DT-Web: DB00153

Identification

Name

Ergocalciferol

Accession Number

DB00153 (APRD00426, NUTR00005)

Type

small molecule

Description

Ergocalciferol (Vitamin D2) is a derivative of ergosterol formed by ultraviolet rays breaking of the C9-C10 bond. It differs from cholecalciferol in having a double bond between C22 and C23 and a methyl group at C24. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

396.6484

Groups

approved

Monoisotopic Weight

396.33921603

Pharmacology

Indication

For use in the management of hypocalcemia and its clinical manifestations in patients with hypoparathyroidism, as well as for the treatment of familial hypophosphatemia (vitamin D resistant rickets). This drug has also been used in the treatment of nutritional rickets or osteomalacia, vitamin D dependent rickets, rickets or osteomalacia secondary to long-term high dose anticonvulsant therapy, early renal osteodystrophy, osteoporosis (in conjunction with calcium), and hypophosphatemia associated with Fanconi syndrome (with treatment of acidosis).

Mechanism of action

Activated ergocalciferol increases serum calcium and phosphate concentrations, primarily by increasing intestinal absorption of calcium and phosphate through binding to a specific receptor in the mucosal cytoplasm of the intestine. Subsequently, calcium is absorbed through formation of a calcium-binding protein. 25-hydroxyergocalciferol is the intermediary metabolite of ergocalciferol. Although this metabolite exhibits 2-5 times more activity than unactivated ergocalciferol in curing rickets and inducing calcium absorption and mobilization (from bone) in animals, this increased activity is still insufficient to affect these functions at physiologic concentrations. Activated ergocalciferol stimulate resorption of bone and are required for normal mineralization of bone. Physiological doses of ergocalciferol also promotes calcium reabsorption by the kidneys, but the significance of this effect is not known.

Absorption

Readily absorbed from small intestine (proximal or distal), requires presence of bile salts.

Protein binding

>99.8%

Biotransformation

Within the liver, ergocalciferol is hydroxylated to ercalcidiol (25-hydroxyergocalciferol) by the enzyme 25-hydroxylase. Within the kidney, ercalcidiol serves as a substrate for 1-alpha-hydroxylase, yielding ercalcitriol (1,25-dihydroxyergocalciferol), the biologically active form of vitamin D2.

Route of elimination

Not Available

Toxicity

LD₅₀ = 23.7 mg/kg (Orally in mice); LD₅₀ = 10 mg/kg (Orally in rats ); Nausea, vomiting and diarrhea, weight loss, irritability, weakness, fatigue, lassitude, and headache.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug

Mechanism of interaction

Cholecalciferol

Vitamin D analogs may enhance the adverse/toxic effect of other Vitamin D analogs. Avoid combined use of multiple vitamin D analogs (at pharmacologic doses). Prescribing information for calcitriol, doxercalciferol, paricalcitol, and alfacalcidol each specifically cautions against such combined use. Though not specified in the prescribing information for calcipotriene, cholecalciferol, and ergocalciferol, each contains warnings regarding the potential for vitamin D toxicity.

Colesevelam

Bile acid sequestrants such as colesevelam may decrease the serum concentration of Vitamin D Analogs. More specifically, bile acid sequestrants may impair absorption of Vitamin D Analogs. Avoid concomitant administration of vitamin D analogs and bile acid sequestrants (e.g., cholestyramine). Monitor plasma calcium concentrations in patients receiving combined therapy with these agents. This is particularly important in patients receiving higher doses of a bile acid sequestant (i.e., 30 g/day or more of cholestyramine or equivalent) or in patients experiencing bile acid sequestrant-induced steatorrhea. Specific recommendations regarding the separation of administration of these agents are not defined; however, it would seem prudent to separate the administration of these agents by several hours to minimize the potential risk of interaction. Similar precautions do not apply to parenterally administered vitamin D analogs.

Food Interactions

Not Available

Vitamin D3 receptor
Name	Vitamin D3 receptor
Gene Name	VDR
Pharmacological action	yes
Actions	agonist
References	Carvallo L, Henriquez B, Olate J, van Wijnen AJ, Lian JB, Stein GS, Onate S, Stein JL, Montecino M: The 1alpha,25-dihydroxy Vitamin D3 receptor preferentially recruits the coactivator SRC-1 during up-regulation of the osteocalcin gene. J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):420-4. Epub 2007 Jan 10. - Pubmed Liu W, Tretiakova M, Kong J, Turkyilmaz M, Li YC, Krausz T: Expression of vitamin D3 receptor in kidney tumors. Hum Pathol. 2006 Oct;37(10):1268-78. Epub 2006 Jul 27. - Pubmed Ewing AK, Attner M, Chakravarti D: Novel regulatory role for human Acf1 in transcriptional repression of vitamin D3 receptor-regulated genes. Mol Endocrinol. 2007 Aug;21(8):1791-806. Epub 2007 May 22. - Pubmed Gallagher JC, Sai AJ: Vitamin D insufficiency, deficiency, and bone health. J Clin Endocrinol Metab. 2010 Jun;95(6):2630-3. - Pubmed Straube S, Derry S, Moore RA, McQuay HJ: Vitamin D for the treatment of chronic painful conditions in adults. Cochrane Database Syst Rev. 2010 Jan 20;(1):CD007771. - Pubmed Jurutka PW, Bartik L, Whitfield GK, Mathern DR, Barthel TK, Gurevich M, Hsieh JC, Kaczmarska M, Haussler CA, Haussler MR: Vitamin D receptor: key roles in bone mineral pathophysiology, molecular mechanism of action, and novel nutritional ligands. J Bone Miner Res. 2007 Dec;22 Suppl 2:V2-10. - Pubmed Mikhak B, Hunter DJ, Spiegelman D, Platz EA, Hollis BW, Giovannucci E: Vitamin D receptor (VDR) gene polymorphisms and haplotypes, interactions with plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D, and prostate cancer risk. Prostate. 2007 Jun 15;67(9):911-23. - Pubmed Marks HD, Fleet JC, Peleg S: Transgenic expression of the human Vitamin D receptor (hVDR) in the duodenum of VDR-null mice attenuates the age-dependent decline in calcium absorption. J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):513-6. Epub 2007 Jan 5. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	1.6884

