DT-Web

DB00535 - Cefdinir


Identification
Name Cefdinir
Accession Number DB00535 (APRD00644)
Type small molecule
Description Cefdinir (marketed by Abbott Laboratories under the brand name Omnicef) is a semi-synthetic, broad-spectrum antibiotic in the third generation of the cephalosporin class, proven effective for common bacterial infections of the ear, sinus, throat, and skin. It was approved by the U.S. Food and Drug Administration (FDA) in December of 1997.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 395.414
Groups approved
Monoisotopic Weight 395.035809931
Pharmacology
Indication For the treatment of the respiratory, skin, soft tissue, and ENT infections caused by H. influenzae (including b-lactamase producing strains), H. parainfluenzae (including b-lactamase producing strains), S. pneumoniae (penicillin-susceptible strains), S. pyogenes, S. aureus (including b-lactamase producing strains), and M. catarrhalis.
Mechanism of action As with other cephalosporins, bactericidal activity of cefdinir results from inhibition of cell wall synthesis by acting on penicillin binding proteins (PBPs).
Absorption Maximal plasma cefdinir concentrations occur 2 to 4 hours postdose following capsule or suspension administration. Estimated bioavailability of cefdinir capsules is 21% following administration of a 300 mg capsule dose, and 16% following administration of a 600 mg capsule dose. Estimated absolute bioavailability of cefdinir suspension is 25%. Absorption is reduced by approximately 15% when administered with a high fat meal.
Protein binding 60%-70%, binding is independent of concentration.
Biotransformation Cefdinir is not appreciably metabolized. Activity is primarily due to parent drug.
Route of elimination Cefdinir is not appreciably metabolized. Cefdinir is eliminated principally via renal excretion with a mean plasma elimination half-life (t 1/2 ) of 1.7 (?0.6) hours.
Toxicity Information on cefdinir overdosage in humans is not available. In acute rodent toxicity studies, a single oral 5600-mg/kg dose produced no adverse effects. Toxic signs and symptoms following overdosage with other b-lactam antibiotics have included nausea, vomiting, epigastric distress, diarrhea, and convulsions.
Affected organisms
  • Enteric gram-negative rods
Interactions
Drug Interactions Not Available
Food Interactions
  • Avoid taking antacids at same time (up to 2 hours before or after antibiotic).
  • Avoid taking iron preparations at same time (up to 2 hours before or after antibiotic).
  • Take without regard to meals.

Targets


Penicillin-binding protein 2
Name Penicillin-binding protein 2
Gene Name penA
Pharmacological action yes
Actions inhibitor
References
  • Ochiai S, Sekiguchi S, Hayashi A, Shimadzu M, Ishiko H, Matsushima-Nishiwaki R, Kozawa O, Yasuda M, Deguchi T: Decreased affinity of mosaic-structure recombinant penicillin-binding protein 2 for oral cephalosporins in Neisseria gonorrhoeae. J Antimicrob Chemother. 2007 Jul;60(1):54-60. Epub 2007 May 31. - Pubmed
DTHybrid score 0.0335
Penicillin-binding protein 3
Name Penicillin-binding protein 3
Gene Name pbp3
Pharmacological action yes
Actions inhibitor
References
  • Sanbongi Y, Suzuki T, Osaki Y, Senju N, Ida T, Ubukata K: Molecular evolution of beta-lactam-resistant Haemophilus influenzae: 9-year surveillance of penicillin-binding protein 3 mutations in isolates from Japan. Antimicrob Agents Chemother. 2006 Jul;50(7):2487-92. - Pubmed
DTHybrid score 0.0083
Myeloperoxidase
Name Myeloperoxidase
Gene Name MPO
Pharmacological action no
Actions inhibitor
References
  • Labro MT, el Benna J, Charlier N, Abdelghaffar H, Hakim J: Cefdinir (CI-983), a new oral amino-2-thiazolyl cephalosporin, inhibits human neutrophil myeloperoxidase in the extracellular medium but not the phagolysosome. J Immunol. 1994 Mar 1;152(5):2447-55. - Pubmed
DTHybrid score 0.5371

Transporters


Organic cation/carnitine transporter 2
Name Organic cation/carnitine transporter 2
Gene Name SLC22A5
Actions inhibitor
References
  • Ganapathy ME, Huang W, Rajan DP, Carter AL, Sugawara M, Iseki K, Leibach FH, Ganapathy V: beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. J Biol Chem. 2000 Jan 21;275(3):1699-707. - Pubmed
DTHybrid score 0.439
Oligopeptide transporter, small intestine isoform
Name Oligopeptide transporter, small intestine isoform
Gene Name SLC15A1
Actions substrate,inhibitor
References
