DT-Web

DB04599 - Aniracetam


Identification
Name Aniracetam
Accession Number DB04599
Type small molecule
Description Compound with anti-depressive properties used as a mental performance enhancer.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 219.2365
Groups experimental
Monoisotopic Weight 219.089543287
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


5-hydroxytryptamine 2A receptor
Name 5-hydroxytryptamine 2A receptor
Gene Name HTR2A
Pharmacological action unknown
Actions Not Available
References
  • Nakamura K, Kurasawa M: Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism. Eur J Pharmacol. 2001 May 18;420(1):33-43. - Pubmed
DTHybrid score 0.2913
D(2) dopamine receptor
Name D(2) dopamine receptor
Gene Name DRD2
Pharmacological action unknown
Actions Not Available
References
  • Nakamura K, Kurasawa M: Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism. Eur J Pharmacol. 2001 May 18;420(1):33-43. - Pubmed
DTHybrid score 0.3494
Glutamate receptor 2
Name Glutamate receptor 2
Gene Name GRIA2
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.8827
Glutamate receptor 3
Name Glutamate receptor 3
Gene Name GRIA3
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.2925

Predictions


Id Partner name Gene Name Score
1387 Inositol monophosphatase 2 IMPA2 0.1283
23 D(1A) dopamine receptor DRD1 0.1272
2026 Inositol monophosphatase IMPA1 0.1117
4119 Cytochrome P450 2D6 CYP2D6 0.0899
320 5-hydroxytryptamine 1A receptor HTR1A 0.0831
590 5-hydroxytryptamine 2C receptor HTR2C 0.0809
638 D(3) dopamine receptor DRD3 0.076
556 Alpha-1A adrenergic receptor ADRA1A 0.0755
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0754
1721 Glycogen synthase kinase-3 beta GSK3B 0.072
4512 Cytochrome P450 3A4 CYP3A4 0.0603
432 D(4) dopamine receptor DRD4 0.0591
318 Alpha-2A adrenergic receptor ADRA2A 0.0567
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0516
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0516
4200 Cytochrome P450 1A2 CYP1A2 0.0502
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0479
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0468
632 Alpha-1B adrenergic receptor ADRA1B 0.0463
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0452
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0451
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0448
163 D(1B) dopamine receptor DRD5 0.0448
436 5-hydroxytryptamine 2B receptor HTR2B 0.044
378 Alpha-2C adrenergic receptor ADRA2C 0.0434
716 5-hydroxytryptamine 7 receptor HTR7 0.0425
629 Alpha-2B adrenergic receptor ADRA2B 0.0422
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0414
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0414
492 Histamine H1 receptor HRH1 0.0398
1588 Multidrug resistance protein 1 ABCB1 0.0377
725 5-hydroxytryptamine 1D receptor HTR1D 0.0346
885 5-hydroxytryptamine 1B receptor HTR1B 0.0311
4757 Cytochrome P450 2C9 CYP2C9 0.027
1256 5-hydroxytryptamine 6 receptor HTR6 0.027
6016 Cytochrome P450 2C19 CYP2C19 0.0264
824 Sodium-dependent serotonin transporter SLC6A4 0.0264
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0261
274 Muscarinic acetylcholine receptor M5 CHRM5 0.025
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0243
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0242
6145 Solute carrier family 22 member 1 SLC22A1 0.0241
789 Alpha-1D adrenergic receptor ADRA1D 0.0236
540 Sodium-dependent noradrenaline transporter SLC6A2 0.022
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0194
174 Sigma 1-type opioid receptor SIGMAR1 0.0194
587 Serum albumin ALB 0.0193
6013 Cytochrome P450 2E1 CYP2E1 0.019
94 5-hydroxytryptamine 4 receptor HTR4 0.0185
4118 Cytochrome P450 3A5 CYP3A5 0.0183
6030 Cytochrome P450 2B6 CYP2B6 0.0183
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0175
6107 Cytochrome P450 3A7 CYP3A7 0.0171
4924 Cytochrome P450 2C8 CYP2C8 0.0157
131 Synaptic vesicular amine transporter SLC18A2 0.0131
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0127
465 Calmodulin CALM1 0.0118
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0109
713 Sodium-dependent dopamine transporter SLC6A3 0.0103
341 5-hydroxytryptamine 3 receptor HTR3A 0.0102
3923 Cholinesterase BCHE 0.01
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0097
172 Potassium channel subfamily K member 1 KCNK1 0.0095
3426 Glutamine synthetase glnA 0.0093
3987 Glutamine synthetase GLUL 0.0093
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0091
922 Glutamate receptor 4 GRIA4 0.0088
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0084
528 5-hydroxytryptamine 1E receptor HTR1E 0.0084
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0082
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0081
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0081
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0081
4027 Glutamate receptor delta-1 subunit GRID1 0.0081
4018 Glutamate receptor delta-2 subunit GRID2 0.0081
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0081
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0081
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0081
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0081
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0081
664 Glutamate decarboxylase 2 GAD2 0.0081
3890 Glutamate decarboxylase 2 GAD2 0.0081
1912 Excitatory amino acid transporter 1 SLC1A3 0.0081
4016 Excitatory amino acid transporter 5 SLC1A7 0.0081
4019 Excitatory amino acid transporter 4 SLC1A6 0.0081
1047 Excitatory amino acid transporter 2 SLC1A2 0.0081
927 Metabotropic glutamate receptor 8 GRM8 0.0081
925 Metabotropic glutamate receptor 4 GRM4 0.0081
926 Metabotropic glutamate receptor 7 GRM7 0.0081
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0081
