DT-Web

DB04057 - Beta-Dadf, Msa, Multisubstrate Adduct Inhibitor


Identification
Name Beta-Dadf, Msa, Multisubstrate Adduct Inhibitor
Accession Number DB04057 (EXPT02233)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 815.6374
Groups experimental
Monoisotopic Weight 815.191197975
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase
Name Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase
Gene Name ATIC
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.8061

Predictions


Id Partner name Gene Name Score
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0809
1043 Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase GART 0.0356
24 Thymidylate synthase TMP1 0.0274
359 Thymidylate synthase TYMS 0.0274
2626 Thymidylate synthase thyA 0.0274
2729 Thymidylate synthase thyA 0.0274
5352 Thymidylate synthase THYA 0.0274
365 Dihydrofolate reductase DHFR 0.0272
2381 Dihydrofolate reductase DFR1 0.0272
2833 Dihydrofolate reductase Not Available 0.0272
2931 Dihydrofolate reductase folA 0.0272
3544 Dihydrofolate reductase folA 0.0272
3682 Dihydrofolate reductase folA 0.0272
6642 Dihydrofolate reductase folA 0.0272
6756 Dihydrofolate reductase dfrA 0.0272
4773 Deoxycytidine kinase DCK 0.0236
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0232
2361 Response regulator pleD pleD 0.0216
2516 GMP reductase 1 GMPR 0.0216
4106 Guanylate kinase GUK1 0.0202
4516 Guanylate kinase gmk 0.0202
413 Amidophosphoribosyltransferase PPAT 0.0202
2515 Amidophosphoribosyltransferase purF 0.0202
3714 Amidophosphoribosyltransferase purF 0.0202
4553 Bifunctional adenosylcobalamin biosynthesis protein cobU cobU 0.0185
338 DNA polymerase UL30 0.0173
379 DNA polymerase UL54 0.0173
697 DNA polymerase ORF28 0.0173
2482 DNA polymerase 43 0.0173
4104 DNA polymerase BALF5 0.0173
2966 PyrR bifunctional protein [Includes: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase pyrR 0.0172
3300 Xanthine phosphoribosyltransferase xpt 0.0163
3681 Xanthine phosphoribosyltransferase gpt 0.0163
2684 Histidine triad nucleotide-binding protein 1 HINT1 0.0152
2339 Protein-glutamine gamma-glutamyltransferase E TGM3 0.0147
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0122
3763 5,10-methylenetetrahydrofolate reductase metF 0.0122
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0122
5094 5,10-methylenetetrahydrofolate reductase metF 0.0122
59 AMT protein AMT 0.0122
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0122
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0122
3917 Methylenetetrahydrofolate reductase MTHFR 0.0119
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0113
13 Aminomethyltransferase, mitochondrial AMT 0.0106
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0103
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.01
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0094
3884 SHMT2 protein SHMT2 0.0089
3901 SHMT2 protein SHMT2 0.0089
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0089
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0089
3879 Serine hydroxymethyltransferase 2 Not Available 0.0089
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0087
809 Methionine synthase MTR 0.0083
2935 Methionine synthase metH 0.0083
5818 Folate receptor alpha FOLR1 0.0079
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0077
293 Gamma-glutamyl hydrolase GGH 0.0068
1650 Heme carrier protein 1 SLC46A1 0.0061
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0061
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0053
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0048
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0046
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0045
6020 Aldehyde oxidase AOX1 0.0043
738 Monocarboxylate transporter 1 SLC16A1 0.0042
6148 Multidrug resistance-associated protein 7 ABCC10 0.0041
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.004
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0038
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0037
1024 Solute carrier family 22 member 11 SLC22A11 0.0034
2164 Multidrug resistance-associated protein 4 ABCC4 0.0034
6143 Solute carrier family 22 member 7 SLC22A7 0.0034
862 Multidrug resistance-associated protein 1 ABCC1 0.0032
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0032
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0032
6142 Solute carrier family 22 member 8 SLC22A8 0.003
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.003
587 Serum albumin ALB 0.0028
1729 Solute carrier family 22 member 6 SLC22A6 0.0028
1588 Multidrug resistance protein 1 ABCB1 0.0023
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