DT-Web

DB07080 - N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE


Identification
Name N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE
Accession Number DB07080
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 481.333
Groups experimental
Monoisotopic Weight 481.03941779
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Oxysterols receptor LXR-beta
Name Oxysterols receptor LXR-beta
Gene Name NR1H2
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.7413
Nuclear receptor coactivator 2
Name Nuclear receptor coactivator 2
Gene Name NCOA2
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.1417
Retinoic acid receptor RXR-beta
Name Retinoic acid receptor RXR-beta
Gene Name RXRB
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.7825
Oxysterols receptor LXR-alpha
Name Oxysterols receptor LXR-alpha
Gene Name NR1H3
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.0633
Nuclear receptor coactivator 1
Name Nuclear receptor coactivator 1
Gene Name NCOA1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.9219
Nuclear receptor subfamily 1 group I member 2
Name Nuclear receptor subfamily 1 group I member 2
Gene Name NR1I2
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.4268

Predictions


Id Partner name Gene Name Score
136 Estrogen receptor ESR1 0.4454
459 Retinoic acid receptor RXR-alpha RXRA 0.3228
869 Estrogen receptor beta ESR2 0.3117
238 Peroxisome proliferator-activated receptor gamma PPARG 0.1039
780 Retinoic acid receptor RXR-gamma RXRG 0.0993
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0866
229 Retinoic acid receptor beta RARB 0.0852
730 Retinoic acid receptor alpha RARA 0.0838
162 Retinoic acid receptor gamma-1 RARG 0.0828
856 Vitamin D3 receptor VDR 0.0703
3233 Bile acid receptor NR1H4 0.0588
284 DNA-directed RNA polymerase beta chain rpoB 0.0495
5773 DNA-directed RNA polymerase beta chain rpoB 0.0495
4512 Cytochrome P450 3A4 CYP3A4 0.0472
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0363
1588 Multidrug resistance protein 1 ABCB1 0.0339
4924 Cytochrome P450 2C8 CYP2C8 0.0326
6350 Nuclear receptor subfamily 1 group I member 3 NR1I3 0.0318
5934 Cytochrome P450 26A1 CYP26A1 0.029
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0281
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.028
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0262
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0259
4200 Cytochrome P450 1A2 CYP1A2 0.0251
275 Arachidonate 5-lipoxygenase ALOX5 0.025
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0226
737 Mineralocorticoid receptor NR3C2 0.0212
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0208
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0198
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0198
4757 Cytochrome P450 2C9 CYP2C9 0.0195
146 Androgen receptor AR 0.0184
614 Progesterone receptor PGR 0.0178
331 Retinol-binding protein I, cellular RBP1 0.0171
776 Bile salt export pump ABCB11 0.017
992 Protein tyrosine kinase 2 beta PTK2B 0.0162
862 Multidrug resistance-associated protein 1 ABCC1 0.0146
587 Serum albumin ALB 0.0144
4118 Cytochrome P450 3A5 CYP3A5 0.0141
20 Prostaglandin G/H synthase 1 PTGS1 0.0134
3811 Cytochrome P450 19A1 CYP19A1 0.0127
1898 Cytochrome P450 1B1 CYP1B1 0.0126
6030 Cytochrome P450 2B6 CYP2B6 0.0124
6141 Sodium/bile acid cotransporter SLC10A1 0.0122
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0116
373 Transthyretin TTR 0.0113
6107 Cytochrome P450 3A7 CYP3A7 0.0104
6024 Cytochrome P450 1A1 CYP1A1 0.0101
6016 Cytochrome P450 2C19 CYP2C19 0.0101
817 DNA topoisomerase 2-alpha TOP2A 0.0092
719 Retinoic acid receptor responder protein 1 RARRES1 0.0089
770 Retinoic acid-induced protein 3 GPRC5A 0.0089
4077 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PPP2CB 0.0087
86 SEC14-like protein 4 SEC14L4 0.0087
468 Cytochrome P450 4A11 CYP4A11 0.0087
375 SEC14-like protein 3 SEC14L3 0.0087
4076 Diacylglycerol kinase alpha DGKA 0.0087
844 Epidermal growth factor receptor EGFR 0.0086
708 Alpha-tocopherol transfer protein TTPA 0.0082
283 SEC14-like protein 2 SEC14L2 0.0081
6148 Multidrug resistance-associated protein 7 ABCC10 0.0078
4078 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform PPP2CA 0.0077
997 Protein kinase C beta type PRKCB 0.0077
84 Nuclear receptor 0B1 NR0B1 0.0072
899 Glutathione S-transferase Mu 3 GSTM3 0.0072
905 Glutathione transferase omega-1 GSTO1 0.0072
569 Retinal dehydrogenase 2 ALDH1A2 0.0071
5923 Microtubule-associated protein tau MAPT 0.0071
5924 Microtubule-associated protein 4 MAP4 0.007
1970 Protein kinase C alpha type PRKCA 0.007
611 Retinal dehydrogenase 1 ALDH1A1 0.0068
1852 Microtubule-associated protein 2 MAP2 0.0066
