DT-Web

DB00905 - Bimatoprost


Identification
Name Bimatoprost
Accession Number DB00905 (APRD00826, DB06863)
Type small molecule
Description Bimatoprost ophthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension, by reducing intraocular pressure. It is a prostaglandin analogue that works by increasing the outflow of aqueous fluid from the eyes. It binds to the prostanoid FP receptor.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 415.5656
Groups approved
Monoisotopic Weight 415.272258677
Pharmacology
Indication For the reduction of elevated intraocular pressure in patients with open angle glaucoma or ocular hypertension who are intolerant of other intraocular pressure lowering medications or insufficiently responsive (failed to achieve target IOP determined after multiple measurements over time) to another intraocular pressure lowering medication.
Mechanism of action Bimatoprost is believed to lower intraocular pressure (IOP) in humans by increasing outflow of aqueous humor through both the trabecular meshwork and uveoscleral routes. Bimatoprost reduces the pressure in the eye by mimicking the action of a naturally-occuring prostaglandin. Prostaglandins are a group of chemicals found in many places in the body. In the eye, they increase the drainage of the aqueous humour out of the eyeball. Bimatoprost is a synthetic compound related to one of the natural prostaglandins, and works by increasing the drainage of aqueous humour out of the eyeball. Bimatoprost may also lower the rate of aqueous formation in the eye. Both these effects decrease the pressure within the eye.
Absorption Systemically absorbed when administered to the eye.
Protein binding Approximately 88% of bimatoprost is bound in human plasma.
Biotransformation Bimatoprost undergoes oxidation, N-deethylation and glucuronidation to form a variety of metabolites.
Route of elimination Up to 67% of the administered dose was excreted in the urine while 25% of the dose was recovered in the feces.
Toxicity In oral (by gavage) mouse and rat studies, doses up to 100 mg/kg/day did not produce any toxicity. This dose expressed as mg/m2 is at least 70 times higher than the accidental dose of one bottle of bimatoprost for a 10 kg child.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Latanoprost The concomitant use of bimatoprost and latanoprost may result in increased intraocular pressure. Consider avoiding this combination of therapy. Monitor for paradoxical increases in intraocular pressure during concomitant use.
Food Interactions Not Available

Targets


Prostaglandin F2-alpha receptor
Name Prostaglandin F2-alpha receptor
Gene Name PTGFR
Pharmacological action yes
Actions agonist
References
  • Sharif NA, Williams GW, Kelly CR: Bimatoprost and its free acid are prostaglandin FP receptor agonists. Eur J Pharmacol. 2001 Dec 7;432(2-3):211-3. - Pubmed
  • Sharif NA, Kelly CR, Crider JY: Agonist activity of bimatoprost, travoprost, latanoprost, unoprostone isopropyl ester and other prostaglandin analogs at the cloned human ciliary body FP prostaglandin receptor. J Ocul Pharmacol Ther. 2002 Aug;18(4):313-24. - Pubmed
  • Sharif NA, Kelly CR, Crider JY, Williams GW, Xu SX: Ocular hypotensive FP prostaglandin (PG) analogs: PG receptor subtype binding affinities and selectivities, and agonist potencies at FP and other PG receptors in cultured cells. J Ocul Pharmacol Ther. 2003 Dec;19(6):501-15. - Pubmed
  • Lim KS, Nau CB, O'Byrne MM, Hodge DO, Toris CB, McLaren JW, Johnson DH: Mechanism of action of bimatoprost, latanoprost, and travoprost in healthy subjects. A crossover study. Ophthalmology. 2008 May;115(5):790-795.e4. - Pubmed
  • Mintz EE: Group supervision: an experiential approach. Int J Group Psychother. 1978 Oct;28(4):467-9. - Pubmed
  • Neacsu AM: [Receptors involved in the mechanism of action of topical prostaglandines] Oftalmologia. 2009;53(2):3-7. - Pubmed
  • Wan Z, Woodward DF, Cornell CL, Fliri HG, Martos JL, Pettit SN, Wang JW, Kharlamb AB, Wheeler LA, Garst ME, Landsverk KJ, Struble CS, Stamer WD: Bimatoprost, prostamide activity, and conventional drainage. Invest Ophthalmol Vis Sci. 2007 Sep;48(9):4107-15. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.9227
Prostaglandin E2 receptor, EP1 subtype
Name Prostaglandin E2 receptor, EP1 subtype
Gene Name PTGER1
Pharmacological action yes
Actions agonist
References
  • Sharif NA, Kelly CR, Crider JY, Williams GW, Xu SX: Ocular hypotensive FP prostaglandin (PG) analogs: PG receptor subtype binding affinities and selectivities, and agonist potencies at FP and other PG receptors in cultured cells. J Ocul Pharmacol Ther. 2003 Dec;19(6):501-15. - Pubmed
  • Ota T, Aihara M, Saeki T, Narumiya S, Araie M: The effects of prostaglandin analogues on prostanoid EP1, EP2, and EP3 receptor-deficient mice. Invest Ophthalmol Vis Sci. 2006 Aug;47(8):3395-9. - Pubmed
DTHybrid score 0.6526
Prostaglandin E2 receptor, EP3 subtype
