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DB08221 - N-{4-METHYL-3-[(3-PYRIMIDIN-4-YLPYRIDIN-2-YL)AMINO]PHENYL}-3-(TRIFLUOROMETHYL)BENZAMIDE


Identification
Name N-{4-METHYL-3-[(3-PYRIMIDIN-4-YLPYRIDIN-2-YL)AMINO]PHENYL}-3-(TRIFLUOROMETHYL)BENZAMIDE
Accession Number DB08221
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 449.4278
Groups experimental
Monoisotopic Weight 449.146344838
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Angiopoietin-1 receptor
Name Angiopoietin-1 receptor
Gene Name TEK
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.5938

Predictions


Id Partner name Gene Name Score
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0329
823 Fibroblast growth factor receptor 2 FGFR2 0.0323
183 Vascular endothelial growth factor A VEGFA 0.0315
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0314
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0312
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0306
844 Epidermal growth factor receptor EGFR 0.0305
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0295
504 Mast/stem cell growth factor receptor KIT 0.027
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0269
407 Vascular endothelial growth factor receptor 2 KDR 0.0264
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0245
2216 Fibroblast growth factor receptor 4 FGFR4 0.0233
5798 Mitogen-activated protein kinase 11 MAPK11 0.0225
3856 Fibroblast growth factor receptor 3 FGFR3 0.0215
6824 Tyrosine-protein kinase Lyn LYN 0.0215
4512 Cytochrome P450 3A4 CYP3A4 0.0207
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0194
862 Multidrug resistance-associated protein 1 ABCC1 0.0176
165 FL cytokine receptor FLT3 0.017
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0164
936 Ephrin type-A receptor 2 EPHA2 0.0158
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0156
587 Serum albumin ALB 0.0153
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0146
26 Vascular endothelial growth factor receptor 3 FLT4 0.0142
32 Vascular endothelial growth factor receptor 1 FLT1 0.0141
1618 High affinity nerve growth factor receptor NTRK1 0.014
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0125
228 Beta platelet-derived growth factor receptor PDGFRB 0.0124
4924 Cytochrome P450 2C8 CYP2C8 0.0118
1588 Multidrug resistance protein 1 ABCB1 0.0111
776 Bile salt export pump ABCB11 0.009
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0084
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0078
4118 Cytochrome P450 3A5 CYP3A5 0.0064
6030 Cytochrome P450 2B6 CYP2B6 0.006
4119 Cytochrome P450 2D6 CYP2D6 0.0058
6016 Cytochrome P450 2C19 CYP2C19 0.0052
4757 Cytochrome P450 2C9 CYP2C9 0.005
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