DT-Web

DB08897 - Aclidinium


Identification
Name Aclidinium
Accession Number DB08897
Type small molecule
Description Aclidinium is an anticholinergic for the long-term management of chronic obstructive pulmonary disease (COPD). It has a much higher propensity to bind to muscarinic receptors than nicotinic receptors. FDA approved on July 24, 2012.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 564.555
Groups approved
Monoisotopic Weight 563.07996248
Pharmacology
Indication Aclidinium bromide inhalation powder is indicated for the long-term, maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema.
Mechanism of action Aclidinium is a long-acting, competitive, and reversible anticholinergic drug that is specific for the acetylcholine muscarinic receptors. It binds to all 5 muscarinic receptor subtypes to a similar affinity. Aclidinium's effects on the airways are mediated through the M3 receptor at the smooth muscle to cause bronchodilation. Prevention of acetylcholine-induced bronchoconstriction effects was dose-dependent and lasted longer than 24 hours.
Absorption Bioavailability, healthy subjects = 6%; T max, healthy subjects = 10 minutes; Time to steady state, healthy subjects = 2 days;
Protein binding Not Available
Biotransformation The major route of metabolism of aclidinium bromide is hydrolysis, which occurs both chemically and enzymatically by esterases in the plasma. Aclidinium bromide is rapidly and extensively hydrolyzed to its alcohol and dithienylglycolic acid derivatives, neither of which binds to muscarinic receptors and are pharmacologically inactive.
Route of elimination Intravenously administered radiolabelled aclidinium bromide was administered to healthy volunteers and was extensively metabolized with 1% excreted as unchanged aclidinium. Approximately 54% to 65% of the radioactivity was excreted in urine and 20% to 33% of the dose was excreted in feces. The combined results indicated that almost the entire aclidinium bromide dose was eliminated by hydrolysis. After dry powder inhalation, urinary excretion of aclidinium is about 0.09% of the dose.
Toxicity Most common adverse reactions (>=3% incidence and greater than placebo) are headache, nasopharyngitis and cough.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Pramlintide May increase the risk of inhibition of GI motility via pharmacodynamic synergism. Consider alternate therapy.
Food Interactions Not Available

Targets


Muscarinic acetylcholine receptor M1
Name Muscarinic acetylcholine receptor M1
Gene Name CHRM1
Pharmacological action yes
Actions antagonist
References
  • FDA label -
DTHybrid score 0.8828
Muscarinic acetylcholine receptor M2
Name Muscarinic acetylcholine receptor M2
Gene Name CHRM2
Pharmacological action yes
Actions antagonist
References
  • FDA label -
DTHybrid score 0.7842
Muscarinic acetylcholine receptor M3
Name Muscarinic acetylcholine receptor M3
Gene Name CHRM3
Pharmacological action yes
Actions antagonist
References
  • FDA label -
DTHybrid score 0.7754
Muscarinic acetylcholine receptor M4
Name Muscarinic acetylcholine receptor M4
Gene Name CHRM4
Pharmacological action yes
Actions antagonist
References
  • FDA label -
DTHybrid score 0.5417
Muscarinic acetylcholine receptor M5
Name Muscarinic acetylcholine receptor M5
Gene Name CHRM5
Pharmacological action yes
Actions antagonist
References
  • FDA label -
DTHybrid score 0.4415

Enzymes


Cholinesterase
Name Cholinesterase
Gene Name BCHE
Actions substrate
References
  • Cazzola M, Page CP, Matera MG: Aclidinium bromide for the treatment of chronic obstructive pulmonary disease. Expert Opin Pharmacother. 2013 Jun;14(9):1205-14. doi: 10.1517/14656566.2013.789021. Epub 2013 Apr 9. - Pubmed
DTHybrid score 0.6382

Predictions


Id Partner name Gene Name Score
492 Histamine H1 receptor HRH1 0.1463
4119 Cytochrome P450 2D6 CYP2D6 0.1447
4512 Cytochrome P450 3A4 CYP3A4 0.1297
