DT-Web

DB06714 - Propylhexedrine


Identification
Name Propylhexedrine
Accession Number DB06714
Type small molecule
Description Propylhexedrine is an alpha-adrenergic agonist often used in nasal decongestant inhalers. It is used to give temporary relief for nasal congestion from colds, allergic rhinitis, or allergies.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 155.2804
Groups approved
Monoisotopic Weight 155.167399677
Pharmacology
Indication It is used to provide temporary symptomatic relief of nasal congestion due to colds, allergies and allergic rhinitis.
Mechanism of action Propylhexidrine causes the norepinephrine, dopamine, and serotonin (5HT) transporters to reverse their direction of flow. This inversion leads to a release of these transmitters from the vesicles to the cytoplasm and from the cytoplasm to the synapse. It also antagonizes the action of VMAT2, causing the release of more neurotransmitters.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity The signs and symptoms that are produced after the acute overdosage of Propylhexidrine include Psychosis, Burning sensation.
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Synaptic vesicular amine transporter
Name Synaptic vesicular amine transporter
Gene Name SLC18A2
Pharmacological action yes
Actions Not Available
References
  • Sulzer D, Sonders MS, Poulsen NW, Galli A: Mechanisms of neurotransmitter release by amphetamines: a review. Prog Neurobiol. 2005 Apr;75(6):406-33. - Pubmed
  • Docherty JR: Pharmacology of stimulants prohibited by the World Anti-Doping Agency (WADA). Br J Pharmacol. 2008 Jun;154(3):606-22. doi: 10.1038/bjp.2008.124. - Pubmed
DTHybrid score 0.7459
Trace amine-associated receptor 1
Name Trace amine-associated receptor 1
Gene Name TAAR1
Pharmacological action unknown
Actions agonist
References
  • Reese EA, Bunzow JR, Arttamangkul S, Sonders MS, Grandy DK: Trace amine-associated receptor 1 displays species-dependent stereoselectivity for isomers of methamphetamine, amphetamine, and para-hydroxyamphetamine. J Pharmacol Exp Ther. 2007 Apr;321(1):178-86. Epub 2007 Jan 11. - Pubmed
  • Xie Z, Westmoreland SV, Bahn ME, Chen GL, Yang H, Vallender EJ, Yao WD, Madras BK, Miller GM: Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by monoamine transporters and attenuation by the D2 autoreceptor in vitro. J Pharmacol Exp Ther. 2007 Apr;321(1):116-27. Epub 2007 Jan 18. - Pubmed
  • Wolinsky TD, Swanson CJ, Smith KE, Zhong H, Borowsky B, Seeman P, Branchek T, Gerald CP: The Trace Amine 1 receptor knockout mouse: an animal model with relevance to schizophrenia. Genes Brain Behav. 2007 Oct;6(7):628-39. Epub 2006 Dec 21. - Pubmed
  • Xie Z, Miller GM: Trace amine-associated receptor 1 is a modulator of the dopamine transporter. J Pharmacol Exp Ther. 2007 Apr;321(1):128-36. Epub 2007 Jan 18. - Pubmed
  • Miller GM, Verrico CD, Jassen A, Konar M, Yang H, Panas H, Bahn M, Johnson R, Madras BK: Primate trace amine receptor 1 modulation by the dopamine transporter. J Pharmacol Exp Ther. 2005 Jun;313(3):983-94. Epub 2005 Mar 11. - Pubmed
DTHybrid score 0.4755

Predictions


Id Partner name Gene Name Score
713 Sodium-dependent dopamine transporter SLC6A3 0.1431
540 Sodium-dependent noradrenaline transporter SLC6A2 0.095
556 Alpha-1A adrenergic receptor ADRA1A 0.0895
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0839
4119 Cytochrome P450 2D6 CYP2D6 0.0742
6147 Solute carrier family 22 member 3 SLC22A3 0.0536
824 Sodium-dependent serotonin transporter SLC6A4 0.0534
118 Organic cation/carnitine transporter 2 SLC22A5 0.047
3939 Amine oxidase [flavin-containing] B MAOB 0.0468
3941 Amine oxidase [flavin-containing] A MAOA 0.0465
318 Alpha-2A adrenergic receptor ADRA2A 0.0405
632 Alpha-1B adrenergic receptor ADRA1B 0.0357
5718 Cytochrome P450 2A6 CYP2A6 0.0277
378 Alpha-2C adrenergic receptor ADRA2C 0.0265
629 Alpha-2B adrenergic receptor ADRA2B 0.0262
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0238
502 5-hydroxytryptamine 2A receptor HTR2A 0.0172
831 D(2) dopamine receptor DRD2 0.0149
474 Acetylcholinesterase ACHE 0.0132
4120 NADPH--cytochrome P450 reductase POR 0.0123
3923 Cholinesterase BCHE 0.0121
436 5-hydroxytryptamine 2B receptor HTR2B 0.011
590 5-hydroxytryptamine 2C receptor HTR2C 0.0097
776 Bile salt export pump ABCB11 0.0095
6144 Solute carrier family 22 member 2 SLC22A2 0.0087
6145 Solute carrier family 22 member 1 SLC22A1 0.0084
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0082
1517 Beta-3 adrenergic receptor ADRB3 0.0079
6030 Cytochrome P450 2B6 CYP2B6 0.0076
4118 Cytochrome P450 3A5 CYP3A5 0.007
1588 Multidrug resistance protein 1 ABCB1 0.0063
193 Beta-1 adrenergic receptor ADRB1 0.0057
4512 Cytochrome P450 3A4 CYP3A4 0.0056
766 Beta-2 adrenergic receptor ADRB2 0.0056
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