DT-Web

DB01442 - MMDA


Identification
Name MMDA
Accession Number DB01442
Type small molecule
Description MMDA, or 3-methoxy-4,5-methylenedioxyamphetamine, is a stimulant and psychedelic drug of the amphetamine class. It also acts as an entheogen and an entactogen. MMDA bears resemblance to the psychopharmacologically active essential oils elemicin and myristicin found in nutmeg. The effects of MMDA includes feelings of euphoria and warmth, as well as realistic closed-eye visuals.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 209.2417
Groups illicit
Monoisotopic Weight 209.105193351
Pharmacology
Indication MMDA is a recreational drug. It has no current medical uses and is a Schedule I controlled substance in the USA at present.
Mechanism of action The mechanism that produces the psychedelic activity of MMDA has not been definitively established. There are, as of the present time, no reported studies on the human pharmacokinetics or metabolism of MMDA. Based on its structural relationship with other similar drugs for which the pharmacology is known, it is likely that MMDA has multiple mechanisms of action, and probably acts both as a 5HT2A agonist in a similar manner to hallucinogenic amphetamines such as DOM, and also as a serotonin releaser by reversing the direction of the serotonin reuptake transporter in a similar manner to MDMA.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


5-hydroxytryptamine 2A receptor
Name 5-hydroxytryptamine 2A receptor
Gene Name HTR2A
Pharmacological action yes
Actions agonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Fleckenstein AE, Volz TJ, Riddle EL, Gibb JW, Hanson GR: New insights into the mechanism of action of amphetamines. Annu Rev Pharmacol Toxicol. 2007;47:681-98. - Pubmed
  • Kokoshka JM, Metzger RR, Wilkins DG, Gibb JW, Hanson GR, Fleckenstein AE: Methamphetamine treatment rapidly inhibits serotonin, but not glutamate, transporters in rat brain. Brain Res. 1998 Jul 13;799(1):78-83. - Pubmed
  • Haughey HM, Fleckenstein AE, Metzger RR, Hanson GR: The effects of methamphetamine on serotonin transporter activity: role of dopamine and hyperthermia. J Neurochem. 2000 Oct;75(4):1608-17. - Pubmed
DTHybrid score 0.2441
Sodium-dependent dopamine transporter
Name Sodium-dependent dopamine transporter
Gene Name SLC6A3
Pharmacological action yes
Actions negative modulator
References
  • Sulzer D, Sonders MS, Poulsen NW, Galli A: Mechanisms of neurotransmitter release by amphetamines: a review. Prog Neurobiol. 2005 Apr;75(6):406-33. - Pubmed
  • Fleckenstein AE, Volz TJ, Riddle EL, Gibb JW, Hanson GR: New insights into the mechanism of action of amphetamines. Annu Rev Pharmacol Toxicol. 2007;47:681-98. - Pubmed
  • Haughey HM, Brown JM, Wilkins DG, Hanson GR, Fleckenstein AE: Differential effects of methamphetamine on Na(+)/Cl(-)-dependent transporters. Brain Res. 2000 Apr 28;863(1-2):59-65. - Pubmed
DTHybrid score 0.6677
Sodium-dependent serotonin transporter
Name Sodium-dependent serotonin transporter
Gene Name SLC6A4
Pharmacological action yes
Actions negative modulator
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Fleckenstein AE, Volz TJ, Riddle EL, Gibb JW, Hanson GR: New insights into the mechanism of action of amphetamines. Annu Rev Pharmacol Toxicol. 2007;47:681-98. - Pubmed
  • Haughey HM, Brown JM, Wilkins DG, Hanson GR, Fleckenstein AE: Differential effects of methamphetamine on Na(+)/Cl(-)-dependent transporters. Brain Res. 2000 Apr 28;863(1-2):59-65. - Pubmed
DTHybrid score 0.5341
Sodium-dependent noradrenaline transporter
Name Sodium-dependent noradrenaline transporter
Gene Name SLC6A2
Pharmacological action yes
Actions negative modulator
References
  • Fleckenstein AE, Volz TJ, Riddle EL, Gibb JW, Hanson GR: New insights into the mechanism of action of amphetamines. Annu Rev Pharmacol Toxicol. 2007;47:681-98. - Pubmed
DTHybrid score 0.6842
Synaptic vesicular amine transporter
Name Synaptic vesicular amine transporter
Gene Name SLC18A2
Pharmacological action yes
Actions inhibitor
References
  • Sulzer D, Sonders MS, Poulsen NW, Galli A: Mechanisms of neurotransmitter release by amphetamines: a review. Prog Neurobiol. 2005 Apr;75(6):406-33. - Pubmed
  • Henry JP, Sagne C, Bedet C, Gasnier B: The vesicular monoamine transporter: from chromaffin granule to brain. Neurochem Int. 1998 Mar;32(3):227-46. - Pubmed
  • Fleckenstein AE, Volz TJ, Riddle EL, Gibb JW, Hanson GR: New insights into the mechanism of action of amphetamines. Annu Rev Pharmacol Toxicol. 2007;47:681-98. - Pubmed
