DT-Web

DB04628 - Allosamidin


Identification
Name Allosamidin
Accession Number DB04628
Type small molecule
Description Allosamidin exhibits extremely potent inhibitory activity against chitinases from a number of sources, particularly from Candida albicans, and can be utilized as potent antifungal agent.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 622.6194
Groups experimental
Monoisotopic Weight 622.269752072
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Chitinase B
Name Chitinase B
Gene Name chiB
Pharmacological action unknown
Actions Not Available
References
  • Cederkvist FH, Saua SF, Karlsen V, Sakuda S, Eijsink VG, Sorlie M: Thermodynamic analysis of allosamidin binding to a family 18 chitinase. Biochemistry. 2007 Oct 30;46(43):12347-54. Epub 2007 Oct 4. - Pubmed
  • Vaaje-Kolstad G, Houston DR, Rao FV, Peter MG, Synstad B, van Aalten DM, Eijsink VG: Structure of the D142N mutant of the family 18 chitinase ChiB from Serratia marcescens and its complex with allosamidin. Biochim Biophys Acta. 2004 Jan 14;1696(1):103-11. - Pubmed
DTHybrid score 1.9027
Chitinase A
Name Chitinase A
Gene Name chiA
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 1.0531

Predictions


Id Partner name Gene Name Score
1682 Chitotriosidase-1 CHIT1 0.4837
5362 Chitinase chiB1 0.1714
6883 Chitinase chiB 0.1714
2033 Beta-hexosaminidase beta chain HEXB 0.1178
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