DT-Web

DB04674 - 2-HYDROXY-3,5-DIIODOBENZOIC ACID


Identification
Name 2-HYDROXY-3,5-DIIODOBENZOIC ACID
Accession Number DB04674
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 389.9138
Groups experimental
Monoisotopic Weight 389.824980834
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Endothelin-1 receptor
Name Endothelin-1 receptor
Gene Name EDNRA
Pharmacological action unknown
Actions Not Available
References
  • Blandin V, Vigne P, Breittmayer JP, Frelin C: Allosteric inhibition of endothelin ETA receptors by 3, 5-dibromosalicylic acid. Mol Pharmacol. 2000 Dec;58(6):1461-9. - Pubmed
DTHybrid score 0.5158
Aldo-keto reductase family 1 member C1
Name Aldo-keto reductase family 1 member C1
Gene Name AKR1C1
Pharmacological action unknown
Actions Not Available
References
  • Dhagat U, Carbone V, Chung RP, Matsunaga T, Endo S, Hara A, El-Kabbani O: A salicylic acid-based analogue discovered from virtual screening as a potent inhibitor of human 20alpha-hydroxysteroid dehydrogenase. Med Chem. 2007 Nov;3(6):546-50. - Pubmed
DTHybrid score 0.6261

Carriers


Predictions


Id Partner name Gene Name Score
49 Endothelin B receptor EDNRB 0.2094
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.1313
4757 Cytochrome P450 2C9 CYP2C9 0.0775
4512 Cytochrome P450 3A4 CYP3A4 0.0629
776 Bile salt export pump ABCB11 0.0465
6016 Cytochrome P450 2C19 CYP2C19 0.0457
290 Prostaglandin G/H synthase 2 PTGS2 0.0308
20 Prostaglandin G/H synthase 1 PTGS1 0.029
587 Serum albumin ALB 0.025
1275 Estrogen sulfotransferase SULT1E1 0.0244
1729 Solute carrier family 22 member 6 SLC22A6 0.0242
1588 Multidrug resistance protein 1 ABCB1 0.0209
6143 Solute carrier family 22 member 7 SLC22A7 0.0201
6258 Protein S100-A7 S100A7 0.0191
6149 Solute carrier family 22 member 10 SLC22A10 0.0154
520 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0132
2306 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0132
2367 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0132
4924 Cytochrome P450 2C8 CYP2C8 0.013
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0118
6142 Solute carrier family 22 member 8 SLC22A8 0.0115
2183 Fatty acid-binding protein, adipocyte FABP4 0.0114
738 Monocarboxylate transporter 1 SLC16A1 0.0108
1024 Solute carrier family 22 member 11 SLC22A11 0.0099
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0098
594 Thyroxine-binding globulin SERPINA7 0.0082
758 Thyroid hormone receptor alpha THRA 0.008
346 Thyroid hormone receptor beta-1 THRB 0.0079
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.007
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0065
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0064
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0062
869 Estrogen receptor beta ESR2 0.006
646 Malate dehydrogenase, cytoplasmic MDH1 0.0059
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0058
666 NADP-dependent malic enzyme ME1 0.0058
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0057
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0056
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0055
5346 Oxidoreductase, aldo/keto reductase family TM_1009 0.0054
4403 Protein iolS iolS 0.0054
5330 General stress protein 69 yhdN 0.0054
5322 Oxidoreductase ydhF ydhF 0.0054
5333 Alcohol dehydrogenase, iron-containing TM_0920 0.0054
5326 Oxidoreductase, short chain dehydrogenase/reductase family TM_0441 0.0054
5157 Dehydrogenase/reductase SDR family member 11 DHRS11 0.0054
5332 MtdA bifunctional protein mtdA 0.0054
5342 NADH-dependent butanol dehydrogenase, putative TM_0820 0.0054
3772 3-oxoacyl-[acyl-carrier-protein] reductase fabG 0.0054
3778 NAD(P) transhydrogenase subunit beta pntB 0.0054
5343 NADP-dependent fatty aldehyde dehydrogenase aldH 0.0054
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0052
146 Androgen receptor AR 0.0051
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0051
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.005
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0048
136 Estrogen receptor ESR1 0.0048
2375 ADP-L-glycero-D-manno-heptose-6-epimerase hldD 0.0047
654 Flavin reductase BLVRB 0.0047
5073 Ferredoxin--NADP reductase petH 0.0047
5076 Ferredoxin--NADP reductase fpr 0.0047
5119 Ferredoxin--NADP reductase petH 0.0047
5121 Ferredoxin--NADP reductase fpr 0.0047
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0047
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0046
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0046
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0046
5328 Prostaglandin F synthase Tb11.02.2310 0.0046
2305 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 0.0046
4582 Putative pteridine reductase 2 ptr2 0.0046
2286 Isocitrate dehydrogenase [NADP] icd 0.0046
2302 Isocitrate dehydrogenase [NADP] icd 0.0046
2771 Isocitrate dehydrogenase [NADP] icd 0.0046
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0046
989 L-xylulose reductase DCXR 0.0046
3446 NADP-dependent alcohol dehydrogenase adh 0.0046
2636 Shikimate dehydrogenase aroE 0.0046
3515 Shikimate dehydrogenase aroE 0.0046
199 Monocarboxylate transporter 8 SLC16A2 0.0045
