DT-Web

DB01426 - Ajmaline


Identification
Name Ajmaline
Accession Number DB01426
Type small molecule
Description An alkaloid found in the root of Rauwolfia serpentina, among other plant sources. It is a class Ia antiarrhythmic agent that apparently acts by changing the shape and threshold of cardiac action potentials. Ajmaline produces potent sodium channel blocking effects and a very short half-life which makes it a very useful drug for acute intravenous treatments. The drug has been very popular in some countries for the treatment of atrial fibrillation in patients with the Wolff-Parkinson-White syndrome and in well tolerated monomorphic ventricular tachycardias. It has also been used for many years as a drug to challenge the conduction system of the heart in cases of bundle branch block and syncope. In these cases, abnormal prolongation of the HV interval has been taken as a proof for infrahisian conduction defects tributary for permanent pacemaker implantation.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 326.4326
Groups approved
Monoisotopic Weight 326.199428086
Pharmacology
Indication For use as an antiarrhythmic agent.
Mechanism of action The class I antiarrhythmic agents interfere with the sodium channel. A class IA agent lengthens the action potential (right shift) which brings about improvement in abnormal heart rhythms. This drug in particular has a high affinity for the Nav 1.5 sodium channel.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Sodium channel protein type 5 subunit alpha
Name Sodium channel protein type 5 subunit alpha
Gene Name SCN5A
Pharmacological action yes
Actions inhibitor
References
  • Barajas-Martinez HM, Hu D, Cordeiro JM, Wu Y, Kovacs RJ, Meltser H, Kui H, Elena B, Brugada R, Antzelevitch C, Dumaine R: Lidocaine-induced Brugada syndrome phenotype linked to a novel double mutation in the cardiac sodium channel. Circ Res. 2008 Aug 15;103(4):396-404. Epub 2008 Jul 3. - Pubmed
  • Khodorov BI, Zaborovskaya LD: Blockade of sodium and potassium channels in the node of Ranvier by ajmaline and N-propyl ajmaline. Gen Physiol Biophys. 1983 Aug;2(4):233-68. - Pubmed
  • Hermida JS, Dassonvalle E, Six I, Amant C, Coviaux F, Clerc J, Herent D, Hermida A, Rochette J, Jarry G: Prospective evaluation of the familial prevalence of the brugada syndrome. Am J Cardiol. 2010 Dec 15;106(12):1758-62. - Pubmed
  • Hoogendijk MG, Potse M, Vinet A, de Bakker JM, Coronel R: ST segment elevation by current-to-load mismatch: an experimental and computational study. Heart Rhythm. 2011 Jan;8(1):111-8. Epub 2010 Oct 30. - Pubmed
  • Leoni AL, Gavillet B, Rougier JS, Marionneau C, Probst V, Le Scouarnec S, Schott JJ, Demolombe S, Bruneval P, Huang CL, Colledge WH, Grace AA, Le Marec H, Wilde AA, Mohler PJ, Escande D, Abriel H, Charpentier F: Variable Na(v)1.5 protein expression from the wild-type allele correlates with the penetrance of cardiac conduction disease in the Scn5a(+/-) mouse model. PLoS One. 2010 Feb 19;5(2):e9298. - Pubmed
  • Hoogendijk MG, Potse M, Linnenbank AC, Verkerk AO, den Ruijter HM, van Amersfoorth SC, Klaver EC, Beekman L, Bezzina CR, Postema PG, Tan HL, Reimer AG, van der Wal AC, Ten Harkel AD, Dalinghaus M, Vinet A, Wilde AA, de Bakker JM, Coronel R: Mechanism of right precordial ST-segment elevation in structural heart disease: excitation failure by current-to-load mismatch. Heart Rhythm. 2010;7(2):238-48. Epub 2009 Oct 12. - Pubmed
DTHybrid score 0.4799

Enzymes


Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3146

Carriers


Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.1599
6016 Cytochrome P450 2C19 CYP2C19 0.0955
4757 Cytochrome P450 2C9 CYP2C9 0.0952
4200 Cytochrome P450 1A2 CYP1A2 0.0927
587 Serum albumin ALB 0.0862
1588 Multidrug resistance protein 1 ABCB1 0.0842
4924 Cytochrome P450 2C8 CYP2C8 0.0704
4118 Cytochrome P450 3A5 CYP3A5 0.0606
6030 Cytochrome P450 2B6 CYP2B6 0.0553
6107 Cytochrome P450 3A7 CYP3A7 0.0477
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0445
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0387
824 Sodium-dependent serotonin transporter SLC6A4 0.0382
556 Alpha-1A adrenergic receptor ADRA1A 0.0364
6024 Cytochrome P450 1A1 CYP1A1 0.0356
492 Histamine H1 receptor HRH1 0.035
465 Calmodulin CALM1 0.0343
6013 Cytochrome P450 2E1 CYP2E1 0.0339
103 Muscarinic acetylcholine receptor M1 CHRM1 0.033
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0319
6145 Solute carrier family 22 member 1 SLC22A1 0.0287
6144 Solute carrier family 22 member 2 SLC22A2 0.0282
766 Beta-2 adrenergic receptor ADRB2 0.0273
193 Beta-1 adrenergic receptor ADRB1 0.0264
320 5-hydroxytryptamine 1A receptor HTR1A 0.026
502 5-hydroxytryptamine 2A receptor HTR2A 0.0244
713 Sodium-dependent dopamine transporter SLC6A3 0.0236
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0236
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0233
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0232
831 D(2) dopamine receptor DRD2 0.0229
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0228
5718 Cytochrome P450 2A6 CYP2A6 0.0204
