DB04626 - Apramycin
| Identification | |||||
|---|---|---|---|---|---|
| Name | Apramycin | ||||
| Accession Number | DB04626 | ||||
| Type | small molecule | ||||
| Description | Apramycin is an aminoglycoside antibiotic and has a bactericidal action against many gram-negative bacteria. Apramycin is a structurally unique antibiotic that contains a bicyclic sugar moiety and a monosubstituted deoxystreptamine. It is not approved for use in humans. | ||||
| Structure |
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| Categories (*) | |||||
| Molecular Weight | 539.5771 | ||||
| Groups | experimental | ||||
| Monoisotopic Weight | 539.280257179 | ||||
| Pharmacology | |||||
| Indication | For the treatment of bacterial infections in animals. | ||||
| Mechanism of action | Apramycin stands out among aminoglycosides for its mechanism of action which is based on blocking translocation and its ability to bind also to the eukaryotic decoding site despite differences in key residues required for apramycin recognition by the bacterial target. The drug binds in the deep groove of the RNA which forms a continuously stacked helix comprising non-canonical C.A and G.A base pairs and a bulged-out adenine. The binding mode of apramycin at the human decoding-site RNA is distinct from aminoglycoside recognition of the bacterial target, suggesting a molecular basis for the actions of apramycin in eukaryotes and bacteria. | ||||
| Absorption | Not Available | ||||
| Protein binding | Not Available | ||||
| Biotransformation | Not Available | ||||
| Route of elimination | Not Available | ||||
| Toxicity | Not Available | ||||
| Affected organisms |
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| Interactions | |||||
| Drug Interactions |
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| Food Interactions | Not Available | ||||
Targets
| 16S rRNA | |
|---|---|
| Name | 16S rRNA |
| Gene Name | Not Available |
| Pharmacological action | unknown |
| Actions | Not Available |
| References |
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| DTHybrid score | Not Available |
Predictions
| Id | Partner name | Gene Name | Score |
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