DT-Web

DB07954 - 3-ISOBUTYL-1-METHYLXANTHINE


Identification
Name 3-ISOBUTYL-1-METHYLXANTHINE
Accession Number DB07954
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 222.2438
Groups experimental
Monoisotopic Weight 222.111675712
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


cGMP-specific 3',5'-cyclic phosphodiesterase
Name cGMP-specific 3',5'-cyclic phosphodiesterase
Gene Name PDE5A
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
cGMP-inhibited 3',5'-cyclic phosphodiesterase B
Name cGMP-inhibited 3',5'-cyclic phosphodiesterase B
Gene Name PDE3B
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Name High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Gene Name PDE7A
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Name cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Gene Name PDE4D
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Name High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Gene Name PDE9A
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
Name High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
Gene Name PDE8A
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
cGMP-dependent 3',5'-cyclic phosphodiesterase
Name cGMP-dependent 3',5'-cyclic phosphodiesterase
Gene Name PDE2A
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Name Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Gene Name PDE6G
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available

Predictions


Id Partner name Gene Name Score
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.3669
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.3277
901 Glutathione S-transferase Mu 4 GSTM4 0.2579
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.2011
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.195
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.1891
691 cAMP-specific 3',5'-cyclic phosphodiesterase 7B PDE7B 0.1697
6217 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B PDE8B 0.1324
4512 Cytochrome P450 3A4 CYP3A4 0.1246
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0988
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0844
4118 Cytochrome P450 3A5 CYP3A5 0.0754
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0739
1729 Solute carrier family 22 member 6 SLC22A6 0.0617
1178 Adenosine A2a receptor ADORA2A 0.0616
16 Adenosine A1 receptor ADORA1 0.0604
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0479
492 Histamine H1 receptor HRH1 0.0477
6136 Multidrug resistance-associated protein 5 ABCC5 0.0369
2164 Multidrug resistance-associated protein 4 ABCC4 0.0305
6148 Multidrug resistance-associated protein 7 ABCC10 0.0249
6024 Cytochrome P450 1A1 CYP1A1 0.0205
6013 Cytochrome P450 2E1 CYP2E1 0.0195
3957 Adenosine deaminase ADA 0.0183
1830 5'-nucleotidase NT5E 0.0183
4757 Cytochrome P450 2C9 CYP2C9 0.0166
4119 Cytochrome P450 2D6 CYP2D6 0.0162
6107 Cytochrome P450 3A7 CYP3A7 0.0161
2684 Histidine triad nucleotide-binding protein 1 HINT1 0.0153
6016 Cytochrome P450 2C19 CYP2C19 0.0146
2516 GMP reductase 1 GMPR 0.0141
2361 Response regulator pleD pleD 0.0141
4106 Guanylate kinase GUK1 0.0135
4516 Guanylate kinase gmk 0.0135
413 Amidophosphoribosyltransferase PPAT 0.0135
2515 Amidophosphoribosyltransferase purF 0.0135
3714 Amidophosphoribosyltransferase purF 0.0135
4553 Bifunctional adenosylcobalamin biosynthesis protein cobU cobU 0.0121
2966 PyrR bifunctional protein [Includes: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase pyrR 0.0113
338 DNA polymerase UL30 0.0113
379 DNA polymerase UL54 0.0113
697 DNA polymerase ORF28 0.0113
2482 DNA polymerase 43 0.0113
4104 DNA polymerase BALF5 0.0113
3300 Xanthine phosphoribosyltransferase xpt 0.0107
3681 Xanthine phosphoribosyltransferase gpt 0.0107
2339 Protein-glutamine gamma-glutamyltransferase E TGM3 0.0096
4200 Cytochrome P450 1A2 CYP1A2 0.0095
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0084
1792 Tissue-type plasminogen activator PLAT 0.0082
527 Prostacyclin receptor PTGIR 0.0071
268 Adenosine A2b receptor ADORA2B 0.0071
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0067
1588 Multidrug resistance protein 1 ABCB1 0.0067
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0065
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0065
128 Adenine phosphoribosyltransferase APRT 0.0065
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0064
4122 Histone deacetylase 2 HDAC2 0.0061
851 5'-AMP-activated protein kinase subunit beta-2 PRKAB2 0.0056
388 AMP deaminase 1 AMPD1 0.0056
4198 Fructose-1,6-bisphosphatase 1 FBP1 0.005
1291 cAMP response element-binding protein CREB1 0.0049
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0049