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.1092
474 Acetylcholinesterase ACHE 0.1016
1588 Multidrug resistance protein 1 ABCB1 0.1011
502 5-hydroxytryptamine 2A receptor HTR2A 0.0995
556 Alpha-1A adrenergic receptor ADRA1A 0.0923
831 D(2) dopamine receptor DRD2 0.0826
590 5-hydroxytryptamine 2C receptor HTR2C 0.0685
4200 Cytochrome P450 1A2 CYP1A2 0.0649
23 D(1A) dopamine receptor DRD1 0.0634
6016 Cytochrome P450 2C19 CYP2C19 0.057
4757 Cytochrome P450 2C9 CYP2C9 0.0553
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0547
789 Alpha-1D adrenergic receptor ADRA1D 0.0539
632 Alpha-1B adrenergic receptor ADRA1B 0.0513
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0464
6030 Cytochrome P450 2B6 CYP2B6 0.0455
432 D(4) dopamine receptor DRD4 0.0452
6013 Cytochrome P450 2E1 CYP2E1 0.0441
638 D(3) dopamine receptor DRD3 0.0437
824 Sodium-dependent serotonin transporter SLC6A4 0.043
320 5-hydroxytryptamine 1A receptor HTR1A 0.0376
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0372
318 Alpha-2A adrenergic receptor ADRA2A 0.0371
341 5-hydroxytryptamine 3 receptor HTR3A 0.0343
4924 Cytochrome P450 2C8 CYP2C8 0.0323
2129 Sucrase-isomaltase, intestinal SI 0.0317
378 Alpha-2C adrenergic receptor ADRA2C 0.0312
629 Alpha-2B adrenergic receptor ADRA2B 0.0309
4118 Cytochrome P450 3A5 CYP3A5 0.0304
833 Organic cation/carnitine transporter 1 SLC22A4 0.0299
6145 Solute carrier family 22 member 1 SLC22A1 0.0288
528 5-hydroxytryptamine 1E receptor HTR1E 0.0281
6144 Solute carrier family 22 member 2 SLC22A2 0.0281
436 5-hydroxytryptamine 2B receptor HTR2B 0.0276
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0276
766 Beta-2 adrenergic receptor ADRB2 0.0273
1256 5-hydroxytryptamine 6 receptor HTR6 0.0261
163 D(1B) dopamine receptor DRD5 0.0255
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0254
124 Histamine H2 receptor HRH2 0.0242
716 5-hydroxytryptamine 7 receptor HTR7 0.0237
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0229
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0229
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0229
118 Organic cation/carnitine transporter 2 SLC22A5 0.0221
465 Calmodulin CALM1 0.0213
2433 Capsid protein P40 UL80 0.0213
3569 Capsid protein P40 BVRF2 0.0213
725 5-hydroxytryptamine 1D receptor HTR1D 0.021
885 5-hydroxytryptamine 1B receptor HTR1B 0.0206
2049 Gastrin/cholecystokinin type B receptor CCKBR 0.0191
3076 Antigen 85-C fbpC 0.0187
6107 Cytochrome P450 3A7 CYP3A7 0.0176
713 Sodium-dependent dopamine transporter SLC6A3 0.0161
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0159
5718 Cytochrome P450 2A6 CYP2A6 0.0151
2796 Parathion hydrolase opd 0.0147
6539 Parathion hydrolase opd 0.0147
3454 Esterase estA 0.0141
587 Serum albumin ALB 0.0139
6147 Solute carrier family 22 member 3 SLC22A3 0.0134
1656 CYP2B protein CYP2B 0.0133
6432 Transporter snf 0.0133
6024 Cytochrome P450 1A1 CYP1A1 0.013
723 Cytosolic phospholipase A2 PLA2G4A 0.0124
2929 (S)-2-haloacid dehalogenase dhlB 0.0124
2995 (S)-2-haloacid dehalogenase Not Available 0.0124
6106 Cytochrome P450 2C18 CYP2C18 0.012
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.012
20 Prostaglandin G/H synthase 1 PTGS1 0.0116
290 Prostaglandin G/H synthase 2 PTGS2 0.0105
244 Angiotensin-converting enzyme ACE 0.0101
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0097
1360 Sphingomyelin phosphodiesterase SMPD1 0.0093
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0093
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0091
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0086
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0085
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0083
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0082
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0082
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0081
