DT-Web

DB01809 - 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine


Identification
Name 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
Accession Number DB01809 (EXPT02633)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 281.3556
Groups experimental
Monoisotopic Weight 281.164045633
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Tyrosine-protein kinase HCK
Name Tyrosine-protein kinase HCK
Gene Name HCK
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.6433
Proto-oncogene tyrosine-protein kinase receptor ret
Name Proto-oncogene tyrosine-protein kinase receptor ret
Gene Name RET
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.7629

Predictions


Id Partner name Gene Name Score
504 Mast/stem cell growth factor receptor KIT 0.1294
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.1272
407 Vascular endothelial growth factor receptor 2 KDR 0.0691
6824 Tyrosine-protein kinase Lyn LYN 0.068
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0544
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0528
1144 Hepatocyte growth factor receptor MET 0.0485
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0402
4512 Cytochrome P450 3A4 CYP3A4 0.0402
1588 Multidrug resistance protein 1 ABCB1 0.0333
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0323
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0296
6837 Serine/threonine-protein kinase 17B STK17B 0.0296
4757 Cytochrome P450 2C9 CYP2C9 0.0269
5787 Angiopoietin-1 receptor TEK 0.0258
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0257
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0248
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0239
6599 HTH-type transcriptional regulator ttgR ttgR 0.0237
165 FL cytokine receptor FLT3 0.0235
2240 Cell division protein kinase 2 CDK2 0.0234
823 Fibroblast growth factor receptor 2 FGFR2 0.023
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0219
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0214
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0214
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0214
26 Vascular endothelial growth factor receptor 3 FLT4 0.021
4924 Cytochrome P450 2C8 CYP2C8 0.0206
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0205
32 Vascular endothelial growth factor receptor 1 FLT1 0.0204
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0187
228 Beta platelet-derived growth factor receptor PDGFRB 0.0184
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.018
489 Monocarboxylate transporter 2 SLC16A7 0.0165
2216 Fibroblast growth factor receptor 4 FGFR4 0.0164
5798 Mitogen-activated protein kinase 11 MAPK11 0.0162
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0158
3856 Fibroblast growth factor receptor 3 FGFR3 0.015
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0135
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0127
738 Monocarboxylate transporter 1 SLC16A1 0.0125
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0119
936 Ephrin type-A receptor 2 EPHA2 0.0114
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0111
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0107
1618 High affinity nerve growth factor receptor NTRK1 0.0105
862 Multidrug resistance-associated protein 1 ABCC1 0.0094
4118 Cytochrome P450 3A5 CYP3A5 0.0092
6030 Cytochrome P450 2B6 CYP2B6 0.0092
4119 Cytochrome P450 2D6 CYP2D6 0.0083
6016 Cytochrome P450 2C19 CYP2C19 0.008
776 Bile salt export pump ABCB11 0.0069
2164 Multidrug resistance-associated protein 4 ABCC4 0.0056
6107 Cytochrome P450 3A7 CYP3A7 0.0044
4200 Cytochrome P450 1A2 CYP1A2 0.0039
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