  • Ganapathy ME, Prasad PD, Mackenzie B, Ganapathy V, Leibach FH: Interaction of anionic cephalosporins with the intestinal and renal peptide transporters PEPT 1 and PEPT 2. Biochim Biophys Acta. 1997 Mar 13;1324(2):296-308. - Pubmed
  • Terada T, Saito H, Mukai M, Inui K: Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells. Am J Physiol. 1997 Nov;273(5 Pt 2):F706-11. - Pubmed
  • Tsuji A: Transporter-mediated Drug Interactions. Drug Metab Pharmacokinet. 2002;17(4):253-74. - Pubmed
DTHybrid score 0.72
Oligopeptide transporter, kidney isoform
Name Oligopeptide transporter, kidney isoform
Gene Name SLC15A2
Actions inhibitor
References
  • Ganapathy ME, Prasad PD, Mackenzie B, Ganapathy V, Leibach FH: Interaction of anionic cephalosporins with the intestinal and renal peptide transporters PEPT 1 and PEPT 2. Biochim Biophys Acta. 1997 Mar 13;1324(2):296-308. - Pubmed
  • Terada T, Saito H, Mukai M, Inui K: Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells. Am J Physiol. 1997 Nov;273(5 Pt 2):F706-11. - Pubmed
DTHybrid score 0.7206

Predictions


Id Partner name Gene Name Score
244 Angiotensin-converting enzyme ACE 0.1747
633 Penicillin-binding proteins 1A/1B pbpA 0.1242
1729 Solute carrier family 22 member 6 SLC22A6 0.1032
6142 Solute carrier family 22 member 8 SLC22A8 0.0641
1 Peptidoglycan synthetase ftsI ftsI 0.0525
4155 Peptidoglycan synthetase ftsI ftsI 0.0525
833 Organic cation/carnitine transporter 1 SLC22A4 0.0514
645 Penicillin-binding protein 1A mrcA 0.0485
5805 Penicillin-binding protein 1A ponA 0.0485
6185 Penicillin-binding protein 1A mrcA 0.0485
6799 Penicillin-binding protein 1A pbpA 0.0485
1588 Multidrug resistance protein 1 ABCB1 0.0447
4119 Cytochrome P450 2D6 CYP2D6 0.0429
4512 Cytochrome P450 3A4 CYP3A4 0.0393
290 Prostaglandin G/H synthase 2 PTGS2 0.0391
587 Serum albumin ALB 0.0387
20 Prostaglandin G/H synthase 1 PTGS1 0.037
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.036
1385 Angiotensin-converting enzyme 2 ACE2 0.035
4757 Cytochrome P450 2C9 CYP2C9 0.0343
543 Penicillin-binding protein 1B mrcB 0.0336
6186 Penicillin-binding protein 1B ponB 0.0336
6822 Penicillin-binding protein 1b pbp1b 0.0336
6844 Penicillin-binding protein 1b pbp1b 0.0336
115 Penicillin-binding protein 2 mrdA 0.0335
6069 Penicillin-binding protein 2 mrdA 0.0335
6187 Penicillin-binding protein 2 pbpA 0.0335
6686 Penicillin-binding protein 2 pbp2 0.0335
6939 Penicillin-binding protein 2 mrdA 0.0335
7163 Penicillin-binding protein 2 pbpA 0.0335
4200 Cytochrome P450 1A2 CYP1A2 0.0332
6145 Solute carrier family 22 member 1 SLC22A1 0.0329
1024 Solute carrier family 22 member 11 SLC22A11 0.0325
1736 Somatostatin SST 0.0311
4186 Neuropeptide Y receptor type 2 NPY2R 0.0311
6144 Solute carrier family 22 member 2 SLC22A2 0.0311
6016 Cytochrome P450 2C19 CYP2C19 0.0306
6067 Penicillin binding protein 2a mecA 0.0291
153 Dopamine beta-hydroxylase DBH 0.0256
3923 Cholinesterase BCHE 0.0253
309 Antithrombin-III SERPINC1 0.0251
6147 Solute carrier family 22 member 3 SLC22A3 0.0247
234 Plasminogen PLG 0.0246
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0244
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0239
563 Thyroid peroxidase TPO 0.0238
56 Delta-aminolevulinic acid dehydratase ALAD 0.023
2356 Delta-aminolevulinic acid dehydratase hemB 0.023
3613 Delta-aminolevulinic acid dehydratase hemB 0.023
3674 Delta-aminolevulinic acid dehydratase hemB 0.023
4604 Liver carboxylesterase 1 CES1 0.023
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0228
275 Arachidonate 5-lipoxygenase ALOX5 0.0215
503 Somatostatin receptor type 1 SSTR1 0.0214
723 Cytosolic phospholipase A2 PLA2G4A 0.021
3866 Serum amyloid A protein SAA1 0.0209
1932 Apolipoprotein E APOE 0.0208
1200 AMBP protein AMBP 0.0208
54 Prothrombin F2 0.0207
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0203
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0201
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0201
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0201
3872 Somatostatin receptor type 5 SSTR5 0.02
6008 Somatostatin receptor type 2 SSTR2 0.02
2544 Bacterial leucyl aminopeptidase Not Available 0.0198
738 Monocarboxylate transporter 1 SLC16A1 0.0197
6143 Solute carrier family 22 member 7 SLC22A7 0.0191
856 Vitamin D3 receptor VDR 0.0189
6020 Aldehyde oxidase AOX1 0.0188
477 DNA topoisomerase 4 subunit A parC 0.0178
886 DNA topoisomerase 4 subunit A parC 0.0178
6226 DNA topoisomerase 4 subunit A parC 0.0178
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0176
404 DNA gyrase subunit A gyrA 0.0175
