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DB00702 - Icodextrin


Identification
Name Icodextrin
Accession Number DB00702 (APRD01026)
Type small molecule
Description Icodextrin is an iso-osmotic peritoneal dialysis solution containing glucose polymers. It is used primarily for ambulatory peritoneal dialysis (CAPD) of diabetic patients and automated peritoneal dialysis (APD) for patients with end-stage renal disease. It is injected as a solution into the peritoneal cavity. The drug is absorbed via convective transport via peritoneal lymphatic pathways.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight Not Available
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication Used for continuous ambulatory peritoneal dialysis (CAPD) of diabetic patients or automated peritoneal dialysis (APD) for the management of end-stage renal disease.
Mechanism of action Icodextrin is a starch-derived, water-soluble glucose polymer linked by alpha (1-4) and alpha (1-6) glycosidic bonds with an average molecular weight between 13,000 and 19,000 daltons. It functions as a colloid osmotic agent to achieve ultrafiltration during long (12-16 hour) peritoneal dialysis dwells. In other words it helps clean waste out of the body when the kidneys are not functioning properly. Icodectrin acts in the peritoneal cavity by exerting osmotic pressure across small intercellular pores resulting in transcapillary ultrafiltration through the dwell. This is due to the fact that the polymer is minimially absorbed across the peritoneal membrane. Icodextrin achieves superior fluid removal compared with glucose-based dialysates.
Absorption 40% of instilled icodextrin was absorbed from the peritoneal solution during a 12-hour dwell.
Protein binding Not Available
Biotransformation Icodextrin is metabolized by alpha-amylase into oligosaccharides with a lower degree of polymerization), including maltose, maltotriose, maltotetraose, and higher molecular weight species.
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Enzymes


Pancreatic alpha-amylase
Name Pancreatic alpha-amylase
Gene Name AMY2A
Actions substrate
References
  • Flore KM, Delanghe JR: Analytical interferences in point-of-care testing glucometers by icodextrin and its metabolites: an overview. Perit Dial Int. 2009 Jul-Aug;29(4):377-83. - Pubmed
  • Garcia-Lopez E, Lindholm B: Icodextrin metabolites in peritoneal dialysis. Perit Dial Int. 2009 Jul-Aug;29(4):370-6. - Pubmed
DTHybrid score 1.137