DTHybrid score 0.6474
Chromaffin granule amine transporter
Name Chromaffin granule amine transporter
Gene Name SLC18A1
Pharmacological action yes
Actions inhibitor
References
  • Sulzer D, Sonders MS, Poulsen NW, Galli A: Mechanisms of neurotransmitter release by amphetamines: a review. Prog Neurobiol. 2005 Apr;75(6):406-33. - Pubmed
  • Henry JP, Sagne C, Bedet C, Gasnier B: The vesicular monoamine transporter: from chromaffin granule to brain. Neurochem Int. 1998 Mar;32(3):227-46. - Pubmed
  • Fleckenstein AE, Volz TJ, Riddle EL, Gibb JW, Hanson GR: New insights into the mechanism of action of amphetamines. Annu Rev Pharmacol Toxicol. 2007;47:681-98. - Pubmed
DTHybrid score Not Available
Amine oxidase [flavin-containing] A
Name Amine oxidase [flavin-containing] A
Gene Name MAOA
Pharmacological action yes
Actions inhibitor
References
  • Sulzer D, Sonders MS, Poulsen NW, Galli A: Mechanisms of neurotransmitter release by amphetamines: a review. Prog Neurobiol. 2005 Apr;75(6):406-33. - Pubmed
DTHybrid score 0.6561
Amine oxidase [flavin-containing] B
Name Amine oxidase [flavin-containing] B
Gene Name MAOB
Pharmacological action yes
Actions inhibitor
References
  • Sulzer D, Sonders MS, Poulsen NW, Galli A: Mechanisms of neurotransmitter release by amphetamines: a review. Prog Neurobiol. 2005 Apr;75(6):406-33. - Pubmed
DTHybrid score 1.0485

Predictions


Id Partner name Gene Name Score
4119 Cytochrome P450 2D6 CYP2D6 0.2918
556 Alpha-1A adrenergic receptor ADRA1A 0.2104
4512 Cytochrome P450 3A4 CYP3A4 0.1522
1636 Trace amine-associated receptor 1 TAAR1 0.1419
318 Alpha-2A adrenergic receptor ADRA2A 0.1391
4200 Cytochrome P450 1A2 CYP1A2 0.1308
831 D(2) dopamine receptor DRD2 0.1169
590 5-hydroxytryptamine 2C receptor HTR2C 0.1127
1588 Multidrug resistance protein 1 ABCB1 0.1045
6016 Cytochrome P450 2C19 CYP2C19 0.1017
632 Alpha-1B adrenergic receptor ADRA1B 0.0911
4757 Cytochrome P450 2C9 CYP2C9 0.0886
492 Histamine H1 receptor HRH1 0.0864
320 5-hydroxytryptamine 1A receptor HTR1A 0.0828
436 5-hydroxytryptamine 2B receptor HTR2B 0.0735
23 D(1A) dopamine receptor DRD1 0.0723
6030 Cytochrome P450 2B6 CYP2B6 0.0718
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0679
629 Alpha-2B adrenergic receptor ADRA2B 0.0673
378 Alpha-2C adrenergic receptor ADRA2C 0.0623
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0483
6013 Cytochrome P450 2E1 CYP2E1 0.0474
725 5-hydroxytryptamine 1D receptor HTR1D 0.0457
4118 Cytochrome P450 3A5 CYP3A5 0.0451
6147 Solute carrier family 22 member 3 SLC22A3 0.0443
885 5-hydroxytryptamine 1B receptor HTR1B 0.0435
193 Beta-1 adrenergic receptor ADRB1 0.0414
6145 Solute carrier family 22 member 1 SLC22A1 0.0414
4924 Cytochrome P450 2C8 CYP2C8 0.0367
6144 Solute carrier family 22 member 2 SLC22A2 0.0366
118 Organic cation/carnitine transporter 2 SLC22A5 0.0363
766 Beta-2 adrenergic receptor ADRB2 0.0354
638 D(3) dopamine receptor DRD3 0.0351
5718 Cytochrome P450 2A6 CYP2A6 0.0332
789 Alpha-1D adrenergic receptor ADRA1D 0.0331
617 Muscarinic acetylcholine receptor M2 CHRM2 0.033
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0326
6107 Cytochrome P450 3A7 CYP3A7 0.0326
511 5-hydroxytryptamine 1F receptor HTR1F 0.0325
3810 Catechol O-methyltransferase COMT 0.0309
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0303
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0299
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0295
432 D(4) dopamine receptor DRD4 0.029
1517 Beta-3 adrenergic receptor ADRB3 0.0289
474 Acetylcholinesterase ACHE 0.0286
1656 CYP2B protein CYP2B 0.0281
3923 Cholinesterase BCHE 0.0268
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.026
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0255
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0254
716 5-hydroxytryptamine 7 receptor HTR7 0.0251
341 5-hydroxytryptamine 3 receptor HTR3A 0.024
2864 Penton protein PIII 0.0236
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0219
163 D(1B) dopamine receptor DRD5 0.0219
1757 Myeloperoxidase MPO 0.0217
5841 Insulin-like growth factor IB IGF1 0.0206
587 Serum albumin ALB 0.0191
4120 NADPH--cytochrome P450 reductase POR 0.0189
94 5-hydroxytryptamine 4 receptor HTR4 0.0183
1256 5-hydroxytryptamine 6 receptor HTR6 0.0179
174 Sigma 1-type opioid receptor SIGMAR1 0.0172
146 Androgen receptor AR 0.0167
3811 Cytochrome P450 19A1 CYP19A1 0.0159
6432 Transporter snf 0.0153
273 Apoptosis regulator Bcl-2 BCL2 0.0149