6224 DNA gyrase subunit A gyrA 0.0175
239 Coagulation factor X F10 0.0167
3917 Methylenetetrahydrofolate reductase MTHFR 0.0164
6012 Tryptophan 2,3-dioxygenase TDO2 0.0155
4924 Cytochrome P450 2C8 CYP2C8 0.015
3060 Leukotriene A-4 hydrolase LTA4H 0.0149
6024 Cytochrome P450 1A1 CYP1A1 0.0145
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0144
6106 Cytochrome P450 2C18 CYP2C18 0.0141
713 Sodium-dependent dopamine transporter SLC6A3 0.0139
6165 Copper-transporting ATPase 1 ATP7A 0.0132
6163 Copper-transporting ATPase 2 ATP7B 0.0132
817 DNA topoisomerase 2-alpha TOP2A 0.0131
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.013
862 Multidrug resistance-associated protein 1 ABCC1 0.0129
318 Alpha-2A adrenergic receptor ADRA2A 0.0129
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0126
6146 High affinity copper uptake protein 1 SLC31A1 0.0125
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0123
159 Penicillin-binding protein 2B penA 0.0123
6121 Penicillin-binding protein 2B penA 0.0123
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0121
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0121
4118 Cytochrome P450 3A5 CYP3A5 0.012
908 Glutathione S-transferase theta-1 GSTT1 0.0119
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0119
3941 Amine oxidase [flavin-containing] A MAOA 0.0118
4252 Penicillin-binding protein 5 dacA 0.0117
3939 Amine oxidase [flavin-containing] B MAOB 0.0117
6030 Cytochrome P450 2B6 CYP2B6 0.0117
3947 Xanthine dehydrogenase/oxidase XDH 0.0117
6013 Cytochrome P450 2E1 CYP2E1 0.0114
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0111
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0111
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0106
3810 Catechol O-methyltransferase COMT 0.0106
896 Glutathione S-transferase Mu 1 GSTM1 0.0105
6107 Cytochrome P450 3A7 CYP3A7 0.0103
509 Thymidine kinase TK 0.0101
570 Thymidine kinase TK 0.0101
2559 Thymidine kinase TK 0.0101
3430 Thymidine kinase tdk 0.0101
3518 Thymidine kinase TK 0.0101
5301 Thymidine kinase tdk 0.0101
5771 Thymidine kinase ORF36 0.0101
7009 Thymidine kinase ORF36 0.0101
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0099
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0099
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0099
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0098
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0098
904 Glutathione S-transferase P GSTP1 0.0094
6137 Multidrug resistance-associated protein 6 ABCC6 0.0092
3760 Penicillin-binding protein 5 precursor dacA 0.0091
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0089
6010 Thiamine transporter 1 SLC19A2 0.0089
3426 Glutamine synthetase glnA 0.0089
3987 Glutamine synthetase GLUL 0.0089
492 Histamine H1 receptor HRH1 0.0088
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0088
338 DNA polymerase UL30 0.0087
379 DNA polymerase UL54 0.0087
697 DNA polymerase ORF28 0.0087
2482 DNA polymerase 43 0.0087
4104 DNA polymerase BALF5 0.0087
6168 Solute carrier family 22 member 16 SLC22A16 0.0086
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0085
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0085
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0085
632 Alpha-1B adrenergic receptor ADRA1B 0.0084
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0084
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0083
551 Carnitine O-acetyltransferase CRAT 0.0083
867 Penicillin-binding protein 3 pbpC 0.0083
7154 Penicillin-binding protein 3 pbp3 0.0083
7157 Penicillin-binding protein 3 LMHCC_2184 0.0083
7162 Penicillin-binding protein 3 pbpB 0.0083
7172 Penicillin-binding protein 3 pbp3 0.0083
6113 MecA PBP2' (penicillin binding protein 2') mecA 0.0082
556 Alpha-1A adrenergic receptor ADRA1A 0.0081
175 Thiamin pyrophosphokinase 1 TPK1 0.008
624 Guanidinoacetate N-methyltransferase GAMT 0.0078
2164 Multidrug resistance-associated protein 4 ABCC4 0.0076
5718 Cytochrome P450 2A6 CYP2A6 0.0075
1636 Trace amine-associated receptor 1 TAAR1 0.0073
1141 Sialidase-1 NEU1 0.0068
64 Neuraminidase NA 0.0068
641 Neuraminidase NA 0.0068
2676 Neuraminidase NA 0.0068
3026 Neuraminidase NA 0.0068
3519 Neuraminidase NA 0.0068
6007 Neuraminidase NA 0.0068
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0067
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0067
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0065
629 Alpha-2B adrenergic receptor ADRA2B 0.0065