Cytochrome P450 24A1, mitochondrial
Name	Cytochrome P450 24A1, mitochondrial
Gene Name	CYP24A1
Actions	substrate
References	Masuda S, Strugnell SA, Knutson JC, St-Arnaud R, Jones G: Evidence for the activation of 1alpha-hydroxyvitamin D2 by 25-hydroxyvitamin D-24-hydroxylase: delineation of pathways involving 1alpha,24-dihydroxyvitamin D2 and 1alpha,25-dihydroxyvitamin D2. Biochim Biophys Acta. 2006 Feb;1761(2):221-34. Epub 2006 Feb 2. - Pubmed Sakaki T, Kagawa N, Yamamoto K, Inouye K: Metabolism of vitamin D3 by cytochromes P450. Front Biosci. 2005 Jan 1;10:119-34. Print 2005 Jan 1. - Pubmed Abe D, Sakaki T, Kusudo T, Kittaka A, Saito N, Suhara Y, Fujishima T, Takayama H, Hamamoto H, Kamakura M, Ohta M, Inouye K: Metabolism of 2 alpha-propoxy-1 alpha,25-dihydroxyvitamin D3 and 2 alpha-(3-hydroxypropoxy)-1 alpha,25-dihydroxyvitamin D3 by human CYP27A1 and CYP24A1. Drug Metab Dispos. 2005 Jun;33(6):778-84. Epub 2005 Mar 11. - Pubmed Sakaki T: [Recent studies on vitamin D metabolizing enzymes] Clin Calcium. 2006 Jul;16(7):1129-35. - Pubmed Inouye K, Sakaki T: Enzymatic studies on the key enzymes of vitamin D metabolism; 1 alpha-hydroxylase (CYP27B1) and 24-hydroxylase (CYP24). Biotechnol Annu Rev. 2001;7:179-94. - Pubmed
DTHybrid score	1.1136
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Name	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Gene Name	CYP27B1
Actions	substrate
References	Turunen MM, Dunlop TW, Carlberg C, Vaisanen S: Selective use of multiple vitamin D response elements underlies the 1 alpha,25-dihydroxyvitamin D3-mediated negative regulation of the human CYP27B1 gene. Nucleic Acids Res. 2007;35(8):2734-47. Epub 2007 Apr 10. - Pubmed Gallagher JC, Sai AJ: Vitamin D insufficiency, deficiency, and bone health. J Clin Endocrinol Metab. 2010 Jun;95(6):2630-3. - Pubmed Sakaki T, Kagawa N, Yamamoto K, Inouye K: Metabolism of vitamin D3 by cytochromes P450. Front Biosci. 2005 Jan 1;10:119-34. Print 2005 Jan 1. - Pubmed Sakaki T: [Recent studies on vitamin D metabolizing enzymes] Clin Calcium. 2006 Jul;16(7):1129-35. - Pubmed Inouye K, Sakaki T: Enzymatic studies on the key enzymes of vitamin D metabolism; 1 alpha-hydroxylase (CYP27B1) and 24-hydroxylase (CYP24). Biotechnol Annu Rev. 2001;7:179-94. - Pubmed
DTHybrid score	0.9993
Cytochrome P450 27, mitochondrial
Name	Cytochrome P450 27, mitochondrial
Gene Name	CYP27A1
Actions	substrate
References	Binkley N, Ramamurthy R, Krueger D: Low vitamin D status: definition, prevalence, consequences, and correction. Endocrinol Metab Clin North Am. 2010 Jun;39(2):287-301, table of contents. - Pubmed Masuda S, Strugnell SA, Knutson JC, St-Arnaud R, Jones G: Evidence for the activation of 1alpha-hydroxyvitamin D2 by 25-hydroxyvitamin D-24-hydroxylase: delineation of pathways involving 1alpha,24-dihydroxyvitamin D2 and 1alpha,25-dihydroxyvitamin D2. Biochim Biophys Acta. 2006 Feb;1761(2):221-34. Epub 2006 Feb 2. - Pubmed Sakaki T, Kagawa N, Yamamoto K, Inouye K: Metabolism of vitamin D3 by cytochromes P450. Front Biosci. 2005 Jan 1;10:119-34. Print 2005 Jan 1. - Pubmed Abe D, Sakaki T, Kusudo T, Kittaka A, Saito N, Suhara Y, Fujishima T, Takayama H, Hamamoto H, Kamakura M, Ohta M, Inouye K: Metabolism of 2 alpha-propoxy-1 alpha,25-dihydroxyvitamin D3 and 2 alpha-(3-hydroxypropoxy)-1 alpha,25-dihydroxyvitamin D3 by human CYP27A1 and CYP24A1. Drug Metab Dispos. 2005 Jun;33(6):778-84. Epub 2005 Mar 11. - Pubmed Sakaki T: [Recent studies on vitamin D metabolizing enzymes] Clin Calcium. 2006 Jul;16(7):1129-35. - Pubmed
DTHybrid score	0.593
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Binkley N, Ramamurthy R, Krueger D: Low vitamin D status: definition, prevalence, consequences, and correction. Endocrinol Metab Clin North Am. 2010 Jun;39(2):287-301, table of contents. - Pubmed
DTHybrid score	0.4646
Cytochrome P450 2R1
Name	Cytochrome P450 2R1
Gene Name	CYP2R1
Actions	substrate
References	Ramos-Lopez E, Bruck P, Jansen T, Pfeilschifter JM, Radeke HH, Badenhoop K: CYP2R1-, CYP27B1- and CYP24-mRNA expression in German type 1 diabetes patients. J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):807-10. Epub 2007 Jan 16. - Pubmed Ramos-Lopez E, Bruck P, Jansen T, Herwig J, Badenhoop K: CYP2R1 (vitamin D 25-hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans. Diabetes Metab Res Rev. 2007 Jul 2;. - Pubmed Masuda S, Strugnell SA, Knutson JC, St-Arnaud R, Jones G: Evidence for the activation of 1alpha-hydroxyvitamin D2 by 25-hydroxyvitamin D-24-hydroxylase: delineation of pathways involving 1alpha,24-dihydroxyvitamin D2 and 1alpha,25-dihydroxyvitamin D2. Biochim Biophys Acta. 2006 Feb;1761(2):221-34. Epub 2006 Feb 2. - Pubmed
DTHybrid score	0.5038