Name Prostaglandin E2 receptor, EP3 subtype
Gene Name PTGER3
Pharmacological action yes
Actions agonist
References
  • Sharif NA, Kelly CR, Crider JY, Williams GW, Xu SX: Ocular hypotensive FP prostaglandin (PG) analogs: PG receptor subtype binding affinities and selectivities, and agonist potencies at FP and other PG receptors in cultured cells. J Ocul Pharmacol Ther. 2003 Dec;19(6):501-15. - Pubmed
  • Gabelt BT, Hennes EA, Bendel MA, Constant CE, Okka M, Kaufman PL: Prostaglandin subtype-selective and non-selective IOP-lowering comparison in monkeys. J Ocul Pharmacol Ther. 2009 Feb;25(1):1-8. - Pubmed
  • Ota T, Aihara M, Saeki T, Narumiya S, Araie M: The effects of prostaglandin analogues on prostanoid EP1, EP2, and EP3 receptor-deficient mice. Invest Ophthalmol Vis Sci. 2006 Aug;47(8):3395-9. - Pubmed
DTHybrid score 0.5346
Aldo-keto reductase family 1 member C3
Name Aldo-keto reductase family 1 member C3
Gene Name AKR1C3
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.6913

Predictions


Id Partner name Gene Name Score
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.2205
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.2024
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0987
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0879
290 Prostaglandin G/H synthase 2 PTGS2 0.0808
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0794
6145 Solute carrier family 22 member 1 SLC22A1 0.0555
527 Prostacyclin receptor PTGIR 0.0523
2972 6-deoxyerythronolide B hydroxylase eryF 0.0464
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0418
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.04
6136 Multidrug resistance-associated protein 5 ABCC5 0.0386
1729 Solute carrier family 22 member 6 SLC22A6 0.0367
2164 Multidrug resistance-associated protein 4 ABCC4 0.0315
1024 Solute carrier family 22 member 11 SLC22A11 0.0308
6143 Solute carrier family 22 member 7 SLC22A7 0.0304
4119 Cytochrome P450 2D6 CYP2D6 0.028
6144 Solute carrier family 22 member 2 SLC22A2 0.0279
6142 Solute carrier family 22 member 8 SLC22A8 0.0265
4512 Cytochrome P450 3A4 CYP3A4 0.0252
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0251
4200 Cytochrome P450 1A2 CYP1A2 0.0241
6167 Organic solute transporter subunit beta OSTB 0.0238
6166 Organic solute transporter subunit alpha OSTA 0.0238
1792 Tissue-type plasminogen activator PLAT 0.0203
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0189
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.0182
373 Transthyretin TTR 0.0181
146 Androgen receptor AR 0.0176
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0172
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0172
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0147
6016 Cytochrome P450 2C19 CYP2C19 0.0146
3811 Cytochrome P450 19A1 CYP19A1 0.0142
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0139
4924 Cytochrome P450 2C8 CYP2C8 0.0136
20 Prostaglandin G/H synthase 1 PTGS1 0.0133
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0132
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.013
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.013
4757 Cytochrome P450 2C9 CYP2C9 0.0124
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0105
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0076
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0075
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0075
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0072
76 Nitric-oxide synthase, brain NOS1 0.0069
4120 NADPH--cytochrome P450 reductase POR 0.0068
6168 Solute carrier family 22 member 16 SLC22A16 0.006
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0053
646 Malate dehydrogenase, cytoplasmic MDH1 0.0048
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0047
666 NADP-dependent malic enzyme ME1 0.0047
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0047
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0046
3947 Xanthine dehydrogenase/oxidase XDH 0.0046
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0045
5346 Oxidoreductase, aldo/keto reductase family TM_1009 0.0043
4403 Protein iolS iolS 0.0043
5330 General stress protein 69 yhdN 0.0043
5322 Oxidoreductase ydhF ydhF 0.0043
5333 Alcohol dehydrogenase, iron-containing TM_0920 0.0043
5326 Oxidoreductase, short chain dehydrogenase/reductase family TM_0441 0.0043
5157 Dehydrogenase/reductase SDR family member 11 DHRS11 0.0043
5332 MtdA bifunctional protein mtdA 0.0043
5342 NADH-dependent butanol dehydrogenase, putative TM_0820 0.0043
3772 3-oxoacyl-[acyl-carrier-protein] reductase fabG 0.0043
3778 NAD(P) transhydrogenase subunit beta pntB 0.0043
5343 NADP-dependent fatty aldehyde dehydrogenase aldH 0.0043
6137 Multidrug resistance-associated protein 6 ABCC6 0.0043
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0042
7 Nitric oxide synthase, inducible NOS2 0.0042
291 Nitric-oxide synthase, endothelial NOS3 0.0041
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0041