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0129
696 Kappa-type opioid receptor OPRK1 0.0128
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0121
776 Bile salt export pump ABCB11 0.0113
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0111
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0111
6106 Cytochrome P450 2C18 CYP2C18 0.0111
467 Delta-type opioid receptor OPRD1 0.011
6024 Cytochrome P450 1A1 CYP1A1 0.0106
5698 Riboflavin synthase alpha chain ribE 0.0105
408 Riboflavin kinase RFK 0.0101
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0101
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0098
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0097
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0093
833 Organic cation/carnitine transporter 1 SLC22A4 0.009
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0089
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0087
6182 Cytochrome P450 2J2 CYP2J2 0.0086
847 Mu-type opioid receptor OPRM1 0.0084
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0082
3913 Glutamic acid decarboxylase GAD65 0.008
1483 Membrane copper amine oxidase AOC3 0.0076
923 Glutamate receptor 3 GRIA3 0.0075
654 Flavin reductase BLVRB 0.0075
153 Dopamine beta-hydroxylase DBH 0.0073
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0072
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0072
6031 Cytochrome P450 3A43 CYP3A43 0.0067
3917 Methylenetetrahydrofolate reductase MTHFR 0.0066
735 Alanine aminotransferase 1 GPT 0.0065
3904 Alanine aminotransferase 2 GPT2 0.0065
124 Histamine H2 receptor HRH2 0.0064
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0061
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0061
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.006
694 Matrix protein 2 M 0.0059
904 Glutathione S-transferase P GSTP1 0.0058
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0056
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0054
6014 Cytochrome P450 2A13 CYP2A13 0.0052
1360 Sphingomyelin phosphodiesterase SMPD1 0.0049
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0047
921 Glutamate receptor 2 GRIA2 0.0047
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0046
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0044
2981 Phospholipase A2, membrane associated PLA2G2A 0.0044
828 Phenylalanine-4-hydroxylase PAH 0.0043
3109 Phenylalanine-4-hydroxylase phhA 0.0043
3426 Glutamine synthetase glnA 0.0043
3987 Glutamine synthetase GLUL 0.0043
528 5-hydroxytryptamine 1E receptor HTR1E 0.0042
1729 Solute carrier family 22 member 6 SLC22A6 0.0041
482 Glycine receptor subunit alpha-1 GLRA1 0.004
6133 Sodium channel subunit beta-2 SCN2B 0.0038
6134 Sodium channel subunit beta-3 SCN3B 0.0038
6132 Sodium channel subunit beta-1 SCN1B 0.0038
6135 Sodium channel subunit beta-4 SCN4B 0.0038
6127 Carbonic anhydrase-related protein CA8 0.0038
6129 Carbonic anhydrase-related protein 11 CA11 0.0038
6128 Carbonic anhydrase-related protein 10 CA10 0.0038
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0038
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0038
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0038
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0037
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0036
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0036
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0036
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0036
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0036
6130 Carbonic anhydrase 13 CA13 0.0036
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0035
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0035
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0035
1618 High affinity nerve growth factor receptor NTRK1 0.0034
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0034
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0033
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0033
6131 Carbonic anhydrase 14 CA14 0.0032
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0032
319 Opioid receptor, sigma 1 OPRS1 0.0031
6122 Carbonic anhydrase 3 CA3 0.0031
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0031
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.003
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.003
734 D1 dopamine receptor-interacting protein calcyon CALY 0.003
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0029
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0029
