DT-Web

DB07662 - N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE


Identification
Name N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE
Accession Number DB07662
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 369.215
Groups experimental
Monoisotopic Weight 368.027273705
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Proto-oncogene tyrosine-protein kinase Src
Name Proto-oncogene tyrosine-protein kinase Src
Gene Name SRC
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.6258
Epidermal growth factor receptor
Name Epidermal growth factor receptor
Gene Name EGFR
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.5454

Predictions


Id Partner name Gene Name Score
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0729
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0461
1588 Multidrug resistance protein 1 ABCB1 0.0381
6824 Tyrosine-protein kinase Lyn LYN 0.033
2599 Tyrosine-protein kinase HCK HCK 0.0282
6782 Ribosomal protein S6 kinase alpha-1 RPS6KA1 0.0273
4512 Cytochrome P450 3A4 CYP3A4 0.026
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0249
4118 Cytochrome P450 3A5 CYP3A5 0.0239
5300 Antigen peptide transporter 1 TAP1 0.0229
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0224
2782 Complement C1s subcomponent C1S 0.0221
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0212
6460 Casein kinase I isoform gamma-3 CSNK1G3 0.0207
3817 Complement C1q subcomponent subunit C C1QC 0.0202
3816 Complement C1q subcomponent subunit B C1QB 0.0202
3815 Complement C1q subcomponent subunit A C1QA 0.0202
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.02
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.02
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.02
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.02
3814 Complement C1r subcomponent C1R 0.02
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.0198
504 Mast/stem cell growth factor receptor KIT 0.0193
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0191
5787 Angiopoietin-1 receptor TEK 0.0187
1540 Mitogen-activated protein kinase 14 MAPK14 0.0187
587 Serum albumin ALB 0.0176
3950 Cell division protein kinase 9 CDK9 0.0171
3968 Cell division protein kinase 8 CDK8 0.0171
4924 Cytochrome P450 2C8 CYP2C8 0.017
3959 Cell division protein kinase 4 CDK4 0.015
3482 Cell division protein kinase 7 CDK7 0.0148
3955 Cell division protein kinase 6 CDK6 0.0138
4119 Cytochrome P450 2D6 CYP2D6 0.0134
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0133
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.013
183 Vascular endothelial growth factor A VEGFA 0.013
6016 Cytochrome P450 2C19 CYP2C19 0.0129
6024 Cytochrome P450 1A1 CYP1A1 0.0127
1742 D-HSCDK2 CDK2deltaT 0.0119
1771 Cell division control protein 2 homolog CDK1 0.0119
3321 Cell division control protein 2 homolog CRK2 0.0119
4609 U1 small nuclear ribonucleoprotein A SNRPA 0.0117
1058 Cell division protein kinase 5 CDK5 0.0116
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0107
4563 Acetyl transferase rimL 0.0102
2750 Aspartate 1-decarboxylase panD 0.0102
2240 Cell division protein kinase 2 CDK2 0.0098
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0096
3490 Sigma factor sigB regulation protein rsbQ rsbQ 0.0094
4200 Cytochrome P450 1A2 CYP1A2 0.0089
4600 Malonamidase E2 Not Available 0.0088
4757 Cytochrome P450 2C9 CYP2C9 0.0087
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0085
4608 Putative cytochrome P450 SCO1207 0.0085
4963 Putative cytochrome P450 SCO2884 0.0085
6254 Putative cytochrome P450 SCO6998 0.0085
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0082
6142 Solute carrier family 22 member 8 SLC22A8 0.008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0079
862 Multidrug resistance-associated protein 1 ABCC1 0.0079
1152 Glycogen phosphorylase, muscle form PYGM 0.0077
1898 Cytochrome P450 1B1 CYP1B1 0.0077
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0063
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0062
3811 Cytochrome P450 19A1 CYP19A1 0.006
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0059
6106 Cytochrome P450 2C18 CYP2C18 0.0056
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0055
118 Organic cation/carnitine transporter 2 SLC22A5 0.0049
5718 Cytochrome P450 2A6 CYP2A6 0.0046
6030 Cytochrome P450 2B6 CYP2B6 0.0042
6107 Cytochrome P450 3A7 CYP3A7 0.0041
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0035
2216 Fibroblast growth factor receptor 4 FGFR4 0.0034
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0033
936 Ephrin type-A receptor 2 EPHA2 0.0032
3856 Fibroblast growth factor receptor 3 FGFR3 0.0031
