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DB06733 - Bafilomycin A1


Identification
Name Bafilomycin A1
Accession Number DB06733
Type small molecule
Description The bafilomycins are a family of toxic macrolide antibiotic derived from Streptomyces griseus. These compounds all appear in the same fermentation and have quite similar biological activity. Bafilomycins are specific inhibitors of vacuolar-type H+-ATPase. (V-ATPase). The most used bafilomycin is bafilomycin A1. This is a useful tool as it can prevent the re-acidification of synaptic vesicles once they have undergone exocytosis. [Wikipedia]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight Not Available
Groups experimental
Monoisotopic Weight Not Available
Pharmacology
Indication Not Available
Mechanism of action The bafilomycins are a family of toxic macrolide antibiotic derived from Streptomyces griseus. These compounds all appear in the same fermentation and have quite similar biological activity. Bafilomycins are specific inhibitors of vacuolar-type H+-ATPase. (V-ATPase).
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


V-type proton ATPase catalytic subunit A
Name V-type proton ATPase catalytic subunit A
Gene Name ATP6V1A
Pharmacological action yes
Actions inhibitor
References
  • Takami M, Suda K, Sahara T, Itoh K, Nagai K, Sasaki T, Udagawa N, Takahashi N: Involvement of vacuolar H+ -ATPase in incorporation of risedronate into osteoclasts. Bone. 2003 Apr;32(4):341-9. - Pubmed
DTHybrid score 1.2272

Predictions


Id Partner name Gene Name Score
6055 Receptor-type tyrosine-protein phosphatase S PTPRS 0.2659
1376 Tyrosine-protein phosphatase non-receptor type 4 PTPN4 0.0871
6056 Receptor-type tyrosine-protein phosphatase epsilon PTPRE 0.0871
687 Tyrosine-protein phosphatase non-receptor type 1 PTPN1 0.0812
853 Farnesyl pyrophosphate synthetase FDPS 0.0483
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