DT-Web

DB03966 - Clorobiocin


Identification
Name Clorobiocin
Accession Number DB03966 (EXPT00847)
Type small molecule
Description Clorobiocin is an aminocoumarin antibiotic, similar to novobiocin and coumermycin A1.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 696.12
Groups experimental
Monoisotopic Weight 695.200762711
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


DNA gyrase subunit B
Name DNA gyrase subunit B
Gene Name gyrB
Pharmacological action unknown
Actions Not Available
References
  • Tsai FT, Singh OM, Skarzynski T, Wonacott AJ, Weston S, Tucker A, Pauptit RA, Breeze AL, Poyser JP, O'Brien R, Ladbury JE, Wigley DB: The high-resolution crystal structure of a 24-kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin. Proteins. 1997 May;28(1):41-52. - Pubmed
  • Hooper DC, Wolfson JS, McHugh GL, Winters MB, Swartz MN: Effects of novobiocin, coumermycin A1, clorobiocin, and their analogs on Escherichia coli DNA gyrase and bacterial growth. Antimicrob Agents Chemother. 1982 Oct;22(4):662-71. - Pubmed
DTHybrid score 0.8688

Predictions


Id Partner name Gene Name Score
4150 DNA gyrase subunit B gyrB 0.8688
6225 DNA gyrase subunit B gyrB 0.8688
477 DNA topoisomerase 4 subunit A parC 0.2638
886 DNA topoisomerase 4 subunit A parC 0.2638
6226 DNA topoisomerase 4 subunit A parC 0.2638
5645 DNA topoisomerase 4 subunit B parE 0.0136
6227 DNA topoisomerase 4 subunit B parE 0.0136
3794 Osmolarity sensor protein envZ envZ 0.0135
5643 General secretion pathway protein E epsE 0.0135
5641 Rod shape-determining protein MreB TM_0588 0.0135
4178 DNA repair protein RAD51 homolog 1 RAD51 0.0135
5644 Sensor protein phoQ phoQ 0.0135
5649 Potassium-transporting ATPase B chain kdpB 0.0135
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0135
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0135
5642 Chaperone clpB clpB 0.0135
2282 Protein recA recA 0.0126
2315 Protein recA recA 0.0126
2332 Protein recA recA 0.0126
5263 Protein recA recA 0.0126
5646 Galactokinase GALK1 0.0126
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0126
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0126
5302 TrwB trwB 0.0126
5265 FtsH ftsH 0.0126
4751 Mitogen-activated protein kinase 12 MAPK12 0.0117
740 Argininosuccinate synthase ASS1 0.0117
865 Argininosuccinate synthase ASS1 0.0117
2680 Argininosuccinate synthase argG 0.0117
3194 Argininosuccinate synthase argG 0.0117
2867 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ispE 0.0117
2397 Dihydroxyacetone kinase dhaK 0.0116
6433 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 PFKFB4 0.0116
2852 DNA mismatch repair protein mutL mutL 0.0116
5312 Kinesin-like protein KIF1A KIF1A 0.0113
3231 Death-associated protein kinase 1 DAPK1 0.011
2299 UDP-N-acetylmuramate--L-alanine ligase murC 0.0108
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0108
2615 Chemotaxis protein cheA cheA 0.0106
2371 Pantothenate kinase coaA 0.0106
2892 Acetylglutamate kinase argB 0.0105
3550 Acetylglutamate kinase argB 0.0105
825 Arsenical pump-driving ATPase ASNA1 0.0105
3435 Arsenical pump-driving ATPase arsA 0.0105
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0105
1881 Hexokinase-1 HK1 0.0105
2727 S-adenosylmethionine synthetase metK 0.01
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0099
936 Ephrin type-A receptor 2 EPHA2 0.0098
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0096
958 Insulin-like growth factor 1 receptor IGF1R 0.0095
2251 Thymidylate kinase tmk 0.0086
2254 Thymidylate kinase DTYMK 0.0086
3522 Thymidylate kinase tmk 0.0086
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0082
207 Glutathione synthetase GSS 0.0081
5269 Glutathione synthetase gshB 0.0081
4192 DNA topoisomerase 2-beta TOP2B 0.008
3822 Actin, alpha skeletal muscle ACTA1 0.008
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0079
1836 Mitogen-activated protein kinase 10 MAPK10 0.0077
1721 Glycogen synthase kinase-3 beta GSK3B 0.0074
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0074
2236 Casein kinase II subunit alpha CSNK2A1 0.0072
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