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0045
992 Protein tyrosine kinase 2 beta PTK2B 0.0045
2236 Casein kinase II subunit alpha CSNK2A1 0.0045
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0044
4119 Cytochrome P450 2D6 CYP2D6 0.0044
4200 Cytochrome P450 1A2 CYP1A2 0.0044
444 Alcohol dehydrogenase 1B ADH1B 0.0043
6862 Aldo-keto reductase family 1 member B10 AKR1B10 0.0043
4531 Putative ketoacyl reductase actIII 0.0042
6297 Prostaglandin reductase 1 PTGR1 0.0042
3062 Aspartate-semialdehyde dehydrogenase asd 0.0042
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0042
6141 Sodium/bile acid cotransporter SLC10A1 0.0041
2675 Pteridine reductase 1 PTR1 0.0041
2159 Quinone oxidoreductase CRYZ 0.004
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.004
1124 Sepiapterin reductase SPR 0.004
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.004
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.004
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0037
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0037
6228 Nuclear receptor coactivator 1 NCOA1 0.0037
822 Aldose reductase AKR1B1 0.0037
6241 Nuclear receptor coactivator 2 NCOA2 0.0036
3809 Estrogen-related receptor gamma ESRRG 0.0036
365 Dihydrofolate reductase DHFR 0.0035
2381 Dihydrofolate reductase DFR1 0.0035
2833 Dihydrofolate reductase Not Available 0.0035
2931 Dihydrofolate reductase folA 0.0035
3544 Dihydrofolate reductase folA 0.0035
3682 Dihydrofolate reductase folA 0.0035
6642 Dihydrofolate reductase folA 0.0035
6756 Dihydrofolate reductase dfrA 0.0035
6151 Monocarboxylate transporter 10 SLC16A10 0.0035
6024 Cytochrome P450 1A1 CYP1A1 0.0032
862 Multidrug resistance-associated protein 1 ABCC1 0.0032
1898 Cytochrome P450 1B1 CYP1B1 0.003
3810 Catechol O-methyltransferase COMT 0.0027
76 Nitric-oxide synthase, brain NOS1 0.0027
4120 NADPH--cytochrome P450 reductase POR 0.0027
817 DNA topoisomerase 2-alpha TOP2A 0.0026
6013 Cytochrome P450 2E1 CYP2E1 0.0024
3811 Cytochrome P450 19A1 CYP19A1 0.0021
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0019
5718 Cytochrome P450 2A6 CYP2A6 0.0018
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0018
816 Biliverdin reductase A BLVRA 0.0018
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0018
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0018
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0018
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0017
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0017
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0017
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0017
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0017
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0017
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0017
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0017
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0017
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0017
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0017
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0017
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0017
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0017
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0017
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0017
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0017
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0017
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0017
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0017
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0017
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0017
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0017
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0017
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0017
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0017
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0017
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0017
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0017
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0017
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0017
644 Heme oxygenase 2 HMOX2 0.0017
4982 Heme oxygenase 2 pbsA2 0.0017
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0017
729 GDP-L-fucose synthetase TSTA3 0.0017
3463 GDP-L-fucose synthetase fcl 0.0017
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0017
167 L-lactate dehydrogenase C chain LDHC 0.0017
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0017
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0017
206 3-keto-steroid reductase HSD17B7 0.0017
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0017
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0017
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0017
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0017
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0017
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0017
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0017
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0017