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0079
275 Arachidonate 5-lipoxygenase ALOX5 0.0079
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0065
85 Growth hormone receptor GHR 0.0065
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0064
1618 High affinity nerve growth factor receptor NTRK1 0.0064
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0061
467 Delta-type opioid receptor OPRD1 0.0059
696 Kappa-type opioid receptor OPRK1 0.0058
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0057
164 Histamine H4 receptor HRH4 0.0057
3811 Cytochrome P450 19A1 CYP19A1 0.0055
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0054
131 Synaptic vesicular amine transporter SLC18A2 0.005
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0049
737 Mineralocorticoid receptor NR3C2 0.0048
4784 Beta-mannosidase manB 0.0046
6695 Beta-mannosidase BT_0458 0.0046
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0045
3947 Xanthine dehydrogenase/oxidase XDH 0.0044
614 Progesterone receptor PGR 0.0043
193 Beta-1 adrenergic receptor ADRB1 0.0043
232 Corticosteroid-binding globulin SERPINA6 0.0043
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0042
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0042
3480 Mannan endo-1,4-beta-mannosidase manA 0.0041
468 Cytochrome P450 4A11 CYP4A11 0.0041
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.004
146 Androgen receptor AR 0.0039
94 5-hydroxytryptamine 4 receptor HTR4 0.0036
871 Glucocorticoid receptor NR3C1 0.0036
4787 Envelope glycoprotein gp160 env 0.0036
4820 Envelope glycoprotein gp160 env 0.0036
5727 Envelope glycoprotein gp160 env 0.0036
144 Hemoglobin subunit alpha HBA1 0.0036
2297 Genome polyprotein Not Available 0.0034
2322 Genome polyprotein Not Available 0.0034
2694 Genome polyprotein Not Available 0.0034
2719 Genome polyprotein Not Available 0.0034
2860 Genome polyprotein Not Available 0.0034
2928 Genome polyprotein Not Available 0.0034
3160 Genome polyprotein Not Available 0.0034
3260 Genome polyprotein Not Available 0.0034
4783 Genome polyprotein Not Available 0.0034
5726 Genome polyprotein Not Available 0.0034
5779 Genome polyprotein Not Available 0.0034
5867 Genome polyprotein Not Available 0.0034
6253 Genome polyprotein Not Available 0.0034
6301 Genome polyprotein Not Available 0.0034
6380 Genome polyprotein Not Available 0.0034
6381 Genome polyprotein Not Available 0.0034
6437 Genome polyprotein Not Available 0.0034
6520 Genome polyprotein Not Available 0.0034
6521 Genome polyprotein Not Available 0.0034
6652 Genome polyprotein Not Available 0.0034
6734 Genome polyprotein Not Available 0.0034
6735 Genome polyprotein Not Available 0.0034
6736 Genome polyprotein Not Available 0.0034
6737 Genome polyprotein Not Available 0.0034
6738 Genome polyprotein Not Available 0.0034
6739 Genome polyprotein Not Available 0.0034
6744 Genome polyprotein Not Available 0.0034
6748 Genome polyprotein Not Available 0.0034
6894 Genome polyprotein Not Available 0.0034
6898 Genome polyprotein Not Available 0.0034
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0033
1517 Beta-3 adrenergic receptor ADRB3 0.0033
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0033
1898 Cytochrome P450 1B1 CYP1B1 0.0033
3426 Glutamine synthetase glnA 0.0033
3987 Glutamine synthetase GLUL 0.0033
380 Cytochrome P450 17A1 CYP17A1 0.0032
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0032
1178 Adenosine A2a receptor ADORA2A 0.0031
3437 Eosinophil lysophospholipase CLC 0.003
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0029
6182 Cytochrome P450 2J2 CYP2J2 0.0028
6131 Carbonic anhydrase 14 CA14 0.0026
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0025
2207 Rhodopsin RHO 0.0024
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0023
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0023
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0023
