DT-Web

DB02076 - 6-Phosphogluconic Acid


Identification
Name 6-Phosphogluconic Acid
Accession Number DB02076 (EXPT00290)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 276.1352
Groups experimental
Monoisotopic Weight 276.024633148
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


6-phosphogluconate dehydrogenase, decarboxylating
Name 6-phosphogluconate dehydrogenase, decarboxylating
Gene Name PGD
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.6989
Glucose-6-phosphate isomerase
Name Glucose-6-phosphate isomerase
Gene Name GPI
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.2109
Thermoresistant gluconokinase
Name Thermoresistant gluconokinase
Gene Name gntK
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.561

Predictions


Id Partner name Gene Name Score
2677 Glucose-6-phosphate isomerase B pgiB 0.1405
2597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] glmS 0.1002
3134 Phospho-2-dehydro-3-deoxyheptonate aldolase aroF 0.0937
2310 2-dehydro-3-deoxyphosphooctonate aldolase kdsA 0.071
2542 2-dehydro-3-deoxyphosphooctonate aldolase kdsA 0.071
5466 Putative sugar kinase STM4066 0.0656
4517 Probable butyrate kinase 2 buk2 0.0656
2878 Probable serine/threonine-protein kinase pknB pknB 0.0655
2717 Folylpolyglutamate synthase fgs 0.0625
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0617
2299 UDP-N-acetylmuramate--L-alanine ligase murC 0.0604
5312 Kinesin-like protein KIF1A KIF1A 0.0604
3669 Ribokinase rbsK 0.0571
2615 Chemotaxis protein cheA cheA 0.057
6433 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 PFKFB4 0.0562
3309 6-phosphofructokinase pfkA 0.0561
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0545
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0526
1750 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 PFKFB1 0.0468
36 Insulin receptor INSR 0.0466
48 Pyridoxal kinase PDXK 0.0458
766 Beta-2 adrenergic receptor ADRB2 0.0409
4198 Fructose-1,6-bisphosphatase 1 FBP1 0.0404
790 DNA polymerase subunit alpha B POLA2 0.0348
2393 Maltose-6'-phosphate glucosidase glvA 0.0312
2538 6-phospho-beta-glucosidase bglT bglT 0.0312
2439 Alpha,alpha-trehalose-phosphate synthase [UDP-forming] otsA 0.0272
1881 Hexokinase-1 HK1 0.0271
2503 Phosphomannomutase/phosphoglucomutase algC 0.026
822 Aldose reductase AKR1B1 0.0178
6217 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B PDE8B 0.0175
1152 Glycogen phosphorylase, muscle form PYGM 0.0163
6216 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A PDE8A 0.0163
691 cAMP-specific 3',5'-cyclic phosphodiesterase 7B PDE7B 0.015
2164 Multidrug resistance-associated protein 4 ABCC4 0.0145
779 High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A PDE7A 0.0141
6024 Cytochrome P450 1A1 CYP1A1 0.0139
6013 Cytochrome P450 2E1 CYP2E1 0.0132
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.0126
4200 Cytochrome P450 1A2 CYP1A2 0.0116
1024 Solute carrier family 22 member 11 SLC22A11 0.0112
290 Prostaglandin G/H synthase 2 PTGS2 0.0109
2757 Inorganic pyrophosphatase ppa 0.0107
6238 Inorganic pyrophosphatase ppa 0.0107
6968 Inorganic pyrophosphatase PPA1 0.0107
2383 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0107
2937 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0107
4620 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0107
6594 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0107
6609 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0107
6646 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0107
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0106
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0105
558 Solute carrier family 12 member 1 SLC12A1 0.0105
20 Prostaglandin G/H synthase 1 PTGS1 0.0102
6142 Solute carrier family 22 member 8 SLC22A8 0.0097
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0096
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0096
2755 Hypoxanthine-guanine-xanthine phosphoribosyltransferase LACZ 0.0095
4553 Bifunctional adenosylcobalamin biosynthesis protein cobU cobU 0.0094
2647 RNA-directed RNA polymerase P2 0.0094
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0093
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0093
2434 NH(3)-dependent NAD(+) synthetase nadE 0.009
2910 NH(3)-dependent NAD(+) synthetase nadE 0.009
3217 NH(3)-dependent NAD(+) synthetase nadE 0.009
1729 Solute carrier family 22 member 6 SLC22A6 0.0089
587 Serum albumin ALB 0.0089
3010 Regulatory protein blaR1 blaR1 0.0087
4924 Cytochrome P450 2C8 CYP2C8 0.0087
2149 Angiogenin ANG 0.0087
2727 S-adenosylmethionine synthetase metK 0.0084
2885 Carboxyethyl-arginine beta-lactam-synthase bls 0.0082
4600 Malonamidase E2 Not Available 0.0082
4757 Cytochrome P450 2C9 CYP2C9 0.008
357 Carbonic anhydrase 2 CA2 0.0078
118 Organic cation/carnitine transporter 2 SLC22A5 0.0077
6395 Myosin-14 MYH14 0.0074
2428 Thiamine-phosphate pyrophosphorylase thiE 0.0074
492 Histamine H1 receptor HRH1 0.0073
4512 Cytochrome P450 3A4 CYP3A4 0.0071
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0067
5294 Nucleoside diphosphate kinase A NME1 0.0062
5818 Folate receptor alpha FOLR1 0.0059
293 Gamma-glutamyl hydrolase GGH 0.0052
1650 Heme carrier protein 1 SLC46A1 0.0046
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0045
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0042
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0041
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0037
3917 Methylenetetrahydrofolate reductase MTHFR 0.0037
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0036
6020 Aldehyde oxidase AOX1 0.0034
24 Thymidylate synthase TMP1 0.0034
359 Thymidylate synthase TYMS 0.0034
2626 Thymidylate synthase thyA 0.0034
2729 Thymidylate synthase thyA 0.0034
5352 Thymidylate synthase THYA 0.0034
365 Dihydrofolate reductase DHFR 0.0033
2381 Dihydrofolate reductase DFR1 0.0033
2833 Dihydrofolate reductase Not Available 0.0033
2931 Dihydrofolate reductase folA 0.0033
3544 Dihydrofolate reductase folA 0.0033
3682 Dihydrofolate reductase folA 0.0033
6642 Dihydrofolate reductase folA 0.0033
6756 Dihydrofolate reductase dfrA 0.0033
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0033
6148 Multidrug resistance-associated protein 7 ABCC10 0.0033
738 Monocarboxylate transporter 1 SLC16A1 0.0032
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.003
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0029
6143 Solute carrier family 22 member 7 SLC22A7 0.0027
862 Multidrug resistance-associated protein 1 ABCC1 0.0026
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0026
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0025
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0024
1588 Multidrug resistance protein 1 ABCB1 0.0019
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