632 Alpha-1B adrenergic receptor ADRA1B 0.0203
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0199
118 Organic cation/carnitine transporter 2 SLC22A5 0.0195
789 Alpha-1D adrenergic receptor ADRA1D 0.0191
3923 Cholinesterase BCHE 0.0189
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0183
6106 Cytochrome P450 2C18 CYP2C18 0.0177
318 Alpha-2A adrenergic receptor ADRA2A 0.0172
172 Potassium channel subfamily K member 1 KCNK1 0.017
862 Multidrug resistance-associated protein 1 ABCC1 0.017
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0163
833 Organic cation/carnitine transporter 1 SLC22A4 0.0157
844 Epidermal growth factor receptor EGFR 0.0156
847 Mu-type opioid receptor OPRM1 0.0152
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0151
590 5-hydroxytryptamine 2C receptor HTR2C 0.0148
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0147
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0145
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0137
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0137
23 D(1A) dopamine receptor DRD1 0.0135
3941 Amine oxidase [flavin-containing] A MAOA 0.0126
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0125
6147 Solute carrier family 22 member 3 SLC22A3 0.0125
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.012
696 Kappa-type opioid receptor OPRK1 0.0116
3939 Amine oxidase [flavin-containing] B MAOB 0.0108
20 Prostaglandin G/H synthase 1 PTGS1 0.0106
6220 Aryl hydrocarbon receptor AHR 0.0099
33 Cystine/glutamate transporter SLC7A11 0.0097
467 Delta-type opioid receptor OPRD1 0.0096
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0093
1517 Beta-3 adrenergic receptor ADRB3 0.0088
638 D(3) dopamine receptor DRD3 0.0087
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0086
885 5-hydroxytryptamine 1B receptor HTR1B 0.0086
341 5-hydroxytryptamine 3 receptor HTR3A 0.0085
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0083
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0083
380 Cytochrome P450 17A1 CYP17A1 0.008
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.008
629 Alpha-2B adrenergic receptor ADRA2B 0.0077
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0076
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0076
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0075
2164 Multidrug resistance-associated protein 4 ABCC4 0.0074
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0073
1898 Cytochrome P450 1B1 CYP1B1 0.0073
378 Alpha-2C adrenergic receptor ADRA2C 0.0072
731 HIV-1 protease HIV-1 protease 0.0071
921 Glutamate receptor 2 GRIA2 0.007
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.007
432 D(4) dopamine receptor DRD4 0.0069
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0068
776 Bile salt export pump ABCB11 0.0068
1050 Bile salt sulfotransferase SULT2A1 0.0067
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0066
436 5-hydroxytryptamine 2B receptor HTR2B 0.0066
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0065
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0064
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0058
1757 Myeloperoxidase MPO 0.0057
163 D(1B) dopamine receptor DRD5 0.0056
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0054
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0054
1729 Solute carrier family 22 member 6 SLC22A6 0.0054
1656 CYP2B protein CYP2B 0.0054
474 Acetylcholinesterase ACHE 0.0053
131 Synaptic vesicular amine transporter SLC18A2 0.0053
751 Potassium channel subfamily K member 6 KCNK6 0.0052
5787 Angiopoietin-1 receptor TEK 0.0052
725 5-hydroxytryptamine 1D receptor HTR1D 0.005
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.005
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0049
183 Vascular endothelial growth factor A VEGFA 0.0048
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0048
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0048
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0048
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0047
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0047
290 Prostaglandin G/H synthase 2 PTGS2 0.0046
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0046
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0045
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0044
2112 Toll-like receptor 9 TLR9 0.0044
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0043
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0043
768 FK506-binding protein 1A FKBP1A 0.0043
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0043
6432 Transporter snf 0.0042
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0042
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0042
124 Histamine H2 receptor HRH2 0.0041
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0041
1618 High affinity nerve growth factor receptor NTRK1 0.004
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.004
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0039
716 5-hydroxytryptamine 7 receptor HTR7 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0039
