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DB04338 - SB220025


Identification
Name SB220025
Accession Number DB04338 (EXPT02849)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 338.3821
Groups experimental
Monoisotopic Weight 338.165522843
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Mitogen-activated protein kinase 14
Name Mitogen-activated protein kinase 14
Gene Name MAPK14
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 2.01
Mitogen-activated protein kinase 1
Name Mitogen-activated protein kinase 1
Gene Name MAPK1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.0273

Predictions


Id Partner name Gene Name Score
1372 Insulin receptor substrate 1 IRS1 0.065
1836 Mitogen-activated protein kinase 10 MAPK10 0.0554
36 Insulin receptor INSR 0.0421
1714 Mitogen-activated protein kinase 3 MAPK3 0.0352
3959 Cell division protein kinase 4 CDK4 0.0284
1742 D-HSCDK2 CDK2deltaT 0.0274
1771 Cell division control protein 2 homolog CDK1 0.0274
3321 Cell division control protein 2 homolog CRK2 0.0274
2240 Cell division protein kinase 2 CDK2 0.0269
1058 Cell division protein kinase 5 CDK5 0.0266
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.023
4750 Protein S100-A11 S100A11 0.0216
3060 Leukotriene A-4 hydrolase LTA4H 0.0209
3482 Cell division protein kinase 7 CDK7 0.0189
4751 Mitogen-activated protein kinase 12 MAPK12 0.0189
3005 Threonine-phosphate decarboxylase cobD 0.0188
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0181
2530 Protein kinase C theta type PRKCQ 0.0174
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0173
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0173
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0173
1422 Serine/threonine-protein kinase 6 AURKA 0.0135
1517 Beta-3 adrenergic receptor ADRB3 0.0127
2207 Rhodopsin RHO 0.0122
6024 Cytochrome P450 1A1 CYP1A1 0.0115
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0109
1569 G1/S-specific cyclin-D1 CCND1 0.0106
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0102
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0102
1629 Transcription factor AP-1 JUN 0.0086
193 Beta-1 adrenergic receptor ADRB1 0.0086
766 Beta-2 adrenergic receptor ADRB2 0.0083
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0082
1898 Cytochrome P450 1B1 CYP1B1 0.0056
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0048
1588 Multidrug resistance protein 1 ABCB1 0.0038
4512 Cytochrome P450 3A4 CYP3A4 0.0033
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