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0049
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0049
297 Adenylate cyclase type 1 ADCY1 0.0049
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0047
10 Glycogen phosphorylase, liver form PYGL 0.0046
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0045
6021 Adenosine kinase ADK 0.0045
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0043
1898 Cytochrome P450 1B1 CYP1B1 0.0039
6143 Solute carrier family 22 member 7 SLC22A7 0.0038
4924 Cytochrome P450 2C8 CYP2C8 0.0028
5590 N utilization substance protein B homolog nusB 0.0028
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0028
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0028
5591 Complement component C8 gamma chain C8G 0.0028
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0028
5582 Regulator of transcription; stringent starvation protein A sspA 0.0028
5587 Iron(III)-binding periplasmic protein fbpA 0.0028
2838 Ribose-5-phosphate isomerase A rpiA 0.0028
2952 Ribose-5-phosphate isomerase A rpiA 0.0028
5595 Ribose-5-phosphate isomerase A rpiA 0.0028
4238 50S ribosomal protein L4 rplD 0.0028
5578 50S ribosomal protein L4 rplD 0.0028
6173 50S ribosomal protein L4 rplD 0.0028
6219 50S ribosomal protein L4 rplD 0.0028
4695 UPF0124 protein yfiH yfiH 0.0028
5060 Intron-associated endonuclease 1 ITEVIR 0.0028
5593 Transferase Not Available 0.0028
5581 Beta-fructosidase bfrA 0.0028
5588 Cell division protein FtsY TM_0570 0.0028
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0028
2300 Lysozyme E 0.0028
3633 Lysozyme R 0.0028
5597 Lysozyme 17 0.0028
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0028
5600 Pyruvate decarboxylase pdc 0.0028
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.0028
4375 Glutamine synthetase 1 glnA1 0.0028
5575 Short tail fiber protein 12 0.0028
5574 Invasin YPTB1668 0.0028
5580 Hexon protein PII 0.0028
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0027
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0027
4992 Cytochrome c peroxidase Not Available 0.0027
3132 Tryptophan synthase alpha chain trpA 0.0025
6568 Tryptophan synthase alpha chain trpA 0.0025
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0024
3729 Citrate synthase gltA 0.0024
4575 Citrate synthase cit 0.0024
4580 Citrate synthase gltA 0.0024
5328 Prostaglandin F synthase Tb11.02.2310 0.0024
5006 RNASE4 protein RNASE4 0.0024
2555 Pol polyprotein pol 0.0024
3242 Pol polyprotein gag-pol 0.0024
3471 Pol polyprotein gag-pro-pol 0.0024
5256 Pol polyprotein pol 0.0024
6469 Pol polyprotein gag-pol 0.0024
6565 Pol polyprotein Not Available 0.0024
4533 Glyoxalase family protein BC_1747 0.0024
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0024
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0024
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0024
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.0024
2521 Cell division protein ftsZ ftsZ 0.0023
3301 Cell division protein ftsZ ftsZ 0.0023
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0023
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0022
2603 Beta-lactamase II blm 0.0022
2149 Angiogenin ANG 0.0022
3583 6-phosphogluconolactonase pgl 0.0022
857 Malate dehydrogenase, mitochondrial MDH2 0.0021
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.0021
3486 Fumarate hydratase class II fumC 0.0021
2286 Isocitrate dehydrogenase [NADP] icd 0.0021
2302 Isocitrate dehydrogenase [NADP] icd 0.0021
2771 Isocitrate dehydrogenase [NADP] icd 0.0021
2942 Sialidase nanH 0.0021
3546 Sialidase nedA 0.0021
1123 Eosinophil cationic protein RNASE3 0.0021
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.002
332 Beta-lactamase blaZ 0.002
2478 Beta-lactamase ampC 0.002
2613 Beta-lactamase ampC 0.002
2635 Beta-lactamase ampC 0.002
2700 Beta-lactamase penP 0.002
5445 Beta-lactamase blaB 0.002
6019 Beta-lactamase SHV-7 0.002
6701 Beta-lactamase cphA 0.002
2697 Uridine-cytidine kinase 2 UCK2 0.002
2452 Tryptophanyl-tRNA synthetase trpS 0.002
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.002
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.002
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.002
411 Glycine N-methyltransferase GNMT 0.0019
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0019
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0019
5579 Carboxypeptidase B CPB1 0.0018
3384 Macrophage migration inhibitory factor MIF 0.0018
5682 Ribonuclease pancreatic RNASE1 0.0014
822 Aldose reductase AKR1B1 0.0014
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0013
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