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0065
810 Heme oxygenase 1 HMOX1 0.0063
3391 Heme oxygenase 1 pbsA1 0.0063
273 Apoptosis regulator Bcl-2 BCL2 0.0061
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0061
5718 Cytochrome P450 2A6 CYP2A6 0.006
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0059
6085 Fatty acid-binding protein, intestinal FABP2 0.0059
29 Tubulin beta-1 chain TUBB1 0.0059
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0056
3932 Glutathione S-transferase A2 GSTA2 0.0056
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0053
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0053
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0051
904 Glutathione S-transferase P GSTP1 0.005
6106 Cytochrome P450 2C18 CYP2C18 0.0042
6031 Cytochrome P450 3A43 CYP3A43 0.0037
4119 Cytochrome P450 2D6 CYP2D6 0.0037
756 Sex hormone-binding globulin SHBG 0.0035
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0034
6136 Multidrug resistance-associated protein 5 ABCC5 0.0034
6753 Apolipoprotein M APOM 0.0032
2528 Fatty acid metabolism regulator protein fadR 0.0032
6740 Fatty acid metabolism regulator protein fadR 0.0032
394 Calcineurin subunit B isoform 1 PPP3R1 0.0032
6742 Recoverin RCVRN 0.0032
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0032
6743 Non-fluorescent flavoprotein luxF 0.0032
6747 Chalcone/stilbene synthase family protein MT1417 0.0032
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0032
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0032
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0032
6751 Gag polyprotein gag 0.0032
6749 Polyprotein Not Available 0.0032
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0031
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0031
6143 Solute carrier family 22 member 7 SLC22A7 0.0029
5961 Insulin INS 0.0028
6527 Lymphocyte antigen 96 LY96 0.0028
6755 Poliovirus receptor PVR 0.0028
6147 Solute carrier family 22 member 3 SLC22A3 0.0027
1024 Solute carrier family 22 member 11 SLC22A11 0.0026
6750 ADP-ribosylation factor 6 ARF6 0.0026
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0025
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0025
6524 Protein tonB tonB 0.0025
2616 Ganglioside GM2 activator GM2A 0.0024
6144 Solute carrier family 22 member 2 SLC22A2 0.0024
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0023
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0023
6145 Solute carrier family 22 member 1 SLC22A1 0.0023
6013 Cytochrome P450 2E1 CYP2E1 0.0023
6142 Solute carrier family 22 member 8 SLC22A8 0.0023
4210 Toll-like receptor 4 TLR4 0.0023
2297 Genome polyprotein Not Available 0.0022
2322 Genome polyprotein Not Available 0.0022
2694 Genome polyprotein Not Available 0.0022
2719 Genome polyprotein Not Available 0.0022
2860 Genome polyprotein Not Available 0.0022
2928 Genome polyprotein Not Available 0.0022
3160 Genome polyprotein Not Available 0.0022
3260 Genome polyprotein Not Available 0.0022
4783 Genome polyprotein Not Available 0.0022
5726 Genome polyprotein Not Available 0.0022
5779 Genome polyprotein Not Available 0.0022
5867 Genome polyprotein Not Available 0.0022
6253 Genome polyprotein Not Available 0.0022
6301 Genome polyprotein Not Available 0.0022
6380 Genome polyprotein Not Available 0.0022
6381 Genome polyprotein Not Available 0.0022
6437 Genome polyprotein Not Available 0.0022
6520 Genome polyprotein Not Available 0.0022
6521 Genome polyprotein Not Available 0.0022
6652 Genome polyprotein Not Available 0.0022
6734 Genome polyprotein Not Available 0.0022
6735 Genome polyprotein Not Available 0.0022
6736 Genome polyprotein Not Available 0.0022
6737 Genome polyprotein Not Available 0.0022
6738 Genome polyprotein Not Available 0.0022
6739 Genome polyprotein Not Available 0.0022
6744 Genome polyprotein Not Available 0.0022
6748 Genome polyprotein Not Available 0.0022
6894 Genome polyprotein Not Available 0.0022
6898 Genome polyprotein Not Available 0.0022
6316 ADP-ribosylation factor 1 ARF1 0.0022
864 Gag-Pol polyprotein gag-pol 0.002
2237 Gag-Pol polyprotein gag-pol 0.002
2326 Gag-Pol polyprotein gag-pol 0.002
2451 Gag-Pol polyprotein gag-pol 0.002
2901 Gag-Pol polyprotein gag-pol 0.002
3165 Gag-Pol polyprotein gag-pol 0.002
3722 Gag-Pol polyprotein gag-pol 0.002
6306 Gag-Pol polyprotein gag-pol 0.002
6624 Gag-Pol polyprotein gag-pol 0.002
2427 Ferrichrome-iron receptor fhuA 0.0018
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0017
768 FK506-binding protein 1A FKBP1A 0.0017
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0016
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0015
465 Calmodulin CALM1 0.0013
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