DB04796 - Inecalcitol
| Identification | |
|---|---|
| Name | Inecalcitol |
| Accession Number | DB04796 |
| Type | small molecule |
| Description | Not Available |
| Structure |
|
| Categories (*) | |
| Molecular Weight | 412.6047 |
| Groups | experimental |
| Monoisotopic Weight | 412.297745146 |
| Pharmacology | |
| Indication | Investigated for use/treatment in prostate cancer, psoriasis and hyperparathyroidism. |
| Mechanism of action | Inecalcitol is an analogue of calcitriol, the naturally active metabolite of vitamin D. Calcitriol and their analogues activate the vitamin D receptor (VDR). Vitamin D has a major role in regulating calcium absorption from the gut, storage in mineral form in the bones, and excretion by the kidney and effectively prevents rickets in infants. Vitamin D and calcitriol can cause hypercalcemia at high or frequently repeated doses; in turn, hypercalcemia can cause kidney toxicity by accumulation of calcium-containing micro-crystals and heart and muscle dysfunction by impairing contractions. [Hybrigenics Website] The mechanism of action is currently unknown, but it is proposed that inecalcitol exerts its superagonistic action through enhancing coactivator binding by the VDR. |
| Absorption | Not Available |
| Protein binding | Not Available |
| Biotransformation | Not Available |
| Route of elimination | Not Available |
| Toxicity | Not Available |
| Affected organisms | Not Available |
| Interactions | |
| Drug Interactions | Not Available |
| Food Interactions | Not Available |
Targets
| Vitamin D3 receptor | |
|---|---|
| Name | Vitamin D3 receptor |
| Gene Name | VDR |
| Pharmacological action | unknown |
| Actions | Not Available |
| References |
|
| DTHybrid score | 0.941 |
Predictions
| Id | Partner name | Gene Name | Score |
|---|---|---|---|
| 3997 | Cytochrome P450 24A1, mitochondrial | CYP24A1 | 0.1823 |
| 493 | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial | CYP27B1 | 0.1168 |
| 6891 | Mediator of RNA polymerase II transcription subunit 1 | MED1 | 0.0935 |
| 6228 | Nuclear receptor coactivator 1 | NCOA1 | 0.0897 |
| 1992 | Vitamin D-binding protein | GC | 0.0578 |
| 581 | Cytochrome P450 2R1 | CYP2R1 | 0.0377 |
| 606 | Cytochrome P450 27, mitochondrial | CYP27A1 | 0.0339 |
| 4512 | Cytochrome P450 3A4 | CYP3A4 | 0.0314 |
| 1757 | Myeloperoxidase | MPO | 0.0248 |
| 6025 | UDP-glucuronosyltransferase 1-4 | UGT1A4 | 0.0216 |
| 6182 | Cytochrome P450 2J2 | CYP2J2 | 0.0079 |
| 6017 | Cholesterol side-chain cleavage enzyme, mitochondrial | CYP11A1 | 0.006 |
| 6024 | Cytochrome P450 1A1 | CYP1A1 | 0.0041 |
| 6030 | Cytochrome P450 2B6 | CYP2B6 | 0.0039 |
| 4924 | Cytochrome P450 2C8 | CYP2C8 | 0.0036 |
| 6016 | Cytochrome P450 2C19 | CYP2C19 | 0.0034 |
| 4757 | Cytochrome P450 2C9 | CYP2C9 | 0.0033 |
| 4119 | Cytochrome P450 2D6 | CYP2D6 | 0.0032 |