DT-Web

DB08488 - 4-{[(E)-2-(5-CHLOROTHIEN-2-YL)VINYL]SULFONYL}-1-(1H-PYRROLO[3,2-C]PYRIDIN-2-YLMETHYL)PIPERAZIN-2-ONE


Identification
Name 4-{[(E)-2-(5-CHLOROTHIEN-2-YL)VINYL]SULFONYL}-1-(1H-PYRROLO[3,2-C]PYRIDIN-2-YLMETHYL)PIPERAZIN-2-ONE
Accession Number DB08488
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 436.936
Groups experimental
Monoisotopic Weight 436.043059517
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Coagulation factor X
Name Coagulation factor X
Gene Name F10
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.4291

Predictions


Id Partner name Gene Name Score
54 Prothrombin F2 0.0698
309 Antithrombin-III SERPINC1 0.0533
369 Coagulation factor VII F7 0.0188
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0177
798 Osteocalcin BGLAP 0.0167
1719 Heparanase HPSE 0.0164
3831 Low-density lipoprotein receptor-related protein 1 LRP1 0.016
2058 P-selectin SELP 0.0156
6182 Cytochrome P450 2J2 CYP2J2 0.0145
1334 Tissue factor pathway inhibitor TFPI 0.0132
1757 Myeloperoxidase MPO 0.0118
19 Coagulation factor VIII F8 0.0113
2139 Tissue factor F3 0.0111
3851 Serine protease hepsin HPN 0.01
400 Coagulation factor IX F9 0.0084
5461 Coagulation factor IX F9 0.0084
1547 Coagulation factor XI F11 0.0081
422 Vitamin K-dependent protein C PROC 0.0071
3842 Multiple coagulation factor deficiency protein 2 MCFD2 0.007
3841 ERGIC-53 protein LMAN1 0.007
3840 Asialoglycoprotein receptor 2 ASGR2 0.007
1847 78 kDa glucose-regulated protein HSPA5 0.007
1635 von Willebrand factor VWF 0.007
4118 Cytochrome P450 3A5 CYP3A5 0.0067
1588 Multidrug resistance protein 1 ABCB1 0.0063
1516 Calnexin CANX 0.0061
4512 Cytochrome P450 3A4 CYP3A4 0.0055
3830 Calreticulin CALR 0.005
3839 Phytanoyl-CoA dioxygenase, peroxisomal PHYH 0.0049
4200 Cytochrome P450 1A2 CYP1A2 0.0032
604 Vitamin K-dependent protein Z PROZ 0.003
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.003
1245 Vitamin K-dependent protein S PROS1 0.0028
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0027
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0024
4924 Cytochrome P450 2C8 CYP2C8 0.0022
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0021
6016 Cytochrome P450 2C19 CYP2C19 0.0021
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0021
4757 Cytochrome P450 2C9 CYP2C9 0.002
3917 Methylenetetrahydrofolate reductase MTHFR 0.0019
6020 Aldehyde oxidase AOX1 0.0018
3947 Xanthine dehydrogenase/oxidase XDH 0.0017
5718 Cytochrome P450 2A6 CYP2A6 0.0013
6024 Cytochrome P450 1A1 CYP1A1 0.0013
6013 Cytochrome P450 2E1 CYP2E1 0.0012
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