3601 Dihydropteroate synthase 1 folP1 0.0065
3807 Dihydropteroate synthase 1 folP1 0.0065
3808 Dihydropteroate synthase 2 folP2 0.0065
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0064
192 Creatine kinase, ubiquitous mitochondrial CKMT1A 0.0063
456 Creatine kinase, sarcomeric mitochondrial CKMT2 0.0063
92 Creatine kinase B-type CKB 0.0063
414 Sodium- and chloride-dependent creatine transporter 1 SLC6A8 0.0063
474 Acetylcholinesterase ACHE 0.0063
122 P2Y purinoceptor 12 P2RY12 0.0062
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0062
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.006
332 Beta-lactamase blaZ 0.0059
2478 Beta-lactamase ampC 0.0059
2613 Beta-lactamase ampC 0.0059
2635 Beta-lactamase ampC 0.0059
2700 Beta-lactamase penP 0.0059
5445 Beta-lactamase blaB 0.0059
6019 Beta-lactamase SHV-7 0.0059
6701 Beta-lactamase cphA 0.0059
131 Synaptic vesicular amine transporter SLC18A2 0.0059
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0059
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0059
6036 Eosinophil peroxidase EPX 0.0059
3830 Calreticulin CALR 0.0057
788 Creatine kinase M-type CKM 0.0057
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0056
6034 Hydroxyindole O-methyltransferase ASMT 0.0055
6035 Nuclear receptor ROR-beta RORB 0.0055
1898 Cytochrome P450 1B1 CYP1B1 0.0053
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0053
5482 Sialidase-2 NEU2 0.0052
860 Nicotinamide N-methyltransferase NNMT 0.0051
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0051
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0051
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0051
699 Nicotinic acid receptor 1 GPR109A 0.0051
928 Nicotinic acid receptor 2 GPR109B 0.0051
378 Alpha-2C adrenergic receptor ADRA2C 0.0049
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0048
707 72 kDa type IV collagenase MMP2 0.0048
765 Indoleamine 2,3-dioxygenase IDO1 0.0047
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0046
2472 Voltage-gated potassium channel kcsA 0.0046
6366 Voltage-gated potassium channel kcsA 0.0046
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0046
6102 Arylamine N-acetyltransferase 2 NAT2 0.0045
776 Bile salt export pump ABCB11 0.0045
362 Melatonin receptor type 1B MTNR1B 0.0045
571 Melatonin receptor type 1A MTNR1A 0.0045
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0043
380 Cytochrome P450 17A1 CYP17A1 0.0042
6151 Monocarboxylate transporter 10 SLC16A10 0.004
828 Phenylalanine-4-hydroxylase PAH 0.0039
3109 Phenylalanine-4-hydroxylase phhA 0.0039
737 Mineralocorticoid receptor NR3C2 0.0039
65 Matrix metalloproteinase-9 Not Available 0.0039
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0038
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0038
163 D(1B) dopamine receptor DRD5 0.0038
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0037
193 Beta-1 adrenergic receptor ADRB1 0.0036
5126 Arginase rocF 0.0036
432 D(4) dopamine receptor DRD4 0.0036
766 Beta-2 adrenergic receptor ADRB2 0.0035
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0035
638 D(3) dopamine receptor DRD3 0.0034
1341 Histamine H3 receptor HRH3 0.0034
124 Histamine H2 receptor HRH2 0.0034
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0034
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0033
6136 Multidrug resistance-associated protein 5 ABCC5 0.0033
499 Arginine decarboxylase ADC 0.0033
164 Histamine H4 receptor HRH4 0.0032
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0032
500 Monocarboxylate transporter 4 SLC16A3 0.0032
789 Alpha-1D adrenergic receptor ADRA1D 0.0031
23 D(1A) dopamine receptor DRD1 0.0031
577 Argininosuccinate lyase ASL 0.0031
834 Arginase-2, mitochondrial ARG2 0.0031
150 Cationic amino acid transporter 3 SLC7A3 0.003
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.003
58 Cationic amino acid transporter 4 SLC7A4 0.003
824 Sodium-dependent serotonin transporter SLC6A4 0.003
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0029
465 Calmodulin CALM1 0.0029
831 D(2) dopamine receptor DRD2 0.0029
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0029
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0028
740 Argininosuccinate synthase ASS1 0.0028
865 Argininosuccinate synthase ASS1 0.0028
2680 Argininosuccinate synthase argG 0.0028
3194 Argininosuccinate synthase argG 0.0028
558 Solute carrier family 12 member 1 SLC12A1 0.0027
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0027
4203 Histamine N-methyltransferase HNMT 0.0026
