinase phoQ phoQ 0.0437
6839 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial PDK3 0.0381
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.031
111 Cysteinyl leukotriene receptor 2 CYSLTR2 0.0107
1448 fMet-Leu-Phe receptor FPR1 0.0107
325 Prostaglandin D2 receptor PTGDR 0.0107
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0076
512 DNA-directed RNA polymerase alpha chain rpoA 0.0073
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0073
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0064
284 DNA-directed RNA polymerase beta chain rpoB 0.0059
5773 DNA-directed RNA polymerase beta chain rpoB 0.0059
5315 Chaperone protein htpG htpG 0.0028
5304 UPF0166 protein TM_0021 TM_0021 0.0028
5293 Shikimate kinase 2 aroL 0.0028
5287 Signaling protein Not Available 0.0028
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0028
3199 Phosphopantetheine adenylyltransferase coaD 0.0028
3543 Phosphopantetheine adenylyltransferase coaD 0.0028
3567 Phosphopantetheine adenylyltransferase coaD 0.0028
5289 Phosphopantetheine adenylyltransferase coaD 0.0028
5288 Shikimate kinase aroK 0.0028
5276 Chromosomal replication initiator protein dnaA dnaA 0.0028
5266 Activator of hgdC 0.0028
5292 Putative partitioning protein TT_C1605 0.0028
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0028
2874 Nitrogenase iron protein 1 nifH1 0.0028
5259 Transcriptional regulator ntrC1 0.0028
6699 Transcriptional regulator Cgl2612 0.0028
4346 Polynucleotide kinase pseT 0.0028
5281 Plasmid segregation protein parM parM 0.0028
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0028
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0028
5299 D-alanine--D-alanine ligase ddl 0.0028
6598 D-alanine--D-alanine ligase ddl 0.0028
5264 DNA replication protein REP 0.0028
5283 D-alanine--D-alanine ligase B ddlB 0.0028
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0028
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0028
5284 Large T antigen Not Available 0.0028
5291 Glycogen synthase 1 glgA1 0.0028
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0028
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0028
5277 Preprotein translocase subunit secA secA 0.0028
5285 Kinesin heavy chain KIF5B 0.0028
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0028
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0028
5261 Phosphoribosylformylglycinamidine synthase purL 0.0028
5308 Preprotein translocase secA 1 subunit secA1 0.0028
4200 Cytochrome P450 1A2 CYP1A2 0.0027
3470 Hypothetical protein MG245 homolog MPN_348 0.0025
4106 Guanylate kinase GUK1 0.0025
4516 Guanylate kinase gmk 0.0025
2284 Adenylate kinase adk 0.0025
2296 Adenylate kinase adk 0.0025
2311 Adenylate kinase adk 0.0025
2312 Adenylate kinase Not Available 0.0025
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0025
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0025
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0025
5302 TrwB trwB 0.0025
4837 Cag-alfa cag-alfa 0.0025
4774 NTPase P4 Not Available 0.0025
5265 FtsH ftsH 0.0025
3175 Glutamate--cysteine ligase gshA 0.0025
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0025
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0025
2270 Dephospho-CoA kinase coaE 0.0025
5646 Galactokinase GALK1 0.0025
6277 Heat shock cognate 71 kDa protein HSPA8 0.0025
413 Amidophosphoribosyltransferase PPAT 0.0025
2515 Amidophosphoribosyltransferase purF 0.0025
3714 Amidophosphoribosyltransferase purF 0.0025
3426 Glutamine synthetase glnA 0.0025
3987 Glutamine synthetase GLUL 0.0025
5189 Trimethylamine dehydrogenase tmd 0.0025
4838 PMS1 protein homolog 2 PMS2 0.0025
4839 DNA polymerase III subunit tau dnaX 0.0025
4512 Cytochrome P450 3A4 CYP3A4 0.0023
2683 Mono-ADP-ribosyltransferase C3 C3 0.0023
2390 Nonsecretory ribonuclease RNASE2 0.0023
2922 Glycerol kinase glpK 0.0023
5271 Focal adhesion kinase 1 PTK2 0.0023
5312 Kinesin-like protein KIF1A KIF1A 0.0023
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0021
2892 Acetylglutamate kinase argB 0.0021
3550 Acetylglutamate kinase argB 0.0021
2371 Pantothenate kinase coaA 0.0021
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0021
3669 Ribokinase rbsK 0.0021
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0021
2615 Chemotaxis protein cheA cheA 0.0021
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0021
825 Arsenical pump-driving ATPase ASNA1 0.0021
3435 Arsenical pump-driving ATPase arsA 0.0021
1881 Hexokinase-1 HK1 0.0021
2727 S-adenosylmethionine synthetase metK 0.002
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.002
340 Apoptotic protease-activating factor 1 APAF1 0.002
5300 Antigen peptide transporter 1 TAP1 0.002
408 Riboflavin kinase RFK 0.002
2282 Protein recA recA 0.002
2315 Protein recA recA 0.002
2332 Protein recA recA 0.002
5263 Protein recA recA 0.002
2334 Dethiobiotin synthetase bioD 0.002
6555 Dethiobiotin synthetase bioD 0.002
2697 Uridine-cytidine kinase 2 UCK2 0.002
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.002
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.002
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.002
788 Creatine kinase M-type CKM 0.0019
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0019
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0019
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0019
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0019
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0018
6395 Myosin-14 MYH14 0.0018
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0018
48 Pyridoxal kinase PDXK 0.0017
2251 Thymidylate kinase tmk 0.0017
2254 Thymidylate kinase DTYMK 0.0017
3522 Thymidylate kinase tmk 0.0017
1422 Serine/threonine-protein kinase 6 AURKA 0.0017
702 UMP-CMP kinase CMPK1 0.0017
3379 Kinesin-like protein KIF11 KIF11 0.0017
3822 Actin, alpha skeletal muscle ACTA1 0.0017
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0016
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0016
207 Glutathione synthetase GSS 0.0016
5269 Glutathione synthetase gshB 0.0016
504 Mast/stem cell growth factor receptor KIT 0.0015
509 Thymidine kinase TK 0.0015
570 Thymidine kinase TK 0.0015
2559 Thymidine kinase TK 0.0015
3430 Thymidine kinase tdk 0.0015
3518 Thymidine kinase TK 0.0015
5301 Thymidine kinase tdk 0.0015
5771 Thymidine kinase ORF36 0.0015
7009 Thymidine kinase ORF36 0.0015
1721 Glycogen synthase kinase-3 beta GSK3B 0.0015
5294 Nucleoside diphosphate kinase A NME1 0.0015
5682 Ribonuclease pancreatic RNASE1 0.0014
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0013
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0013
4773 Deoxycytidine kinase DCK 0.0012
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