DB08848 - Guvacine
| Identification | |
|---|---|
| Name | Guvacine |
| Accession Number | DB08848 |
| Type | small molecule |
| Description | Guvacine is a pyridine alkaloid found in the Areca nut (also known as the Betel nut). It is an experimental drug with no approved indication. Experimental studies are still being investigated to determine all of the physiological effects and mechanisms of action of guvacine. Currently it has been determined that guvacine is a specific GABA reuptake inhibitor with no significant affinity at GABA receptors. |
| Structure |
|
| Categories (*) | |
| Molecular Weight | 127.1412 |
| Groups | experimental |
| Monoisotopic Weight | 127.063328537 |
| Pharmacology | |
| Indication | There is no approved indication for guvacine. |
| Mechanism of action | Experimental studies are still being investigated to determine the exact mechanisms of action of guvacine. What is known is that guvacine binds selectively to presynaptic GABA reuptake transporters and prevents the reuptake of GABA, but has no affinity for GABA postsynaptic receptors. |
| Absorption | Not Available |
| Protein binding | Not Available |
| Biotransformation | Not Available |
| Route of elimination | Not Available |
| Toxicity | Not Available |
| Affected organisms |
|
| Interactions | |
| Drug Interactions | Not Available |
| Food Interactions | Not Available |
Targets
| Sodium- and chloride-dependent GABA transporter 2 | |
|---|---|
| Name | Sodium- and chloride-dependent GABA transporter 2 |
| Gene Name | Not Available |
| Pharmacological action | unknown |
| Actions | inhibitor |
| References |
|
| DTHybrid score | Not Available |
| Sodium- and chloride-dependent GABA transporter 1 | |
| Name | Sodium- and chloride-dependent GABA transporter 1 |
| Gene Name | SLC6A1 |
| Pharmacological action | unknown |
| Actions | inhibitor |
| References |
|
| DTHybrid score | 0.7969 |
| Sodium- and chloride-dependent GABA transporter 3 | |
| Name | Sodium- and chloride-dependent GABA transporter 3 |
| Gene Name | Not Available |
| Pharmacological action | unknown |
| Actions | inhibitor |
| References |
|
| DTHybrid score | Not Available |
| Sodium- and chloride-dependent betaine transporter | |
| Name | Sodium- and chloride-dependent betaine transporter |
| Gene Name | Not Available |
| Pharmacological action | unknown |
| Actions | inhibitor |
| References |
|
| DTHybrid score | Not Available |