468 Cytochrome P450 4A11 CYP4A11 0.0026
3811 Cytochrome P450 19A1 CYP19A1 0.0026
976 Platelet glycoprotein IX GP9 0.0025
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0025
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0025
136 Estrogen receptor ESR1 0.0024
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0023
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0021
2300 Lysozyme E 0.0021
3633 Lysozyme R 0.0021
5597 Lysozyme 17 0.0021
5682 Ribonuclease pancreatic RNASE1 0.002
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.002
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.002
769 High-affinity choline transporter 1 SLC5A7 0.002
3933 Choline/ethanolaminephosphotransferase CEPT1 0.002
861 Choline kinase alpha CHKA 0.002
844 Epidermal growth factor receptor EGFR 0.002
700 Choline dehydrogenase, mitochondrial CHDH 0.002
3927 Choline transporter-like protein 3 SLC44A3 0.002
1686 Choline transporter-like protein 1 SLC44A1 0.002
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.002
3926 Choline transporter-like protein 2 SLC44A2 0.002
3925 Choline transporter-like protein 4 SLC44A4 0.002
576 Choline O-acetyltransferase CHAT 0.002
3922 Phospholipase D2 PLD2 0.002
3924 Phospholipase D1 PLD1 0.002
7 Nitric oxide synthase, inducible NOS2 0.0019
357 Carbonic anhydrase 2 CA2 0.0019
291 Nitric-oxide synthase, endothelial NOS3 0.0019
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0019
1517 Beta-3 adrenergic receptor ADRB3 0.0018
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0017
6218 Pannexin-1 PANX1 0.0017
1039 Histone deacetylase 9 HDAC9 0.0017
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0017
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0017
751 Potassium channel subfamily K member 6 KCNK6 0.0017
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0017
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0016
1360 Sphingomyelin phosphodiesterase SMPD1 0.0016
172 Potassium channel subfamily K member 1 KCNK1 0.0015
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0015
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0015
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0014
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0014
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0014
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0014
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0014
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0014
6149 Solute carrier family 22 member 10 SLC22A10 0.0014
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0013
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0013
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0012
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0012
6014 Cytochrome P450 2A13 CYP2A13 0.0012
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0012
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0011
6432 Transporter snf 0.0011
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0011
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0011
489 Monocarboxylate transporter 2 SLC16A7 0.0011
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0011
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.001
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.001
6141 Sodium/bile acid cotransporter SLC10A1 0.001
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0009
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0009
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0009
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0008
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0008
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0008
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0008
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0008
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0008
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0008
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0008
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0008
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0008
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0007
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0007
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0007
502 5-hydroxytryptamine 2A receptor HTR2A 0.0007
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0007
6148 Multidrug resistance-associated protein 7 ABCC10 0.0007
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