DT-Web

DB04463 - 3-(4-Amino-1-Tert-Butyl-1h-Pyrazolo[3,4-D]Pyrimidin-3-Yl)Phenol


Identification
Name 3-(4-Amino-1-Tert-Butyl-1h-Pyrazolo[3,4-D]Pyrimidin-3-Yl)Phenol
Accession Number DB04463 (EXPT00389)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 283.3284
Groups experimental
Monoisotopic Weight 283.143310191
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Carbonyl reductase [NADPH] 1
Name Carbonyl reductase [NADPH] 1
Gene Name CBR1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.6246

Enzymes


Carbonyl reductase [NADPH] 1
Name Carbonyl reductase [NADPH] 1
Gene Name CBR1
Actions Not Available
References Not Available
DTHybrid score 0.6246

Predictions


Id Partner name Gene Name Score
5354 DevB protein VC_A0897 0.138
842 Chloride channel protein 2 CLCN2 0.1214
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0769
131 Synaptic vesicular amine transporter SLC18A2 0.0377
831 D(2) dopamine receptor DRD2 0.0316
4119 Cytochrome P450 2D6 CYP2D6 0.0262
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0101
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.009
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0078
1588 Multidrug resistance protein 1 ABCB1 0.0076
638 D(3) dopamine receptor DRD3 0.0076
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0075
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0075
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0075
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0074
6168 Solute carrier family 22 member 16 SLC22A16 0.0074
4512 Cytochrome P450 3A4 CYP3A4 0.0067
23 D(1A) dopamine receptor DRD1 0.0067
502 5-hydroxytryptamine 2A receptor HTR2A 0.0064
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0062
6024 Cytochrome P450 1A1 CYP1A1 0.0059
4120 NADPH--cytochrome P450 reductase POR 0.0056
6107 Cytochrome P450 3A7 CYP3A7 0.0055
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0055
76 Nitric-oxide synthase, brain NOS1 0.0055
6137 Multidrug resistance-associated protein 6 ABCC6 0.0053
4118 Cytochrome P450 3A5 CYP3A5 0.0052
6016 Cytochrome P450 2C19 CYP2C19 0.005
6148 Multidrug resistance-associated protein 7 ABCC10 0.005
7 Nitric oxide synthase, inducible NOS2 0.0049
4200 Cytochrome P450 1A2 CYP1A2 0.0049
291 Nitric-oxide synthase, endothelial NOS3 0.0048
4757 Cytochrome P450 2C9 CYP2C9 0.0048
3947 Xanthine dehydrogenase/oxidase XDH 0.0047
817 DNA topoisomerase 2-alpha TOP2A 0.0046
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0044
776 Bile salt export pump ABCB11 0.0043
1898 Cytochrome P450 1B1 CYP1B1 0.0043
862 Multidrug resistance-associated protein 1 ABCC1 0.0039
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0037
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0036
6030 Cytochrome P450 2B6 CYP2B6 0.0034
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