Id	Partner name	Gene Name	Score
1992	Vitamin D-binding protein	GC	0.2713
945	Adrenocorticotropic hormone receptor	MC2R	0.1686
1566	Corticoliberin	CRH	0.1257
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.1172
3233	Bile acid receptor	NR1H4	0.0945
6891	Mediator of RNA polymerase II transcription subunit 1	MED1	0.0935
6228	Nuclear receptor coactivator 1	NCOA1	0.0897
6016	Cytochrome P450 2C19	CYP2C19	0.0894
4119	Cytochrome P450 2D6	CYP2D6	0.085
1757	Myeloperoxidase	MPO	0.0774
4757	Cytochrome P450 2C9	CYP2C9	0.074
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0688
6182	Cytochrome P450 2J2	CYP2J2	0.0677
4924	Cytochrome P450 2C8	CYP2C8	0.0656
85	Growth hormone receptor	GHR	0.0623
6030	Cytochrome P450 2B6	CYP2B6	0.0616
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0571
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0567
6024	Cytochrome P450 1A1	CYP1A1	0.0513
1588	Multidrug resistance protein 1	ABCB1	0.0501
4118	Cytochrome P450 3A5	CYP3A5	0.0487
4200	Cytochrome P450 1A2	CYP1A2	0.0404
468	Cytochrome P450 4A11	CYP4A11	0.0347
3426	Glutamine synthetase	glnA	0.0346
3987	Glutamine synthetase	GLUL	0.0346
6106	Cytochrome P450 2C18	CYP2C18	0.0328
6107	Cytochrome P450 3A7	CYP3A7	0.0324
3923	Cholinesterase	BCHE	0.0277
6013	Cytochrome P450 2E1	CYP2E1	0.0255
871	Glucocorticoid receptor	NR3C1	0.0163
587	Serum albumin	ALB	0.0163
5718	Cytochrome P450 2A6	CYP2A6	0.0144
3811	Cytochrome P450 19A1	CYP19A1	0.013
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0128
492	Histamine H1 receptor	HRH1	0.0123
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0112
20	Prostaglandin G/H synthase 1	PTGS1	0.0109
136	Estrogen receptor	ESR1	0.0102
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.01
556	Alpha-1A adrenergic receptor	ADRA1A	0.0091
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0089
824	Sodium-dependent serotonin transporter	SLC6A4	0.0088
862	Multidrug resistance-associated protein 1	ABCC1	0.0088
731	HIV-1 protease	HIV-1 protease	0.0087
847	Mu-type opioid receptor	OPRM1	0.0084
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0082
232	Corticosteroid-binding globulin	SERPINA6	0.008
318	Alpha-2A adrenergic receptor	ADRA2A	0.008
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0079
1729	Solute carrier family 22 member 6	SLC22A6	0.0077
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0075
831	D(2) dopamine receptor	DRD2	0.0075
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0074
467	Delta-type opioid receptor	OPRD1	0.007
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0069
260	Cytochrome P450 51	ERG11	0.0069
761	Cytochrome P450 51	ERG11	0.0069
3163	Cytochrome P450 51	cyp51	0.0069
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0068
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0066
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0066
6145	Solute carrier family 22 member 1	SLC22A1	0.0062
614	Progesterone receptor	PGR	0.0062
290	Prostaglandin G/H synthase 2	PTGS2	0.0061
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0059
1898	Cytochrome P450 1B1	CYP1B1	0.0059
818	50S ribosomal protein L10	rplJ	0.0058
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0058
776	Bile salt export pump	ABCB11	0.0058
632	Alpha-1B adrenergic receptor	ADRA1B	0.0057
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0057
23	D(1A) dopamine receptor	DRD1	0.0057
696	Kappa-type opioid receptor	OPRK1	0.0055
6144	Solute carrier family 22 member 2	SLC22A2	0.0053
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0053
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0053
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0051
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.005
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.005
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0049
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0049
6142	Solute carrier family 22 member 8	SLC22A8	0.0048
766	Beta-2 adrenergic receptor	ADRB2	0.0048
789	Alpha-1D adrenergic receptor	ADRA1D	0.0047
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0047
713	Sodium-dependent dopamine transporter	SLC6A3	0.0046
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0046
629	Alpha-2B adrenergic receptor	ADRA2B	0.0045
118	Organic cation/carnitine transporter 2	SLC22A5	0.0043
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0042
6031	Cytochrome P450 3A43	CYP3A43	0.0042
378	Alpha-2C adrenergic receptor	ADRA2C	0.0042
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
638	D(3) dopamine receptor	DRD3	0.0041
29	Tubulin beta-1 chain	TUBB1	0.004
952	Dipeptidyl peptidase 4	DPP4	0.004
725	5-hydroxytryptamine 1D receptor	HTR1D	0.004
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0039
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0038
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0038
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0038
817	DNA topoisomerase 2-alpha	TOP2A	0.0037
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0037
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0036
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0036
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0036
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0036
68	Cannabinoid receptor 1	CNR1	0.0036
122	P2Y purinoceptor 12	P2RY12	0.0035
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0035
