DT-Web

DB08553 - (1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime


Identification
Name (1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime
Accession Number DB08553
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 373.4509
Groups experimental
Monoisotopic Weight 373.190260383
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


B-Raf proto-oncogene serine/threonine-protein kinase
Name B-Raf proto-oncogene serine/threonine-protein kinase
Gene Name BRAF
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.8844

Predictions


Id Partner name Gene Name Score
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0484
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0317
4512 Cytochrome P450 3A4 CYP3A4 0.0212
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0187
26 Vascular endothelial growth factor receptor 3 FLT4 0.018
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0177
32 Vascular endothelial growth factor receptor 1 FLT1 0.0176
228 Beta platelet-derived growth factor receptor PDGFRB 0.0155
4924 Cytochrome P450 2C8 CYP2C8 0.0154
504 Mast/stem cell growth factor receptor KIT 0.0153
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0151
407 Vascular endothelial growth factor receptor 2 KDR 0.0149
1588 Multidrug resistance protein 1 ABCB1 0.0144
5798 Mitogen-activated protein kinase 11 MAPK11 0.0143
862 Multidrug resistance-associated protein 1 ABCC1 0.0138
4200 Cytochrome P450 1A2 CYP1A2 0.0133
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0131
4119 Cytochrome P450 2D6 CYP2D6 0.0127
587 Serum albumin ALB 0.012
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0111
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0106
5787 Angiopoietin-1 receptor TEK 0.0105
6142 Solute carrier family 22 member 8 SLC22A8 0.0103
936 Ephrin type-A receptor 2 EPHA2 0.0099
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0098
1729 Solute carrier family 22 member 6 SLC22A6 0.0093
823 Fibroblast growth factor receptor 2 FGFR2 0.0092
165 FL cytokine receptor FLT3 0.0089
1618 High affinity nerve growth factor receptor NTRK1 0.0087
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0086
6030 Cytochrome P450 2B6 CYP2B6 0.0075
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0075
6016 Cytochrome P450 2C19 CYP2C19 0.0065
4757 Cytochrome P450 2C9 CYP2C9 0.0063
2164 Multidrug resistance-associated protein 4 ABCC4 0.0046
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0041
6107 Cytochrome P450 3A7 CYP3A7 0.0036
4118 Cytochrome P450 3A5 CYP3A5 0.0034
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