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0017
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0017
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0017
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0017
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0017
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0017
711 UDP-glucose 6-dehydrogenase UGDH 0.0017
3672 UDP-glucose 6-dehydrogenase hasB 0.0017
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0017
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0017
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0017
107 C-4 methylsterol oxidase SC4MOL 0.0017
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0017
3726 D-3-phosphoglycerate dehydrogenase serA 0.0017
4291 D-3-phosphoglycerate dehydrogenase serA 0.0017
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0017
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0017
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0017
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0017
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0017
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0017
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0017
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0017
643 Peroxisomal bifunctional enzyme EHHADH 0.0017
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0017
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0017
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0017
34 7-dehydrocholesterol reductase DHCR7 0.0017
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0017
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0017
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0017
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0017
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0017
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0016
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0016
328 Sorbitol dehydrogenase SORD 0.0016
597 Dihydropteridine reductase QDPR 0.0016
396 Alcohol dehydrogenase 4 ADH4 0.0016
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0016
857 Malate dehydrogenase, mitochondrial MDH2 0.0016
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0016
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0016
77 L-lactate dehydrogenase B chain LDHB 0.0016
12 Alcohol dehydrogenase class 3 ADH5 0.0015
2981 Phospholipase A2, membrane associated PLA2G2A 0.0015
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0015
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0015
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0015
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0015
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0015
473 L-lactate dehydrogenase A chain LDHA 0.0015
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0015
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0015
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0015
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0014
6026 Alcohol dehydrogenase 6 ADH6 0.0014
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0014
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0014
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0014
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0014
13 Aminomethyltransferase, mitochondrial AMT 0.0014
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0014
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0014
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0014
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0014
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0014
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0014
626 Cysteine dioxygenase type 1 CDO1 0.0014
627 11-cis retinol dehydrogenase RDH5 0.0014
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0014
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0014
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0014
569 Retinal dehydrogenase 2 ALDH1A2 0.0013
611 Retinal dehydrogenase 1 ALDH1A1 0.0013
251 Alcohol dehydrogenase 1A ADH1A 0.0013
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0013
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0013
810 Heme oxygenase 1 HMOX1 0.0013
3391 Heme oxygenase 1 pbsA1 0.0013
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0012
275 Arachidonate 5-lipoxygenase ALOX5 0.0012
279 Tyrosinase TYR 0.0012
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0012
380 Cytochrome P450 17A1 CYP17A1 0.0012
714 Glutathione reductase, mitochondrial GSR 0.0011
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0011
517 Alcohol dehydrogenase 1C ADH1C 0.0011
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.001
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.001
6106 Cytochrome P450 2C18 CYP2C18 0.001
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.001
468 Cytochrome P450 4A11 CYP4A11 0.001
6020 Aldehyde oxidase AOX1 0.0009
2164 Multidrug resistance-associated protein 4 ABCC4 0.0009
3947 Xanthine dehydrogenase/oxidase XDH 0.0009
6030 Cytochrome P450 2B6 CYP2B6 0.0008
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