4205 Carbonic anhydrase 9 CA9 0.0028
3007 Carbonic anhydrase 12 CA12 0.0028
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0026
6126 Carbonic anhydrase 7 CA7 0.0026
20 Prostaglandin G/H synthase 1 PTGS1 0.0026
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0025
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0023
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0022
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0022
6020 Aldehyde oxidase AOX1 0.0022
592 Carbonic anhydrase 4 CA4 0.0021
295 Carbonic anhydrase 1 CA1 0.002
6151 Monocarboxylate transporter 10 SLC16A10 0.0018
4486 Phenol 2-hydroxylase component B pheA2 0.0018
4477 Dihydrolipoyl dehydrogenase lpdV 0.0018
5077 Dihydrolipoyl dehydrogenase Not Available 0.0018
5117 Dihydrolipoyl dehydrogenase lpd 0.0018
4439 Ferredoxin reductase bphA4 0.0018
5078 Amine oxidase, flavin-containing PSPTO1126 0.0018
526 Thioredoxin reductase trxB 0.0018
3767 Thioredoxin reductase trxB 0.0018
5122 Mersacidin decarboxylase mrsD 0.0017
5095 Putidaredoxin reductase camA 0.0017
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0017
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0017
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0017
5109 Outer membrane protein p64k or PM-6 m-6 0.0017
5115 FkbI fkbI 0.0017
3133 UDP-galactopyranose mutase glf 0.0017
5099 UDP-galactopyranose mutase glf 0.0017
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0017
3763 5,10-methylenetetrahydrofolate reductase metF 0.0017
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0017
5094 5,10-methylenetetrahydrofolate reductase metF 0.0017
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0017
5111 Phenylacetone monooxygenase pamO 0.0017
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0017
5083 Cryptochrome DASH cry 0.0017
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0017
5081 L-aspartate oxidase nadB 0.0017
1410 Oxidoreductase HSD17B6 0.0017
4725 Oxidoreductase Not Available 0.0017
5124 Oxidoreductase Not Available 0.0017
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0017
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0017
1898 Cytochrome P450 1B1 CYP1B1 0.0017
357 Carbonic anhydrase 2 CA2 0.0017
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0017
4440 NADH peroxidase npr 0.0015
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0015
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0015
3102 Flavohemoprotein hmp 0.0015
4969 Flavohemoprotein hmp 0.0015
3594 Deoxyribodipyrimidine photo-lyase phr 0.0015
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0015
5080 Deoxyribodipyrimidine photo-lyase phr 0.0015
5072 N,N-dimethylglycine oxidase dmg 0.0015
465 Calmodulin CALM1 0.0015
2470 Pyruvate oxidase pox5 0.0015
5073 Ferredoxin--NADP reductase petH 0.0015
5076 Ferredoxin--NADP reductase fpr 0.0015
5119 Ferredoxin--NADP reductase petH 0.0015
5121 Ferredoxin--NADP reductase fpr 0.0015
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0015
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0015
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0015
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0015
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0015
2268 Cholesterol oxidase choB 0.0015
2822 Cholesterol oxidase choA 0.0015
2526 NADPH-ferredoxin reductase fprA fprA 0.0015
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0015
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0015
6689 TraN protein traN 0.0015
6672 Destrin DSTN 0.0015
6680 Cofilin-1 CFL1 0.0015
6670 Ig kappa chain V-I region Bi Not Available 0.0015
6671 Ig heavy chain V-III region VH26 Not Available 0.0015
4905 Cytochrome c2 Not Available 0.0015
4939 Cytochrome c2 cycA 0.0015
4964 Cytochrome c2 cycA 0.0015
4979 Cytochrome c2 cycA 0.0015
6673 Cytochrome c2 cycA 0.0015
6688 TraF protein traF 0.0015
6404 Rhomboid protease glpG glpG 0.0015
6797 Rhomboid protease glpG glpG 0.0015
3710 Acyl-CoA thioesterase 2 tesB 0.0015
6685 Outer membrane protein II porB 0.0015
6690 BenF-like porin PFL_1329 0.0015
6681 Probable N-acetylneuraminic acid outer membrane channel protein nanC nanC 0.0015
6687 TraO protein traO 0.0015
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0015
6559 Cytochrome c oxidase subunit 2 ctaC 0.0015
6669 Cytochrome c oxidase subunit 2 ctaC 0.0015
6668 Cytochrome c oxidase subunit 1-beta ctaDII 0.0015
6679 Colicin-Ia cia 0.0015
6676 Fe(3+)-pyochelin receptor fptA 0.0015
115 Penicillin-binding protein 2 mrdA 0.0015