4026 Aspartyl aminopeptidase DNPEP 0.0081
4020 Glutamyl aminopeptidase ENPEP 0.0081
4017 5-oxoprolinase OPLAH 0.0081
3941 Amine oxidase [flavin-containing] A MAOA 0.0077
474 Acetylcholinesterase ACHE 0.0072
625 Glutamate carboxypeptidase 2 FOLH1 0.007
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.007
5718 Cytochrome P450 2A6 CYP2A6 0.0068
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0068
5 Glutaminase liver isoform, mitochondrial GLS2 0.0068
917 Glutaminase kidney isoform, mitochondrial GLS 0.0068
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0068
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0068
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0068
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0068
5261 Phosphoribosylformylglycinamidine synthase purL 0.0068
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0067
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0065
665 Phosphoserine aminotransferase PSAT1 0.0065
4652 Phosphoserine aminotransferase serC 0.0065
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0065
420 Glutamate decarboxylase 1 GAD1 0.0065
3900 Glutamate decarboxylase 1 GAD1 0.0065
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0065
916 Metabotropic glutamate receptor 1 GRM1 0.0064
6144 Solute carrier family 22 member 2 SLC22A2 0.0063
3939 Amine oxidase [flavin-containing] B MAOB 0.0061
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0061
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0061
124 Histamine H2 receptor HRH2 0.0061
1671 Excitatory amino acid transporter 3 SLC1A1 0.006
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.006
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0059
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0059
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0059
3877 Growth-inhibiting protein 18 GIG18 0.0059
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0059
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0059
426 Aspartate aminotransferase, mitochondrial GOT2 0.0058
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0058
763 Tyrosine aminotransferase TAT 0.0057
5493 Tyrosine aminotransferase Not Available 0.0057
3904 Alanine aminotransferase 2 GPT2 0.0056
735 Alanine aminotransferase 1 GPT 0.0056
705 Glutamate receptor 1 GRIA1 0.0056
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0055
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0055
6151 Monocarboxylate transporter 10 SLC16A10 0.0055
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0055
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0054
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0053
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0053
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0052
33 Cystine/glutamate transporter SLC7A11 0.0051
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0051
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0049
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0048
6024 Cytochrome P450 1A1 CYP1A1 0.0046
6106 Cytochrome P450 2C18 CYP2C18 0.0042
6432 Transporter snf 0.0042
738 Monocarboxylate transporter 1 SLC16A1 0.0042
6859 Protein S100-A4 S100A4 0.0041
20 Prostaglandin G/H synthase 1 PTGS1 0.004
694 Matrix protein 2 M 0.0039
3937 Fatty-acid amide hydrolase FAAH 0.0038
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0036
380 Cytochrome P450 17A1 CYP17A1 0.0035
427 Substance-P receptor TACR1 0.0034
776 Bile salt export pump ABCB11 0.0033
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0031
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.003
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0027
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0027
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0025
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0024
696 Kappa-type opioid receptor OPRK1 0.0024
6147 Solute carrier family 22 member 3 SLC22A3 0.0024
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0023
193 Beta-1 adrenergic receptor ADRB1 0.0023
766 Beta-2 adrenergic receptor ADRB2 0.0022
3947 Xanthine dehydrogenase/oxidase XDH 0.002
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.002
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.002
1898 Cytochrome P450 1B1 CYP1B1 0.002
1656 CYP2B protein CYP2B 0.0019
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0018
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0018
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0018
164 Histamine H4 receptor HRH4 0.0017
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0017
904 Glutathione S-transferase P GSTP1 0.0016
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0016
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0015
118 Organic cation/carnitine transporter 2 SLC22A5 0.0015
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0015
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0015
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0014
153 Dopamine beta-hydroxylase DBH 0.0014
1360 Sphingomyelin phosphodiesterase SMPD1 0.0014
833 Organic cation/carnitine transporter 1 SLC22A4 0.0014
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0013
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0012
468 Cytochrome P450 4A11 CYP4A11 0.0012
3810 Catechol O-methyltransferase COMT 0.0012
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.001
1618 High affinity nerve growth factor receptor NTRK1 0.001
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0009
862 Multidrug resistance-associated protein 1 ABCC1 0.0009
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0008
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0007
467 Delta-type opioid receptor OPRD1 0.0006
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