504 Mast/stem cell growth factor receptor KIT 0.0038
6142 Solute carrier family 22 member 8 SLC22A8 0.0038
1256 5-hydroxytryptamine 6 receptor HTR6 0.0038
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0036
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0035
6506 Stathmin-4 STMN4 0.0033
94 5-hydroxytryptamine 4 receptor HTR4 0.0033
6182 Cytochrome P450 2J2 CYP2J2 0.0033
173 Toll-like receptor 7 TLR7 0.0033
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0033
817 DNA topoisomerase 2-alpha TOP2A 0.0033
738 Monocarboxylate transporter 1 SLC16A1 0.0033
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0032
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0032
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0032
1636 Trace amine-associated receptor 1 TAAR1 0.0031
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0031
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.003
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.003
528 5-hydroxytryptamine 1E receptor HTR1E 0.0029
228 Beta platelet-derived growth factor receptor PDGFRB 0.0029
6141 Sodium/bile acid cotransporter SLC10A1 0.0029
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0029
565 Extracellular calcium-sensing receptor CASR 0.0028
6031 Cytochrome P450 3A43 CYP3A43 0.0028
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0028
1864 RET proto-oncogene RET 0.0028
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0028
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0028
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0028
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0027
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0026
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0025
3811 Cytochrome P450 19A1 CYP19A1 0.0025
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0025
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0025
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0025
891 Dihydropteroate synthase folP 0.0025
5359 Dihydropteroate synthase folP 0.0025
7175 Dihydropteroate synthase sulI 0.0025
161 Tubulin beta chain TUBB 0.0024
312 Tubulin beta chain TUB2 0.0024
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0024
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0024
1360 Sphingomyelin phosphodiesterase SMPD1 0.0024
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0024
6134 Sodium channel subunit beta-3 SCN3B 0.0024
6132 Sodium channel subunit beta-1 SCN1B 0.0024
6135 Sodium channel subunit beta-4 SCN4B 0.0024
6127 Carbonic anhydrase-related protein CA8 0.0024
6133 Sodium channel subunit beta-2 SCN2B 0.0024
6128 Carbonic anhydrase-related protein 10 CA10 0.0024
6129 Carbonic anhydrase-related protein 11 CA11 0.0024
6126 Carbonic anhydrase 7 CA7 0.0024
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0023
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0022
6148 Multidrug resistance-associated protein 7 ABCC10 0.0022
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0022
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0021
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0021
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0021
295 Carbonic anhydrase 1 CA1 0.0021
952 Dipeptidyl peptidase 4 DPP4 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
6130 Carbonic anhydrase 13 CA13 0.002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.002
174 Sigma 1-type opioid receptor SIGMAR1 0.002
365 Dihydrofolate reductase DHFR 0.002
2381 Dihydrofolate reductase DFR1 0.002
2833 Dihydrofolate reductase Not Available 0.002
2931 Dihydrofolate reductase folA 0.002
3544 Dihydrofolate reductase folA 0.002
3682 Dihydrofolate reductase folA 0.002
6642 Dihydrofolate reductase folA 0.002
6756 Dihydrofolate reductase dfrA 0.002
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.002
6131 Carbonic anhydrase 14 CA14 0.0019
4203 Histamine N-methyltransferase HNMT 0.0019
592 Carbonic anhydrase 4 CA4 0.0019
871 Glucocorticoid receptor NR3C1 0.0019
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0019
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0019
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
6122 Carbonic anhydrase 3 CA3 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
1178 Adenosine A2a receptor ADORA2A 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0017
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0017
3007 Carbonic anhydrase 12 CA12 0.0017
4205 Carbonic anhydrase 9 CA9 0.0017
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0017
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0016
146 Androgen receptor AR 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
4228 Keratin, type II cytoskeletal 7 KRT7 0.0016
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0016
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0016
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0016
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0016
468 Cytochrome P450 4A11 CYP4A11 0.0016
1629 Transcription factor AP-1 JUN 0.0016
3947 Xanthine dehydrogenase/oxidase XDH 0.0016
