DT-Web

DB08824 - Ioflupane I 123


Identification
Name Ioflupane I 123
Accession Number DB08824
Type small molecule
Description Ioflupane (I-123) is a radiopharmaceutical used to image dopamine neurons and diagnose Parkinsonian syndromes.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 431.2836
Groups approved
Monoisotopic Weight 431.07575061
Pharmacology
Indication Ioflupane I-123 is a SPECT (single photon emission computerized tomography) agent used to distinguish between Parkinson's syndrome tremors and essential tremor.
Mechanism of action Iodine-123 labeled ioflupane binds to presynaptic dopamine transporters. When Iodine-123 decays, a gammay ray is emmitted and detected through SPECT.
Absorption Absorption is 100% because administered I.V.
Protein binding Not Available
Biotransformation Not Available
Route of elimination About 60% is excreted in the urine and 14% in the feces after 48 hours.
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions
  • No known food interactions.

Transporters


Sodium-dependent dopamine transporter
Name Sodium-dependent dopamine transporter
Gene Name SLC6A3
Actions Not Available
References
  • http://md.gehealthcare.com/files/pdfs/msds/datscan.pdf -
DTHybrid score 0.3505

Predictions


Id Partner name Gene Name Score
540 Sodium-dependent noradrenaline transporter SLC6A2 0.1333
824 Sodium-dependent serotonin transporter SLC6A4 0.0891
4119 Cytochrome P450 2D6 CYP2D6 0.0503
131 Synaptic vesicular amine transporter SLC18A2 0.0422
3941 Amine oxidase [flavin-containing] A MAOA 0.0325
492 Histamine H1 receptor HRH1 0.0292
3939 Amine oxidase [flavin-containing] B MAOB 0.0284
632 Alpha-1B adrenergic receptor ADRA1B 0.0279
4512 Cytochrome P450 3A4 CYP3A4 0.0234
556 Alpha-1A adrenergic receptor ADRA1A 0.0234
1636 Trace amine-associated receptor 1 TAAR1 0.0192
6016 Cytochrome P450 2C19 CYP2C19 0.0182
318 Alpha-2A adrenergic receptor ADRA2A 0.018
4200 Cytochrome P450 1A2 CYP1A2 0.0164
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0153
6030 Cytochrome P450 2B6 CYP2B6 0.0153
4757 Cytochrome P450 2C9 CYP2C9 0.0148
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0127
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0122
341 5-hydroxytryptamine 3 receptor HTR3A 0.0121
502 5-hydroxytryptamine 2A receptor HTR2A 0.0117
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0095
3923 Cholinesterase BCHE 0.0094
6147 Solute carrier family 22 member 3 SLC22A3 0.0084
4118 Cytochrome P450 3A5 CYP3A5 0.0083
1588 Multidrug resistance protein 1 ABCB1 0.0081
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0078
118 Organic cation/carnitine transporter 2 SLC22A5 0.0074
1656 CYP2B protein CYP2B 0.0074
629 Alpha-2B adrenergic receptor ADRA2B 0.0073
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0073
590 5-hydroxytryptamine 2C receptor HTR2C 0.0067
6144 Solute carrier family 22 member 2 SLC22A2 0.0063
193 Beta-1 adrenergic receptor ADRB1 0.0062
766 Beta-2 adrenergic receptor ADRB2 0.0061
1757 Myeloperoxidase MPO 0.006
5718 Cytochrome P450 2A6 CYP2A6 0.0058
6107 Cytochrome P450 3A7 CYP3A7 0.0057
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0057
4120 NADPH--cytochrome P450 reductase POR 0.0057
378 Alpha-2C adrenergic receptor ADRA2C 0.0053
436 5-hydroxytryptamine 2B receptor HTR2B 0.0052
6145 Solute carrier family 22 member 1 SLC22A1 0.0042
6013 Cytochrome P450 2E1 CYP2E1 0.004
320 5-hydroxytryptamine 1A receptor HTR1A 0.0039
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0039
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0038
1517 Beta-3 adrenergic receptor ADRB3 0.0037
23 D(1A) dopamine receptor DRD1 0.0035
4924 Cytochrome P450 2C8 CYP2C8 0.0035
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0033
831 D(2) dopamine receptor DRD2 0.0032
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0026
153 Dopamine beta-hydroxylase DBH 0.0025
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0022
3810 Catechol O-methyltransferase COMT 0.002
163 D(1B) dopamine receptor DRD5 0.0019
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0019
432 D(4) dopamine receptor DRD4 0.0018
638 D(3) dopamine receptor DRD3 0.0018
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