4237	50S ribosomal protein L22	rplV	0.0035
6143	Solute carrier family 22 member 7	SLC22A7	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0035
939	50S ribosomal protein L3	rplC	0.0035
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0035
811	Translocator protein	TSPO	0.0035
2164	Multidrug resistance-associated protein 4	ABCC4	0.0035
322	Vasopressin V2 receptor	AVPR2	0.0034
193	Beta-1 adrenergic receptor	ADRB1	0.0034
161	Tubulin beta chain	TUBB	0.0034
312	Tubulin beta chain	TUB2	0.0034
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0034
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0034
6020	Aldehyde oxidase	AOX1	0.0033
474	Acetylcholinesterase	ACHE	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0033
814	Ryanodine receptor 1	RYR1	0.0033
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0032
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0032
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0032
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0032
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0032
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0032
592	Carbonic anhydrase 4	CA4	0.0032
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0032
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0031
146	Androgen receptor	AR	0.0031
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0031
432	D(4) dopamine receptor	DRD4	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.003
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.003
6043	Putative G-protein coupled receptor 44	GPR44	0.003
716	5-hydroxytryptamine 7 receptor	HTR7	0.003
756	Sex hormone-binding globulin	SHBG	0.0029
833	Organic cation/carnitine transporter 1	SLC22A4	0.0029
284	DNA-directed RNA polymerase beta chain	rpoB	0.0029
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0029
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0028
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0028
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0028
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0028
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0028
6147	Solute carrier family 22 member 3	SLC22A3	0.0027
723	Cytosolic phospholipase A2	PLA2G4A	0.0027
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
295	Carbonic anhydrase 1	CA1	0.0027
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0026
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0026
6148	Multidrug resistance-associated protein 7	ABCC10	0.0026
49	Endothelin B receptor	EDNRB	0.0026
407	Vascular endothelial growth factor receptor 2	KDR	0.0025
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0025
3947	Xanthine dehydrogenase/oxidase	XDH	0.0025
768	FK506-binding protein 1A	FKBP1A	0.0025
4604	Liver carboxylesterase 1	CES1	0.0025
1024	Solute carrier family 22 member 11	SLC22A11	0.0024
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0024
705	Glutamate receptor 1	GRIA1	0.0024
578	Endothelin-1 receptor	EDNRA	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
357	Carbonic anhydrase 2	CA2	0.0024
1483	Membrane copper amine oxidase	AOC3	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0023
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0023
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0023
844	Epidermal growth factor receptor	EGFR	0.0023
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0023
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0023
777	Tumor necrosis factor	TNF	0.0023
869	Estrogen receptor beta	ESR2	0.0023
70	Type-1 angiotensin II receptor	AGTR1	0.0023
737	Mineralocorticoid receptor	NR3C2	0.0022
504	Mast/stem cell growth factor receptor	KIT	0.0022
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
6220	Aryl hydrocarbon receptor	AHR	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
6137	Multidrug resistance-associated protein 6	ABCC6	0.0021
2449	Tubulin alpha-3 chain	TUBA1A	0.0021
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
1656	CYP2B protein	CYP2B	0.0021
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0021
163	D(1B) dopamine receptor	DRD5	0.0021
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0021
2539	Tubulin alpha-1 chain	TUBA4A	0.0021
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0021
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0021
6014	Cytochrome P450 2A13	CYP2A13	0.002
3941	Amine oxidase [flavin-containing] A	MAOA	0.002
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.002
465	Calmodulin	CALM1	0.002
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
373	Transthyretin	TTR	0.0019
3932	Glutathione S-transferase A2	GSTA2	0.0019
2499	Tubulin beta-2C chain	TUBB2C	0.0019
233	Potassium channel subfamily K member 2	KCNK2	0.0019
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0019
477	DNA topoisomerase 4 subunit A	parC	0.0019
886	DNA topoisomerase 4 subunit A	parC	0.0019
6226	DNA topoisomerase 4 subunit A	parC	0.0019
404	DNA gyrase subunit A	gyrA	0.0018
6224	DNA gyrase subunit A	gyrA	0.0018
124	Histamine H2 receptor	HRH2	0.0018
4120	NADPH--cytochrome P450 reductase	POR	0.0018
6102	Arylamine N-acetyltransferase 2	NAT2	0.0018
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0018
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
26	Vascular endothelial growth factor receptor 3	FLT4	0.0018
4238	50S ribosomal protein L4	rplD	0.0018
5578	50S ribosomal protein L4	rplD	0.0018
