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DB04788 - Tagetitoxin


Identification
Name Tagetitoxin
Accession Number DB04788
Type small molecule
Description Tagetitoxin is a bacterial phytotoxin. It preferentially inhibits eukaryotic RNA polymerase.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 416.298
Groups experimental
Monoisotopic Weight 416.029066598
Pharmacology
Indication Not Available
Mechanism of action Tagetitoxin inhibits all RNAP catalytic reactions. Tagetitoxin binding is mediated exclusively through polar interactions with the beta and beta' residues whose substitutions confer resistance to tagetitoxin in vitro.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


DNA-directed RNA polymerase beta chain
Name DNA-directed RNA polymerase beta chain
Gene Name rpoB
Pharmacological action unknown
Actions Not Available
References
  • Vassylyev DG, Svetlov V, Vassylyeva MN, Perederina A, Igarashi N, Matsugaki N, Wakatsuki S, Artsimovitch I: Structural basis for transcription inhibition by tagetitoxin. Nat Struct Mol Biol. 2005 Dec;12(12):1086-93. Epub 2005 Nov 6. - Pubmed
DTHybrid score 1.1104
DNA-directed RNA polymerase beta' chain
Name DNA-directed RNA polymerase beta' chain
Gene Name rpoC
Pharmacological action unknown
Actions Not Available
References
  • Vassylyev DG, Svetlov V, Vassylyeva MN, Perederina A, Igarashi N, Matsugaki N, Wakatsuki S, Artsimovitch I: Structural basis for transcription inhibition by tagetitoxin. Nat Struct Mol Biol. 2005 Dec;12(12):1086-93. Epub 2005 Nov 6. - Pubmed
DTHybrid score Not Available

Predictions


Id Partner name Gene Name Score
284 DNA-directed RNA polymerase beta chain rpoB 1.1104
208 DNA-directed RNA polymerase beta' chain rpoC 1.1104
5775 DNA-directed RNA polymerase omega chain rpoZ 0.4926
5776 RNA polymerase pricipal sigma factor TTHA0532 0.4922
512 DNA-directed RNA polymerase alpha chain rpoA 0.2828
5772 DNA-directed RNA polymerase alpha chain rpoA 0.2828
6769 DNA-directed RNA polymerase subunit alpha rpoA 0.2828
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