6069 Penicillin-binding protein 2 mrdA 0.0015
6118 Penicillin-binding protein 2 penA 0.0015
6187 Penicillin-binding protein 2 pbpA 0.0015
6686 Penicillin-binding protein 2 pbp2 0.0015
6939 Penicillin-binding protein 2 mrdA 0.0015
7163 Penicillin-binding protein 2 pbpA 0.0015
6674 Nuclear factor erythroid 2-related factor 1 NFE2L1 0.0015
327 Glutathione reductase gor 0.0015
5110 Glutathione reductase GR2 0.0015
756 Sex hormone-binding globulin SHBG 0.0015
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0015
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0015
126 D-lactate dehydrogenase dld 0.0014
3545 D-lactate dehydrogenase Not Available 0.0014
4510 D-lactate dehydrogenase ldhA 0.0014
6141 Sodium/bile acid cotransporter SLC10A1 0.0014
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0014
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0014
2893 Glycine oxidase thiO 0.0014
605 Fumarate reductase flavoprotein subunit frdA 0.0014
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0014
3673 Fumarate reductase flavoprotein subunit fccA 0.0014
4912 Fumarate reductase flavoprotein subunit ifcA 0.0014
6549 Fumarate reductase flavoprotein subunit frdA 0.0014
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0014
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0013
2567 Thymidylate synthase thyX thyX 0.0013
2823 Trypanothione reductase TPR 0.0013
2769 P-hydroxybenzoate hydroxylase pobA 0.0013
2809 P-hydroxybenzoate hydroxylase pobA 0.0013
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0013
4760 Mll3241 protein mll3241 0.0013
3395 Iron(III) dicitrate transport protein fecA fecA 0.0013
6385 H subunit of photosynthetic reaction center complex puhA 0.0013
6474 Outer membrane protein W ompW 0.0013
6678 Colicin I receptor cirA 0.0013
3578 Protein crcA crcA 0.0013
6675 Colicin-E3 ceaC 0.0013
2925 Long-chain fatty acid transport protein fadL 0.0013
6480 Outer membrane usher protein papC papC 0.0013
6438 Outer membrane protein G ompG 0.0013
2447 Ammonia channel amtB 0.0013
2380 Monomeric sarcosine oxidase soxA 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
6645 D-amino-acid oxidase DAO 0.0012
6428 Light-harvesting protein B-800/850 beta chain Not Available 0.0012
6427 Light-harvesting protein B-800/850 alpha chain Not Available 0.0012
6533 Light-harvesting protein B-800/850 alpha chain A1 0.0012
6524 Protein tonB tonB 0.0012
2679 Vitamin B12 transporter btuB btuB 0.0012
6143 Solute carrier family 22 member 7 SLC22A7 0.0011
6677 Myelin P2 protein PMP2 0.0011
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0011
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.001
714 Glutathione reductase, mitochondrial GSR 0.001
6142 Solute carrier family 22 member 8 SLC22A8 0.001
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.001
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.001
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.001
6352 Reaction center protein H chain puhA 0.001
6456 Reaction center protein H chain puhA 0.001
6682 Reaction center protein H chain puhA 0.001
6353 Reaction center protein L chain pufL 0.001
6454 Reaction center protein L chain pufL 0.001
6683 Reaction center protein L chain pufL 0.001
6354 Reaction center protein M chain pufM 0.001
6455 Reaction center protein M chain pufM 0.001
6684 Reaction center protein M chain pufM 0.001
6351 Photosynthetic reaction center cytochrome c subunit pufC 0.001
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0009
2828 Squalene--hopene cyclase shc 0.0009
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0009
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0009
76 Nitric-oxide synthase, brain NOS1 0.0009
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0009
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0009
2207 Rhodopsin RHO 0.0009
164 Histamine H4 receptor HRH4 0.0009
3947 Xanthine dehydrogenase/oxidase XDH 0.0008
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0008
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0008
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0008
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0008
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0008
6148 Multidrug resistance-associated protein 7 ABCC10 0.0007
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0007
2164 Multidrug resistance-associated protein 4 ABCC4 0.0006
862 Multidrug resistance-associated protein 1 ABCC1 0.0006
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