6173	50S ribosomal protein L4	rplD	0.0018
6219	50S ribosomal protein L4	rplD	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
683	Potassium transporter	GK0582	0.0018
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0018
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0018
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0017
32	Vascular endothelial growth factor receptor 1	FLT1	0.0017
543	Penicillin-binding protein 1B	mrcB	0.0017
6186	Penicillin-binding protein 1B	ponB	0.0017
6822	Penicillin-binding protein 1b	pbp1b	0.0017
6844	Penicillin-binding protein 1b	pbp1b	0.0017
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0017
1050	Bile salt sulfotransferase	SULT2A1	0.0017
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0017
159	Penicillin-binding protein 2B	penA	0.0017
6121	Penicillin-binding protein 2B	penA	0.0017
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0016
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0016
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0016
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0016
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0016
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0016
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0016
1852	Microtubule-associated protein 2	MAP2	0.0016
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0016
173	Toll-like receptor 7	TLR7	0.0016
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0016
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0015
6138	Multidrug resistance protein 3	ABCB4	0.0015
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0015
3939	Amine oxidase [flavin-containing] B	MAOB	0.0015
427	Substance-P receptor	TACR1	0.0015
380	Cytochrome P450 17A1	CYP17A1	0.0015
275	Arachidonate 5-lipoxygenase	ALOX5	0.0015
1629	Transcription factor AP-1	JUN	0.0015
1541	Metalloproteinase	mmp20	0.0014
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0014
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
6141	Sodium/bile acid cotransporter	SLC10A1	0.0014
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0014
1010	Cytochrome P450 51A1	CYP51A1	0.0014
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0014
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0013
6136	Multidrug resistance-associated protein 5	ABCC5	0.0013
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0013
1353	DNA topoisomerase 1	TOP1	0.0013
3552	DNA topoisomerase 1	topA	0.0013
4122	Histone deacetylase 2	HDAC2	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0013
891	Dihydropteroate synthase	folP	0.0013
5359	Dihydropteroate synthase	folP	0.0013
7175	Dihydropteroate synthase	sulI	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
780	Retinoic acid receptor RXR-gamma	RXRG	0.0012
16	Adenosine A1 receptor	ADORA1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
6126	Carbonic anhydrase 7	CA7	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
571	Melatonin receptor type 1A	MTNR1A	0.0012
362	Melatonin receptor type 1B	MTNR1B	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0012
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0012
1295	Fatty acid synthase	FASN	0.0012
904	Glutathione S-transferase P	GSTP1	0.0012
482	Glycine receptor subunit alpha-1	GLRA1	0.0012
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0012
1178	Adenosine A2a receptor	ADORA2A	0.0011
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0011
239	Coagulation factor X	F10	0.0011
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0011
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0011
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0011
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0011
88	Retinoic acid receptor RXR-beta	RXRB	0.0011
365	Dihydrofolate reductase	DHFR	0.0011
2381	Dihydrofolate reductase	DFR1	0.0011
2833	Dihydrofolate reductase	Not Available	0.0011
2931	Dihydrofolate reductase	folA	0.0011
3544	Dihydrofolate reductase	folA	0.0011
3682	Dihydrofolate reductase	folA	0.0011
6642	Dihydrofolate reductase	folA	0.0011
6756	Dihydrofolate reductase	dfrA	0.0011
921	Glutamate receptor 2	GRIA2	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0011
5787	Angiopoietin-1 receptor	TEK	0.0011
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0011
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0011
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
54	Prothrombin	F2	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4203	Histamine N-methyltransferase	HNMT	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.001
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.001
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5300	Antigen peptide transporter 1	TAP1	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
6824	Tyrosine-protein kinase Lyn	LYN	0.001
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.001
605	Fumarate reductase flavoprotein subunit	frdA	0.001
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.001
3673	Fumarate reductase flavoprotein subunit	fccA	0.001
4912	Fumarate reductase flavoprotein subunit	ifcA	0.001
6549	Fumarate reductase flavoprotein subunit	frdA	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
4773	Deoxycytidine kinase	DCK	0.0009
1517	Beta-3 adrenergic receptor	ADRB3	0.0009
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0009