1063 Signal transducer and activator of transcription 5B STAT5B 0.0029
484 Tyrosine-protein kinase ABL2 ABL2 0.0028
823 Fibroblast growth factor receptor 2 FGFR2 0.0026
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0026
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0025
228 Beta platelet-derived growth factor receptor PDGFRB 0.0025
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0024
165 FL cytokine receptor FLT3 0.0024
407 Vascular endothelial growth factor receptor 2 KDR 0.0021
776 Bile salt export pump ABCB11 0.0013
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0013
2300 Lysozyme E 0.0013
3633 Lysozyme R 0.0013
5597 Lysozyme 17 0.0013
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0013
5591 Complement component C8 gamma chain C8G 0.0013
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0013
5582 Regulator of transcription; stringent starvation protein A sspA 0.0013
2838 Ribose-5-phosphate isomerase A rpiA 0.0013
2952 Ribose-5-phosphate isomerase A rpiA 0.0013
5595 Ribose-5-phosphate isomerase A rpiA 0.0013
4238 50S ribosomal protein L4 rplD 0.0013
5578 50S ribosomal protein L4 rplD 0.0013
6173 50S ribosomal protein L4 rplD 0.0013
6219 50S ribosomal protein L4 rplD 0.0013
4695 UPF0124 protein yfiH yfiH 0.0013
5590 N utilization substance protein B homolog nusB 0.0013
5588 Cell division protein FtsY TM_0570 0.0013
4375 Glutamine synthetase 1 glnA1 0.0013
5587 Iron(III)-binding periplasmic protein fbpA 0.0013
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0013
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.0013
5593 Transferase Not Available 0.0013
5581 Beta-fructosidase bfrA 0.0013
5060 Intron-associated endonuclease 1 ITEVIR 0.0013
5575 Short tail fiber protein 12 0.0013
5600 Pyruvate decarboxylase pdc 0.0013
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0013
5580 Hexon protein PII 0.0013
5574 Invasin YPTB1668 0.0013
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0011
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0011
4992 Cytochrome c peroxidase Not Available 0.0011
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0011
4533 Glyoxalase family protein BC_1747 0.0011
3132 Tryptophan synthase alpha chain trpA 0.0011
6568 Tryptophan synthase alpha chain trpA 0.0011
5328 Prostaglandin F synthase Tb11.02.2310 0.0011
3729 Citrate synthase gltA 0.0011
4575 Citrate synthase cit 0.0011
4580 Citrate synthase gltA 0.0011
5006 RNASE4 protein RNASE4 0.0011
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0011
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0011
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0011
2555 Pol polyprotein pol 0.0011
3242 Pol polyprotein gag-pol 0.0011
3471 Pol polyprotein gag-pro-pol 0.0011
5256 Pol polyprotein pol 0.0011
6469 Pol polyprotein gag-pol 0.0011
6565 Pol polyprotein Not Available 0.0011
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.001
2603 Beta-lactamase II blm 0.001
3583 6-phosphogluconolactonase pgl 0.001
2149 Angiogenin ANG 0.001
2521 Cell division protein ftsZ ftsZ 0.001
3301 Cell division protein ftsZ ftsZ 0.001
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.001
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.001
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.001
2286 Isocitrate dehydrogenase [NADP] icd 0.001
2302 Isocitrate dehydrogenase [NADP] icd 0.001
2771 Isocitrate dehydrogenase [NADP] icd 0.001
3486 Fumarate hydratase class II fumC 0.001
2942 Sialidase nanH 0.001
3546 Sialidase nedA 0.001
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.0009
857 Malate dehydrogenase, mitochondrial MDH2 0.0009
1123 Eosinophil cationic protein RNASE3 0.0009
332 Beta-lactamase blaZ 0.0009
2478 Beta-lactamase ampC 0.0009
2613 Beta-lactamase ampC 0.0009
2635 Beta-lactamase ampC 0.0009
2700 Beta-lactamase penP 0.0009
5445 Beta-lactamase blaB 0.0009
6019 Beta-lactamase SHV-7 0.0009
6701 Beta-lactamase cphA 0.0009
2697 Uridine-cytidine kinase 2 UCK2 0.0009
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0009
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0009
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0009
2452 Tryptophanyl-tRNA synthetase trpS 0.0009
5579 Carboxypeptidase B CPB1 0.0008
3384 Macrophage migration inhibitory factor MIF 0.0008
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0008
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0008
411 Glycine N-methyltransferase GNMT 0.0008
128 Adenine phosphoribosyltransferase APRT 0.0007
5682 Ribonuclease pancreatic RNASE1 0.0006
822 Aldose reductase AKR1B1 0.0006
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0006
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