Predictions


Id Partner name Gene Name Score
3030 Salivary alpha-amylase AMY1A 0.1716
4622 Amylase Not Available 0.0841
2978 Maltogenic alpha-amylase amyM 0.0816
929 Maltase-glucoamylase, intestinal MGAM 0.0753
1016 Lysosomal alpha-glucosidase GAA 0.075
4830 Aldose 1-epimerase galM 0.0492
2129 Sucrase-isomaltase, intestinal SI 0.0305
5012 Ig lambda chain V-II region MGC Not Available 0.0132
4385 Cytochrome c' Not Available 0.0132
4967 Cytochrome c' cycA 0.0132
5038 Cytochrome c' Not Available 0.0132
5223 Cytochrome c' cycP 0.0132
5036 Small inducible cytokine A8 CCL8 0.0132
5023 Glycoside hydrolase Not Available 0.0116
5024 Glycoside hydrolase Not Available 0.0116
5006 RNASE4 protein RNASE4 0.0115
4771 Dissimilatory copper-containing nitrite reductase nir 0.0115
4905 Cytochrome c2 Not Available 0.0108
4939 Cytochrome c2 cycA 0.0108
4964 Cytochrome c2 cycA 0.0108
4979 Cytochrome c2 cycA 0.0108
6673 Cytochrome c2 cycA 0.0108
2149 Angiogenin ANG 0.0106
2430 Chondroitinase B cslB 0.0101
6374 Disintegrin and metalloproteinase domain-containing protein 28 ADAM28 0.0089
183 Vascular endothelial growth factor A VEGFA 0.0077
3689 Endoglucanase A celA 0.0023
5411 Slt-IIvB stxB2e 0.0023
5046 Ecotin eco 0.0023
5563 Galectin-2 LGALS2 0.0023
3009 Beta-glucanase Not Available 0.0023
5569 Endo-1,4-beta glucanase EngF engF 0.0023
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0023
5554 D-galactose-binding periplasmic protein mglB 0.0023
3741 D-galactose-binding periplasmic protein precursor mglB 0.0023
5568 Endoglucanase C307 celC307 0.0023
5553 Endoglucanase E1 Acel_0614 0.0023
1875 Pulmonary surfactant-associated protein D SFTPD 0.0023
4668 Laminarinase TM_0024 0.0023
5562 Hexokinase Not Available 0.0023
3744 Endoglucanase SS precursor celS 0.0023
3793 Aspartate ammonia-lyase aspA 0.0023
5559 Neopullulanase nplT 0.0023
4670 Cellulase B celB 0.0023
5570 Endoglucanase E-4 celD 0.0023
4667 BH0236 protein BH0236 0.0023
4671 Endoglucanase C cenC 0.0023
4509 Acetoin(diacetyl) reductase budC 0.002
1184 Interferon beta IFNB1 0.002
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.002
1503 Galectin-7 LGALS7 0.002
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.002
5498 Maltoporin lamB 0.002
5561 Maltoporin lamB 0.002
5247 Endo-1,4-beta-xylanase Not Available 0.002
5248 Endo-1,4-beta-xylanase xlnA 0.002
5250 Endo-1,4-beta-xylanase xyl 0.002
4669 Endo-1,4-beta-xylanase A xynA 0.002
4715 Endo-1,4-beta-xylanase A xlnA 0.002
5560 Endo-1,4-beta-xylanase A xynA 0.002
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.002
5416 Coat protein VP1 Not Available 0.002
5176 YtnJ moxC 0.002
2705 Dimethyl sulfoxide reductase dmsA 0.002
4819 Hydrolase Not Available 0.0018
5249 Hydrolase Not Available 0.0018
5436 Hydrolase Not Available 0.0018
3091 Maltodextrin phosphorylase malP 0.0018
3547 Enterotoxin type B entB 0.0018
2531 Alpha-amylase amyE 0.0018
2948 Alpha-amylase amy 0.0018
3169 Alpha-amylase Not Available 0.0018
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0018
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0018
2606 Neopullulanase 2 tvaII 0.0018
2541 Neopullulanase 1 tvaI 0.0018
3747 Cellulase B precursor celB 0.0018
4811 Amylosucrase ams 0.0018
2324 Botulinum neurotoxin type B botB 0.0018
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0018
4666 Fucose-binding lectin PA-IIL lecB 0.0017
1881 Hexokinase-1 HK1 0.0017
2372 Bifunctional tail protein 9 0.0017
2826 Glucose--fructose oxidoreductase gfo 0.0017
3365 Beta-amylase spoII 0.0017
3225 Shiga toxin B-chain stxB 0.0017
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0016
2508 Cyclomaltodextrin glucanotransferase cgt 0.0016
2523 Cyclomaltodextrin glucanotransferase cgt 0.0016
3207 Cyclomaltodextrin glucanotransferase amyA 0.0016
6614 Lactase-like protein LCTL 0.0016
1675 Glucokinase GCK 0.0016
4662 Glucokinase glk 0.0016
4692 A/G-specific adenine glycosylase mutY 0.0016
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0016
2802 Endoglucanase G celCCG 0.0016
3668 Maltose-binding periplasmic protein precursor malE 0.0016
2570 Tetanus toxin tetX 0.0016
4272 POSSIBLE CELLULASE CELA1 celA1 0.0016
2440 Endoglucanase F celCCF 0.0015
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0014
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
2252 Endoglucanase 5A cel5A 0.0014
2245 Xylose isomerase xylA 0.0014
2253 Xylose isomerase xylA 0.0014
2260 Xylose isomerase xylA 0.0014
2431 Xylose isomerase xylA 0.0014
2723 Cholera enterotoxin subunit B ctxB 0.0013
10 Glycogen phosphorylase, liver form PYGL 0.0013
2427 Ferrichrome-iron receptor fhuA 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.001
20 Prostaglandin G/H synthase 1 PTGS1 0.0007
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