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0009
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0009
3086	Plasmepsin-2	Not Available	0.0009
459	Retinoic acid receptor RXR-alpha	RXRA	0.0009
165	FL cytokine receptor	FLT3	0.0009
1048	Protein S100-A13	S100A13	0.0009
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0009
2226	Protein S100-A12	S100A12	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
1648	Elastin	ELN	0.0009
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0009
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0009
6131	Carbonic anhydrase 14	CA14	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
153	Dopamine beta-hydroxylase	DBH	0.0009
183	Vascular endothelial growth factor A	VEGFA	0.0009
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3404	Exotoxin A	eta	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
94	5-hydroxytryptamine 4 receptor	HTR4	0.0008
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0008
1867	Major prion protein	PRNP	0.0008
2232	Interleukin-5	IL5	0.0008
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
6432	Transporter	snf	0.0008
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
1025	Aquaporin-1	AQP1	0.0008
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0008
3856	Fibroblast growth factor receptor 3	FGFR3	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
2091	Endoplasmin	HSP90B1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
896	Glutathione S-transferase Mu 1	GSTM1	0.0007
473	L-lactate dehydrogenase A chain	LDHA	0.0007
738	Monocarboxylate transporter 1	SLC16A1	0.0007
461	Glycine receptor subunit alpha-3	GLRA3	0.0007
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0007
2112	Toll-like receptor 9	TLR9	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
469	Annexin A1	ANXA1	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
5924	Microtubule-associated protein 4	MAP4	0.0007
5923	Microtubule-associated protein tau	MAPT	0.0007
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0007
2298	Cytochrome P450-cam	camC	0.0007
518	Peroxidase/catalase T	katG	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
24	Thymidylate synthase	TMP1	0.0007
359	Thymidylate synthase	TYMS	0.0007
2626	Thymidylate synthase	thyA	0.0007
2729	Thymidylate synthase	thyA	0.0007
5352	Thymidylate synthase	THYA	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0007
164	Histamine H4 receptor	HRH4	0.0007
125	DNA polymerase beta	POLB	0.0007
1618	High affinity nerve growth factor receptor	NTRK1	0.0007
4311	tRNA	TRDMT1	0.0007
4325	tRNA	trmD	0.0007
4328	tRNA	trmD	0.0007
131	Synaptic vesicular amine transporter	SLC18A2	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
3937	Fatty-acid amide hydrolase	FAAH	0.0006
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0006
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0006
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0006
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0006
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0006
144	Hemoglobin subunit alpha	HBA1	0.0006
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
106	Cannabinoid receptor 2	CNR2	0.0006
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0006
6174	50S ribosomal protein L32	rpmF	0.0006
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0006
3809	Estrogen-related receptor gamma	ESRRG	0.0006
273	Apoptosis regulator Bcl-2	BCL2	0.0006
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0006
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0006
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0006
1196	Complement decay-accelerating factor	CD55	0.0006
6085	Fatty acid-binding protein, intestinal	FABP2	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0006
563	Thyroid peroxidase	TPO	0.0006
4192	DNA topoisomerase 2-beta	TOP2B	0.0006
6167	Organic solute transporter subunit beta	OSTB	0.0006
6166	Organic solute transporter subunit alpha	OSTA	0.0006
3611	Cytidine deaminase	cdd	0.0006
3707	Cytidine deaminase	cdd	0.0006
4211	Cytidine deaminase	CDA	0.0006
936	Ephrin type-A receptor 2	EPHA2	0.0006
1291	cAMP response element-binding protein	CREB1	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
1525	Heparin-binding growth factor 2	FGF2	0.0006
634	Squalene monooxygenase	SQLE	0.0006
7196	Squalene monooxygenase	ERG1	0.0006
4210	Toll-like receptor 4	TLR4	0.0005
2808	Chloramphenicol acetyltransferase 3	cat3	0.0005
1341	Histamine H3 receptor	HRH3	0.0005
84	Nuclear receptor 0B1	NR0B1	0.0005
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
1262	Corticotropin-lipotropin	POMC	0.0005
1192	Sulfotransferase 1A1	SULT1A1	0.0005
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0005
117	Sterol O-acyltransferase 1	SOAT1	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0005
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0005
244	Angiotensin-converting enzyme	ACE	0.0005
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0005
6211	Tubulin epsilon chain	TUBE1	0.0005
6212	Tubulin gamma-1 chain	TUBG1	0.0005
6210	Tubulin delta chain	TUBD1	0.0005
823	Fibroblast growth factor receptor 2	FGFR2	0.0005
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0005
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0005
3810	Catechol O-methyltransferase	COMT	0.0005
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0005
2417	Chloramphenicol acetyltransferase	cat	0.0005
