DT-Web

DB07768 - (10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE


Identification
Name (10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE
Accession Number DB07768
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 288.4244
Groups experimental
Monoisotopic Weight 288.20893014
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Aldo-keto reductase family 1 member C1
Name Aldo-keto reductase family 1 member C1
Gene Name AKR1C1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.6682
Aldo-keto reductase family 1 member C2
Name Aldo-keto reductase family 1 member C2
Gene Name AKR1C2
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.4022

Predictions


Id Partner name Gene Name Score
578 Endothelin-1 receptor EDNRA 0.0761
373 Transthyretin TTR 0.0459
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0358
6141 Sodium/bile acid cotransporter SLC10A1 0.029
776 Bile salt export pump ABCB11 0.0231
2164 Multidrug resistance-associated protein 4 ABCC4 0.0217
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0209
6143 Solute carrier family 22 member 7 SLC22A7 0.0201
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0193
290 Prostaglandin G/H synthase 2 PTGS2 0.0189
20 Prostaglandin G/H synthase 1 PTGS1 0.0177
6013 Cytochrome P450 2E1 CYP2E1 0.0171
587 Serum albumin ALB 0.0165
1729 Solute carrier family 22 member 6 SLC22A6 0.0164
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0154
666 NADP-dependent malic enzyme ME1 0.0154
646 Malate dehydrogenase, cytoplasmic MDH1 0.0154
6149 Solute carrier family 22 member 10 SLC22A10 0.0154
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0146
1588 Multidrug resistance protein 1 ABCB1 0.0138
5346 Oxidoreductase, aldo/keto reductase family TM_1009 0.0138
4403 Protein iolS iolS 0.0138
5330 General stress protein 69 yhdN 0.0137
5322 Oxidoreductase ydhF ydhF 0.0137
5326 Oxidoreductase, short chain dehydrogenase/reductase family TM_0441 0.0137
5333 Alcohol dehydrogenase, iron-containing TM_0920 0.0137
5157 Dehydrogenase/reductase SDR family member 11 DHRS11 0.0137
5332 MtdA bifunctional protein mtdA 0.0137
4757 Cytochrome P450 2C9 CYP2C9 0.0137
5342 NADH-dependent butanol dehydrogenase, putative TM_0820 0.0137
3772 3-oxoacyl-[acyl-carrier-protein] reductase fabG 0.0137
3778 NAD(P) transhydrogenase subunit beta pntB 0.0137
5343 NADP-dependent fatty aldehyde dehydrogenase aldH 0.0137
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.013
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0129
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0126
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0124
2375 ADP-L-glycero-D-manno-heptose-6-epimerase hldD 0.012
654 Flavin reductase BLVRB 0.0119
5073 Ferredoxin--NADP reductase petH 0.0119
5076 Ferredoxin--NADP reductase fpr 0.0119
5119 Ferredoxin--NADP reductase petH 0.0119
5121 Ferredoxin--NADP reductase fpr 0.0119
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0119
5328 Prostaglandin F synthase Tb11.02.2310 0.0117
4582 Putative pteridine reductase 2 ptr2 0.0117
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0116
2305 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 0.0116
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0116
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0116
2286 Isocitrate dehydrogenase [NADP] icd 0.0116
2302 Isocitrate dehydrogenase [NADP] icd 0.0116
2771 Isocitrate dehydrogenase [NADP] icd 0.0116
989 L-xylulose reductase DCXR 0.0116
3446 NADP-dependent alcohol dehydrogenase adh 0.0116
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0116
2636 Shikimate dehydrogenase aroE 0.0116
3515 Shikimate dehydrogenase aroE 0.0116
444 Alcohol dehydrogenase 1B ADH1B 0.011
738 Monocarboxylate transporter 1 SLC16A1 0.0108
6862 Aldo-keto reductase family 1 member B10 AKR1B10 0.0107
6297 Prostaglandin reductase 1 PTGR1 0.0107
4531 Putative ketoacyl reductase actIII 0.0106
3062 Aspartate-semialdehyde dehydrogenase asd 0.0106
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0105
2675 Pteridine reductase 1 PTR1 0.0102
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0102
2159 Quinone oxidoreductase CRYZ 0.0102
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.01
1124 Sepiapterin reductase SPR 0.01
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0098
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0095
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0095
822 Aldose reductase AKR1B1 0.0092
1024 Solute carrier family 22 member 11 SLC22A11 0.0089
365 Dihydrofolate reductase DHFR 0.0088
2381 Dihydrofolate reductase DFR1 0.0088
2833 Dihydrofolate reductase Not Available 0.0088
2931 Dihydrofolate reductase folA 0.0088
3544 Dihydrofolate reductase folA 0.0088
3682 Dihydrofolate reductase folA 0.0088
6642 Dihydrofolate reductase folA 0.0088
6756 Dihydrofolate reductase dfrA 0.0088
4924 Cytochrome P450 2C8 CYP2C8 0.0085
6016 Cytochrome P450 2C19 CYP2C19 0.0081
6142 Solute carrier family 22 member 8 SLC22A8 0.0078
76 Nitric-oxide synthase, brain NOS1 0.0068
4120 NADPH--cytochrome P450 reductase POR 0.0067
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0052
816 Biliverdin reductase A BLVRA 0.0047
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0047
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0047
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0047
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0046
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0046
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0046
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0046
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0046
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0046
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0046
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0046
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0046
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0046
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0046
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0046
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0046
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0046
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0046
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0046
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0046
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0046