6148 Multidrug resistance-associated protein 7 ABCC10 0.0041
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0039
817 DNA topoisomerase 2-alpha TOP2A 0.0038
2375 ADP-L-glycero-D-manno-heptose-6-epimerase hldD 0.0038
654 Flavin reductase BLVRB 0.0038
5073 Ferredoxin--NADP reductase petH 0.0038
5076 Ferredoxin--NADP reductase fpr 0.0038
5119 Ferredoxin--NADP reductase petH 0.0038
5121 Ferredoxin--NADP reductase fpr 0.0038
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0038
4582 Putative pteridine reductase 2 ptr2 0.0037
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0037
989 L-xylulose reductase DCXR 0.0037
5328 Prostaglandin F synthase Tb11.02.2310 0.0037
2305 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 0.0037
2636 Shikimate dehydrogenase aroE 0.0037
3515 Shikimate dehydrogenase aroE 0.0037
3446 NADP-dependent alcohol dehydrogenase adh 0.0037
2286 Isocitrate dehydrogenase [NADP] icd 0.0037
2302 Isocitrate dehydrogenase [NADP] icd 0.0037
2771 Isocitrate dehydrogenase [NADP] icd 0.0037
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0037
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0037
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0036
776 Bile salt export pump ABCB11 0.0036
1898 Cytochrome P450 1B1 CYP1B1 0.0035
444 Alcohol dehydrogenase 1B ADH1B 0.0035
6862 Aldo-keto reductase family 1 member B10 AKR1B10 0.0034
6297 Prostaglandin reductase 1 PTGR1 0.0034
4531 Putative ketoacyl reductase actIII 0.0034
3062 Aspartate-semialdehyde dehydrogenase asd 0.0034
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0034
862 Multidrug resistance-associated protein 1 ABCC1 0.0033
2675 Pteridine reductase 1 PTR1 0.0032
2159 Quinone oxidoreductase CRYZ 0.0032
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0032
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0032
1124 Sepiapterin reductase SPR 0.0032
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.003
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.003
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.003
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.003
822 Aldose reductase AKR1B1 0.003
365 Dihydrofolate reductase DHFR 0.0028
2381 Dihydrofolate reductase DFR1 0.0028
2833 Dihydrofolate reductase Not Available 0.0028
2931 Dihydrofolate reductase folA 0.0028
3544 Dihydrofolate reductase folA 0.0028
3682 Dihydrofolate reductase folA 0.0028
6642 Dihydrofolate reductase folA 0.0028
6756 Dihydrofolate reductase dfrA 0.0028
6030 Cytochrome P450 2B6 CYP2B6 0.0027
1588 Multidrug resistance protein 1 ABCB1 0.0023
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0016
816 Biliverdin reductase A BLVRA 0.0015
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0015
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0015
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0015
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0014
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0014
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0014
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0014
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0014
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0014
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0014
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0014
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0014
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0014
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0014
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0014
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0014
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0014
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0014
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0014
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0014
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0014
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0014
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0014
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0014
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0014
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0014
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0014
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0014
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0014
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0014
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0014
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0014
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0014
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0014
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0014
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0014
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0014
644 Heme oxygenase 2 HMOX2 0.0014
4982 Heme oxygenase 2 pbsA2 0.0014
729 GDP-L-fucose synthetase TSTA3 0.0014
3463 GDP-L-fucose synthetase fcl 0.0014