3278	Chloramphenicol acetyltransferase	cat	0.0005
2810	Dr hemagglutinin structural subunit	draA	0.0005
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0005
3601	Dihydropteroate synthase 1	folP1	0.0005
3807	Dihydropteroate synthase 1	folP1	0.0005
3808	Dihydropteroate synthase 2	folP2	0.0005
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0005
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0005
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0005
1714	Mitogen-activated protein kinase 3	MAPK3	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0005
7	Nitric oxide synthase, inducible	NOS2	0.0005
3913	Glutamic acid decarboxylase	GAD65	0.0005
6149	Solute carrier family 22 member 10	SLC22A10	0.0005
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0004
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0004
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
319	Opioid receptor, sigma 1	OPRS1	0.0004
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0004
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
4103	Proteasome subunit beta type 2	PSMB2	0.0004
4101	Proteasome subunit beta type 1	PSMB1	0.0004
4102	Proteasome subunit beta type 5	PSMB5	0.0004
1630	Integrin beta-2	ITGB2	0.0004
976	Platelet glycoprotein IX	GP9	0.0004
1374	Natriuretic peptides B	NPPB	0.0004
1827	Gap junction alpha-1 protein	GJA1	0.0004
1908	Vascular cell adhesion protein 1	VCAM1	0.0004
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0004
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0004
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0004
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0004
2216	Fibroblast growth factor receptor 4	FGFR4	0.0004
4217	Telomerase reverse transcriptase	TERT	0.0004
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0004
735	Alanine aminotransferase 1	GPT	0.0004
3904	Alanine aminotransferase 2	GPT2	0.0004
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
6146	High affinity copper uptake protein 1	SLC31A1	0.0004
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0004
251	Alcohol dehydrogenase 1A	ADH1A	0.0004
174	Sigma 1-type opioid receptor	SIGMAR1	0.0004
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0004
594	Thyroxine-binding globulin	SERPINA7	0.0004
6048	Troponin C, skeletal muscle	TNNC2	0.0004
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0004
719	Retinoic acid receptor responder protein 1	RARRES1	0.0003
770	Retinoic acid-induced protein 3	GPRC5A	0.0003
820	Glycine receptor subunit alpha-2	GLRA2	0.0003
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0003
268	Adenosine A2b receptor	ADORA2B	0.0003
828	Phenylalanine-4-hydroxylase	PAH	0.0003
3109	Phenylalanine-4-hydroxylase	phhA	0.0003
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0003
6044	Serum paraoxonase/lactonase 3	PON3	0.0003
758	Thyroid hormone receptor alpha	THRA	0.0003
444	Alcohol dehydrogenase 1B	ADH1B	0.0003
33	Cystine/glutamate transporter	SLC7A11	0.0003
484	Tyrosine-protein kinase ABL2	ABL2	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0003
572	Integrin alpha-L	ITGAL	0.0003
5798	Mitogen-activated protein kinase 11	MAPK11	0.0003
199	Monocarboxylate transporter 8	SLC16A2	0.0003
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0003
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0003
2320	Thymidine kinase, cytosolic	TK1	0.0003
291	Nitric-oxide synthase, endothelial	NOS3	0.0003
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0003
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0003
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0003
569	Retinal dehydrogenase 2	ALDH1A2	0.0003
267	Plasminogen activator inhibitor 1	SERPINE1	0.0003
1864	RET proto-oncogene	RET	0.0003
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0003
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0003
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0003
346	Thyroid hormone receptor beta-1	THRB	0.0003
1275	Estrogen sulfotransferase	SULT1E1	0.0003
611	Retinal dehydrogenase 1	ALDH1A1	0.0003
760	Fibroblast growth factor 1	FGF1	0.0003
517	Alcohol dehydrogenase 1C	ADH1C	0.0003
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0003
1268	Neuropeptide S receptor	NPSR1	0.0003
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0003
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0003
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0003
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0003
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0003
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0003
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0003
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0003
6221	Steroid hormone receptor ERR1	ESRRA	0.0003
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0003
5934	Cytochrome P450 26A1	CYP26A1	0.0003
6218	Pannexin-1	PANX1	0.0003
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0003
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0003
751	Potassium channel subfamily K member 6	KCNK6	0.0003
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0003
1039	Histone deacetylase 9	HDAC9	0.0003
908	Glutathione S-transferase theta-1	GSTT1	0.0003
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0003
6073	Potassium channel subfamily K member 9	KCNK9	0.0003
6072	Potassium channel subfamily K member 3	KCNK3	0.0003