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0046
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0046
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0046
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0046
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0046
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0046
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0046
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0046
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0046
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0046
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0046
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0046
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0046
644 Heme oxygenase 2 HMOX2 0.0046
4982 Heme oxygenase 2 pbsA2 0.0046
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0046
729 GDP-L-fucose synthetase TSTA3 0.0046
3463 GDP-L-fucose synthetase fcl 0.0046
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0046
167 L-lactate dehydrogenase C chain LDHC 0.0046
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0046
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0046
206 3-keto-steroid reductase HSD17B7 0.0046
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0046
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0046
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0046
107 C-4 methylsterol oxidase SC4MOL 0.0046
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0046
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0046
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0046
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0046
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0046
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0046
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0046
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0046
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0046
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0046
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0046
711 UDP-glucose 6-dehydrogenase UGDH 0.0046
3672 UDP-glucose 6-dehydrogenase hasB 0.0046
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0046
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0046
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0046
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0046
3726 D-3-phosphoglycerate dehydrogenase serA 0.0046
4291 D-3-phosphoglycerate dehydrogenase serA 0.0046
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0046
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0046
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0046
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0046
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0046
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0046
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0046
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0046
643 Peroxisomal bifunctional enzyme EHHADH 0.0046
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0046
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0046
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0046
34 7-dehydrocholesterol reductase DHCR7 0.0046
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0046
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0043
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0043
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0043
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0043
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0043
396 Alcohol dehydrogenase 4 ADH4 0.0042
328 Sorbitol dehydrogenase SORD 0.0042
597 Dihydropteridine reductase QDPR 0.0042
857 Malate dehydrogenase, mitochondrial MDH2 0.0042
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0041
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0041
77 L-lactate dehydrogenase B chain LDHB 0.004
12 Alcohol dehydrogenase class 3 ADH5 0.004
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0039
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0039
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0039
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0039
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0039
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0039
473 L-lactate dehydrogenase A chain LDHA 0.0038
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0038
6026 Alcohol dehydrogenase 6 ADH6 0.0038
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0037
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0037
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0037
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0037
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0037
627 11-cis retinol dehydrogenase RDH5 0.0037
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0037
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0036
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0036
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0036
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0036
626 Cysteine dioxygenase type 1 CDO1 0.0036
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0036
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0036
13 Aminomethyltransferase, mitochondrial AMT 0.0036
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0036
569 Retinal dehydrogenase 2 ALDH1A2 0.0035
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0035
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0035
611 Retinal dehydrogenase 1 ALDH1A1 0.0034
251 Alcohol dehydrogenase 1A ADH1A 0.0033
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0033
810 Heme oxygenase 1 HMOX1 0.0032
3391 Heme oxygenase 1 pbsA1 0.0032
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0031
279 Tyrosinase TYR 0.0031
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.003
380 Cytochrome P450 17A1 CYP17A1 0.003
714 Glutathione reductase, mitochondrial GSR 0.0029
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0029
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0028
517 Alcohol dehydrogenase 1C ADH1C 0.0028
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0026
468 Cytochrome P450 4A11 CYP4A11 0.0025
6020 Aldehyde oxidase AOX1 0.0024
3947 Xanthine dehydrogenase/oxidase XDH 0.0022
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