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0022
4785 Ig gamma-1 chain C region IGHG1 0.0022
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0022
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0021
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0021
102 DNA topoisomerase I, mitochondrial TOP1MT 0.002
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0019
847 Mu-type opioid receptor OPRM1 0.0018
3941 Amine oxidase [flavin-containing] A MAOA 0.0018
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0017
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0017
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0017
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0017
3927 Choline transporter-like protein 3 SLC44A3 0.0017
861 Choline kinase alpha CHKA 0.0017
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0017
769 High-affinity choline transporter 1 SLC5A7 0.0017
700 Choline dehydrogenase, mitochondrial CHDH 0.0017
1686 Choline transporter-like protein 1 SLC44A1 0.0017
3926 Choline transporter-like protein 2 SLC44A2 0.0017
3925 Choline transporter-like protein 4 SLC44A4 0.0017
576 Choline O-acetyltransferase CHAT 0.0017
3922 Phospholipase D2 PLD2 0.0017
3924 Phospholipase D1 PLD1 0.0017
1353 DNA topoisomerase 1 TOP1 0.0017
3552 DNA topoisomerase 1 topA 0.0017
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0017
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0017
4604 Liver carboxylesterase 1 CES1 0.0016
904 Glutathione S-transferase P GSTP1 0.0016
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0015
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0015
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0014
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0014
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0014
6163 Copper-transporting ATPase 2 ATP7B 0.0013
6165 Copper-transporting ATPase 1 ATP7A 0.0013
4498 Ornithine cyclodeaminase PP3533 0.0012
6146 High affinity copper uptake protein 1 SLC31A1 0.0012
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0012
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0012
776 Bile salt export pump ABCB11 0.0012
5449 Hypothetical gliding protein mglB 0.0012
5443 UPF0189 protein ymdB ymdB 0.0012
5440 UPF0067 protein yebR yebR 0.0012
4705 Manganese catalase Not Available 0.0012
5439 33 kDa chaperonin hslO 0.0012
5446 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase HI_1679 0.0012
2720 Copper-containing nitrite reductase nirK 0.0012
5448 Ribonuclease Z rnz 0.0012
3781 Thiol:disulfide interchange protein dsbC precursor dsbC 0.0012
5447 Lethal(3)malignant brain tumor-like protein L3MBTL1 0.0012
5454 Internalin-A inlA 0.0012
332 Beta-lactamase blaZ 0.0012
2478 Beta-lactamase ampC 0.0012
2613 Beta-lactamase ampC 0.0012
2635 Beta-lactamase ampC 0.0012
2700 Beta-lactamase penP 0.0012
5445 Beta-lactamase blaB 0.0012
6019 Beta-lactamase SHV-7 0.0012
6701 Beta-lactamase cphA 0.0012
908 Glutathione S-transferase theta-1 GSTT1 0.0012
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0011
896 Glutathione S-transferase Mu 1 GSTM1 0.0011
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0011
5450 Prolyl endopeptidase Pep pep 0.0011
3356 Diaminopimelate decarboxylase lysA 0.001
6137 Multidrug resistance-associated protein 6 ABCC6 0.001
597 Dihydropteridine reductase QDPR 0.001
4771 Dissimilatory copper-containing nitrite reductase nir 0.001
862 Multidrug resistance-associated protein 1 ABCC1 0.001
3274 Hydroxylamine reductase hcp 0.001
4804 Hydroxylamine reductase hcp 0.001
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.001
2714 Chorismate mutase aroH 0.001
4611 Chorismate mutase aroG 0.001
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.001
3462 Tyrosine-protein kinase transforming protein Abl ABL 0.001
6136 Multidrug resistance-associated protein 5 ABCC5 0.001
3399 Limonene-1,2-epoxide hydrolase limA 0.001