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0016
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0015
4604 Liver carboxylesterase 1 CES1 0.0015
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0015
4120 NADPH--cytochrome P450 reductase POR 0.0014
3086 Plasmepsin-2 Not Available 0.0014
373 Transthyretin TTR 0.0014
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0014
357 Carbonic anhydrase 2 CA2 0.0014
4148 Serine/threonine-protein kinase mTOR MTOR 0.0014
208 DNA-directed RNA polymerase beta' chain rpoC 0.0014
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0014
6143 Solute carrier family 22 member 7 SLC22A7 0.0013
3404 Exotoxin A eta 0.0013
6020 Aldehyde oxidase AOX1 0.0013
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0013
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0012
1010 Cytochrome P450 51A1 CYP51A1 0.0012
232 Corticosteroid-binding globulin SERPINA6 0.0012
3856 Fibroblast growth factor receptor 3 FGFR3 0.0012
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0012
6102 Arylamine N-acetyltransferase 2 NAT2 0.0012
473 L-lactate dehydrogenase A chain LDHA 0.0011
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0011
6014 Cytochrome P450 2A13 CYP2A13 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
164 Histamine H4 receptor HRH4 0.0011
2290 ADP-ribosyl cyclase 2 BST1 0.001
614 Progesterone receptor PGR 0.001
2300 Lysozyme E 0.001
3633 Lysozyme R 0.001
5597 Lysozyme 17 0.001
407 Vascular endothelial growth factor receptor 2 KDR 0.001
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.001
4311 tRNA TRDMT1 0.001
4325 tRNA trmD 0.001
4328 tRNA trmD 0.001
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.001
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.001
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.001
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.001
260 Cytochrome P450 51 ERG11 0.001
761 Cytochrome P450 51 ERG11 0.001
3163 Cytochrome P450 51 cyp51 0.001
144 Hemoglobin subunit alpha HBA1 0.001
518 Peroxidase/catalase T katG 0.001
777 Tumor necrosis factor TNF 0.0009
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0009
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0009
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0009
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0009
563 Thyroid peroxidase TPO 0.0009
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0009
65 Matrix metalloproteinase-9 Not Available 0.0009
26 Vascular endothelial growth factor receptor 3 FLT4 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
4122 Histone deacetylase 2 HDAC2 0.0009
16 Adenosine A1 receptor ADORA1 0.0009
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0009
32 Vascular endothelial growth factor receptor 1 FLT1 0.0009
634 Squalene monooxygenase SQLE 0.0009
7196 Squalene monooxygenase ERG1 0.0009
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0009
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0009
1262 Corticotropin-lipotropin POMC 0.0008
1341 Histamine H3 receptor HRH3 0.0008
3932 Glutathione S-transferase A2 GSTA2 0.0008
537 ATP synthase delta chain, mitochondrial ATP5D 0.0008
1192 Sulfotransferase 1A1 SULT1A1 0.0008
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0008
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0008
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0008
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0008
165 FL cytokine receptor FLT3 0.0008
244 Angiotensin-converting enzyme ACE 0.0008
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0008
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0008
482 Glycine receptor subunit alpha-1 GLRA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
70 Type-1 angiotensin II receptor AGTR1 0.0008
6137 Multidrug resistance-associated protein 6 ABCC6 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0007
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0007
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0007
122 P2Y purinoceptor 12 P2RY12 0.0007
6136 Multidrug resistance-associated protein 5 ABCC5 0.0007
581 Cytochrome P450 2R1 CYP2R1 0.0007
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0007
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0007
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0007
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0007
4773 Deoxycytidine kinase DCK 0.0007
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0007
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0007
1992 Vitamin D-binding protein GC 0.0007
319 Opioid receptor, sigma 1 OPRS1 0.0007
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0007
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
7 Nitric oxide synthase, inducible NOS2 0.0007
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0007
737 Mineralocorticoid receptor NR3C2 0.0006
976 Platelet glycoprotein IX GP9 0.0006
4103 Proteasome subunit beta type 2 PSMB2 0.0006
4102 Proteasome subunit beta type 5 PSMB5 0.0006
4101 Proteasome subunit beta type 1 PSMB1 0.0006
1630 Integrin beta-2 ITGB2 0.0006
1374 Natriuretic peptides B NPPB 0.0006
