DT-Web

DB07236 - 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL


Identification
Name 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL
Accession Number DB07236
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 277.2741
Groups experimental
Monoisotopic Weight 277.073893223
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Estrogen receptor beta
Name Estrogen receptor beta
Gene Name ESR2
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.1608
Nuclear receptor coactivator 1
Name Nuclear receptor coactivator 1
Gene Name NCOA1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.0129

Predictions


Id Partner name Gene Name Score
136 Estrogen receptor ESR1 0.1449
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0866
856 Vitamin D3 receptor VDR 0.0703
238 Peroxisome proliferator-activated receptor gamma PPARG 0.066
3233 Bile acid receptor NR1H4 0.0588
6560 Nuclear receptor coactivator 5 NCOA5 0.0526
3437 Eosinophil lysophospholipase CLC 0.0424
756 Sex hormone-binding globulin SHBG 0.0335
6350 Nuclear receptor subfamily 1 group I member 3 NR1I3 0.0318
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0262
6241 Nuclear receptor coactivator 2 NCOA2 0.025
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0226
737 Mineralocorticoid receptor NR3C2 0.0212
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0198
1588 Multidrug resistance protein 1 ABCB1 0.0195
2907 Oxysterols receptor LXR-beta NR1H2 0.0185
6283 Oxysterols receptor LXR-alpha NR1H3 0.0185
459 Retinoic acid receptor RXR-alpha RXRA 0.0183
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0153
992 Protein tyrosine kinase 2 beta PTK2B 0.0145
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0141
373 Transthyretin TTR 0.0135
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0134
2107 Microtubule-associated protein 1A MAP1A 0.013
4512 Cytochrome P450 3A4 CYP3A4 0.0128
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0118
88 Retinoic acid receptor RXR-beta RXRB 0.0117
4200 Cytochrome P450 1A2 CYP1A2 0.0104
1852 Microtubule-associated protein 2 MAP2 0.0097
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0097
3811 Cytochrome P450 19A1 CYP19A1 0.0097
817 DNA topoisomerase 2-alpha TOP2A 0.0084
4924 Cytochrome P450 2C8 CYP2C8 0.0079
862 Multidrug resistance-associated protein 1 ABCC1 0.0074
4757 Cytochrome P450 2C9 CYP2C9 0.0068
6020 Aldehyde oxidase AOX1 0.0062
587 Serum albumin ALB 0.0056
6030 Cytochrome P450 2B6 CYP2B6 0.0054
6145 Solute carrier family 22 member 1 SLC22A1 0.0051
3809 Estrogen-related receptor gamma ESRRG 0.005
6085 Fatty acid-binding protein, intestinal FABP2 0.0039
5718 Cytochrome P450 2A6 CYP2A6 0.0038
3810 Catechol O-methyltransferase COMT 0.0037
6013 Cytochrome P450 2E1 CYP2E1 0.0034
6753 Apolipoprotein M APOM 0.0032
2528 Fatty acid metabolism regulator protein fadR 0.0032
6740 Fatty acid metabolism regulator protein fadR 0.0032
394 Calcineurin subunit B isoform 1 PPP3R1 0.0032
6742 Recoverin RCVRN 0.0032
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0032
6743 Non-fluorescent flavoprotein luxF 0.0032
6747 Chalcone/stilbene synthase family protein MT1417 0.0032
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0032
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0032
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0032
6751 Gag polyprotein gag 0.0032
6749 Polyprotein Not Available 0.0032
5961 Insulin INS 0.0028
6527 Lymphocyte antigen 96 LY96 0.0028
6755 Poliovirus receptor PVR 0.0028
1898 Cytochrome P450 1B1 CYP1B1 0.0027
1192 Sulfotransferase 1A1 SULT1A1 0.0027
6750 ADP-ribosylation factor 6 ARF6 0.0026
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0025
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0025
6524 Protein tonB tonB 0.0025
2616 Ganglioside GM2 activator GM2A 0.0024
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0023
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0023
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0023
4210 Toll-like receptor 4 TLR4 0.0023
6024 Cytochrome P450 1A1 CYP1A1 0.0022
2297 Genome polyprotein Not Available 0.0022
2322 Genome polyprotein Not Available 0.0022
2694 Genome polyprotein Not Available 0.0022
2719 Genome polyprotein Not Available 0.0022
2860 Genome polyprotein Not Available 0.0022
2928 Genome polyprotein Not Available 0.0022
3160 Genome polyprotein Not Available 0.0022
3260 Genome polyprotein Not Available 0.0022
4783 Genome polyprotein Not Available 0.0022
5726 Genome polyprotein Not Available 0.0022
5779 Genome polyprotein Not Available 0.0022
5867 Genome polyprotein Not Available 0.0022
6253 Genome polyprotein Not Available 0.0022
6301 Genome polyprotein Not Available 0.0022
6380 Genome polyprotein Not Available 0.0022
6381 Genome polyprotein Not Available 0.0022
6437 Genome polyprotein Not Available 0.0022
6520 Genome polyprotein Not Available 0.0022
6521 Genome polyprotein Not Available 0.0022
6652 Genome polyprotein Not Available 0.0022
6734 Genome polyprotein Not Available 0.0022
6735 Genome polyprotein Not Available 0.0022
6736 Genome polyprotein Not Available 0.0022
6737 Genome polyprotein Not Available 0.0022
6738 Genome polyprotein Not Available 0.0022
6739 Genome polyprotein Not Available 0.0022
6744 Genome polyprotein Not Available 0.0022
6748 Genome polyprotein Not Available 0.0022
6894 Genome polyprotein Not Available 0.0022
6898 Genome polyprotein Not Available 0.0022
6316 ADP-ribosylation factor 1 ARF1 0.0022
6107 Cytochrome P450 3A7 CYP3A7 0.0021
864 Gag-Pol polyprotein gag-pol 0.002
2237 Gag-Pol polyprotein gag-pol 0.002
2326 Gag-Pol polyprotein gag-pol 0.002
2451 Gag-Pol polyprotein gag-pol 0.002
2901 Gag-Pol polyprotein gag-pol 0.002
3165 Gag-Pol polyprotein gag-pol 0.002
3722 Gag-Pol polyprotein gag-pol 0.002
6306 Gag-Pol polyprotein gag-pol 0.002
6624 Gag-Pol polyprotein gag-pol 0.002
4118 Cytochrome P450 3A5 CYP3A5 0.002
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.002
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0019
6016 Cytochrome P450 2C19 CYP2C19 0.0019
4604 Liver carboxylesterase 1 CES1 0.0018
2427 Ferrichrome-iron receptor fhuA 0.0018
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0017
768 FK506-binding protein 1A FKBP1A 0.0017
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0016
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0016
776 Bile salt export pump ABCB11 0.0015
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0015
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0014
6148 Multidrug resistance-associated protein 7 ABCC10 0.0014
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0014
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0014
465 Calmodulin CALM1 0.0013
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0013
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0013
6147 Solute carrier family 22 member 3 SLC22A3 0.0013
1024 Solute carrier family 22 member 11 SLC22A11 0.0012
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0012
6144 Solute carrier family 22 member 2 SLC22A2 0.0011
6142 Solute carrier family 22 member 8 SLC22A8 0.0011
4119 Cytochrome P450 2D6 CYP2D6 0.001
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