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.001
1757 Myeloperoxidase MPO 0.001
4608 Putative cytochrome P450 SCO1207 0.0009
4963 Putative cytochrome P450 SCO2884 0.0009
6254 Putative cytochrome P450 SCO6998 0.0009
5180 L(+)-mandelate dehydrogenase mdlB 0.0009
577 Argininosuccinate lyase ASL 0.0009
3500 Putative family 31 glucosidase yicI yicI 0.0009
4878 Glycoprotein hormones alpha chain CGA 0.0009
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0009
1072 Granzyme B GZMB 0.0009
4889 Ig epsilon chain C region IGHE 0.0009
4877 Beta-mannanase man 0.0009
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0009
4189 Alpha-galactosidase A GLA 0.0009
4850 Beta-2-glycoprotein 1 APOH 0.0009
4880 Membrane cofactor protein CD46 0.0009
4856 CD209 antigen CD209 0.0009
1354 Beta-glucuronidase GUSB 0.0009
757 Fusion glycoprotein F0 F 0.0009
4875 Fusion glycoprotein F0 F 0.0009
4869 Major capsid protein A430L 0.0009
4852 Reticulon-4 receptor RTN4R 0.0009
4845 ADAM 33 ADAM33 0.0009
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0009
442 Envelope glycoprotein gp41 0.0009
4859 Envelope glycoprotein env 0.0009
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0009
4721 Beta-1,4-mannanase manA 0.0009
3352 Structural polyprotein Not Available 0.0009
3628 Structural polyprotein Not Available 0.0009
4892 Structural polyprotein Not Available 0.0009
1615 Chymase CMA1 0.0009
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0009
2597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] glmS 0.0008
365 Dihydrofolate reductase DHFR 0.0008
2381 Dihydrofolate reductase DFR1 0.0008
2833 Dihydrofolate reductase Not Available 0.0008
2931 Dihydrofolate reductase folA 0.0008
3544 Dihydrofolate reductase folA 0.0008
3682 Dihydrofolate reductase folA 0.0008
6642 Dihydrofolate reductase folA 0.0008
6756 Dihydrofolate reductase dfrA 0.0008
287 Beta-1,4-galactosyltransferase 1 B4GALT1 0.0008
4861 Interleukin-6 receptor alpha chain IL6R 0.0008
793 T-cell surface antigen CD2 CD2 0.0008
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0008
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0008
3837 Cytokine receptor common beta chain CSF2RB 0.0008
4890 Hemagglutinin HA 0.0007
6566 Hemagglutinin Not Available 0.0007
1379 Interleukin-12 subunit beta IL12B 0.0007
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0007
6858 Inactive carboxylesterase 4 CES1P1 0.0007
1184 Interferon beta IFNB1 0.0007
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0007
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0007
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0006
554 Low-density lipoprotein receptor LDLR 0.0006
852 Heparin cofactor 2 SERPIND1 0.0006
1859 Prostatic acid phosphatase ACPP 0.0006
3444 Cyanovirin-N Not Available 0.0006
3140 Hemagglutinin-neuraminidase HN 0.0006
3609 Hemagglutinin-neuraminidase HN 0.0006
595 Fibrinogen alpha chain FGA 0.0006
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0006
4666 Fucose-binding lectin PA-IIL lecB 0.0005
2372 Bifunctional tail protein 9 0.0005
958 Insulin-like growth factor 1 receptor IGF1R 0.0005
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0005
3814 Complement C1r subcomponent C1R 0.0005
64 Neuraminidase NA 0.0005
641 Neuraminidase NA 0.0005
2676 Neuraminidase NA 0.0005
3026 Neuraminidase NA 0.0005
3519 Neuraminidase NA 0.0005
6007 Neuraminidase NA 0.0005
1243 Cathepsin D CTSD 0.0005
1439 Lactotransferrin LTF 0.0005
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0005
309 Antithrombin-III SERPINC1 0.0005
2430 Chondroitinase B cslB 0.0004
6307 Ig gamma-2 chain C region IGHG2 0.0004
2581 Chondroitinase AC cslA 0.0004
6847 Lactase-phlorizin hydrolase LCT 0.0004
6500 Phospholipase A2 PLA2G1B 0.0004
76 Nitric-oxide synthase, brain NOS1 0.0003
952 Dipeptidyl peptidase 4 DPP4 0.0003
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