DT-Web

DB07602 - S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE


Identification
Name S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE
Accession Number DB07602
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 411.477
Groups experimental
Monoisotopic Weight 411.136510253
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Epidermal growth factor receptor
Name Epidermal growth factor receptor
Gene Name EGFR
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.5234

Predictions


Id Partner name Gene Name Score
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0729
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0482
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0436
1588 Multidrug resistance protein 1 ABCB1 0.0341
5300 Antigen peptide transporter 1 TAP1 0.0229
4512 Cytochrome P450 3A4 CYP3A4 0.0225
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0224
2782 Complement C1s subcomponent C1S 0.0221
4118 Cytochrome P450 3A5 CYP3A5 0.0218
3817 Complement C1q subcomponent subunit C C1QC 0.0202
3816 Complement C1q subcomponent subunit B C1QB 0.0202
3815 Complement C1q subcomponent subunit A C1QA 0.0202
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.02
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.02
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.02
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.02
3814 Complement C1r subcomponent C1R 0.02
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.0198
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0191
587 Serum albumin ALB 0.0176
3950 Cell division protein kinase 9 CDK9 0.0171
3968 Cell division protein kinase 8 CDK8 0.0171
4924 Cytochrome P450 2C8 CYP2C8 0.016
5787 Angiopoietin-1 receptor TEK 0.0158
3959 Cell division protein kinase 4 CDK4 0.015
3482 Cell division protein kinase 7 CDK7 0.0148
3955 Cell division protein kinase 6 CDK6 0.0138
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.013
183 Vascular endothelial growth factor A VEGFA 0.013
6016 Cytochrome P450 2C19 CYP2C19 0.0129
4119 Cytochrome P450 2D6 CYP2D6 0.0125
1742 D-HSCDK2 CDK2deltaT 0.0119
1771 Cell division control protein 2 homolog CDK1 0.0119
3321 Cell division control protein 2 homolog CRK2 0.0119
1058 Cell division protein kinase 5 CDK5 0.0116
6024 Cytochrome P450 1A1 CYP1A1 0.0115
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0113
4757 Cytochrome P450 2C9 CYP2C9 0.0087
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0085
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0082
862 Multidrug resistance-associated protein 1 ABCC1 0.0079
4200 Cytochrome P450 1A2 CYP1A2 0.0078
1152 Glycogen phosphorylase, muscle form PYGM 0.0077
2240 Cell division protein kinase 2 CDK2 0.0064
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0063
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0062
1898 Cytochrome P450 1B1 CYP1B1 0.0062
3811 Cytochrome P450 19A1 CYP19A1 0.006
6106 Cytochrome P450 2C18 CYP2C18 0.0056
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0055
118 Organic cation/carnitine transporter 2 SLC22A5 0.0049
5718 Cytochrome P450 2A6 CYP2A6 0.0046
6030 Cytochrome P450 2B6 CYP2B6 0.0042
6107 Cytochrome P450 3A7 CYP3A7 0.0041
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