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0014
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0014
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0014
206 3-keto-steroid reductase HSD17B7 0.0014
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0014
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0014
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0014
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0014
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0014
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0014
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0014
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0014
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0014
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0014
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0014
34 7-dehydrocholesterol reductase DHCR7 0.0014
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0014
711 UDP-glucose 6-dehydrogenase UGDH 0.0014
3672 UDP-glucose 6-dehydrogenase hasB 0.0014
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0014
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0014
107 C-4 methylsterol oxidase SC4MOL 0.0014
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0014
3726 D-3-phosphoglycerate dehydrogenase serA 0.0014
4291 D-3-phosphoglycerate dehydrogenase serA 0.0014
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0014
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0014
167 L-lactate dehydrogenase C chain LDHC 0.0014
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0014
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0014
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0014
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0014
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0014
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0014
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0014
643 Peroxisomal bifunctional enzyme EHHADH 0.0014
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0014
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0014
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0014
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0013
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0013
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0013
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0013
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0013
396 Alcohol dehydrogenase 4 ADH4 0.0013
328 Sorbitol dehydrogenase SORD 0.0013
597 Dihydropteridine reductase QDPR 0.0013
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0013
857 Malate dehydrogenase, mitochondrial MDH2 0.0013
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0013
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0013
12 Alcohol dehydrogenase class 3 ADH5 0.0013
77 L-lactate dehydrogenase B chain LDHB 0.0012
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0012
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0012
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0012
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0012
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0012
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0012
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0012
473 L-lactate dehydrogenase A chain LDHA 0.0012
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0011
13 Aminomethyltransferase, mitochondrial AMT 0.0011
6026 Alcohol dehydrogenase 6 ADH6 0.0011
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0011
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0011
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0011
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0011
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0011
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
627 11-cis retinol dehydrogenase RDH5 0.0011
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0011
626 Cysteine dioxygenase type 1 CDO1 0.0011
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0011
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0011
569 Retinal dehydrogenase 2 ALDH1A2 0.0011
611 Retinal dehydrogenase 1 ALDH1A1 0.0011
251 Alcohol dehydrogenase 1A ADH1A 0.001
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.001
810 Heme oxygenase 1 HMOX1 0.001
3391 Heme oxygenase 1 pbsA1 0.001
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.001
279 Tyrosinase TYR 0.001
380 Cytochrome P450 17A1 CYP17A1 0.0009
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0009
714 Glutathione reductase, mitochondrial GSR 0.0009
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0009
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0009
517 Alcohol dehydrogenase 1C ADH1C 0.0009
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0008
468 Cytochrome P450 4A11 CYP4A11 0.0008
6020 Aldehyde oxidase AOX1 0.0008
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