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0003
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0002
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0002
172	Potassium channel subfamily K member 1	KCNK1	0.0002
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0002
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0002
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0002
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0002
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0002
3957	Adenosine deaminase	ADA	0.0002
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0002
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0002
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0002
6168	Solute carrier family 22 member 16	SLC22A16	0.0002
162	Retinoic acid receptor gamma-1	RARG	0.0002
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0002
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0002
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0002
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0002
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0002
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
2207	Rhodopsin	RHO	0.0002
76	Nitric-oxide synthase, brain	NOS1	0.0002
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0002
489	Monocarboxylate transporter 2	SLC16A7	0.0002
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0002
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0001
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0001
4936	Cytochrome c2 iso-2	Not Available	0.0001
4916	Cyanoglobin	glbN	0.0001
4994	Hemoglobin-like protein HbO	glbO	0.0001
4915	Cytochrome c-550	psbV	0.0001
4959	Cytochrome c-550	psbV	0.0001
5216	Cytochrome c-550	psbV	0.0001
4925	Cytochrome c-type protein SHP	shp	0.0001
4904	Cytochrome c family protein	GSU1996	0.0001
4943	Cytochrome c6	petJ	0.0001
3116	Bacterioferritin	bfr	0.0001
4906	Bacterioferritin	bfr	0.0001
4965	Bacterioferritin	bfr	0.0001
4954	Soluble cytochrome b558	Not Available	0.0001
4934	Cytochrome c-551	nirM	0.0001
5218	Cytochrome c-551	nirM	0.0001
4905	Cytochrome c2	Not Available	0.0001
4939	Cytochrome c2	cycA	0.0001
4964	Cytochrome c2	cycA	0.0001
4979	Cytochrome c2	cycA	0.0001
6673	Cytochrome c2	cycA	0.0001
4910	Cytoglobin	CYGB	0.0001
4984	Neuroglobin	NGB	0.0001
4981	Iron-starvation protein PigA	pigA	0.0001
4909	CooA protein	cooA	0.0001
4998	Hemoglobin-like protein yjbI	yjbI	0.0001
4935	Cytochrome c-554	cycA1	0.0001
4947	Bacterial hemoglobin	vhb	0.0001
4975	Cytochrome c-556	RPA3973	0.0001
4942	Diheme cytochrome c napB	napB	0.0001
4931	Cytochrome P450 167A1	CYP167A1	0.0001
5000	HemO	hemO	0.0001
4972	P450cin	cinA	0.0001
4960	Putative cytochrome P450-family protein	SCO7417	0.0001
4971	Nonaheme cytochrome c	hmcA	0.0001
4989	Cytochrome c551 peroxidase	ccp	0.0001
5222	Cytochrome c551 peroxidase	ccpA	0.0001
4961	Hemophore HasA	hasA	0.0001
4976	Apocytochrome f	petA	0.0001
6407	Apocytochrome f	petA	0.0001
4907	Cytochrome c-L	moxG	0.0001
6865	Cytochrome c-L	moxG	0.0001
4993	Hydroxylamine oxidoreductase	hao1	0.0001
4764	Cytochrome P450 165C4	CYP165C4	0.0001
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0001
644	Heme oxygenase 2	HMOX2	0.0001
4982	Heme oxygenase 2	pbsA2	0.0001
4952	Catalase/peroxidase	katA	0.0001
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0001
4937	Cytochrome oxidase subunit II	rcoxA	0.0001
4903	Methyl-accepting chemotaxis protein	Tar4	0.0001
4999	Cytochrome P450 165B3	CYP165B3	0.0001
3093	Catalase HPII	katE	0.0001
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0001
4922	Cytochrome c, putative	SO_4144	0.0001
4920	Peroxidase/catalase	katG	0.0001
4990	PpcA	ppcA	0.0001
4948	Cytochrome c-553	Not Available	0.0001
4923	Cytochrome c3	DvMF_2499	0.0001
4945	Cytochrome c3	Not Available	0.0001
4949	Cytochrome c3	DVU_3171	0.0001
4968	Cytochrome c3	cytc3	0.0001
4997	Cytochrome c3	SO_2727	0.0001
5219	Cytochrome c3	cyd	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4902	Nine-heme cytochrome c	Ddes_2038	0.0001
3189	High-molecular-weight cytochrome c	hmcA	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4037	Hypothetical protein	GPX1	0.0001
4297	Hypothetical protein	SP_1951	0.0001
4521	Hypothetical protein	BC_2969	0.0001
4540	Hypothetical protein	TM_1070	0.0001
4555	Hypothetical protein	MT1739	0.0001
4569	Hypothetical protein	mshD	0.0001
4578	Hypothetical protein	PA3270	0.0001
4747	Hypothetical protein	PA3967	0.0001
5177	Hypothetical protein	TM_0096	0.0001
5194	Hypothetical protein	PA1204	0.0001
5240	Hypothetical protein	Rv2991	0.0001
5370	Hypothetical protein	TM_1158	0.0001
5710	Hypothetical protein	Tb927.5.1360	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
4992	Cytochrome c peroxidase	Not Available	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
3102	Flavohemoprotein	hmp	0.0001
4969	Flavohemoprotein	hmp	0.0001
4386	Hemoglobin-like protein HbN	glbN	0.0001
3127	Nitrite reductase	nirS	0.0001
3284	Nitrite reductase	nirS	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
3221	Cytochrome c4	cc4	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0
1507	Cytochrome c	CYCS	0
693	Hemoglobin subunit beta	HBB	0
6268	Hydroxyacid oxidase 1	HAO1	0
810	Heme oxygenase 1	HMOX1	0
3391	Heme oxygenase 1	pbsA1	0

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00153 - Ergocalciferol

Targets

Enzymes

Predictions