DT-Web

DB04824 - Phenolphthalein


Identification
Name Phenolphthalein
Accession Number DB04824
Type small molecule
Description Phenolphthalein was withdrawn in Canada due to concerns with carcinogenicity in 1997.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 318.3228
Groups withdrawn
Monoisotopic Weight 318.089208936
Pharmacology
Indication Used for over a century as a laxative.
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


UDP-glucuronosyltransferase 1-9
Name UDP-glucuronosyltransferase 1-9
Gene Name UGT1A9
Pharmacological action unknown
Actions Not Available
References
  • Uesawa Y, Staines AG, Lockley D, Mohri K, Burchell B: Identification of the human liver UDP-glucuronosyltransferase involved in the metabolism of p-ethoxyphenylurea (dulcin). Arch Toxicol. 2007 Mar;81(3):163-8. Epub 2006 Aug 5. - Pubmed
DTHybrid score 0.2038

Predictions


Id Partner name Gene Name Score
4757 Cytochrome P450 2C9 CYP2C9 0.0414
20 Prostaglandin G/H synthase 1 PTGS1 0.0391
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0353
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0338
4512 Cytochrome P450 3A4 CYP3A4 0.0279
290 Prostaglandin G/H synthase 2 PTGS2 0.0257
3810 Catechol O-methyltransferase COMT 0.0223
6016 Cytochrome P450 2C19 CYP2C19 0.0214
587 Serum albumin ALB 0.0211
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0189
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0186
1588 Multidrug resistance protein 1 ABCB1 0.0184
3866 Serum amyloid A protein SAA1 0.0163
1200 AMBP protein AMBP 0.0163
1932 Apolipoprotein E APOE 0.0163
4200 Cytochrome P450 1A2 CYP1A2 0.016
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0157
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0139
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0139
4924 Cytochrome P450 2C8 CYP2C8 0.0138
6102 Arylamine N-acetyltransferase 2 NAT2 0.0136
4604 Liver carboxylesterase 1 CES1 0.0132
4119 Cytochrome P450 2D6 CYP2D6 0.013
4118 Cytochrome P450 3A5 CYP3A5 0.0124
1729 Solute carrier family 22 member 6 SLC22A6 0.0121
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0121
467 Delta-type opioid receptor OPRD1 0.0106
696 Kappa-type opioid receptor OPRK1 0.0106
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0105
4132 Chloride channel protein ClC-Ka CLCNKA 0.0104
6107 Cytochrome P450 3A7 CYP3A7 0.0104
847 Mu-type opioid receptor OPRM1 0.0101
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0096
5718 Cytochrome P450 2A6 CYP2A6 0.0096
2164 Multidrug resistance-associated protein 4 ABCC4 0.0095
738 Monocarboxylate transporter 1 SLC16A1 0.0092
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0083
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0083
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.008
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.008
6030 Cytochrome P450 2B6 CYP2B6 0.0077
275 Arachidonate 5-lipoxygenase ALOX5 0.0076
6103 Arylamine N-acetyltransferase 1 NAT1 0.0076
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0074
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0069
1757 Myeloperoxidase MPO 0.0069
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0066
6500 Phospholipase A2 PLA2G1B 0.0063
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0063
6024 Cytochrome P450 1A1 CYP1A1 0.0062
489 Monocarboxylate transporter 2 SLC16A7 0.0062
723 Cytosolic phospholipase A2 PLA2G4A 0.0061
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0059
6106 Cytochrome P450 2C18 CYP2C18 0.0057
54 Prothrombin F2 0.0056
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0053
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0052
26 Vascular endothelial growth factor receptor 3 FLT4 0.0049
891 Dihydropteroate synthase folP 0.0049
5359 Dihydropteroate synthase folP 0.0049
7175 Dihydropteroate synthase sulI 0.0049
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0048
459 Retinoic acid receptor RXR-alpha RXRA 0.0048
32 Vascular endothelial growth factor receptor 1 FLT1 0.0047
862 Multidrug resistance-associated protein 1 ABCC1 0.0045
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0045
228 Beta platelet-derived growth factor receptor PDGFRB 0.0044
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0044
504 Mast/stem cell growth factor receptor KIT 0.0041
407 Vascular endothelial growth factor receptor 2 KDR 0.0038
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0038
341 5-hydroxytryptamine 3 receptor HTR3A 0.0038
6142 Solute carrier family 22 member 8 SLC22A8 0.0036
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0035
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0034
5798 Mitogen-activated protein kinase 11 MAPK11 0.0033
2021 Thrombomodulin THBD 0.0033
824 Sodium-dependent serotonin transporter SLC6A4 0.0033
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0033
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0032
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0032
1353 DNA topoisomerase 1 TOP1 0.0032
3552 DNA topoisomerase 1 topA 0.0032
1192 Sulfotransferase 1A1 SULT1A1 0.0032
1275 Estrogen sulfotransferase SULT1E1 0.003
267 Plasminogen activator inhibitor 1 SERPINE1 0.003
1050 Bile salt sulfotransferase SULT2A1 0.0029
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0029
6221 Steroid hormone receptor ERR1 ESRRA 0.0029
6013 Cytochrome P450 2E1 CYP2E1 0.0029
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0028
1024 Solute carrier family 22 member 11 SLC22A11 0.0028
1039 Histone deacetylase 9 HDAC9 0.0027
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0027
6143 Solute carrier family 22 member 7 SLC22A7 0.0027
3937 Fatty-acid amide hydrolase FAAH 0.0026
936 Ephrin type-A receptor 2 EPHA2 0.0025
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0025
6042 Prostaglandin reductase 2 PTGR2 0.0025
5787 Angiopoietin-1 receptor TEK 0.0025
165 FL cytokine receptor FLT3 0.0025
1618 High affinity nerve growth factor receptor NTRK1 0.0025
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0024
638 D(3) dopamine receptor DRD3 0.0024
823 Fibroblast growth factor receptor 2 FGFR2 0.0024
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0024
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0024
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0024
1792 Tissue-type plasminogen activator PLAT 0.0023
6043 Putative G-protein coupled receptor 44 GPR44 0.0023
3809 Estrogen-related receptor gamma ESRRG 0.0023
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0023
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0022
273 Apoptosis regulator Bcl-2 BCL2 0.0022
6147 Solute carrier family 22 member 3 SLC22A3 0.0022
6085 Fatty acid-binding protein, intestinal FABP2 0.0022
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0022
23 D(1A) dopamine receptor DRD1 0.0022
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0021
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.002
502 5-hydroxytryptamine 2A receptor HTR2A 0.002
831 D(2) dopamine receptor DRD2 0.002
1313 Lactoylglutathione lyase GLO1 0.0019
3923 Cholinesterase BCHE 0.0019
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0019
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0019
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0019
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0018
2981 Phospholipase A2, membrane associated PLA2G2A 0.0018
6031 Cytochrome P450 3A43 CYP3A43 0.0018
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0018
1898 Cytochrome P450 1B1 CYP1B1 0.0018
6137 Multidrug resistance-associated protein 6 ABCC6 0.0017
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0016
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0016
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0016
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0016
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0016
6141 Sodium/bile acid cotransporter SLC10A1 0.0016
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0016
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0016
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0016
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0016
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0015
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0015
776 Bile salt export pump ABCB11 0.0015
3811 Cytochrome P450 19A1 CYP19A1 0.0015
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0014
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0014
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0014
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0014
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0014
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0014
118 Organic cation/carnitine transporter 2 SLC22A5 0.0013
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0013
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