1827 Gap junction alpha-1 protein GJA1 0.0006
1908 Vascular cell adhesion protein 1 VCAM1 0.0006
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0006
2216 Fibroblast growth factor receptor 4 FGFR4 0.0006
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0006
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0006
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0006
814 Ryanodine receptor 1 RYR1 0.0006
511 5-hydroxytryptamine 1F receptor HTR1F 0.0006
6146 High affinity copper uptake protein 1 SLC31A1 0.0006
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0006
2449 Tubulin alpha-3 chain TUBA1A 0.0006
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0006
705 Glutamate receptor 1 GRIA1 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0005
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0005
543 Penicillin-binding protein 1B mrcB 0.0005
6186 Penicillin-binding protein 1B ponB 0.0005
6822 Penicillin-binding protein 1b pbp1b 0.0005
6844 Penicillin-binding protein 1b pbp1b 0.0005
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0005
645 Penicillin-binding protein 1A mrcA 0.0005
5805 Penicillin-binding protein 1A ponA 0.0005
6185 Penicillin-binding protein 1A mrcA 0.0005
6799 Penicillin-binding protein 1A pbpA 0.0005
268 Adenosine A2b receptor ADORA2B 0.0005
159 Penicillin-binding protein 2B penA 0.0005
6121 Penicillin-binding protein 2B penA 0.0005
6044 Serum paraoxonase/lactonase 3 PON3 0.0005
1024 Solute carrier family 22 member 11 SLC22A11 0.0005
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0005
856 Vitamin D3 receptor VDR 0.0005
6151 Monocarboxylate transporter 10 SLC16A10 0.0005
572 Integrin alpha-L ITGAL 0.0005
904 Glutathione S-transferase P GSTP1 0.0005
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0005
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
6824 Tyrosine-protein kinase Lyn LYN 0.0005
1275 Estrogen sulfotransferase SULT1E1 0.0004
136 Estrogen receptor ESR1 0.0004
153 Dopamine beta-hydroxylase DBH 0.0004
760 Fibroblast growth factor 1 FGF1 0.0004
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0004
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0004
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0004
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0004
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0004
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0004
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0004
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0004
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0004
1268 Neuropeptide S receptor NPSR1 0.0004
823 Fibroblast growth factor receptor 2 FGFR2 0.0004
291 Nitric-oxide synthase, endothelial NOS3 0.0004
5934 Cytochrome P450 26A1 CYP26A1 0.0004
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0004
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0004
6073 Potassium channel subfamily K member 9 KCNK9 0.0004
6072 Potassium channel subfamily K member 3 KCNK3 0.0004
3937 Fatty-acid amide hydrolase FAAH 0.0004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0004
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0004
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0004
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0004
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0004
84 Nuclear receptor 0B1 NR0B1 0.0004
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0004
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0004
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0004
3810 Catechol O-methyltransferase COMT 0.0004
3957 Adenosine deaminase ADA 0.0004
6168 Solute carrier family 22 member 16 SLC22A16 0.0003
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0003
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0003
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0003
469 Annexin A1 ANXA1 0.0003
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0003
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0003
2207 Rhodopsin RHO 0.0003
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0003
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0003
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0003
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0003
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0003
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0003
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0003
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0003
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0003
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0003
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0003
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0003
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0003
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0002
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0002
869 Estrogen receptor beta ESR2 0.0002
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0002
76 Nitric-oxide synthase, brain NOS1 0.0002
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