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DB08478 - N-[2-chloro-5-(trifluoromethyl)phenyl]imidodicarbonimidic diamide


Identification
Name N-[2-chloro-5-(trifluoromethyl)phenyl]imidodicarbonimidic diamide
Accession Number DB08478
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 279.649
Groups experimental
Monoisotopic Weight 279.049857635
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Thymidylate synthase
Name Thymidylate synthase
Gene Name TYMS
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.5763

Predictions


Id Partner name Gene Name Score
24 Thymidylate synthase TMP1 0.5763
2626 Thymidylate synthase thyA 0.5763
2729 Thymidylate synthase thyA 0.5763
5352 Thymidylate synthase THYA 0.5763
3639 Thymidine phosphorylase deoA 0.0784
3936 Thymidine phosphorylase TYMP 0.0784
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0745
365 Dihydrofolate reductase DHFR 0.0441
2381 Dihydrofolate reductase DFR1 0.0441
2833 Dihydrofolate reductase Not Available 0.0441
2931 Dihydrofolate reductase folA 0.0441
3544 Dihydrofolate reductase folA 0.0441
3682 Dihydrofolate reductase folA 0.0441
6642 Dihydrofolate reductase folA 0.0441
6756 Dihydrofolate reductase dfrA 0.0441
3611 Cytidine deaminase cdd 0.0234
3707 Cytidine deaminase cdd 0.0234
4211 Cytidine deaminase CDA 0.0234
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0231
2320 Thymidine kinase, cytosolic TK1 0.0231
4773 Deoxycytidine kinase DCK 0.0196
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0184
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.018
2164 Multidrug resistance-associated protein 4 ABCC4 0.0172
1043 Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase GART 0.0165
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0163
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0145
4757 Cytochrome P450 2C9 CYP2C9 0.0133
2567 Thymidylate synthase thyX thyX 0.0128
4275 PCZA361.16 Not Available 0.0128
4276 DNA polymerase III subunit epsilon dnaQ 0.0128
2410 Deoxyuridine 5'-triphosphate nucleotidohydrolase dut 0.0127
2490 Deoxyuridine 5'-triphosphate nucleotidohydrolase dut 0.0127
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0125
1729 Solute carrier family 22 member 6 SLC22A6 0.0116
2555 Pol polyprotein pol 0.0114
3242 Pol polyprotein gag-pol 0.0114
3471 Pol polyprotein gag-pro-pol 0.0114
5256 Pol polyprotein pol 0.0114
6469 Pol polyprotein gag-pol 0.0114
6565 Pol polyprotein Not Available 0.0114
1353 DNA topoisomerase 1 TOP1 0.0114
3552 DNA topoisomerase 1 topA 0.0114
1588 Multidrug resistance protein 1 ABCB1 0.0107
4604 Liver carboxylesterase 1 CES1 0.0101
2251 Thymidylate kinase tmk 0.0098
2254 Thymidylate kinase DTYMK 0.0098
3522 Thymidylate kinase tmk 0.0098
702 UMP-CMP kinase CMPK1 0.0098
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0097
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0097
6148 Multidrug resistance-associated protein 7 ABCC10 0.0088
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0087
6171 Solute carrier family 28 member 3 SLC28A3 0.0085
509 Thymidine kinase TK 0.0085
570 Thymidine kinase TK 0.0085
2559 Thymidine kinase TK 0.0085
3430 Thymidine kinase tdk 0.0085
3518 Thymidine kinase TK 0.0085
5301 Thymidine kinase tdk 0.0085
5771 Thymidine kinase ORF36 0.0085
7009 Thymidine kinase ORF36 0.0085
5691 DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC rmlC 0.0084
3361 Serpin B5 SERPINB5 0.0084
5694 Transcription antiterminator licT licT 0.0084
4924 Cytochrome P450 2C8 CYP2C8 0.0083
56 Delta-aminolevulinic acid dehydratase ALAD 0.0067
2356 Delta-aminolevulinic acid dehydratase hemB 0.0067
3613 Delta-aminolevulinic acid dehydratase hemB 0.0067
3674 Delta-aminolevulinic acid dehydratase hemB 0.0067
2286 Isocitrate dehydrogenase [NADP] icd 0.0063
2302 Isocitrate dehydrogenase [NADP] icd 0.0063
2771 Isocitrate dehydrogenase [NADP] icd 0.0063
4226 Uridine phosphorylase 2 UPP2 0.0061
4534 Cytohesin-2 CYTH2 0.0061
3917 Methylenetetrahydrofolate reductase MTHFR 0.006
4225 Uridine phosphorylase 1 UPP1 0.0059
3668 Maltose-binding periplasmic protein precursor malE 0.0059
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0054
2592 Beta-galactosidase lacZ 0.0053
413 Amidophosphoribosyltransferase PPAT 0.0051
2515 Amidophosphoribosyltransferase purF 0.0051
3714 Amidophosphoribosyltransferase purF 0.0051
4512 Cytochrome P450 3A4 CYP3A4 0.005
315 Arginase-1 ARG1 0.005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0046
6143 Solute carrier family 22 member 7 SLC22A7 0.0045
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.004
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.004
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.004
5818 Folate receptor alpha FOLR1 0.0037
587 Serum albumin ALB 0.0036
6136 Multidrug resistance-associated protein 5 ABCC5 0.0033
293 Gamma-glutamyl hydrolase GGH 0.0032
1650 Heme carrier protein 1 SLC46A1 0.0029
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0025
5718 Cytochrome P450 2A6 CYP2A6 0.0025
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0023
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0023
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0022
6020 Aldehyde oxidase AOX1 0.0021
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.002
738 Monocarboxylate transporter 1 SLC16A1 0.002
4200 Cytochrome P450 1A2 CYP1A2 0.002
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0018
1024 Solute carrier family 22 member 11 SLC22A11 0.0017
862 Multidrug resistance-associated protein 1 ABCC1 0.0016
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0016
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0015
6142 Solute carrier family 22 member 8 SLC22A8 0.0015
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